[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-care":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,22,0,[8,53,78,109,158,183,209,237,259,289,311,343,368,393,435,462,483,518,544,567,594,617],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100498084","effectiveness-of-a-joint-general-practitioner-pharmacist-intervention-on-benzodiazepine-deprescribing-in-the-elderly-100498084",false,"NCT05765656","Effectiveness of a Joint General Practitioner-Pharmacist Intervention on Benzodiazepine Deprescribing in the Elderly","Evaluation of the Effectiveness of a Joint General Practitioner-Pharmacist Intervention on the Implementation of Benzodiazepine Deprescribing in the Elderly (BESTOPH-MG Trial): Protocol for a Cluster-randomized Controlled Trial","BESTOPH-MG","Inclusion Criteria:\n\n* outpatients aged 65 and over\n* followed by the general practitioner and the pharmacist of the GP-PO pair\n* having a prescription for an anxiolytic or hypnotic BZDR prescribed at least 4 times in the past year\n* the last prescription being less than 3 months old\n* having been dispensed monthly during the last 3 months\n* affiliated to a social security scheme\n* and having given consent to participate in the research.\n\nExclusion Criteria:\n\n* patients living in an institution\n* participating in a clinical trial\n* with epilepsy\n* active depression\n* uncontrolled mental disorders\n* unable to participate in an interview or answer a questionnaire (demented, non-French speaking, illiterate, deaf, ...)\n* under guardianship\n* with a dystonic syndrome\n* and patients who are not sufficiently autonomous to carry out the steps inherent in the study","ALL","65 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","Benzodiazepines or related drug (BZDR) are consumed for hypnotic or anxiolytic purposes in most cases. The consequences of BZDR are multiple with an increased risk of daytime sedation, balance disorders leading to falls and fractures, cognitive disorders, road accidents and dementia. Given their comorbidities, physiological changes, and multiple medications, the elderly are more at risk of suffering from BZDR adverse events.\n\nInterprofessional collaboration has shown efficacy in improving prescribing appropriateness and may affect patients outcomes positively. Morever, motivational interviews (MI) may reduce the extent of substance abuse compared to no intervention.",[27,28,29,30,31,32],"Primary Care","Health Plan Implementation","Benzodiazepine Dependence","Elderly","Anxiety","Deprescribing",[34,35,36,37,38,39],"Primary care","collaborative practice","health plan implementation","deprescribing","benzodiazepine","elderly","RECRUITING","2026-06-19",{"date":43,"type":44},"2026-06-24","ACTUAL",{"date":46,"type":44},"2023-10-16",{"date":48,"type":21},"2027-02-16",{"name":50,"class":51},"Nantes University Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":22,"phases":64,"briefSummary":65,"conditions":66,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100610475","fixed-dose-combinations-pragmatic-randomized-implementation-trial-for-blood-pressure-control-100610475","NCT07228065","Fixed-Dose Combinations Pragmatic Randomized Implementation Trial for Blood Pressure Control","Pharmacy-led Intervention to Increase the Adoption of Fixed-dose Single Pill Blood Pressure Lowering Medications: Hybrid Effectiveness-Implementation Trial","Inclusion Criteria:\n\n* patients with documented hypertension diagnosis\n* had an elevated ambulatory blood pressure reading during the qualifying visit (systolic \\>140 mmHg or diastolic \\>90 mmHg\n* have an upcoming scheduled visit\n* have an active prescription for 1 blood pressure lowering medication with a fixed-dose combination (FDC) alternative\n\nExclusion Criteria:\n\n* have received a prescription for a FDC in the preceding two years\n* reside in a nursing home\n* have a documented allergy to any FDC components\n* are pregnant\n* preferred language is not English or Spanish, defined as documentation in the EHR indicating a primary language other than English or Spanish, or a documented request for an interpreter in a language other than Spanish\n* have a diagnosis of heart failure or renal failure, given that antihypertensive management in these populations typically requires disease-specific regimens and more frequent treatment adjustments","18 Years","80 Years",{"count":63,"type":21},720,[24],"The proposed study is an effectiveness-implementation hybrid type II trial designed to evaluate the impact of provider- and patient-directed interventions on FDC use. The trial will test the effectiveness of theory-driven nudges tailored to address provider and patient barriers. All interventions will be pharmacist-driven, with pharmacists delivering information via nudges to providers and via nudges or more intensive interventions (i.e., CPA) to patients. Data to evaluate outcomes will be extracted from electronic health records.",[67,27],"Hypertension","NOT_YET_RECRUITING","2026-06-17",{"date":71,"type":44},"2026-06-18",{"date":73,"type":21},"2026-07-31",{"date":75,"type":21},"2027-06-30",{"name":77,"class":51},"Brigham and Women's Hospital",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":17,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":22,"phases":90,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":52},"100595961","pilot-trial-of-clinic-based-dating-violence-prevention-program-for-adolescents-and-caregivers-100595961","NCT07039253","Pilot