[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-brain-neoplasm\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-brain-neoplasm":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,40,65,87],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100438340","patient-perceptions-around-quality-of-care-through-telemedicine-in-neuro-oncology-100438340",false,"NCT04988009","Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology","Inclusion Criteria:\n\n* Patients with a CNS tumors: this includes patients with primary brain tumors, brain metastases, and leptomeningeal disease\n* Established patients with a follow up encounter with Neuro-Oncology at the Brain and Spine Center at the University of Texas MD Anderson Cancer Center; this encounter can be\n\n  * An in-person visit\n  * A telemedicine appointment\n\nExclusion Criteria:\n\n* Encounter occurred with the assistance of official language translation support\n* Patients with telephone encounters (without interactive video)\n* New patient or consult visits\n* Neither patient nor caregiver present during the visit are available or able to answer survey questions","ALL","18 Years",{"count":18,"type":19},200,"ESTIMATED","OBSERVATIONAL","This study evaluates patient perceptions around quality of care through telemedicine in neuro-oncology. Studying questionnaires related to perceptions quality of care through telemedicine in patients with brain cancer may help doctors to improve the delivery of care through this modality.",[23,24,25,26],"Central Nervous System Neoplasm","Leptomeningeal Neoplasm","Metastatic Malignant Neoplasm in the Brain","Primary Brain Neoplasm","RECRUITING","2026-03-03",{"date":30,"type":31},"2026-03-05","ACTUAL",{"date":33,"type":31},"2020-08-20",{"date":35,"type":19},"2026-12-31",{"name":37,"class":38},"M.D. Anderson Cancer Center","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":47,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":55,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100614349","an-exercise-intervention-for-improving-mental-and-physical-health-in-patients-with-primary-brain-tumors-and-their-caregivers-et-neuro-trial-100614349","NCT07278440","An Exercise Intervention for Improving Mental and Physical Health in Patients With Primary Brain Tumors and Their Caregivers, ET-NEURO Trial","ET-NEURO: A Pilot Trial of the Exercise Together Program in Primary Brain Tumor Patient-Caregiver Dyads Incorporating Glymphatic MRI","Inclusion Criteria:\n\n* PATIENT INCLUSION:\n* Patient participants must have a histologically confirmed diagnosis of World Health Organization (WHO) grade 1-4 PBT such as glioblastoma, astrocytoma, oligodendroglioma, ependymoma, medulloblastoma, meningioma, and other primary brain tumors. Confirmed by review of the electronic medical record (EMR) and subsequently recorded in health history questionnaire. In cases where the EMR isn't clear, their Oregon Health \\& Science University OHSU provider will be contacted for confirmation\n* Patient participants on active oral chemotherapy, including cytotoxic chemotherapy and molecularly targeted therapy, for the treatment of PBT are allowed\n* Patient participants must be at least 6 weeks after the last dose of intravenous infusion chemotherapy for the treatment of PBT, including bevacizumab, prior to enrollment\n* Patient participants must be at least 6 weeks post-radiation for PBT prior to enrollment. Patient participants must be at least 8 weeks post-craniotomy prior to enrollment\n* Patient participants must have a co-residing spouse or partner caregiver due to the program's focus on intimacy\n* Patient participants must have a Karnofsky performance score of at least 70 or an Eastern Cooperative Oncology Group (ECOG) score of 1 or less\n* Patient participants are permitted to participate in other therapeutic interventional clinical trials for PBT\n* PATIENT AND CAREGIVER INCLUSION:\n* Patient participants and caregiver participants must be 18 years of age or older\n* Patient participants and caregiver participants must state willingness to comply with all study procedures and availability for the duration of the study\n* Patient participants and caregiver participants must have the ability to understand and the willingness to sign a written informed consent document\n* Patient participants and caregiver participants must have home internet sufficient for videoconferencing\n\nExclusion Criteria:\n\n* PATIENT AND CAREGIVER EXCLUSION:\n* Patient and caregiver participants must not have engaged in two or more regular strength training sessions per week (e.g., physical therapy) during the past 30 days, as confirmed by self-report on the health history questionnaire\n* Patient participants and caregiver participants with cognitive difficulties preclude answering survey questions. In the event of a suspected undeclared cognitive impairment, it will be confirmed by physician clearance or professional opinion of the principal investigator\n* Because this exercise intervention has not been evaluated in pregnant populations and the study team