[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preterm-infant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preterm-infant":62},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,47,79,112,145,173,204,230,255,284],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100247174","habituations-mechanisms-in-preterm-and-term-infants-100247174",false,"NCT02496104","Habituation's Mechanisms in Preterm and Term Infants","Habituation's Mechanisms in Preterm and Term Infants. Behavioral Evaluation: APIB (Assessment of Preterm Infant's Behavior). Assessment of the Cortical and Vegetative Responses","HABIPREMA","Inclusion Criteria:\n\n* Preterm infants: preterm infants born from 25 weeks to 32 weeks + 6 days of gestation near to 36 weeks of gestation (corrected postnatal age)\n* Term infants: term newborns with a gestational age between 39 and 41 weeks of gestation at day 3 with an Apgar ≥ 1 at 1 minute of life\n* For both groups: normal neurological physical examination, written informed consent of the parents\n\nExclusion Criteria:\n\n* no malformation or chromosomal abnormality, life threatening disease, administration of morphine or sedatives during the 24 hours before the study, context of maternal drug addiction, deafness, no psychoactive drug or anticonvulsivants during the last month of pregnancy for the term newborns, severe neurological disease",true,"ALL","2 Days","10 Weeks",{"count":22,"type":23},70,"ESTIMATED","OBSERVATIONAL","Each year in France, 7 % of newborns are born preterm (before 37 weeks of gestational age (GA)). The investigators called very preterm infants those who were born before 33 weeks of GA. These very preterm infants have a higher risk of developing neurological complications like developmental disabilities or cerebral palsy. To date, early assessment of these infants is difficult and not reliable enough to detect those who are at risks of developing neurological issues. Now, the investigators need to identify earlier these infants to provide them interventions to improve their development (physical therapy for example). Consequently, the investigators are examining a study whose aim is to assess preterm infants habituation. Habituation is the newborn ability to become familiar with new environmental stimulations (noise, light…). This habituation allows the newborn to maintain his sleep even at onset of a noise or light. To study this phenomenon in infants born preterm near to corrected term (around 40 weeks of postnatal GA), will allow us to better understand neurological development of these infants. The investigators plan to compare habituation skills of preterm infants near to their theorical date of birth (40 weeks of GA) to a population of infants born at term. The investigators will also study the link between habituation abilities and sleep quality as well as neurodevelopmental outcome at the corrected age of two years old.",[27,28],"Habituation, Psychophysiological","Preterm, Infant",[30,31,32,33],"Preterm","Infant","Habituation","APIB","RECRUITING","2026-06-11",{"date":37,"type":38},"2026-06-12","ACTUAL",{"date":40,"type":38},"2015-07-09",{"date":42,"type":23},"2029-01",{"name":44,"class":45},"University Hospital, Brest","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":18,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100642077","circadian-synchronized-breast-milk-feeding-and-sleep-in-preterm-infants-a-multicenter-randomized-controlled-trial-100642077","NCT07645677","Circadian-Synchronized Breast Milk Feeding and Sleep in Preterm Infants: A Multicenter Randomized Controlled Trial","Effect of Circadian-Synchronized Breast Milk Feeding on Sleep in Preterm Infants: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\nPreterm infants born between 28 and 36 weeks of gestation Have reached full enteral feeding Written informed consent signed by a legal guardian\n\nExclusion Criteria:\n\nNeed invasive respiratory support, such as endotracheal intubation Use of sedatives or other medications that may affect the central nervous system or sleep rhythm\n\nPresence of diseases or abnormalities that may affect normal feeding or sleep behavior, including:\n\nCongenital anomalies, such as neurologic or chromosomal abnormalities Congenital gastrointestinal malformations or anorectal malformations Conditions affecting digestion or absorption, such as diarrhea, intestinal obstruction, or necrotizing enterocolitis (NEC) Critical illnesses such as patent ductus arteriosus (PDA), neonatal sepsis, neutropenia, or coagulation disorders","0 Days",{"count":56,"type":23},120,"INTERVENTIONAL",[59],"NA","This clinical trial aims to find out whether a circadian-synchronized breast milk feeding approach can help improve sleep in preterm infants in the neonatal intensive care unit (NICU).