Trial of Clinic-based Dating Violence Prevention Program for Adolescents and Caregivers","Engaging Together for Healthy Relationships Version 2.0: Multisite Pilot Intervention Trial","ETHR2","Inclusion Criteria\n\nProviders:\n\n1. Sees patient at an eligible primary care clinic\n2. Speaks and understands English\n3. Age 18 or older\n4. Identifies as a pediatrician, nurse practitioner, physician assistant (pediatric primary care healthcare provider)\n\nAdolescents\n\n1. Age 12 to 16\n2. Attending an upcoming well-child visit from a provider enrolled in the study\n3. Caregiver who is accompanying well-child visit with adolescent is also participating\n4. Speaks and understands English\n\nParents\n\n1. Is parent or primary caregiver for an adolescent age 12 to 16\n2. Adolescent has an upcoming well-child visit with a provider enrolled in the study\n3. Accompanying child to the well-visit\n4. Adolescent is interested and eligible to participate in study\n5. Speaks and understand English\n\nExclusion Criteria:\n\n* Unable to assent\u002Fconsent\n* Does not meet inclusion criteria",true,"12 Years",{"count":89,"type":21},120,[24],"ETHR V 2.0 pilot trial is a one-arm, multi-site pilot trial to assess the acceptability and feasibility of Engaging Together for Healthy Relationships, a caregiver-adolescent dating violence prevention program delivered within pediatric primary care.",[93,94,27],"Dating Violence","Parent",[96,97,98,99],"dating violence prevention","parental monitoring and communication","pilot trial","middle school","2026-06-02",{"date":102,"type":44},"2026-06-04",{"date":104,"type":44},"2025-08-15",{"date":106,"type":21},"2027-06-15",{"name":108,"class":51},"University of Pittsburgh",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":86,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":122,"conditions":123,"keywords":130,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100639073","meva-cognitive-wellness-platform-study-for-adults-100639073","NCT07595250","MEVA Cognitive Wellness Platform Study for Adults","Phase 1 Validation Study of the MEVA Cognitive Wellness Platform","MEVA","Inclusion Criteria:\n\n* Adults aged 55 to 75 years\n* Community-dwelling (living independently in the community)\n* English fluency sufficient for informed consent, task instructions, and questionnaires\n* Able to provide informed consent using teach-back method\n* Able to use a computer or tablet for simple tap or drag interactions\n* Functional vision sufficient for on-screen tasks with usual corrective lenses\n* Functional hearing sufficient for spoken instructions with or without hearing aids\n* Interest in cognitive wellness and personal well-being\n* Available for baseline visit and possible retest visit approximately 14 days later\n* Transportation to study site or ability to participate remotely if permitted by protocol\n* Assistive devices and accommodations are permitted\n\nExclusion Criteria:\n\n* Severe visual impairment preventing completion of digital tasks\n* Severe motor impairment preventing interaction with tablet or web application\n* Known diagnosis of moderate or severe dementia, or inability to comprehend consent and task instructions\n* Current participation in another cognitive training or technology intervention study likely to confound outcomes\n* Recent hospitalization, emergency room visit, or acute exacerbation of a medical or psychiatric condition within the past 30 days that would impede study participation\n* Current substance use disorder likely to interfere with study adherence or completion\n* Recent intensive use of a similar structured cognitive wellness or brain training application","55 Years","75 Years",{"count":120,"type":21},100,"OBSERVATIONAL","The goal of this observational study is to evaluate the reliability, usability, and feasibility of the MEVA Cognitive Wellness Platform in community-dwelling adults aged 55 to 75.\n\nThe main questions it aims to answer are:\n\nHow consistent is the MEVA Global Cognitive Index when participants complete the MEVA activities again approximately 14 days later? How usable and acceptable is the MEVA platform for older adults in community settings? What completion rates, data quality patterns, and participant feedback are observed during use of the platform?\n\nParticipants will:\n\nComplete a baseline study visit lasting approximately 45 to 60 minutes Complete a 7-activity digital cognitive wellness battery Answer questionnaires about usability, technology acceptance, and wellness experience Complete the Saint Louis University Mental Status (SLUMS) examination as an exploratory comparison measure If selected for the retest group, return approximately 14 days later to complete the MEVA activities again\n\nMEVA is being evaluated as a cognitive wellness platform. It is not intended to diagnose, treat, prevent, screen for, or monitor any disease or medical condition.",[124,125,126,127,128,129,27],"Cognitive Wellness","Healthy Aging","Age-Related Cognitive Change","Aging","Cognitive Change","Health Behavior",[131,132,133,134,135,34,136,137,138,139,140,141,142,143,144,145,146,147],"Cognitive wellness","Healthy aging","Health equity","Test-retest reliability","Community-dwelling older adults","Digital wellness","Older adult