[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-angle-closure-glaucoma\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-angle-closure-glaucoma":124},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,37,58,83,112,140],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":4},"100635188","predicting-the-risk-of-partial-ciliary-block-after-cataract-and-goniosynechialysis-surgery-in-primary-angle-closure-disease-100635188",false,"NCT07549438","Predicting the Risk of Partial Ciliary Block After Cataract and Goniosynechialysis Surgery in Primary Angle-Closure Disease","Risk Prediction of Partial Ciliary Block After Phacoemulsification Combined With Goniosynechialysis in Primary Angle-Closure Disease: A Prospective Multicenter Study","PCB-Risk","Inclusion Criteria:\n\n1. Diagnosis of Primary Angle-Closure Disease (PACD), including Primary Angle-Closure Suspect (PACS), Primary Angle-Closure (PAC), or Primary Angle-Closure Glaucoma (PACG).\n2. Clinical indication for phacoemulsification combined with intraocular lens implantation and goniosynechialysis (Phaco+GSL), due to poorly controlled intraocular pressure, extensive peripheral anterior synechiae (PAS), or the presence of a clinically significant cataract.\n3. Ability to cooperate with required preoperative imaging examinations, including Ultrasound Biomicroscopy (UBM), IOLMaster, and Anterior Segment Optical Coherence Tomography (AS-OCT).\n\nExclusion Criteria:\n\n1. Secondary angle closure (e.g., neovascular glaucoma, uveitic glaucoma, iridocorneal endothelial \\[ICE\\] syndrome, or intraocular tumors\u002Fcysts).\n2. Specific lens abnormalities that confound anatomical assessment, including lens subluxation, hypermature intumescent cataract, or traumatic cataract.\n3. Previous intraocular surgery, including glaucoma filtering surgeries (e.g., trabeculectomy, tube shunts) or vitreoretinal surgeries (Note: Previous laser peripheral iridotomy is permitted).\n4. Use of systemic or topical medications known to affect ciliary body morphology or pupillary function (e.g., topiramate, cholinergic agonists) during the time of imaging.\n5. Poor quality or uninterpretable preoperative UBM or OCT images due to corneal opacity, edema, or other media opacities.\n6. Axial length shorter than 19mm.","ALL",{"count":19,"type":20},1150,"ESTIMATED","OBSERVATIONAL","Primary angle-closure disease (PACD) is a major cause of vision loss, often treated with a combined surgery that removes the eye's natural lens (cataract surgery) and physically opens the eye's drainage system (goniosynechialysis). While effective, this surgery carries a small risk of a severe complication called ciliary block (or aqueous misdirection), where fluid builds up in the wrong part of the eye, pushing structures forward and causing high eye pressure. Recently, doctors have also noticed a \"partial\" form of this block, which can slowly cause the eye's drainage angle to close again without immediate severe symptoms.\n\nThe purpose of this prospective, observational study is to identify which patients are at the highest risk for developing classic or partial ciliary block after this combined surgery. Researchers will use standard, non-invasive eye imaging tools-such as ultrasound biomicroscopy (UBM) and optical coherence tomography (OCT)-to take highly detailed measurements of the front of the eye before surgery. They will specifically look at factors like the width of the anterior chamber, the thickness of the lens, and the eye's overall length. To ensure accuracy, patients with a very short eye length (less than 19mm) will not be included in the study.\n\nBecause this is an observational study, participation will not change a patient's standard surgical plan. Patients will undergo their scheduled surgery and be monitored for 12 months during routine follow-up visits to track their eye pressure, vision, and any structural changes in the eye.