[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"preterm-neonate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:preterm-neonate":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,49,78,107,140,173,206,236,266,291,319],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100570285","peep-for-lung-recruitment-in-preterm-infants-eit-study-100570285",false,"NCT06705257","PEEP FOR LUNG RECRUITMENT IN PRETERM INFANTS-EIT STUDY","EFFECT OF VARYING LEVELS OF PEEP ON PRETERM LUNG RECRUITMENT USING ELECTRICAL IMPEDANCE TOMOGRAPHY- FEASIBILITY STUDY","[PEOPLE]","Inclusion criteria\n\n1. Gestational age \\\u003C32 weeks based on mother's last menstrual period or first trimester ultrasound dating.\n2. Receiving either CPAP or mechanical ventilation respiratory support.\n3. Informed written consent from one of the parents.\n4. Within the first two weeks of life. Investigators pragmatically chose this period, as there could be considerable lung injury after the first two weeks of life, making it difficult to test our hypothesis. Also, this time period would allow parents to settle down with their stressful preterm delivery and investigators could approach anytime within the first two weeks of life.\n\nExclusion criteria\n\n1. Major congenital malformations including congenital lung disease and congenital heart disease as ascertained by the medical team.\n2. Infants diagnosed with pneumothorax i.\n3. Receiving high frequency mechanical ventilation.\n4. Infants with concerns of skin integrity.","ALL","22 Weeks","32 Weeks",{"count":21,"type":22},30,"ESTIMATED","INTERVENTIONAL",[25],"NA","Babies born early (under 32 weeks) are at risk of developing lung problems after birth. A major reason for this is that the lungs are not fully developed. Lungs of preterm babies will often collapse in between breathing due to lung immaturity. Applying gentle pressure, using nasal device through their nostril or through the breathing tube helps to prevent this lung collapse. This would help in air-oxygen going to lungs and also makes the babies breathing more comfortable. This gentle pressure is medically called as PEEP\u002FCPAP and could be delivered by breathing machine (ventilator) and CPAP machine, collectively called as \"continuous distending pressure (CDP)\".\n\nThose babies breathing on their own and receiving inadequate CDP would need more breathing support by placing them on breathing machine (ventilator). The longer the baby receives breathing machine support, higher chance of lung injury . Preterm infants who are already on breathing machine, providing sub optimal PEEP\u002FCPAP could also lead to lung damage. Providing optimal PEEP\u002FCPAP could prevent these negative outcomes. Currently there is not enough evidence to suggest optimal PEEP\u002FCPAP in preterm infants. Neonatal units all around the world uses PEEP\u002FCPAP ranging from 4 to 10cm H20 based on their unit practice. Currently available investigations provide limited one time information (e.g. Chest X-ray) regarding whether baby is receiving optimal PEEP\u002FCPAP. Electrical Impedance Tomography (EIT) is a new technology which could provide better information regarding the pressure delivered. Also, this device would provide continuous information as if the clinicians are doing continuous chest X-ray but without any radiation. In this study, the team will assess the effect of different levels of PEEP\u002FCPAP (4 to 10cm H20) on prevention of lung collapse using EIT. This would be studied in premature infants who are on breathing machine support and CPAP machine support.",[28,29,30,31],"PreTerm Neonate","Positive End Expiratory Pressure (PEEP)","Lung Recruitment","Electrical Impedance Tomography (EIT)",[33,34,35],"positive end expiratory pressure","PRETERM","Electrical Impedance Tomography","RECRUITING","2026-05-01",{"date":39,"type":40},"2026-05-06","ACTUAL",{"date":42,"type":40},"2025-06-15",{"date":44,"type":22},"2026-12-31",{"name":46,"class":47},"South Tees Hospitals NHS Foundation Trust","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100634639","breathing-patterns-in-infants-before-and-after-extubation-100634639","NCT07542301","Breathing Patterns in Infants Before and After Extubation","Inclusion Criteria:\n\n* premature infants (born at ≤32 weeks gestation) who are intubated.