[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preterm-labor-with-preterm-delivery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preterm-labor-with-preterm-delivery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100636779","phase-1-pharmacokinetics-and-placental-transfer-of-caffeine-100636779",false,"NCT07570121","Pharmacokinetics and Placental Transfer of Caffeine","Pharmacokinetics and Placental Transfer of Caffeine: a Pilot Trial of Caffeine Administration Across the Second and Third Trimesters of Pregnancy","AnteCaff","Inclusion Criteria:\n\n1. Pregnant women with risk of preterm delivery at 23 - 31+6 weeks with singleton gestation who are inpatient without a plan for discharge before delivery.\n2. Informed consent provided for participation.\n3. Cesarean delivery.\n\nExclusion Criteria:\n\n1. Known major fetal congenital anomalies or genetic disorders.\n2. Plan in place for limited neonatal resuscitation or comfort care only.\n3. Preterm, premature rupture of membranes prior to 22 weeks gestation with concern for pulmonary hypoplasia.\n4. Pre-eclampsia, gestational hypertension, or other gestational hypertensive disorder.\n5. Fetal arrhythmia.\n6. Seizure disorder.\n7. Oligohydramnios due to renal anomalies or renal impairment.\n8. Current or anticipated use of products that include sodium benzoate.\n9. Maternal age \\\u003C18 years.\n10. Maternal medical conditions in which caffeine or other stimulants would be contraindicated.\n11. High likelihood of receiving terbutaline.\n12. Use of the following medications, which may affect caffeine metabolism: fluvoxamine, ciprofloxacin, methoxsalen, mexiletine, vemurafenib, phenytoin, rifampin, and teriflunomide.\n13. Significant acute or chronic medical, neurologic, or illness in the patient that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability to complete the study, and\u002For compromise the objectives of the study.","FEMALE","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"PHASE1","The goal of this study is to learn how a pregnant person's body processes caffeine and how much caffeine crosses the placenta to the baby. A small dose of caffeine will be given to each pregnant participant before delivery. Blood will be drawn to measure caffeine levels in the pregnant mother. Blood will also be taken from the placenta and from the newborn to measure caffeine levels. This data will be used to form a computer model of the metabolism of caffeine during pregnancy.",[27,28,29,30,31],"Preterm Labor With Preterm Delivery","Premature Birth","Apnea of Prematurity","Respiratory Distress Syndrome","Bronchopulmonary Dysplasia",[33,34,35,36,37,38],"caffeine","preterm labor","prematurity","pharmacokinetics","bronchopulmonary dysplasia","apnea of prematurity","RECRUITING","2026-06-03",{"date":42,"type":43},"2026-06-04","ACTUAL",{"date":45,"type":43},"2026-06-01",{"date":47,"type":21},"2027-06",{"name":49,"class":50},"Indiana University","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":22,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":51},"100475365","comparing-two-prophylactic-antibiotic-protocols-in-women-with-term-prolonged-pre-labor-rupture-of-membrane-and-preterm-labor-100475365","NCT05469984","Comparing Two Prophylactic Antibiotic Protocols in Women With Term Prolonged Pre-labor Rupture of Membrane and Preterm Labor","Comparing Obstetrical Outcomes and Infectious Morbidity Between Two Prophylactic Antibiotic Protocols in Women With Term Prolonged Pre-labor Rupture of Membrane and Preterm Labor","Inclusion Criteria: maternal age \\> 18 years singleton pregnancy vertex presentation prolonged \\>18 h prom or preterm delivery\n\n\\-\n\nExclusion Criteria:\n\n* GBS carrier\n* preterm premature rupture of membrane for conservative treatment\n* intra-uterine fetal death fetal major anomaly\n* drug allergy for the antibiotic in use in this study\n* women receiving antibiotic treatment for other infection such as urinary tract infection",true,"48 Years",{"count":62,"type":21},600,[64],"NA","This randomized prospective trial aimed to compare 2 prophylactic antibiotic regiment (ampicillin alone versus ampicillin plus gentamycin) in term prolonged pre-labor rupture of membrane and in preterm deliveries and examine related obstetrical outcome and infectious morbidity",[27,67],"Premature Rupture of Membranes Prolonged",[69,70,71,72,73],"prolonged term PROM","pre-term labor","prophylactic antibiotic","peripartum infection","bacterial distribution","2025-08-05",{"date":76,"type":43},"2025-08-06",{"date":78,"type":43},"2022-11-25",{"date":80,"type":21},"2025-09-26",{"name":82,"class":83},"Western Galilee Hospital-Nahariya","OTHER_GOV"]