engagement","Psychometrics","Usability","Community health","Wellness tracking","Cognitive engagement","Adult development","General wellness","Montessori-informed activities","Technology acceptance","Exploratory convergent validity","2026-05-18",{"date":150,"type":44},"2026-05-20",{"date":152,"type":21},"2026-05",{"date":154,"type":21},"2026-12",{"name":156,"class":157},"Mentage LLC","INDUSTRY",{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":86,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":166,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":52},"100636818","implementation-of-a-clinical-decision-support-system-in-primary-care-for-the-screening-and-assessment-of-frailty-in-patients-aged-65-and-over-100636818","NCT07570628","Implementation of a Clinical Decision Support System in Primary Care for the Screening and Assessment of Frailty in Patients Aged 65 and Over","Implementation of a Clinical Decision Support System in Primary Care for the Screening and Assessment of Frailty in Patients Aged 65 and Over: A Real-World Prospective Cohort Study","FRAGICLIC","Inclusion Criteria:\n\n* Patients aged 65 years or older\n* Patient or trusted person who provided oral non-opposition after receiving full information about the protocol\n* Managed by the general practitioner if the patient or nurse during the study period. If patients are assessed by a nurse : Patients whose general practitioner is a participating physician in the study\n\nExclusion Criteria:\n\n* Patients unable to express non-opposition or without a trusted person available to express non-opposition\n* Patients whose general practitioner (GP) is not a participating GP in the study\n* Patients or trusted persons who do not speak French",{"count":167,"type":21},726,"This observational study aims to evaluate the real-life use of a digital tool (Fragiclic) by general practitioners (GPs) and nurses to screen and assess frailty in adults aged 65 and over. Frailty is a syndrome that increases the risk of loss of autonomy, falls, hospitalizations, or death. The tool includes simple screening questionnaires (such as SEGAm) and a comprehensive assessment (CGA - Comprehensive Geriatric Assessment) to better manage patients' health.\n\nThe main question it aims to answer is:\n\n* What proportion of patients aged 65 and over will benefit from frailty screening or assessment using Fragiclic over 12 months?\n\nA secondary question is\n\n\\- Does the use of Fragiclic reduce the risk of unplanned hospitalizations or death in these patients?\n\nFor the secondary question, researchers will compare patients who received screening or assessment (with or without a Personalized Care Plan (PCP)) to those who did not, to determine if Fragiclic improves their health outcomes.\n\nParticipants will not have additional tasks: Their GP or nurse will use Fragiclic during routine consultations. Some patients may be asked to provide information about their health or quality of life (via their healthcare provider).\n\nAll data will be collected anonymously and securely",[170,27,171,172,173],"Frailty at Older Adults","Geriatric Assessment","Implementation Research","Interprofessional Collaboration","2026-05-11",{"date":176,"type":44},"2026-05-13",{"date":178,"type":21},"2027-01-02",{"date":180,"type":21},"2029-01-02",{"name":182,"class":51},"CNGE Conseil",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":189,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":191,"enrollmentInfo":192,"targetDuration":4,"studyType":22,"phases":194,"briefSummary":195,"conditions":196,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":208},"100581932","improved-treatment-for-patients-with-long-term-opioid-therapy-for-non-cancer-pain-in-primary-care-100581932","NCT06856733","Improved Treatment for Patients With Long-term Opioid Therapy for Non-cancer Pain in Primary Care","Improved Treatment for Patients With Long-term Opioid Therapy for Non-cancer Pain in Primary Care (Opi-Prim)","Opi-Prim","Inclusion Criteria:\n\n* Having received the equivalent of 90 days or more prescription of opioids for chronic pain made by the general practitioner during the recent 12 months\n* Able to speak Swedish or English\n\nExclusion Criteria:\n\n* Having been referred to a pain clinic (either at hospital or multimodal rehabilitation in primary care) within the last 6 months\n* No current opioid use, severe cognitive dysfunction, e.g., suicidal ideation, psychotic symptoms, or dementia, that prevents informed consent.\n* Using their opioids for cancer pain","70 Years",{"count":193,"type":21},110,[24],"The goal of this clinical trial is to reduce inappropriate long term opioid treatment (LTOT) and to optimize pain management in patients with LTOT for chronic non-cancer pain in primary care through a new person-centred and team-based approach. The main question it aims to answer is:\n\nWhat are the effects of a new person-centred and team-based approach on pain interference in patients with LTOT for chronic non-cancer pain in primary care?\n\nResearchers will compare a new person-centred and team-based approach to usual care to see if pain interference is lower.\n\nParticipants will receive a person-centred team-based treatment consisting of:\n\n* Phase 1 (investigation and assessment, week 1-3): A medication review, pain analysis and other assessments through separate visits to a pharmacist, general practitioner, physiotherapist, psychologist and care manager\n* Phase 2 (treatment plan, week 3-4): A team consultations with all healthcare personnel involved in Phase 1 including the patient where an individualized rehabilitation plan is made based.