\n\nThe study mainly aims to answer the following questions:\n\nCan this feeding approach improve sleep in preterm infants? Can this feeding approach help preterm infants develop more regular sleep patterns compared with routine breast milk feeding?\n\nResearchers will compare a feeding approach that tries to match the time when breast milk was expressed with the time when the baby is fed, with routine breast milk feeding, to see whether this method can improve sleep in preterm infants.\n\nParticipants will:\n\nBe randomly assigned to 1 of 2 groups: circadian-synchronized breast milk feeding or routine breast milk feeding.\n\nReceive the assigned feeding approach for at least 2 weeks during the study. Have one 12-hour continuous sleep monitoring session at 37 weeks of corrected age.\n\nHave changes in different sleep states recorded and analyzed during the study, so that sleep patterns can be compared between the 2 groups.",[62,63],"Preterm Infant","Sleep",[65,66,67,68,62,63],"Breast Milk Feeding","Circadian Rhythm","Chrononutrition","NICU","NOT_YET_RECRUITING","2026-06-09",{"date":37,"type":38},{"date":73,"type":23},"2026-06-01",{"date":75,"type":23},"2027-08-01",{"name":77,"class":45},"Shanghai Jiao Tong University School of Medicine",6,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":87,"enrollmentInfo":88,"targetDuration":90,"studyType":24,"phases":4,"briefSummary":91,"conditions":92,"keywords":96,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100635387","detection-of-respiratory-events-using-acoustic-monitoring-in-extremely-preterm-infants-100635387","NCT07552025","Detection of Respiratory Events Using Acoustic Monitoring in Extremely Preterm Infants","Detection of Respiratory Events Using Acoustic Monitoring in Extremely Preterm Infants (DREAM 2)","DREAM 2","Inclusion Criteria:\n\n* Infants with gestational age \\\u003C 29+0 weeks.\n* Off respiratory support at the time of study recording.\n\nExclusion Criteria:\n\n* Infants with known major congenital anomalies.\n* Infants deemed clinically unstable for the study by the attending physician.","29 Weeks",{"count":89,"type":23},50,"9 Weeks","Extremely preterm infants, born before 29 weeks of pregnancy, often face breathing difficulties, also known as respiratory events, due to their undeveloped lungs and respiratory systems. These respiratory events include pauses in breathing, shallows breaths, and irregular breathing patterns. These problems are most common right after birth but can continue for weeks, leading to extended hospital stays, higher medical costs, and potential long-term health concerns affecting the eyes, lungs, and brain.\n\nCurrently, neonatal intensive care units (NICUs) use methods like measuring oxygen levels, heart rate, and electrical resistance in the chest to monitor for respiratory events. However, these methods have limitations. For instance, they cannot accurately measure airflow and do not distinguish between different types of respiratory events. As a results, some breathing problems might go unnoticed or be managed improperly.\n\nTo address this, the investigators have developed a wireless acoustic sensor that uses advanced microphones and motion sensors to record airflow and chest movements. In initial tests with healthy preterm infants, this sensor proved reliable in detecting breathing patterns and airway obstruction, suggesting it could offer a more precise and non-invasive monitoring method.