\n* medical team is evaluating the baby for extubation readiness\n\nExclusion Criteria:\n\n* Infants with skeletal, neuromuscular, or abdominal surgical disorders that affect the accuracy of RIP measurements will be excluded.",true,"0 Days","6 Months",{"count":21,"type":22},"OBSERVATIONAL","The primary objective of this study is to compare work of breathing indices before and after extubation in intubated premature infants admitted to the Christiana Care Neonatal Intensive Care Unit. The secondary objective is to compare the ability of work of breathing indices to predict extubation failure to routine spontaneous breathing tests (SBTs) in intubated premature infants admitted to the ChristianaCare NICU.",[62,28],"Respiratory Distress Syndrome (RDS)",[64,65,66,67,68],"preterm infants","intubated","respiratory distress","extubation","work of breathing","2026-04-14",{"date":71,"type":40},"2026-04-21",{"date":73,"type":40},"2025-04-14",{"date":75,"type":22},"2026-12",{"name":77,"class":47},"Christiana Care Health Services",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":91,"conditions":92,"keywords":94,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":102,"leadSponsor":104,"locationsCount":48},"100591035","phase-2-minimising-total-radiation-exposure-in-preterm-infants-100591035","NCT06975189","MINImising Total Radiation EXposure in Preterm Infants","Lung Ultrasound to Reduce the Number of Chest X-rays in Very Preterm Infants in the First 2 Weeks After Birth: A Randomised Controlled Trial","MINI T-Rex","Inclusion Criteria:\n\nAll infants born \\\u003C32 weeks' gestation and admitted to the neonatal intensive care unit (NICU) who require lung imaging for respiratory indications will be considered eligible. Each infant must meet all the following criteria to be enrolled in this study:\n\n* The infant is born from 22 to 31+6 weeks' gestation by best obstetric estimate and admitted to the NICU\n* The infant is considered to require lung imaging for respiratory indications\n* The infant has a parent\u002Fguardian who can provide informed consent.\n\nExclusion Criteria\n\n* The infant will only require CXR to be performed solely to confirm device position i.e. central line, endotracheal tube, gastric tubes\n* The infant will only require CXR to be performed for specifically for non-respiratory indications i.e. assessment of cardiac silhouette\n* The infant's Clinician has concern regarding clinical stability and tolerability of ultrasound scans\n* The infant's skin integrity will not tolerate ultrasound gel\n* Refusal of informed consent by their parent\u002Fguardian\u002Flegally acceptable representative\n* The infant does not have a parent\u002Fguardian who can provide informed consent.","24 Hours",{"count":88,"type":22},180,[90],"PHASE2","Being born too early (preterm birth) is the leading cause of death in children world-wide. In Australia, 97% of very preterm babies who are admitted to Neonatal Intensive Care Units need breathing support after birth to survive. Despite this significant global impact, neonatal clinicians have few tools available to guide breathing support. Currently, the only lung imaging tool that is routinely used in the Neonatal Intensive Care Unit is a chest X-ray. To reduce radiation exposure, chest X-rays are usually only performed one or two times a day. As chronic lung disease in babies who survive preterm birth is increasing, there is an urgent need to develop new ways to monitor the lungs of these fragile babies.\n\nLung ultrasound is a form of imaging that is fast, gentle and radiation free. However, it has not been routinely adopted into caring for preterm babies in most countries. This is because there are no randomised controlled trials that have demonstrated the benefit and safety of using lung ultrasound as the first-line imaging tool in preterm babies. The investigators will conduct a randomised controlled trial to demonstrate that lung ultrasound is a quick, safe and accurate alternative to chest x-rays in preterm babies.",[93,28],"Neonatal Respiratory Distress Syndrome",[95,96,97],"Lung ultrasound","Respiratory Distress Syndrome","Prematurity","2026-04-13",{"date":100,"type":40},"2026-04-16",{"date":98,"type":40},{"date":103,"type":22},"2029-12-01",{"name":105,"class":106},"Western