\n* Phase 3 (treatment and follow-up, week 4-24): Implementation of the individualized rehabilitation plan with frequent follow-up contacts (1 per 1-3 weeks) by phone with the care manager.",[197,198,27],"Chronic Pain","Chronic Pain Management","2026-05-08",{"date":176,"type":44},{"date":202,"type":44},"2025-03-10",{"date":204,"type":21},"2029-06-30",{"name":206,"class":207},"Uppsala County Council, Sweden","OTHER_GOV",3,{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":215,"eligibilityCriteria":216,"healthyVolunteers":86,"sex":17,"minAge":60,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":223,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":236},"100613771","feasibility-study-of-a-patient-centered-cds-for-recommended-screenings-in-primary-care-100613771","NCT07270926","Feasibility Study of a Patient-centered CDS for Recommended Screenings in Primary Care","Feasibility Study of a Patient-centered Clinical Decision Support System for Recommended Screenings in Primary Care","ADER-F","Inclusion Criteria:\n\n* Age ≥ 18 years and ≤74 years,\n* Consultant to general practitioner,\n* Without communication barriers in French, able to read and write\n* Have signed the written consent form to participate in the study\n\nExclusion Criteria:\n\n* Under legal protection (guardianship, curatorship, safeguard of justice or deprived of liberty)\n* with a psychiatric pathology or disorder with impaired judgment, as determined by the GP\n* Pregnant or breast-feeding\n* Not affiliated to a social security scheme or not benefiting from a similar scheme\n* Participating in another clinical study that may interfere with the ADER-F study-","74 Years",{"count":219,"type":21},210,[24],"Primary care professionals (PCPs) are responsible for identifying patients who are eligible for all recommended screenings. Eligibility is difficult, given the number of screenings recommended by the French National Authority for Health (HAS), and the complexity of defining risk groups. When eligibility for one or more screenings is identified, the PCP informs the patient and can help him or her make the decision, considering his or her values and preferences.\n\nLack of information for patients and lack of time for PCPs are the main obstacles to prevention in primary care (PC). Another barrier identified is the lack of opportunity for patients who do not consult their PCP very often, as they are less likely to be approached for preventive interventions due to other more urgent reasons for consultation.\n\nA Medical Decision Support System (MDSS) is a software application designed to be a direct aid to clinical decision-making, in which an inference engine matches individual patient characteristics with a computerized knowledge base or machine-learning algorithm to propose a risk assessment or adapted recommendations to the healthcare professional and\u002For patient.\n\nThe aim of the ADER-F research program is to support the development and evaluation of a complex intervention centred on the use of a MDSS called \"Lianeli\".\n\nThis complex intervention will ultimately contribute to structuring new consultations dedicated to prevention in general practice, by improving the physician's sense of self-efficacy in conducting the shared screening decision, and reducing the patient's decision-making conflict.",[27],[34,224,225,226],"Recommended screening","Medical Decision Support System (MDSS)","patient-centered Clinical Decision Support (CDS)","2026-03-30",{"date":229,"type":44},"2026-04-03",{"date":231,"type":44},"2026-03-06",{"date":233,"type":21},"2027-03-06",{"name":235,"class":51},"Hospices Civils de Lyon",20,{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":4,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":244,"targetDuration":4,"studyType":22,"phases":246,"briefSummary":247,"conditions":248,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":52},"100594413","efficacy-of-artificial-intelligence-for-gatekeeping-in-referrals-to-specialized-care-100594413","NCT07019116","Efficacy of Artificial Intelligence for Gatekeeping in Referrals to Specialized Care","Efficacy of an Artificial Intelligence Algorithm for Gatekeeping in Referrals From Primary Care to Specialized Care: a Randomized Controlled Trial","Inclusion Criteria:\n\n* All referrals from a given specialty (waitlist) will be eligible.\n* Specialties will be selected following Rio Grande do Sul Health Department priorities.\n\nExclusion Criteria:\n\n* Referrals that the AI algorithm can not evaluate. These include referrals with attachments (further information in image or PDF files) and referrals with previous rounds of discussion.\n* Referrals in which the algorithm has low confidence in the decision (i.e., informed data lead to a decision with a probability below 80%) will not be included in the study.",{"count":245,"type":21},934,[24],"In Rio Grande do Sul, Brazil, the demand for specialty care referrals has increased sharply with the adoption of the electronic regulatory system, especially in rural areas. In 2023 alone, over 79,000 referrals were submitted monthly, totaling 1.7 million annual gatekeeping decisions. Due to workforce limitations, nearly 70% of referrals are authorized automatically, often without clinical validation. This leads to delays for high-risk patients, unnecessary specialist visits, and a growing backlog, currently over 172,000 pending referrals. To address this, an AI algorithm was developed to triage referrals based on urgency and appropriateness.