[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preterm-infant-development\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preterm-infant-development":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,38,82,123],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":17,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":4},"100636733","development-of-preterm-infants-born-during-the-covid-19-pandemic-100636733",false,"NCT07569523","Development of Preterm Infants Born During the COVID-19 Pandemic","Estudio Del Desarrollo de Los niños Prematuros Nacidos Durante la Pandemia Por el COVID-19","Inclusion Criteria:\n\n* Preterm babies (\\\u003C34 weeks of gestation) born between March 2020 and December 2021 for case group).\n* Preterm babies (\\\u003C34 weeks of gestation) born between January 2023 to December 2024 (control group).\n* Babies who were admitted to the NICU of the Hospital de Sant Pau.\n* Babies who were followed up in External Consultations of the same hospital at least until their first year of age.\n\nExclusion Criteria:\n\n* Preterm infants ≥34 weeks or preterm born outside the periods described in the inclusion criteria.\n* Concurrent diagnosis of genetic pathology or major malformations.\n* Families who discontinued follow-up or did not attend scheduled appointments.","ALL","5 Years",{"count":19,"type":20},120,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate differences in cognitive and psychomotor development among preterm infants (born before 34 weeks of gestation) delivered during the COVID-19 pandemic at Hospital de la Santa Creu i Sant Pau, compared with a control group of preterm infants born at the same hospital.",[24,25],"Preterm Infant Development","COVID - 19","NOT_YET_RECRUITING","2026-05-06",{"date":29,"type":30},"2026-05-11","ACTUAL",{"date":32,"type":20},"2026-05",{"date":34,"type":20},"2029-12",{"name":36,"class":37},"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","OTHER",{"id":39,"slug":40,"hasResults":11,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":46,"enrollmentInfo":47,"targetDuration":46,"studyType":21,"phases":4,"briefSummary":49,"conditions":50,"keywords":54,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":81},"100630687","neonatal-data-and-biobank-to-study-factors-influencing-development-in-preterm-infants-born-at-32-weeks-gestation-andor-1500-g-birth-weight-100630687","NCT07490912","Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born at \u003C32 Weeks' Gestation and\u002For \u003C1500 g Birth Weight","Establishing a Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born at \u003C32 Weeks' Gestation and\u002For \u003C1500 g Birth Weight","Neo-Life","Inclusion Criteria:\n\n* Preterm infants born \\\u003C32 weeks' gestational age and\u002For with a birth weight \\\u003C 1500 g\n* Informed consent of parents\u002F legal guardians\n\nExclusion Criteria:\n\n* none","18 Years",{"count":48,"type":20},1300,"The Neo-Life project aims to establish a prospective neonatal data and biobank to investigate factors influencing the short- and long-term development of very preterm infants. Advances in neonatal care have significantly improved survival rates of infants born with a gestational age of less than 32 weeks and\u002For a birth weight below 1500 g. However, these infants remain at high risk for multiple complications affecting neurological, pulmonary, cardiovascular, renal, and other organ systems, which may lead to long-term morbidity and reduced quality of life. Identifying early risk and protective factors is therefore essential to improve outcomes and develop targeted interventions.\n\nThe primary objective of the project is the prospective and structured collection of clinical data as well as biological samples within a standardized interdisciplinary follow-up program for preterm infants. The study aims to identify biological, clinical, and environmental factors associated with the development and long-term outcomes of different organ systems.\n\nThe study population includes infants born with a gestational age of less than 32 weeks and\u002For a birth weight below 1500 g who receive care at the perinatal center of the University Hospital Cologne. Participation requires informed consent from the parents or legal guardians. There are no specific exclusion criteria. Participants will be followed within the established preterm follow-up program over several years, allowing longitudinal assessment of clinical outcomes and developmental trajectories. Primary outcome is survival without impairment (e.g. neurocognitive, pulmonal, cardiovascular, renal) at the age of 5 years. Secondary outcomes include duration of breastfeeding, nutritional status, body mass index, and parental stress and bonding. In addition, biological samples will be collected to enable the creation of epigenetic, gene expression, and cytokine profiles. These data will contribute to the identification of predictive biomarkers that may help stratify risk and guide individualized preventive or therapeutic strategies in preterm infants.