Health, Australia","OTHER_GOV",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":119,"conditions":120,"keywords":126,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":139},"100578261","prospective-multicentre-mixed-methods-study-to-explore-extubation-practices-and-respiratory-outcomes-in-extremely-preterm-neonates-100578261","NCT06808997","Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.","Criteria and Reasons for Extubation and Non-extubation in Preterm Infants: A Mixed Methods Study Prospectively Exploring Extubation and Reintubation Practices in Extremely Preterm Infants, and Associated Respiratory Outcomes.","CERAINE","Inclusion Criteria:\n\n* Gestational age \\\u003C 28 weeks of gestation\n* Age at admission to the participating unit \\\u003C24 hours\n\nExclusion Criteria:\n\n* Parental opposition to their infant's clinical data collection\n* Participation in a research protocol with potential impact on extubation and\u002For duration of mechanical ventilation","1 Minute","5 Months",{"count":118,"type":22},100,"The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective qualitative and quantitative data. Actual extubation readiness is defined as successful extubation, defined as no reintubation in the 7 days following extubation.\n\nKey research questions are: How do clinicians assess extubation readiness in this population? Does this assessment correlate with actual extubation success? What factors (reasons, clinical status, ventilatory parameters) are associated with extubation readiness? Patients born before 28 weeks gestational age and admitted to the neonatal intensive care unit (NICU) within the first 24 hours are be included. The attending physician will complete a prospectively administered questionnaire with open-ended and multiple-choice questions to daily assess the decision and rationale for extubation or non-extubation of patients mechanically ventilated during the first 15 days of life.\n\nPatient characteristics, respiratory outcomes, and mortality will be recorded until the end of hospitalisation and\u002For definitive weaning from any ventilatory support or supplemental oxygen.",[28,121,122,123,124,125],"Extubation Readiness","Extubation Failure","Respiratory Morbidity","Bronchopulmonary Dysplasia","Mechanical Ventilation",[127,67,128,129],"extremely preterm infants","mechanical ventilation","bronchopulmonary dysplasia","2026-03-11",{"date":132,"type":40},"2026-03-12",{"date":134,"type":40},"2025-02-17",{"date":136,"type":22},"2026-04-30",{"name":138,"class":47},"Centre Hospitalier Intercommunal Creteil",31,{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":19,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":48},"100583621","phase-3-efficacy-of-dexmedetomidine-versus-midazolam-sedation-on-extubation-time-in-mechanically-ventilated-preterm-infants-100583621","NCT06878703","Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants","Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants: a Randomized Controlled Multicenter Trial - DEXPRE","DEXPRE","Inclusion Criteria:\n\n* Patient admitted in NICU (intubated or not yet),\n* Gestational age at birth \\\u003C 32 weeks of gestation (WG),\n* Corrected gestational age \\\u003C45 weeks postmenstrual age Written or electronic informed consent signed by both parents.\n\nRandomization Criteria :\n\n* Indication for sedation in the context of invasive mechanical ventilation,\n* Patient intubated or not yet,\n* Elective sedation (acceptable delay between the decision to sedate and the administration of the sedative agent),\n* Presence or plan of a venous access,\n* No medical contraindication related to the administration of dexmedetomidine or midazolam,\n* No previous use of dexmedetomidine or midazolam within 48 hours, except for the sedation procedure for intubation,\n* No concomitant use of curare agent,\n* No clonidine treatment,\n* No previous extubation within 7 days,\n* No hemodynamic instability\n* No palliative care,\n\nExclusion Criteria:\n\n* Patient admitted in NICU (intubated or not yet),\n* Gestational age at birth \\\u003C 32 weeks of gestation (WG),\n* Corrected gestational age \\\u003C45 weeks postmenstrual age Written or electronic informed consent signed by both parents.",{"count":149,"type":22},380,[151],"PHASE3","Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency. In France, around 8,250 infants are born annually at \\\u003C32 weeks, with an estimated 5,000 needing IMV. Although non-invasive support such as continuous positive airway pressure (CPAP) has become more common, a substantial proportion of these neonates still transition to IMV within the first few days of life. To reduce lung injury and the incidence of bronchopulmonary dysplasia (BPD), a key strategy in neonatal intensive care involves limiting the duration of IMV and promoting earlier extubation.