cannot provide the enhanced monitoring needed to ensure maternal and fetal safety, participants who are pregnant or planning pregnancy are excluded\n* Patient participants and caregiver participants with medical condition, movement condition, pre-existing focal neurological deficits, new focal deficits concerning for recurrent or progressive PBT necessitating second line treatment, post operative deficits\u002Fwound, or medication use that contraindicates participation in moderate intensity exercise. Specific contraindications include the following: poorly controlled diabetes, recent cardiac event, neuromuscular disease, untreated orthostatic hypertension, recent surgery, acute hernia, acute rheumatoid arthritis, severe memory disorders, severe balance disorder, inability to ambulate without a walker or wheelchair, inability to stand for 3 minutes, severe hearing or vision problem\n\n  * Confirmed by a combination of reviewing the EMR, self-report on the health history questionnaire, and\u002For by physician clearance. All patient participants will receive physician clearance by the neuro-oncology investigators prior to participating in the trial. For caregiver participants: must answer 'No' to American College of Sports Medicine pre-participation screening questions. If caregiver participants answer 'Yes' to either question they may be required to obtain physician clearance prior to being considered eligible. Physician clearance may also be requested at the discretion of the principal investigator",true,{"count":49,"type":19},36,"INTERVENTIONAL",[52],"NA","This clinical trial evaluates the effects of a partnered exercise program, called Exercise Together, on participants with primary brain tumors and their caregivers. Standard treatments for primary brain tumors require extensive caregiver support, and both patients and caregivers experience high psychological distress and physical burden as a result. While exercise is known to improve outcomes in cancer patients, its impact on primary brain tumor patients and caregivers remains unstudied. Exercise Together is a supervised, group exercise program previously studied in patients with other types of cancer, though never in patients with primary brain tumors or their caregivers. Exercise Together uses functional resistance training to target muscle groups essential for everyday activities to improve daily functioning. Since exercises are done in a partnered format, Exercise Together is also designed to foster teamwork and strengthen the relationship between the patient and their caregiver. This program may be safe, feasible, and effective in improving the mental and physical health of primary brain tumor patients and their caregivers.",[26],"NOT_YET_RECRUITING","2026-02-11",{"date":58,"type":31},"2026-02-13",{"date":60,"type":19},"2026-02-28",{"date":62,"type":19},"2026-08-02",{"name":64,"class":38},"OHSU Knight Cancer Institute",{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":15,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":50,"phases":75,"briefSummary":77,"conditions":78,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":39},"100349464","phase-1-hyperpolarized-carbon-c-13-pyruvate-in-diagnosing-glioma-in-patients-with-brain-tumors-100349464","NCT03830151","Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors","Hyperpolarized Pyruvate Imaging of Glioma: Imaging-Pathological Correlation","Inclusion Criteria:\n\n* Written informed consent will be obtained from each participants including healthy volunteers.\n* Healthy volunteers will not have contra-indications to MR scanning, but will otherwise not be subject to other selection criteria.\n* All patients will be enrolled in study # 2011-0370, the Stereotactic RadPath trial\n* Patient is \\>18 years old, agrees to participate in the clinical study and to complete all required visits and evaluations. The pediatric population has a different disease profile from the glioma patients we hope to recruit. To reduce heterogeneity in the patient population we will not consider patients younger than 18 for this study.\n* Patient is a candidate for cerebral tumor resection with lesion suspected to be or previously biopsy proven to be a primary brain tumor.\n* Patient is able to understand and give consent to participation in the study.\n* Patient agrees to undergo, prior to the procedure, magnetic resonance imaging (MRI, within 14 days and preferably with 3 days of the planned procedure) with perfusion, diffusion and spectroscopic imaging.\n* Patient has a GFR \\> 60. In patients with moderate renal failure (GFR 30-60), an alternate injection with 2 times half-dose multihance (gadobenate dimeglumine) or gadovist (gadobutrol) will be considered, if a contrast exam is deemed clinically necessary.\n* Specifically for this Study: Patient is willing to give signed informed consent for C13-Pyruvate MR Spectroscopy.\n\nExclusion Criteria:\n\n* Healthy volunteers will be screened using same process but will otherwise not be subject to other selection criteria.