\n\nBy combining comprehensive clinical data with biological samples in a dedicated data and biobank, the Neo-Life project aims to generate a valuable resource for translational research. The findings are expected to improve understanding of the mechanisms underlying organ development and long-term health in preterm infants and to support the development of early interventions that may prevent or mitigate adverse outcomes.",[24,51,52,53],"Preterm Infant Health","Prematurity Complications","Premature Birth",[55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70],"prematurity","preterm infants","very low birth weight infants","very preterm infants","gestational age \u003C32 weeks","Premature birth","\u003C32 weeks gestational age","very low birth weight","\u003C1500 g birth weight","database","biobank","preterm infant development","preterm infant health","preterm infant long-term outcome","prematurity complications","risk and protective factors of preterm infant development","RECRUITING","2026-03-18",{"date":74,"type":30},"2026-03-24",{"date":76,"type":20},"2026-03-13",{"date":78,"type":20},"2056-03-13",{"name":80,"class":37},"University Hospital of Cologne",1,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":101,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":122},"100624563","premabiom-metatranscriptomics-of-the-respiratory-microbiome-to-predict-the-occurrence-of-bronchopulmonary-dysplasia-in-preterm-infants-100624563","NCT07411261","PremaBiom: Metatranscriptomics of the Respiratory Microbiome to Predict the Occurrence of Bronchopulmonary Dysplasia in Preterm Infants","PremaBiom","Inclusion Criteria:\n\n* Preterm infants with gestational age at birth lower than 32 gestational weeks and 6 days.\n* Hospital stay in one of the participant neonatal care units\n* Infants covered by the social security system of at least one of their parents\n* Whose parents have been informed about the study and agree to sign the informed consent form\n\nExclusion Criteria:\n\n* Palliative care only\n* Lack of parental consent\n* Parents who are minors or under legal protection (guardianship, conservatorship, judicial protection)\n* Parents who do not speak French","72 Hours",{"count":91,"type":20},270,"INTERVENTIONAL",[94],"NA","The goal of this clinical trial is to understand the impact of respiratory microbiome maturation in respiratory health of preterm infants under 32 gestational weeks. The main questions it aims to answer are:\n\n* What is the role of microbiome maturation in respiratory health (development of bronchopulmonary dysplasia, childhood asthma and viral respiratory infections) of preterm infants ?\n* Which environmental or health factors are involved in the maturation of the respiratory microbiome ?\n\nParticipants will undergo follow-up from birth until 3 years of corrected age including nasal swabs, stool samples, and for some of them blood and milk sample.",[97,24,98,99,100],"Bronchopulmonary Dysplasia","Asthma Childhood","Bronchiolitis","Viral Respiratory Tract Infections",[102,103,104,105,106,107,108,109,110,111,112],"respiratory microbiome","bronchopulmonary dysplasia","Prematurity","asthma","bronchiolitis","inflammation","inate immunity","respiratory tract infections","dysbiosis","personalized medicine","metatranscriptomics","2026-02-11",{"date":115,"type":30},"2026-02-13",{"date":117,"type":20},"2026-03",{"date":119,"type":20},"2031-03",{"name":121,"class":37},"University Hospital, Caen",6,{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":16,"minAge":130,"maxAge":131,"enrollmentInfo":132,"targetDuration":4,"studyType":92,"phases":134,"briefSummary":135,"conditions":136,"keywords":137,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":150},"100616468","pilot-study-effects-of-ccp-intervention-on-nicu-environment-and-preterm-infants-development-100616468","NCT07306000","Pilot Study: Effects of CCP Intervention on NICU Environment and Preterm Infants Development","Effects of Close Collaboration With Parents Intervention on NICU Care Environments and Long-term Development of Preterm Infants: a Pilot Study","Inclusion Criteria:\n\n* preterm infants born below 32 weeks of gestation and\u002For weighing \\\u003C 1500 g who receive long-term follow-up at each study site.\n\nExclusion Criteria:\n\n* the infant has any major anomalies\n* the infants are triplets or higher order\n* the infant's condition is critical and the survival is uncertain\n* the parents cannot understand the informed consent form in Korean or in Japanese","1 Hour","7 Days",{"count":133,"type":20},100,[94],"Close Collaboration with Parents intervention is an evidence-based educational intervention for the entire multi-professional staff of neonatal intensive care units (NICUs). The goal of the intervention is to strengthen partnership between staff and parents, enhance parental participation in infant care. There are no studies yet about the effects of the Close Collaboration with Parents intervention on the long-term neurodevelopment and socio-emotional development of very preterm infants and their interaction with their parents. Accordingly, a multicenter cluster randomized controlled trial is planned. Prior to initiating this large-scale study, it is essential to validate the measurement instruments. Therefore, a pilot study will be conducted to assess their feasibility and to determine the appropriate sample size.",[24,51],[138,139],"close collaboration with parents","family-centered care","2025-12-29",{"date":142,"type":30},"2025-12-31",{"date":144,"type":30},"2025-12-22",{"date":146,"type":20},"2028-12-31",{"name":148,"class":149},"Turku University Hospital","OTHER_GOV",3]