\n\nHowever, effective sedation and analgesia are essential for preterm infants subjected to intubation and mechanical ventilation. Traditionally, neonatologists combine a sedative (frequently midazolam) with an opioid (morphine, fentanyl, or sufentanil). Although these agents control pain and distress, they may cause respiratory depression, complicate weaning, and potentially contribute to adverse long-term outcomes. Midazolam, one of the few sedatives authorized for use in neonates, can improve comfort and sedation scores, but concerns persist about hypotension, altered cerebral perfusion, and a possible link to intraventricular hemorrhage (IVH). Moreover, combining benzodiazepines and opioids can prolong ventilation, increase the risk of complications, and impede timely extubation.\n\nRationale for Dexmedetomidine (DEX) Dexmedetomidine (DEX) is a highly selective α2-adrenergic agonist that offers sedative, anxiolytic, and analgesic properties with relatively minimal respiratory depression. Unlike certain other sedatives, DEX induces a state akin to natural sleep, allowing for easier arousal and potentially better respiratory drive. Animal studies suggest that DEX might be neuroprotective, reducing inflammation, oxidative stress, and apoptotic processes that can be detrimental to the developing brain. These features make DEX a promising alternative to the commonly used benzodiazepine-opioid regimens in very preterm neonates, who remain especially vulnerable to adverse drug effects.\n\nMinimizing Invasive Mechanical Ventilation Reducing the time on IMV is crucial for preventing ventilator-induced lung injury and decreasing the likelihood of BPD. Early extubation is a central goal in this population, but sedation-related respiratory depression can thwart successful weaning and lead to reintubation. By preserving spontaneous breathing more effectively than midazolam or high-dose opioids, DEX may help neonates maintain adequate ventilation as they transition to non-invasive support. Furthermore, DEX's analgesic action could reduce the need for opioids, thereby mitigating withdrawal risks and other opioid-related complications such as feeding intolerance and extended hospital stays.\n\nObjective of the DEXPRE Trial The objective of the DEXPRE trial is to compare the efficacy of dexmedetomidine-based sedation with that of midazolam-based sedation in very preterm neonates requiring IMV. Specifically, investigators aim to determine whether DEX can facilitate more rapid extubation and better overall respiratory outcomes compared to midazolam. By systematically evaluating sedation quality, respiratory stability, and potential side effects, the trial seeks to generate evidence that will guide future sedation protocols in neonatal intensive care units.",[28,154,155],"Sedation for Invasive Mechanical Ventilation","Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation",[157,158,159,160,161,162,163],"Mechanical ventilation","Sedative agent","Sedation-analgesia","Midazolam","Extubation","Very preterm neonate","Dexmedetomidine","2026-02-06",{"date":166,"type":40},"2026-02-10",{"date":168,"type":40},"2025-10-16",{"date":170,"type":22},"2029-10-16",{"name":172,"class":47},"Assistance Publique - Hôpitaux de Paris",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":55,"sex":17,"minAge":180,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":23,"phases":183,"briefSummary":184,"conditions":185,"keywords":191,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":204,"locationsCount":48},"100590473","the-effect-of-cranial-osteopathy-intervention-in-preterm-babies-100590473","NCT06967870","The Effect of Cranial Osteopathy Intervention in Preterm Babies","The Effect of Cranial Osteopathy Intervention on Sensory Profile, Sleep Quality, Colic Symptoms and Motor Movements in Preterm Babies","Inclusion Criteria:\n\n* Premature birth (\\\u003C37 weeks)\n* Corrected age \\\u003C6 weeks.