\n* The patient is found to have unfavorable anatomy to indicate that stereotactic biopsy could not be safely performed.\n* Pacemakers, electronic stimulation, metallic foreign bodies and devices and\u002For other conditions that are not MR safe, which include but are not limited to: • electronically, magnetically, and mechanically activated implants • ferromagnetic or electronically operated active devices like automatic cardioverter defibrillators and cardiac pacemakers • metallic splinters in the eye • ferromagnetic hemostatic clips in the central nervous system (CNS) or body • cochlear implants • other pacemakers, e.g., for the carotid sinus • insulin pumps and nerve stimulators • non-MR safe lead wires • prosthetic heart valves (if dehiscence is suspected) • non-ferromagnetic stapedial implants • pregnancy • claustrophobia that does not readily respond to oral medication\n* Prior brain tumor treatment, including surgical resection, radiation therapy or chemotherapy for a primary brain neoplasm. Previous biopsy will not disqualify the patient from participation. Remote history (\\> 6month) of non-CNS malignancy in remission, without evidence of current\u002F prior brain metastasis, will also not disqualify patient from participating.\n* History of cardiac arrhythmia","19 Years",{"count":74,"type":19},13,[76],"PHASE1","This trial studies how an imaging agent, hyperpolarized carbon C 13 pyruvate, works in diagnosing glioma in patients with brain tumors. Giving hyperpolarized carbon C 13 pyruvate before an advanced imaging technique called a magnetic resonance spectroscopic imaging (MRSI) scan may help researchers better diagnose glioma in patients with brain tumors.",[26],"2026-01-12",{"date":81,"type":31},"2026-01-13",{"date":83,"type":31},"2019-05-16",{"date":85,"type":19},"2028-12-31",{"name":37,"class":38},{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":15,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":50,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100577529","virtual-home-based-exercise-intervention-rise-to-improve-cancer-related-cognitive-impairment-and-gut-microbiome-in-adolescent-and-young-adult-brain-tumor-survivors-100577529","NCT06799481","Virtual Home-based Exercise Intervention (RISE) to Improve Cancer-Related Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors","Virtually Delivered Home-Based Exercise Intervention on Cognitive Impairment and Gut Microbiome in Adolescent and Young Adult Brain Tumor Survivors: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 15-39 years\n* With primary brain tumor with cranial radiotherapy\n* 6 months to 4 years post cranial radiotherapy\n* Functional Assessment of Cancer Therapy (FACT)-Cognitive Function score \\\u003C 60 based on self-report (used among AYAs with non-neural cancer)\n* Able to provide informed consent\u002Fassent\n* Able to walk and receive clearance from a provider to participate based on the Physical Activity Readiness Questionnaire\n* Currently engaging in \\\u003C 150 minutes of physical activity per week\n* Willing to use smartphone-based applications (app)\n\nExclusion Criteria:\n\n* Secondary malignancies, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain\n* Moderate to severe traumatic brain injury with brain damage beyond that expected from brain tumor and treatment\n* Developmental disorders (e.g., autism) or major psychotic illness (e.g., schizophrenia, depression) to avoid confounding impact related to these disorders","15 Years","39 Years",{"count":97,"type":19},60,[52],"This clinical trial evaluates the impact of a research intervention of virtually supervised exercise program (RISE) on cancer-related cognitive impairment (CRCI), physical activity in adolescent and young adult (AYA) brain tumor survivors. This clinical trial also evaluates the impact of RISE on the collection of microorganisms that exist in the intestines (gut microbiome). Up to 45% of AYA brain tumor survivors experience CRCI, including issues with attention and memory. CRCI can have a negative impact on education, independent living and can worsen long-term quality of life. Moderate-intensity levels of exercise, particularly aerobic and resistance training, have been shown to improve cognitive function. Additionally, exercise can change the composition and function of the gut microbiome, which may lead to improved cognitive function. Unfortunately, only about 50% of AYAs with cancer receive exercise information or meet the physical activity recommendations. Tailoring a virtually delivered exercise intervention to meet the unique needs of AYAs may improve access to exercise. Participating in the virtual home-based exercise intervention, RISE, may improve physical activity and cognitive impairment in AYA brain tumor survivors and may also help researchers understand the relationship of exercise on the gut microbiome and cognitive function.",[101,26],"Cancer-related Cognitive Dysfunction","2026-01-07",{"date":104,"type":31},"2026-01-09",{"date":106,"type":31},"2025-02-13",{"date":108,"type":19},"2027-07-31",{"name":110,"class":38},"Emory University",2]