\n\nThe investigators propose a prospective controlled study with randomized implementation of the AI tool across selected specialty queues in the electronic referral system. The population will consist of referrals from specialties waitlists from municipalities in Rio Grande do Sul. Specialties to be included will be selected by the State Health Department prospectively according to gatekeeping needs. The intervention will be an AI-based triage algorithm. The control will be a standard gatekeeping process. The primary outcome is the proportion of referrals with a final decision (authorized or redirected to primary care) within six months; secondary outcomes include time to decision and appointment, system-level performance metrics. Referrals will be randomly assigned to algorithmic or human gatekeeping with a 1:1 ratio. The algorithm classifies referrals into two groups: not authorized (pending more data or teleconsultation), authorized. Authorization cases are further divided into routine and high-risk referrals to help the manage demand. Each AI prediction provides a probability from 0 to 1 of authorization (or deferring). The implementation threshold is set at 0.8; cases below this level will be classified as low confidence for decision and will not be included. According to the State Health Department's decisions, several referral lines are expected to be selected for the intervention. A sample size 934 (467 per arm) for each included specialty was calculated to detect a 1.2 relative risk for the primary outcome with 90% power and 5% significance.",[27,249],"Primary Care Patients With Chronic Conditions","2026-02-19",{"date":252,"type":44},"2026-02-20",{"date":254,"type":44},"2025-11-15",{"date":256,"type":21},"2029-12",{"name":258,"class":51},"Hospital de Clinicas de Porto Alegre",{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":4,"eligibilityCriteria":265,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":266,"targetDuration":4,"studyType":22,"phases":268,"briefSummary":269,"conditions":270,"keywords":273,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":280,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":52},"100611919","diagnostic-stewardship-intervention-to-reduce-inappropriate-antibiotic-use-for-urinary-tract-infections-in-primary-care-100611919","NCT07246837","Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care","A Randomized Controlled Trial of a Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care","Inclusion Criteria:\n\n* Adults (≥18 years) undergoing urine culture as part of routine outpatient care\n* Able to provide informed consent\n* English- and or Spanish-speaking.\n\nExclusion Criteria:\n\n* Presence of a urinary catheter\n* Inability to read and sign the informed consent\n* Unable to follow study procedures (due to significant visual, auditory, physical or cognitive impairment).",{"count":267,"type":21},252,[24],"Urine culture is the most common microbiological test in the outpatient setting in the United States. Unfortunately, contamination during collection is prevalent and undermines test accuracy, leading to incorrect diagnosis, unnecessary treatment, wasted laboratory resources, and inflated costs. Unnecessary antibiotic treatment increases the risk of developing antimicrobial resistance, one of the most serious threats to patients and public health. The goal of this clinical trial is to test whether a bilingual (English and Spanish) educational intervention, an animated video and pictorial flyer, can reduce urine culture contamination and associated inappropriate antibiotic use in adult patients visiting safety-net primary care clinics.\n\nThe main questions it aims to answer are:\n\n1. Does providing patients with a bilingual educational intervention reduce urine culture contamination rates?\n2. Does the intervention lead to fewer unnecessary urinary antibiotic prescriptions?\n3. Does providing patients with a bilingual educational intervention reduce contaminated urinalyses? Researchers will compare patients randomized to receive the educational intervention (video and flyer) to those receiving usual care to see if the intervention improves urine collection accuracy and reduces inappropriate antibiotic use. Participants will watch a short, animated video with step-by-step instructions for proper midstream clean-catch urine (MSCC) collection, receive a pictorial flyer (with stills from the video) reinforcing the instructions, and provide a urine sample for culture. Hypothesis: patients who receive the educational intervention will have: lower urine culture contamination rates (primary outcome), fewer urinary antibiotic prescriptions (secondary outcome), and fewer contaminated urinalyses (secondary outcome). The objectives are to (1) develop educational tools: Create an animated video and pictorial flyer with step-by-step urine collection instructions for women and men, developed through an iterative, stakeholder-engaged process, (2) assess acceptability: Use mixed methods (quantitative