\n* Discharged to home\n* Stable condition\n* Family agrees to continue home program\n\nExclusion Criteria:\n\n* Having a congenital cyanotic heart problem,\n* Being born earlier than 28 weeks,\n* The family not accepting to participate in the study,\n* Neglecting check-ups and sessions,\n* Using a respiratory appliance,\n* Presence of craniosynostosis,\n* Being included in another physiotherapy program during the study period","1 Week","6 Weeks",{"count":21,"type":22},[25],"There are planing to have 2 groups of premature born cases. Each group will include 15 cases. Participants are need to be 28-37 weeks born and no older than post term 6 weeks. All cases are going to be evaluated. Home based exercise plan is going to be explained. The experimental group is going to take 6 osteopathic sessions weekly. After 6 weeks cases are going to be evaluated again.",[186,28,187,188,189,190],"Osteopathy","Sensory Profiles","Colic","Sleep Quality","Motor Development of Premature Infants",[192,193,194,195,196],"manual therapy","premature","sensory integration","early intervention","cranial","NOT_YET_RECRUITING","2025-05-05",{"date":200,"type":40},"2025-05-13",{"date":198,"type":22},{"date":203,"type":22},"2025-10-08",{"name":205,"class":47},"Abant Izzet Baysal University",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":17,"minAge":180,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":23,"phases":215,"briefSummary":216,"conditions":217,"keywords":218,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":48},"100585349","neonatologist-performed-lung-ultrasound-nplus-to-guide-respiratory-therapy-100585349","NCT06901206","Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy","Neonatologist-Performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy on Non-Invasive Ventilation in Preterm Infants","Inclusion Criteria:\n\n* All preterm infants (\\\u003C33 weeks gestational age) from their 2nd week of life, receiving respiratory support via NCPAP\n* expected to stay on NCPAP for the following 5 days at the NICU, Royal Hospital for Women, Randwick, Sydney\n* provided written informed consent obtained from parents.\n\nExclusion Criteria:\n\n* Neonates with previous abdominal surgery\n* Major congenital anomalies.\n* \\>33+0 weeks\n* Less than 1 week of age\n* Invasive ventilation\n* Bilevel or Multilevel non-invasive ventilation\n* Not expected respiratory support via CPAP for the following 5 days.",{"count":214,"type":22},20,[25],"The goal of this cross-over clinical trial is to evaluate whether Neonatologist-Performed Lung Ultrasound (NPLUS) can be used in preterm babies on non-invasive breathing support to reduce the amount of oxygen they need. The main question it aims to answer is:\n\nWhen a baby's oxygen requirement goes up, does NPLUS help to target interventions and reduce oxygen requirements?\n\nResearchers will compare NPLUS to standard treatment.\n\nParticipants will:\n\nHave a lung ultrasound performed whenever their oxygen requirement increases by more than 10%.\n\nThe ultrasound findings will be used to target interventions that aim to improve air entry in the lungs.\n\nEach time this happens, the researchers will note what happens to the oxygen requirement afterwards.\n\nEach participant will participate for five days. For the first two days, they will be randomized to either the NPLUS arm or the usual care arm.\n\nThere is then a 24 hour period of usual care. For the final two days, participants cross over to the other arm of the trial.",[28,62],[219,220,221,222,223,224,225,226],"NPLUS","Neonatologist performed lung ultrasound","lung ultrasound score","CPAP","loss of aeration","atelectasis","preterm neonate","respiratory distress syndrome","2025-03-23",{"date":229,"type":40},"2025-03-28",{"date":231,"type":22},"2025-03",{"date":233,"type":22},"2026-06",{"name":235,"class":47},"Royal Hospital For Women",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":17,"minAge":243,"maxAge":244,"enrollmentInfo":245,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":247,"conditions":248,"keywords":252,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":48},"100583271","non-invasive-prediction-of-necrotizing-enterocolitis-in-preterm-neonates-with-feeding-intolerance-using-fecal-lipocalin-2-and-electrical-cardiometry-100583271","NCT06874153","Non-Invasive