\n\nThis study aims to assess how well this new sensor performs compared to existing methods in detecting and distinguishing different types of respiratory events in a high-risk group of extremely preterm infants. The investigators will track respiratory patterns in preterm infants at various stages between 32 and 44 weeks of age. By comparing the new sensor's performance with currents standards and gold-standard methods, the investigators hope to improve the management of these respiratory events and reduce the related health risks.",[93,62,94,95],"Apnea of Prematurity","Periodic Breathing","Hypopnea",[97,98,99,100,101,102],"Apnea of prematurity","Preterm infants","Diagnostic accuracy study","Respiratory acoustics","Respiratory events","Neonatal Intensive Unit Care","2026-05-07",{"date":105,"type":38},"2026-05-12",{"date":107,"type":23},"2026-05",{"date":109,"type":23},"2028-09",{"name":111,"class":45},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":57,"phases":122,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":46},"100634385","optimizing-early-nutrition-management-of-extremely-andor-very-preterm-infants-100634385","NCT07538999","Optimizing Early Nutrition Management of Extremely and\u002For Very Preterm Infants","Optimizing Early Nutrition Management of Extremely and\u002For Very Preterm Infants Based on Best Clinical Practice: a Real Word Study","Inclusion Criteria for intervention group:\n\n* (1) Admitted to the Neonatal Department of Children's Hospital of Fudan University during the study period.\n* (2) Preterm infants with a gestational age \\\u003C 32 weeks or a birth weight \\\u003C 1500 g.\n* (3) Admitted to the study center within 24 hours after birth.\n* (4) Obtained informed consent from family members. Exclusion Criteria for intervention group\n* (1) Newborns with severe congenital diseases, severe congenital malformations, chromosomal abnormalities, or genetic metabolic diseases.\n* (2) Death or discharge within two weeks after birth.\n\nInclusion Criteria for control group:\n\n* (1) Admitted to the Neonatal Department of Children's Hospital of Fudan University from January 2025 to December 2025.\n* (2) Preterm infants with a gestational age \\\u003C 32 weeks or a birth weight \\\u003C 1500 g.\n* (3) Admitted to the study center within 24 hours after birth. Exclusion Criteria for control group\n* (1) Newborns with severe congenital diseases, severe congenital malformations, chromosomal abnormalities, or genetic metabolic diseases.\n* (2) Death or discharge within two weeks after birth.","1 Day",{"count":121,"type":23},200,[59],"A clinical quality improvement bundle on early nutrition supplementation is developed to improving the clinical outcomes (including growth, organ function, and neurodevelopment outcomes) of extremely and\u002For very preterm infants. This bundle consists of three aspects: individualized and precise human milk feeding, early enteral zinc supplementation, and routine parenteral carnitine supplementation.",[125,126,62],"Nutrition Intervention","Quality Improvement",[128,129,130,131,132,133,134,135],"preterm infants","nutrition","bundle","zinc supplementation","carnitine supplementation","growth","outcomes","human milk feeding","2026-04-13",{"date":138,"type":38},"2026-04-20",{"date":140,"type":23},"2026-04-01",{"date":142,"type":23},"2029-12-31",{"name":144,"class":45},"Children's Hospital of Fudan University",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":151,"eligibilityCriteria":152,"healthyVolunteers":11,"sex":18,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":157,"conditions":158,"keywords":159,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":46},"100597618","acoustics-as-a-metric-of-airway-pressure-in-premature-infants-using-bubble-continuous-positive-airway-pressure-100597618","NCT07060833","Acoustics as a Metric of Airway Pressure in Premature Infants Using Bubble Continuous Positive Airway Pressure","The Use of Bubble Continuous Positive Airway Pressure in Premature Infants: Acoustics as a Metric of Effective Pressure Delivery","Bubble CPAP","Inclusion Criteria:\n\n* Infants on bCPAP with gestational age \\\u003C 32+0 weeks\n* Postmenstrual age between 28+0 and 36+6 weeks at the time of the study\n* Postnatal age greater than 168 hours (7 days) at the time of the study\n* On the bubble CPAP device with binasal prongs at the time of the study\n* Receiving bubble CPAP levels of 5 to 7 cm H2O with gas flows between 6L\u002Fmin and 