\n\nBy confirming which pre-surgery measurements predict ciliary block, researchers hope to validate a risk-warning model. This will help eye surgeons take preventive steps-such as administering specific medications like mannitol before surgery-to make the procedure safer and improve long-term outcomes for patients with PACD.",[24],"Primary Angle-Closure Glaucoma","NOT_YET_RECRUITING","2026-04-18",{"date":28,"type":29},"2026-04-24","ACTUAL",{"date":31,"type":20},"2026-04-20",{"date":33,"type":20},"2031-04-19",{"name":35,"class":36},"Peking University People's Hospital","OTHER",{"id":38,"slug":39,"hasResults":11,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":4,"eligibilityCriteria":42,"healthyVolunteers":11,"sex":17,"minAge":43,"maxAge":4,"enrollmentInfo":44,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":46,"conditions":47,"keywords":4,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":49,"lastUpdatePostDateStruct":50,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":57},"100634437","the-multi-omics-analysis-of-lens-zonule-relaxation-in-the-pacg-pathogenesis-100634437","NCT07539675","The Multi-Omics Analysis of Lens Zonule Relaxation in The PACG Pathogenesis","Inclusion Criteria:\n\n* Clinically diagnosed with primary angle-closure glaucoma (PACG)\n* Aged ≥ 50 years, no gender restriction\n* Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity\n* Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology\n* Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery\n\nExclusion Criteria:\n\n* Secondary glaucoma\n* History of previous intraocular surgery\n* Systemic diseases that can cause abnormal ocular zonules\n* Other severe ocular diseases\n* Long-term use of medications affecting connective tissue metabolism","50 Years",{"count":45,"type":20},150,"Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.",[24],"RECRUITING","2026-04-13",{"date":31,"type":29},{"date":52,"type":29},"2025-10-01",{"date":54,"type":20},"2027-09-30",{"name":56,"class":36},"Zhongnan Hospital",1,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":17,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":70,"conditions":71,"keywords":72,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":57},"100633165","vitreous-zonule-in-primary-angle-closure-glaucoma-100633165","NCT07523139","Vitreous Zonule in Primary Angle-Closure Glaucoma","A Cross-Sectional, Prospective Observational Study on the Role of the Vitreous Zonule in the Pathogenesis of Primary Angle-Closure Glaucoma","Inclusion Criteria:\n\n1\\. Age between 30 and 80 years, inclusive. 2. Diagnosis of primary angle-closure disease (PACS, PAC, or PACG) according to standardized gonioscopic criteria; or healthy controls with open angles. 3. Lens opacity graded \\\u003C 2 for cortical and nuclear opacities according to the Lens Opacities Classification System III (LOCS III). 4. Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n1\\. Any intraocular disease affecting the anterior or posterior segment, including but not limited to corneal disease, iris abnormalities, lens disorders other than age-related cataract, vitreous disorders, uveoretinal diseases, or optic neuropathies. 2. Prior intraocular surgery or laser treatment, including cataract surgery, trabeculectomy, laser trabeculoplasty, laser peripheral iridotomy, laser iridoplasty, or vitreoretinal surgery. 3. Systemic diseases that may affect ocular examination or confound measurements, such as end-stage cardiac disease, renal disease, pulmonary disease, or advanced malignancy. 4. Inability to undergo ultrasound biomicroscopy (UBM) examination due to inability to maintain supine position or other contraindications. 5. Pregnancy or lactation. 6. Any condition that, in the opinion of the investigator, would compromise the participant's ability to comply with study procedures or affect the validity of the study results.",true,"30 Years","79 Years",{"count":69,"type":20},440,"This study aims to investigate the role of the vitreous zonule (VZ) in the pathogenesis of primary angle-closure glaucoma (PACG) and to explore the feasibility of three-dimensional ultrasound biomicroscopy (3D-UBM) for imaging the circumferential VZ.\n\nThis prospective, observational study will enroll patients with primary angle-closure disease (PACD), including primary angle-closure suspect (PACS), primary angle-closure (PAC), and PACG, as well as healthy controls. All participants will undergo comprehensive ophthalmic examinations, including gonioscopy, biometric measurements using IOLMaster, and UBM imaging. The study consists of three main components: (1) analysis of VZ morphology, location, number of visible quadrants, and anterior segment parameters across different age groups and axial length groups in healthy individuals, with comparisons to age-matched PACD patients; (2) development and validation of a 3D-UBM imaging system using a rotational scanning approach to reconstruct the spatial structure of the VZ; and (3) characterization of VZ features, including density and morphology, in normal eyes versus PACD eyes using 3D-UBM.