Prediction of Necrotizing Enterocolitis in Preterm Neonates with Feeding Intolerance Using Fecal Lipocalin-2 and Electrical Cardiometry","Non-Invasive Prediction of Necrotizing Enterocolitis in Preterm Neonates with Feeding Intolerance","Inclusion Criteria:\n\nPreterm neonates with gestational age ≤ 35 weeks, admitted to NICU, started enteral feeding and diagnosed as having feeding intolerance defined as stage IA and IB by modified bell's staging\n\nExclusion Criteria:\n\n1. Chromosomal anomaly or multiple congenital malformations.\n2. Patient with surgical malformation of the intestinal tract (i.e. omphalocele, gastroschisis, malrotation, intestinal atresia)\n3. Patient diagnosed as hypoxic ischemic encephalopathy.","1 Day","28 Days",{"count":246,"type":22},42,"Prospective observational study to evaluate the efficiency of using electrical cardiometry in combination with fecal lipocalin-2 for prediction of NEC in preterm neonates with feeding intolerance",[249,250,251,28],"Feeding Intolerance in Preterm","NEC","Electrical Cardiometry",[253,250,251,254,255,256],"preterm","SMA flow","feeding intolerance in preterm","Fecal lipocalin-2","2025-03-08",{"date":259,"type":40},"2025-03-13",{"date":261,"type":22},"2025-03-05",{"date":263,"type":22},"2026-06-05",{"name":265,"class":47},"Ain Shams University",{"id":267,"slug":268,"hasResults":11,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":55,"sex":17,"minAge":19,"maxAge":273,"enrollmentInfo":274,"targetDuration":4,"studyType":23,"phases":275,"briefSummary":276,"conditions":277,"keywords":280,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":289,"locationsCount":4},"100577536","the-effect-of-massage-on-preterm-babies-100577536","NCT06799572","The Effect of Massage on Preterm Babies","The Effect of Massage on Pain, Comfort and Feeding Status of Preterm Infants Under Nasal Continuous Positive Airway Pressure (NCPAP)","Inclusion Criteria:\n\n* Infants of parents who agreed to participate in the study,\n\n  * Receiving NCPAP therapy for at least 1 day,\n  * Gestational age greater than 32 weeks\n  * Birth weight over 1500 grams\n  * Infants fed with orogastric + total parenteral nutrition (TPN) will be included.\n\nExclusion Criteria:\n\n* • Infants with necrotising entecolitis, suspected or confirmed sepsis,\n\n  * No skin disease,\n  * Not receiving sedation (considering that it may affect pain response),\n  * Babies who have undergone surgical intervention (abdominal and central nervous system, cardiac surgery)\n  * Babies of substance-abusing mothers,\n  * Infants of parents who do not agree to participate in the study will not be included.\n\nBabies in the massage group who switched from Ncpap to IMV, who underwent surgical intervention with sedation and who developed NEC will be excluded from the study.","37 Weeks",{"count":21,"type":22},[25],"This study was planned as a randomized controlled experimental study with pre-test post-test design in order to examine the effect of massage on pain, comfort and nutritional status in infants undergoing NCPAP in the NICU, considering that massage may be effective in reducing the effectiveness of treatment and complications that may develop due to NCPAP by reducing stress in newborns undergoing NCPAP.In this research, answers to the following questions will be sought; Massage has an effect on pain in preterm infants receiving NCPAP therapy; H1: has an effect on pain. H2: has an effect on comfort. H3: has an effect on feeding intolerance (vomiting, abdominal distension, stool output...)",[28,278,279],"nCPAP","Massage",[281,282,253],"ncpap","massage","2025-01-23",{"date":285,"type":40},"2025-01-29",{"date":287,"type":22},"2025-01-30",{"date":42,"type":22},{"name":290,"class":47},"Özlem BOZBUĞA",{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":55,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":298,"targetDuration":4,"studyType":23,"phases":299,"briefSummary":300,"conditions":301,"keywords":305,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":48},"100567046","using-nirs-to-evaluate-splanchnic-oxygenation-during-blood-transfusion-in-preterm-infant-100567046","NCT06663085","Using