surveys and qualitative interviews) to evaluate and refine the tools for usability and cultural\u002Flinguistic appropriateness, and (3) test effectiveness: Conduct a randomized controlled trial to assess the intervention's impact on urine contamination rates, antibiotic prescribing, and patient satisfaction.",[271,272,27],"Urinary Tract Infection(UTI)","Antimicrobial Stewardship",[274,275,276,277,278,272,27,279],"Urinary Tract Infection","UTI","Inappropriate Antibiotic Use","Diagnostic Stewardship","Antibiotic Resistance","Randomized Controlled Trial","2026-02-11",{"date":282,"type":44},"2026-02-13",{"date":284,"type":44},"2026-01-22",{"date":286,"type":21},"2028-05-31",{"name":288,"class":51},"Baylor College of Medicine",{"id":290,"slug":291,"hasResults":11,"nctId":292,"briefTitle":293,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":297,"briefSummary":298,"conditions":299,"keywords":300,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":52},"100617136","arrival-time-implementation-100617136","NCT07314697","Arrival Time Implementation","Inclusion Criteria:\n\n* In-person outpatient appointments with clinicians at UCLA Health that fall into the study period\n* Appointments scheduled for the department specialties of Primary Care, Pediatrics, or Internal Medicine, Med Peds\n* Has an active MyChart status\n* Opted in to receive SMS communications from UCLA Health\n* Appointments classified as the following visit types:\n\n  * Return\n  * Well adult (physical)\n  * Well child return\n  * New\n  * Well adult new (physical)\n  * Well child (new)\n\nExclusion Criteria:\n\n* Appointments at clinics that are not scheduled through the Patient Access Organization",{"count":296,"type":21},300000,[24],"This is a prospective clinical trial evaluating how behaviorally informed message framing can improve patient on-time arrival for outpatient visits. This trial is being implemented in conjunction with UCLA Health's broader operational quality improvement (QI) efforts to enhance clinic flow and patient experience.\n\nThe main question it aims to answer is how displaying an explicit arrival time (set to 15 minutes before the scheduled appointment) affects when patients arrive for their appointments, compared to a control condition where only the appointment time is displayed and patients are encouraged to arrive 15 min before the appointment (without an explicit arrival time).",[27],[301],"quality improvement","2026-02-09",{"date":304,"type":44},"2026-02-10",{"date":306,"type":44},"2026-01-05",{"date":308,"type":21},"2026-07",{"name":310,"class":51},"University of California, Los Angeles",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":22,"phases":321,"briefSummary":322,"conditions":323,"keywords":327,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":338,"completionDateStruct":340,"leadSponsor":341,"locationsCount":4},"100623547","general-practitioner--pharmacist-support-for-discontinuing-long-term-antidepressants-in-clinically-stable-patients-100623547","NCT07398053","General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients","General Practitioner & Pharmacist Support for Discontinuing Long-term Antidepressants in Clinically Stable Patients: a Cluster Randomised Pragmatic Trial in Primary Care","GPS-AD","Inclusion Criteria:\n\nPatients will be eligible for inclusion in the study if they meet all of the following criteria:\n\n* Are 18 years or older and capable of providing informed consent.\n* Have their Global Medical File (GMD) managed by one of the participating GPs.\n* Have been prescribed AD (any type) by their GP for the treatment of depression, with:\n\n  * at least 6 months of continuous daily use following a first depressive episode, or\n  * at least 2 years of continuous daily use in the context of a relapsed depression\u002Frecurrent episode\n* Are judged by their GP as no longer meeting the criteria for a current depressive disorder.\n\nExclusion Criteria:\n\nPatients will be excluded from participation in the study if they meet any of the following criteria:\n\n* AD discontinuation is considered contra-indicated by the treating GP.\n* The patient is judged by the GP to be at high risk of relapse. This includes any of the following:\n\n  * Current significant depressive symptoms, defined as a score of ≥12 on the PHQ-9\n  * Current significant anxiety symptoms, defined as a score of ≥10 on the Generalised Anxiety Disorder-7 (GAD-7) scale.\n  * Current suicidal ideation, defined as a score \\>0 on item 9 (suicidality) of the PHQ-9.\n  * The patient is currently receiving only psychiatric treatment (out- or inpatient) for depression\n\nIn addition to the criteria increasing the risk of relapse, the following will also be an exclusion criteria:\n\n* The patient has a current psychiatric comorbidity (e.g. bipolar disorder, psychosis, substance use)\n* The patient has a diagnosis of dementia or significant cognitive impairment (assessed by GP judgement) or is living in a nursing home.\n* The AD is prescribed for a primary indication other than depression, such as anxiety alone without comorbid depressive disorder, or chronic pain.\n* The patient has insufficient language proficiency in Dutch or French to participate in the study procedures (e.g. providing consent, completion of questionnaires, interviews).