10L\u002Fmin at the time of the study\n\nExclusion Criteria:\n\n* Infants with known major congenital anomalies\n* Infants with known congenital heart disorders\n* Infants with known neuromuscular disease\n* Infants receiving ventilator-derived CPAP at the time of the study\n* Infants receiving CPAP via a nasal mask interface at the time of the study\n* Infants receiving inotropes, narcotics or sedative agents at the time of the study\n* Infants deemed clinically unstable for the study by the attending neonatologist","28 Weeks","32 Weeks",{"count":156,"type":23},30,"This is an observational, proof-of-concept, feasibility study where 30 preterm infants on bubble CPAP with gestational age \\\u003C 32+0 weeks will be recruited from the neonatal intensive care unit (NICU) at the Montreal Children's Hospital.\n\nThe study's main goals are:\n\n1. To determine the relationship between ambient bubbling sounds and delivered pressures in preterm infants on bCPAP.\n2. To determine the relationship between transmitted bubbling sounds and airway pressures transmitted to the lungs of preterm infants on bCPAP.\n3. To develop models to predict delivered and transmitted bCPAP pressures from the acoustic properties of bubbling sounds.",[62],[151,160,161,100,162,163,164],"Airflow","Neonatal Intensive Care","Acoustic monitoring","Airway pressure monitoring","Bubbling sounds","2026-03-24",{"date":167,"type":38},"2026-03-30",{"date":169,"type":38},"2025-04-03",{"date":171,"type":23},"2026-12",{"name":111,"class":45},{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":181,"targetDuration":183,"studyType":24,"phases":4,"briefSummary":184,"conditions":185,"keywords":189,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":46},"100586774","early-lung-function-trajectories-comparison-between-infants-with-and-without-intrauterine-growth-restriction-100586774","NCT06919757","Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.","Early Lung Function Trajectories: Comparison Between Infants With Intrauterine Growth Restriction and Appropriately Grown Ones.","ELFIGO","Inclusion Criteria:\n\n* Fetuses and Infants born before 32 weeks of gestation, with and without fetal growth restriction\n\nExclusion Criteria:\n\n* Lack of informed consent\n* Need for palliative care\n* Major malformations",{"count":182,"type":23},54,"2 Years","During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound. Since there are currently no curative treatments for this condition, nor methods to optimize the growth of babies in the womb, the only effective strategy is intensive monitoring of fetal conditions, accompanied by early planning of delivery.\n\nThe diagnosis of early FGR (i.e. diagnosed before 32 weeks of gestation) confers a greater risk of short- and long-term respiratory problems.\n\nThe study aims to examine the association between parameters that can be assessed during pregnancy by ultrasound, such as the estimate of lung volumes, the thickness and contractility of the diaphragm, and cardiac kinetics, and any perinatal complications and respiratory function in the first years of life of premature infants, both with and without evidence of fetal growth pathology. Therefore, the study is divided into two phases: a prenatal and a postnatal phase.\n\nThe study includes two groups of patients:\n\n1. Study group: Fetuses and preterm infants with a prenatal history of FGR;\n2. Control group: Preterm infants without a prenatal history of FGR followed during neonatal follow-up.\n\nPregnant women with fetuses with FGR are followed at the Ultrasound clinics dedicated to Growth Pathology.\n\nThese pregnancies usually receive weekly ultrasound monitoring, which includes a Doppler study of the maternal and fetal circulation and an estimate of fetal weight every two weeks. Cardiotocographic monitoring is also planned once or twice a week, depending on fetal well-being.\n\nThe child will be assessed from a respiratory point of view during hospitalization and subsequently in the outpatient clinic, as required by clinical practice.\n\nHe\u002Fshe will undergo respiratory function tests. Visits are scheduled at 3, 6, 12 and 24 months of corrected age, during which at least two respiratory function tests will be performed.