[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preterm-babies\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preterm-babies":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100607678","mechanisms-affecting-the-gut-of-preterm-infants-receiving-blood-transfusion-with-different-enteral-feed-interventions-100607678",false,"NCT07191678","Mechanisms Affecting the Gut of Preterm Infants Receiving Blood Transfusion With Different Enteral Feed Interventions","MAGPIE-2","Inclusion Criteria:\n\n* Very preterm babies (born between 23 to \\\u003C30 weeks of gestational age ) in the WHEAT International trial\n* Written informed consent from parents\n\nExclusion Criteria:\n\n* Babies who are deemed too unstable to perform the non-invasive monitoring and the ultrasound scan measurements by the attending clinical team\n* Babies who have already developed Bells stage 2 NEC, had bowel surgery or congenital abdominal conditions such as congenital diaphragmatic hernia, gastroschisis and exomphalos","ALL","23 Weeks","30 Weeks",{"count":20,"type":21},270,"ESTIMATED","OBSERVATIONAL","MAGPIE-2 is a prospective observational study designed to investigate the physiological mechanisms linking blood transfusion and enteral feeding practices to gut perfusion and oxygenation in very preterm infants. The study is nested within the WHEAT International randomised controlled trial, which compares two standard care approaches: withholding versus continuing milk feeds during red blood cell transfusion. While WHEAT evaluates clinical outcomes such as necrotising enterocolitis (NEC), MAGPIE-2 focuses on the underlying physiological changes that may contribute to NEC development.\n\nNEC is a serious gastrointestinal condition affecting approximately 10% of extremely preterm infants and is associated with high mortality and long-term neurodevelopmental impairment. Previous observational studies have suggested a temporal link between blood transfusion and NEC onset, particularly when feeds are continued during transfusion. However, the mechanisms remain poorly understood.\n\nMAGPIE-2 will use non-invasive monitoring tools-near-infrared spectroscopy (NIRS) and Doppler ultrasound-to measure cerebral and splanchnic (gut) tissue oxygenation and superior mesenteric artery (SMA) blood flow. These measurements will be used to calculate the Splanchnic-Cerebral Oxygenation Ratio (SCOR), a validated marker of gut tissue perfusion and ischaemia. A reduction in SCOR may indicate compromised gut oxygenation, potentially contributing to NEC.\n\nThe study will recruit 270 infants (135 per arm) already enrolled in the WHEAT trial. Weekly measurements will be taken until 34 weeks corrected gestational age or discharge. Peri-transfusion monitoring includes continuous NIRS from 4 hours before to 4 hours after transfusion, and additional 2-hour recordings at approximately 24 and 48 hours post-transfusion. SMA Doppler assessments will be performed weekly.\n\nPrimary outcomes include changes in SCOR post-transfusion between the two feeding strategies. Secondary outcomes include changes in cerebral and splanchnic oxygenation, SMA blood flow velocities, and the impact of severe anaemia (pre-transfusion haemoglobin ≤80 g\u002FL) on these parameters. The study also includes an assessment of inter-operator variability in Doppler measurements.\n\nMAGPIE-2 aims to provide mechanistic insights that could inform safer transfusion and feeding practices in neonatal care, potentially reducing the incidence of NEC in this vulnerable population.",[25,26,27,28],"NEC - Necrotizing Enterocolitis","NEC","Preterm Babies","Preterm Infant Health",[26,30,31,32],"Necrotizing Enterocolitis","Necrotising Enterocolitis","Preterm","RECRUITING","2026-03-26",{"date":36,"type":37},"2026-04-01","ACTUAL",{"date":39,"type":37},"2025-11-03",{"date":41,"type":21},"2027-04-30",{"name":43,"class":44},"Imperial College Healthcare NHS Trust","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":45},"100481061","spectral-analysis-of-bowel-sounds-in-preterm-babies-of-less-than-32-weeks-of-amenorrhea-wa-as-predictive-factor-of-enterocolitis-100481061","NCT05544097","Spectral Analysis of Bowel Sounds in Preterm Babies of Less Than 32 Weeks of Amenorrhea (WA) as Predictive Factor of Enterocolitis","BHAPE","Inclusion Criteria:\n\n* preterm babies of less than 32WA\n\nExclusion Criteria:\n\n* preterm babies of more than 32WA,\n* digestive congenital malformation","32 Weeks",{"count":55,"type":21},50,"INTERVENTIONAL",[58],"NA","The recording or bowels is easy and cheap. The investigators wonder if these sounds are modified in babies with high risk of necrotizing enterocolitis. In this study, the investigators suggest to record and do a spectral analysis of 30 seconds of bowel sounds in preterm babies of less than 32WA before and after enteral nutrition, every day until the end of hospitalization. A spectral analysis will be made for each record to determine frequencies of the signal. The investigators will try to determine physiological frequencies and look for modifications in pathological situations.",[61,62,30,27],"Bowel Sounds","Spectral Analysis",[64,65,30,66],"bowel sounds","spectral analysis","preterm babies","2024-07-09",{"date":69,"type":37},"2024-07-10",{"date":71,"type":37},"2022-09-06",{"date":73,"type":21},"2025-11",{"name":75,"class":44},"Centre Hospitalier Universitaire, Amiens"]