\n\nThe primary outcomes include the presence, quadrant count, and morphological characteristics (vitreous zonule-pars plana angle and maximum distance) of the VZ, as well as anterior segment parameters such as lens vault, anterior chamber depth, trabecular-iris angle, and angle opening distance. By elucidating age-related and axial length-related changes in the VZ and establishing 3D-UBM as a novel imaging modality for the posterior zonular apparatus, this study seeks to provide new evidence for the mechanistic role of the VZ in angle-closure glaucoma and to identify potential imaging biomarkers for early diagnosis and risk stratification.",[24],[73,74,75],"Ultrasound Biomicroscopy","Vitreous Zonule","Three-dimensional Imaging","2026-04-05",{"date":49,"type":29},{"date":79,"type":29},"2025-01-01",{"date":81,"type":20},"2027-06",{"name":35,"class":36},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":17,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":57},"100632716","kahook-dual-blade-goniotomy-in-chronic-primary-angle-closure-glaucoma-100632716","NCT07517302","Kahook Dual Blade Goniotomy in Chronic Primary Angle-Closure Glaucoma","Phacoemulsification and Goniosynechialysis With or Without Kahook Dual Blade Goniotomy in Chronic Primary Angle-Closure Glaucoma: A 1-Year Randomized Controlled Trial","Inclusion Criteria:\n\n* (1) age ≥ 40 years; (2) a confirmed diagnosis of CPACG, defined as the presence of peripheral anterior synechiae (PAS) extending ≥ 180° on indentation gonioscopy, accompanied by glaucomatous optic neuropathy and corresponding visual field defects; (3) a visually significant cataract that impaired daily activities and necessitated phacoemulsification; and (4) inadequately controlled intraocular pressure (IOP), defined as an IOP \\> 21 mmHg despite maximally tolerated anti-glaucoma medications, or an IOP ≤ 21 mmHg dependent on the continuous use of two or more topical medications.\n\nExclusion Criteria:\n\n* (1) any form of secondary angle-closure glaucoma (e.g., neovascular, uveitic, or lens-induced glaucoma); (2) a history of prior intraocular surgery or incisional glaucoma procedures, although eyes with a previous uncomplicated laser peripheral iridotomy (LPI) were permitted; (3) concurrent severe ocular pathologies that could profoundly limit visual prognosis or confound functional assessments (e.g., severe diabetic retinopathy, advanced age-related macular degeneration, or optic atrophy of non-glaucomatous origin); (4) a central corneal endothelial cell density of \\\u003C 1500 cells\u002Fmm² to ensure the safety of the planned anterior chamber interventions; and (5) any severe systemic conditions precluding surgical tolerance or adherence to the 1-year follow-up protocol.","40 Years",{"count":92,"type":20},68,"INTERVENTIONAL",[95],"NA","This prospective randomized controlled trial, conducted by the Ophthalmology Department of Peking University People's Hospital, aims to compare the intraocular pressure (IOP)-lowering efficacy and safety of two surgical regimens-phacoemulsification with intraocular lens implantation plus goniosynechialysis (PEI-GSL) and PEI-GSL combined with Kahook Dual Blade (KDB) ab interno goniotomy (PEI-GSL-KDB)-in 68 patients (34 eyes per group) with chronic primary angle-closure glaucoma (PACG) complicated by age-related cataract. All surgeries are performed by senior glaucoma specialists, with a 1-year follow-up for outcomes assessment. The primary outcome is the 12-month IOP control success rate (IOP ≤21 mmHg with a ≥20% reduction from baseline, with or without topical hypotensive medications), and secondary outcomes include intra- and post-operative complications and changes in peripheral anterior synechiae (PAS). Statistical analyses will use t-tests, chi-square tests, etc., with P\\\u003C0.05 considered statistically significant. The study is scheduled from January 2024 to December 2025, and preliminary research has confirmed the safety and efficacy of combined glaucoma-cataract surgeries, laying a solid foundation for this trial.",[98],"Primary Angle-closure Glaucoma",[100,101,102,103],"KDB Goniotomy","Phacoemulsification","Intraocular Pressure","Goniosynechialysis","2026-04-01",{"date":106,"type":29},"2026-04-08",{"date":108,"type":29},"2025-03-01",{"date":110,"type":20},"2026-07-01",{"name":35,"class":36},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":90,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":93,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":57},"100589264","comparison-of-phaco-surgery-with-goniosynechialysis-versus-trabeculectomy-in-glaucoma-treatment-100589264","NCT06952153","Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment","Comparison of