[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-bilary-cirrhosis-pbc\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-bilary-cirrhosis-pbc":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,39],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100635201","clinical-characterization-of-patients-with-primary-biliary-cirrhosis-treated-with-seladelpar-in-the-real-life-setting-100635201",false,"NCT07549607","Clinical Characterization of Patients With Primary Biliary Cirrhosis Treated With Seladelpar in the Real-life Setting","SENSE registry","Inclusion Criteria:\n\n1. Age ≥ 18 years\n2. Diagnosis of PBC according to EASL criteria\n3. Treatment with seladelpar\n4. Written informed consent\n\nExclusion Criteria:\n\n1. current or previous participation in a phase I to IV interventional clinical trial for seladelpar treatment of PBC\n2. Pregnancy and breastfeeding","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","48 Weeks","OBSERVATIONAL","The seladelpar registry will collect real-world data of patients with PBC diagnosis treated with seladelpar in the real-life scenario in Germany and Switzerland.",[25],"Primary Bilary Cirrhosis (PBC)","NOT_YET_RECRUITING","2026-04-17",{"date":29,"type":30},"2026-04-24","ACTUAL",{"date":32,"type":20},"2026-04-01",{"date":34,"type":20},"2028-10-01",{"name":36,"class":37},"University of Leipzig","OTHER",21,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":46,"targetDuration":48,"studyType":22,"phases":4,"briefSummary":49,"conditions":50,"keywords":4,"overallStatus":53,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":63},"100329484","canadian-network-for-autoimmune-liver-disease-100329484","NCT03569826","Canadian Network for Autoimmune Liver Disease","CaNAL","Inclusion Criteria:\n\n* Diagnosis of Primary Biliary Cholangitis and\u002For Autoimmune Hepatitis\n\nExclusion Criteria:\n\n* Less than 18 years of age",{"count":47,"type":20},2500,"6 Years","CaNAL is a longitudinal observational cohort study of patients diagnosed with Primary Biliary Cholangitis (PBC), Autoimmune Hepatitis (AIH), or overlap syndrome. This study creates a nationwide registry and network focusing on high quality long-term follow-up of individual patient data from major Canadian centers.\n\nPrimary Biliary Cholangitis (PBC) and Autoimmune Hepatitis (AIH) are rare and slowly progressive liver diseases associated with development of cirrhosis, liver cancer (HCC) and liver failure requiring liver transplantation or leading to premature death. The rarity and slowly progressive nature of these autoimmune liver diseases make them difficult to study and only a large scale approach combining patient data from multiple centers across Canada will allow new insights. The primary aim of the Canadian Network for Autoimmune Liver Disease is to build a Canadian registry of patients with PBC, AIH, and overlap syndrome. We capture patient characteristics, laboratory assessments and natural history, patient-reported outcomes including quality of life measures and environmental exposures, response to treatment, and pre- and post-transplant outcomes. We will then identify risk factors associated with critical outcomes for the patient, including response to treatment, progression to transplant, risk of liver cancer, and recurrent disease after transplant. We can identify biomarkers (biochemical indicators of progression of disease) to help diagnose autoimmune liver disease at its earliest stages, ensuring timely treatment and preventing disease progression. CaNAL will provide a better understanding of autoimmune liver diseases, biomarkers predictive of disease progression or non-response to therapy as well as better knowledge of the etiology and pathogenesis. CaNAL will also help to serve as a platform for conducting clinical trials or targeted lab-studies to answer important questions that are unlikely to be evaluated by the pharmaceutical industry.",[25,51,52],"Autoimmune Hepatitis","Overlap Syndrome","RECRUITING","2021-06-04",{"date":56,"type":30},"2021-06-07",{"date":58,"type":30},"2018-02-07",{"date":60,"type":20},"2028-12",{"name":62,"class":37},"University Health Network, Toronto",15]