\n* use of trazodon as AD as this is mainly used for sleep problems",{"count":320,"type":21},324,[24],"In Belgium, many adults who have suffered from depression keep using antidepressants on a daily basis for years afterwards, sometimes longer than guidelines recommend. Yet for some people who have been feeling well for a long time, this is no longer necessary, while the continued use of antidepressants can lead to side effects and causes additional costs for the healthcare system.\n\nHowever, reducing the doses of antidepressants or stopping altogether is not always easy. Some patients are afraid that their depression will return, and GPs and pharmacists often find the subject difficult to broach.\n\nThis is why the GPS-AD study is investigating a new approach in which GPs and pharmacists work more closely together to provide better support to patients. First, the GP invites patients who have been taking antidepressants for a long time for a consultation. Together, they discuss whether tapering of the medication is reasonable and feasible. If they agree to stop the treatment, the GP draws up a tapering plan tailored to the patient. The pharmacist helps monitor this process, offering advice and support to the patient while the doses are gradually reduced.\n\nThe study will extend over a period of two years and will take place in GP practices throughout Belgium. The new approach based on closer collaboration between GPs and pharmacists will be compared to the current standard of care, to determine whether it helps more long-term users to stop taking antidepressants without experiencing a recurrence of depressive symptoms.\n\nThe name of the study, GPS-AD (General Practitioner and Pharmacist Support for Antidepressant Discontinuation), refers to the collaboration between GPs and pharmacists in tapering of antidepressants, and also symbolises the support and guidance (the 'GPS') provided to patients and healthcare providers in assessing whether long-term use of antidepressants is still necessary.",[32,324,325,326,27],"Antidepressant","Depression Disorder","Discontinuation",[37,328,329,330,331,332,333,334,335],"discontinuation","tapering","depression","antidepressants","long-term use","chronic use","medication review","primary care","2026-02-02",{"date":302,"type":44},{"date":339,"type":21},"2026-03-01",{"date":286,"type":21},{"name":342,"class":51},"University Ghent",{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":350,"targetDuration":4,"studyType":22,"phases":352,"briefSummary":353,"conditions":354,"keywords":356,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":360,"lastUpdatePostDateStruct":361,"startDateStruct":363,"completionDateStruct":364,"leadSponsor":366,"locationsCount":52},"100620779","implementing-suicide-prevention-into-primary-care-in-nepal-100620779","NCT07362056","Implementing Suicide Prevention Into Primary Care in Nepal","Integrating a Suicide Prevention Package of Strategies Into Decentralized Primary Health Care Systems: an Implementation Pilot Study in Rural Nepal","Inclusion Criteria:\n\nPrimary Care Providers\n\n* Health workers with a prescribing license employed in government health facilities in Bagmati Province.\n* Are between 21-65 years, per government health system criteria.\n* Participants will be required to have competency in Nepali, be actively engaged in care provision within their health facility\n\nPatients:\n\n* Patient lives in the study site\n* Is under the care of a PCP at a facility site.\n* Patient meets any level of suicide risk based on mhGAP 2.0 criteria.\n* Patients who have been treated for mental illness before or presently (expected in both groups).\n* Speaks Nepali.\n* Levels of Suicide Risk (as defined by mhGAP 2.0)\n\nExclusion Criteria:\n\nPrimary Care Providers\n\n* Healthcare workers without proper government credentials will be excluded.\n* Health workers who plan to migrate or who do not intend to stay in the study area for at least a year.\n\nPatients:\n\n* Patient requiring immediate hospitalization\n* Unable to consent as determined by the diminished capacity tool.",{"count":351,"type":21},147,[24],"Suicide remains a major contributor to global mortality, with particularly high and persistent rates in low-resourced settings such as South Asia. In Nepal, ongoing integration of mental health services into primary care provides a critical opportunity to strengthen suicide risk assessment and management. Despite the scale-up of mhGAP training for primary care providers (PCPs), gaps remain in the systematic detection, referral, and follow-up of individuals at risk for suicide. There is an urgent need to enhance mhGAP implementation with strategies that address provider workload, stigma, and inequities within the health workforce.\n\nUsing experience-based co-design principles and RE-AIM this study will assess the feasibility and acceptability of integrating an implementation strategy package to optimize mhGAP suicide prevention delivery in Nepal's decentralized primary healthcare system. This clinical trial leverages deep collaboration with a community advisory board of individuals with lived experience of suicide throughout the trials' design, delivery and analysis.