\n\nIn addition, routine clinical data (personal data, medical history, blood tests, biological and instrumental tests) present in the medical record of the child will be collected.\n\nData from preterm infants without fetal growth restriction will be collected after informed consent. These infants are routinely followed at our Institution and undergo clinical assessment and lung function tests in the first two years of life as previously indicated.",[186,187,62,188],"Intrauterine Growth Retardation (IUGR)","Lung Function Tests","Respiratory Monitoring",[190,191,192,193,194],"lung volume measurements","pulmonary function test","preterm birth","intrauterine growth retardation","oxygen saturation\u002Fphysiology","2025-08-25",{"date":197,"type":38},"2025-08-26",{"date":199,"type":38},"2025-04-20",{"date":201,"type":23},"2027-03",{"name":203,"class":45},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":57,"phases":214,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":222,"lastUpdatePostDateStruct":223,"startDateStruct":225,"completionDateStruct":227,"leadSponsor":228,"locationsCount":46},"100530635","positive-feeding-of-the-preterm-infant-100530635","NCT06189352","Positive Feeding of the Preterm Infant","Positive Feeding of the Preterm Infant - a Feasibility Study of a Developmental Supportive Feeding Strategy in the NICU","PoP","Inclusion Criteria:\n\n* gestational age of 28 weeks\n* post menstrual age of 28 weeks after transition from regional hospital\n\nExclusion Criteria:\n\n* diagnoses or malformations that makes eating difficult\n* triplets or more\n* parents not speaking\u002Funderstanding Norwegian or English\n* parents with challenges or special needs for follow up",{"count":213,"type":23},15,[59],"The goal of this feasibility study is to assess the feasibility to implement a feeding strategy for preterm infants.\n\nThe main questions it aims to answer are:\n\n* Is it feasible to implement the PoP-intervention in a level 3a category Neonatal intensive care unit?\n* Is the PoP-intervention acceptable for parents of preterm infants and health care personnel working in Neonatal intensive care unit?\n\nParents of preterm infants and health care personnel will be asked to follow a protocol of a feeding strategy based on the preterm infants development and cues throughout the NICU-stay.",[62,217,218,219,220,221],"Breast Feeding","Bottle Feeding","Enteral Feeding","Cue Based Feeding","Develomentally Supportive Care","2025-08-05",{"date":224,"type":38},"2025-08-11",{"date":226,"type":38},"2024-10-14",{"date":107,"type":23},{"name":229,"class":45},"Oslo Metropolitan University",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":18,"minAge":236,"maxAge":237,"enrollmentInfo":238,"targetDuration":183,"studyType":24,"phases":4,"briefSummary":240,"conditions":241,"keywords":242,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":254},"100576495","clinical-impact-of-non-invasive-neurally-adjusted-ventilatory-assist-in-very-preterm-infants-100576495","NCT06786039","Clinical Impact of Non-invasive Neurally Adjusted Ventilatory Assist in Very Preterm Infants","Inclusion Criteria:\n\n* Preterm infants born between 27 weeks 0 days to 31 weeks 6 days of gestation\n* Preterm infants who require respiratory support within the first 48 hours of life\n\nExclusion Criteria:\n\n* Preterm infants who die within the first 48 hours of life\n* Preterm infants who do not require any respiratory support within the first 48 hours of life.\n* Preterm infants with congenital anomalies affecting the lungs, heart, or other organs that could influence breathing\n* Infants whose parents do not consent to participate in the study","1 Hour","48 Hours",{"count":239,"type":23},80,"This is a prospective observational study investigating the impact of NIV-NAVA on short-term clinical outcomes and long-term neurodevelopment in very preterm infants.",[62],[243,244],"infant, premature","Noninvasive NAVA","2025-06-12",{"date":247,"type":38},"2025-06-17",{"date":249,"type":38},"2025-01-20",{"date":251,"type":23},"2030-12-20",{"name":253,"class":45},"Korea University Anam