Phaco Surgery and Goniosynechialysis Versus Trabeculectomy Outcomes in Glaucoma Patients","Inclusion Criteria:\n\n* Age ≥ 40 years\n* Peripheral anterior synechiae (PAS) \\>180°\n* Glaucomatous optic neuropathy with visual field loss\n* Intraocular pressure (IOP) \\> 21 mmHg despite medication\n* Ability to consent and comply with follow-up\n* Cataract grade 1 to 3 according to LOCS III\n* Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20\u002F40 Snellen or worse)\n\nExclusion Criteria:\n\n* Very advanced glaucoma (only light perception vision)\n* Secondary angle-closure etiologies\n* Prior ocular surgeries or laser peripheral iridotomy (PI)\n* Allergy to 5-fluorouracil (5-FU), if used postoperatively\n* Irreversible corneal disease\n* Chronic corticosteroid use\n* Poor follow-up compliance\n* Cataract grade 4 or 5 (LOCS III)\n* Phacomorphic, phacolytic, or subluxated cataracts",{"count":120,"type":20},82,[95],"The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma.\n\nThe main questions it aims to answer are:\n\n* Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy?\n* What are the rates of postoperative complications or adverse events between the two surgical approaches?\n* How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications?\n\nResearchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma.\n\nParticipants will:\n\nBe randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks",[124],"Primary Angle Closure Glaucoma",[126,127,128,129,130],"PACG","Phaco-GSL","trabeculectomy","RCT","Ophthalmic surgery","2025-09-04",{"date":133,"type":29},"2025-09-11",{"date":135,"type":29},"2025-06-01",{"date":137,"type":20},"2027-09-10",{"name":139,"class":36},"University of Medicine and Pharmacy at Ho Chi Minh City",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":17,"minAge":148,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":93,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":48,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":57},"100451857","trabeculectomy-versus-peripheral-iridectomy-plus-goniotomy-in-advanced-pacg-100451857","NCT05163951","Trabeculectomy Versus Peripheral Iridectomy Plus Goniotomy in Advanced PACG","Effectiveness and Safety of Trabeculectomy and Peripheral Iridectomy Plus Goniotomy in Advanced Primary Angle-closure Glaucoma: a Multicenter Non-inferiority Randomized Controlled Trial","TVG","Inclusion Criteria:\n\n1. Age 45-80 years.\n2. Eyes diagnosed with advanced PACG who meet following criteria a, b, and c; or a, b, and d:\n\n   1. PAS: ≥180° range, including nasal and inferior quadrants;\n   2. IOP \\>21 mmHg with or without anti-glaucoma medications (the medications include the maximally tolerated medications), taken with the Goldmann applanation tonometer;\n   3. Glaucomatous optic neuropathy (cup-to-disc \\[C\u002FD\\] ratio ≥0.7, C\u002FD asymmetry \\>0.2, or rim width at the superior and inferior temporal areas \\\u003C0.1 of the vertical diameters of the optic disc);\n   4. Glaucomatous visual field defects (nasal step, arcuate scotoma, and paracentral scotoma on a reliable Humphrey analyzer and a mean deviation of ≤-12 dB).\n3. No or mild cataracts and uncorrected visual acuity of ≥0.63 (Early Treatment Diabetic Retinopathy Study chart);\n4. Axial length of ≥20 mm.\n\nExclusion Criteria:\n\n1. History of ocular surgery or trauma.\n2. Retinal disease that influences the collection of ocular parameters or other types of glaucoma, including open-angle glaucoma, secondary angle-closure glaucoma, steroidal glaucoma, angle recession glaucoma, neovascular glaucoma, nanophthalmos, and pseudoexfoliation syndrome.\n3. Monophthalmia (best-corrected visual acuity of \\\u003C0.01 in the non-study eye).\n4. An International Standardized Ratio of \\>3.0, for patients receiving warfarin or anticoagulant therapy before surgery.\n5. Patients with serious systemic diseases.\n6. Pregnant or lactating women.\n\nIf both eyes are eligible for the study, the eye with the worse visual field or optic nerve will be included.","45 Years","80 Years",{"count":151,"type":20},88,[95],"A multicenter, parallel, open, non-inferior randomized controlled trial is conducted to compare the effectiveness and safety of trabeculectomy and peripheral iridectomy plus goniotomy (TVG) in the treatment of advanced primary angle closure glaucoma with no or mild cataracts.",[124],[156,157],"angle closure","glaucoma","2022-06-09",{"date":160,"type":29},"2022-06-14",{"date":162,"type":29},"2022-01-05",{"date":164,"type":20},"2026-06-30",{"name":166,"class":36},"Sun Yat-sen University"]