NIRS to Evaluate Splanchnic Oxygenation During Blood Transfusion in Preterm Infant","The Effect of Enteral Feeding on Splanchnic Oxygenation During Blood Transfusion in Preterm Infants","Inclusion Criteria:\n\n* Infant with gestational age \\\u003C 37 weeks\n* Planned to receive blood transfusion\n* Had received minimum 25 ml\u002Fkg\u002Fday enteral feeding\n* in stable condition\n\nExclusion Criteria:\n\n* Infant with multiple congenital anomalies\n* Infant with suspected\u002Fconfirmed genetic anomalies\n* Parents or family did not sign the informed consent",{"count":246,"type":22},[25],"To evaluate the differences splanchnic oxygen saturation in preterm infants receiving red blood cell transfusion with and without enteral feeding, and their outcomes.",[302,303,28,304],"Splanchnic Oxygenation","NIRS","Enteral Feeds",[306,307,308,225,309],"transfusion","nirs","splanchnic oxygenation","enteral feeds","2024-10-28",{"date":312,"type":40},"2024-10-29",{"date":314,"type":22},"2024-10-30",{"date":316,"type":22},"2025-01-15",{"name":318,"class":47},"Gadjah Mada University",{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":324,"acronym":4,"eligibilityCriteria":325,"healthyVolunteers":55,"sex":17,"minAge":326,"maxAge":327,"enrollmentInfo":328,"targetDuration":4,"studyType":23,"phases":330,"briefSummary":331,"conditions":332,"keywords":333,"overallStatus":197,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":4},"100564365","effect-of-nursing-interventions-on-pain-and-salivary-cortisol-levels-during-heel-stick-in-preterm-newborns-100564365","NCT06628232","Effect of Nursing Interventions on Pain and Salivary Cortisol Levels During Heel Stick in Preterm Newborns","The Effect of Giving a Pacifier Dipped in Breast Milk, Heel Warming, and Applying Both Together on Pain and Salivary Cortisol Levels During Heel Stick in Preterm Newborns: Randomized Controlled Study.","Inclusion Criteria:\n\n* Mother 18 years of age or older\n* Mother is literate\n* Whether the mother gives birth naturally or by caesarean section\n* Uncomplicated pregnancy and birth history in mother\n* Mother\\'s voluntary participation in the study\n* Preterm babies between 34 0\u002F7-36 6\u002F7 weeks\n* Prematurity at 34 0\u002F7-36 6\u002F7 weeks and weight appropriate for the week (Appropriate Gestational Age- AGA),\n* The baby should be fed at least 1 hour in advance.\n* It has been 1 hour since the last painful intervention on the baby.\n* 6Heel blood should be taken 6 hours after taking analgesic, sedative and anticonvulsant medications.\n\nExclusion Criteria:\n\n* The baby has a fever\n* The baby receiving oxygen therapy,\n* The baby receiving antibiotic treatment\n* The baby has a congenital anomaly\n* The baby having the bed side and heater underneath\n* The baby receiving phototherapy,\n* The baby is connected to a mechanical ventilator\n* Babies whose blood was not collected on the first attempt","34 Weeks","36 Weeks",{"count":329,"type":22},18,[25],"Babies born before the thirty-seventh gestational week are called preterm or premature. Most preterm newborns require Neonatal Intensive Care Unit (NICU) care depending on their gestational age and clinical condition. Although many painful invasive procedures are usually performed on newborns in the NICU, the most common procedure is heel prick. Heel prick is a painful and stressful procedure for the newborn. Neonates do not respond to pain verbally; they respond physiologically, behaviorally and hormonally. Physiologic responses of preterm infants to pain include increased heart and respiratory rate, increased blood pressure and intracranial pressure, decreased oxygenation, and sweating of palms. Among the hormonal symptoms caused by stress in newborns, the most commonly used biochemical method is the measurement of cortisol level. It is reported that there is a significant correlation between salivary and plasma cortisol levels and salivary cortisol level reflects plasma cortisol level. This method is particularly preferred because saliva sampling is much less stressful.",[28],[253,334,335,336,337],"leel prick","pain","salivary cortisol","nursing care","2024-10-02",{"date":340,"type":40},"2024-10-04",{"date":342,"type":22},"2024-11-01",{"date":344,"type":22},"2025-11-01",{"name":346,"class":47},"Namik Kemal University"]