Hospital",2,{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":261,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":18,"minAge":4,"maxAge":119,"enrollmentInfo":263,"targetDuration":4,"studyType":57,"phases":265,"briefSummary":266,"conditions":267,"keywords":269,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":46},"100356299","air-vs-cutaneous-control-mode-for-preterm-infants--32-wg-in-incubators-impact-on-body-growth-and-morbidity-100356299","NCT03919188","Air vs. Cutaneous Control Mode for Preterm Infants ≤ 32 WG in Incubators: Impact on Body Growth and Morbidity","Comparison of Air vs. Cutaneous Control Mode for Preterm Infants ≤ 32 WG Raised in Closed Incubators: Impact on Body Growth and Morbidity","ThermoKPreterm","Inclusion Criteria:\n\n* preterm infant born between 25+0 and 32+0 weeks of gestation\n* preterm infant included in the study before 24 +\u002F- 12 hours of life\n* preterm infant nursed in a closed incubator\n* written informed consent from his parents\n\nExclusion Criteria:\n\n* newborn infant with polymalformative syndrome\n* life threatening events or serious heart disease",{"count":264,"type":23},164,[59],"Previous studies have shown that mortality and morbidity in preterm neonates are correlated with the fall in body temperature on admission. Hypothermia can be decreased by reducing body heat losses to the environment. The investigator research hypothesis is that a new calculation of the air temperature in the incubator would promote the newborn infant weight growth from the period between birth and day 10 of life compared to cutaneous mode. The secondary hypotheses assumes a decrease in the side effects usually observed in both morbidity and mortality.\n\nA software is used to calculate the body heat loss (BHL) of each individual preterm infant, and to propose a specific air temperature setting inside the incubator to reduce BHL to zero. This software has been validated in a previous pilot study (Degorre et al. 2015). This study aims to compare the energy costs of providing incubated preterm infants born between 25 and 32 weeks of gestation with homeothermia using either specific individualized air temperature control (ATC) or skin servocontrol (SSC).",[62,268],"Body Temperature",[270,271,272,273,274],"preterm neonates","incubator management","body temperature","relative air humidity","thermoneutrality","2025-05-23",{"date":277,"type":38},"2025-05-29",{"date":279,"type":38},"2022-01-01",{"date":281,"type":23},"2025-12",{"name":283,"class":45},"Centre Hospitalier Universitaire, Amiens",{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":4,"eligibilityCriteria":290,"healthyVolunteers":17,"sex":18,"minAge":119,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":294,"conditions":295,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":46},"100314454","gut-microbiota-of-preterm-infants-and-full-term-infants-at-early-life-100314454","NCT03373721","Gut Microbiota of Preterm Infants and Full-term Infants at Early Life","Gut Microbial Succession of Preterm Infants and Full-term Infants at Early Life","Inclusion Criteria:\n\nPreterm infants\n\n1. gestational age \\\u003C37 weeks;\n2. no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis;\n3. hospital stay \\> 7 days;\n\nExclusion criteria:\n\n1. NICU stay less than 7 days\n2. Necrotizing enterocolitis infant\n\nControl group:\n\n1. Full-term healthy infants;\n2. gestational age \\>37 weeks;\n3. vaginally born;\n4. no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis.","4 Months",{"count":293,"type":23},102,"The aim of this study is to obtain a longitudinal view of the gut microbial establishment of a cohort of 51 preterm (PT) infants compared to 50 full-term (FT) infants from birth to 90 days of age, and to identify key clinical factors that affect the establishment of neonatal microbiome.\n\nThe hypothesis of the investigators is that the gut microbiota progression of PT group and FT group is different in diversity and composition. Antibiotics and its usage duration is likely the main factor disturbing the colonization and development of the gut microbiome of PT infants.",[62,296],"Gut Microbiome","2024-04-16",{"date":299,"type":38},"2024-04-17",{"date":301,"type":38},"2014-07-20",{"date":303,"type":23},"2028-12-20",{"name":305,"class":45},"Xinhua Hospital, Shanghai Jiao Tong University School of Medicine"]