\n\nThis R34 will generate critical preliminary evidence on the feasibility, acceptability, and implementation of an integrated suicide prevention package within government primary care facilities in Nepal. The findings will inform the design and parameters of a future fully powered effectiveness trial, while aligning with Nepal's national suicide prevention strategy and advancing WHO and NIMH global mental health priorities.",[355,27],"Suicide",[357,335,358,359],"suicide prevention","implementation science","Nepal","2026-01-21",{"date":362,"type":44},"2026-01-23",{"date":254,"type":44},{"date":365,"type":21},"2027-08-15",{"name":367,"class":51},"Yale University",{"id":369,"slug":370,"hasResults":11,"nctId":371,"briefTitle":372,"officialTitle":373,"acronym":4,"eligibilityCriteria":374,"healthyVolunteers":86,"sex":17,"minAge":375,"maxAge":376,"enrollmentInfo":377,"targetDuration":4,"studyType":22,"phases":379,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":391,"locationsCount":52},"100446324","connecting-families-100446324","NCT05091957","Connecting Families","CONNECTING FAMILIES: A Randomized Controlled Trial of Primary Care Poverty Screening and Financial Support Navigation for Families of Young Children","Inclusion Criteria:\n\n* Parents of children (younger than 3 years) attending a regularly scheduled primary care visit.\n* Parents respond affirmatively to the question \"Do you ever have difficulty making ends meet at the end of the month?\"\n* Informed parental consent. Only one child will be enrolled per family. For families with more than one child, we will enroll the youngest eligible child, since literature suggests that impact of reducing family stress may be greater at younger ages; for multiple births, one child will be randomly selected for inclusion.\n\nExclusion Criteria:\n\n1. Parents without legal status in Canada, as they are not eligible for many Canadian social programs.\n2. Families who are receiving system navigation support, such as from a social worker or public health nurse, or who have received system navigation support within one year prior to enrolment.\n3. Child with a previously diagnosed developmental disorder, genetic, chromosomal or syndromic condition.\n4. Child born prematurely (gestational age less than 32 weeks).","1 Day","3 Years",{"count":378,"type":21},80,[24],"Living in poverty has a profound negative impact on parenting stress and children's health. When poverty occurs early in childhood and continues for a long time, the impact on child health can be lifelong. Child poverty is common, affecting about 20% of Canadian children. Many low income families may not be receiving all the social benefits for which they are eligible. There are calls for primary care providers to ask patients if they have difficulty making ends meet at the end of the month and to intervene if poverty is identified, but it is not known if intervening can improve parent's and children's health. This study will test whether a Community Support Worker who helps families with young children navigate the social service system by reviewing social needs (like food, housing or energy insecurity) and income supports can lead to increased family income, reduced parenting stress and an improvement in their child's health. The Community Support Worker will help families complete income tax, apply for benefits and community supports for which they are eligible. The investigators will also study the effect of this intervention on health care utilization. Our study will be conducted in Toronto and Kingston in primary care practices participating in the TARGet Kids! primary care research network. Results from this study will help health care providers and policy makers understand whether Community Support Workers are an effective way to integrate the health and social service systems to improve parent and child health.",[382,27,383],"Poverty","Intervention","2026-01-11",{"date":386,"type":44},"2026-01-13",{"date":388,"type":44},"2022-05-17",{"date":390,"type":21},"2026-04",{"name":392,"class":51},"Queen's University",{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":399,"eligibilityCriteria":400,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":401,"targetDuration":4,"studyType":22,"phases":403,"briefSummary":404,"conditions":405,"keywords":413,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":434},"100581693","one-hour-troponin-using-a-high-sensitivity-point-of-care-assay-in-emergency-primary-care-100581693","NCT06853626","One-hoUr Troponin Using a High-sensitivity Point-Of-Care Assay in Emergency Primary Care","Improved Management of Acute Chest Pain in Emergency Primary Care. The OUT-POC Study (One-hoUr Troponin Using a High-sensitivity Point-Of-Care Assay in Emergency Primary Care)","OUT-POC","Inclusion Criteria:\n\n* Patients (18+ years) with non-traumatic acute chest pain presenting in emergency primary care\n* Troponin testing requested by the treating physician\n\nExclusion Criteria:\n\n* Acute STEMI (direct hospital referral required)\n* Haemodynamically unstable (direct hospital referral required)\n* Not able to provide written, informed consent (i.e., due to time restraints, language barriers, impaired cognitive function, or other reasons)",{"count":402,"type":21},2500,[24],"Acute chest pain is a prevalent medical emergency in primary emergency care settings. Triage of chest pain prior to hospital admission presents significant challenges due to the absence of sufficiently sensitive diagnostic tools. Clinical signs, symptoms, risk assessment scores, or a normal electrocardiogram (ECG) can reliably exclude acute myocardial infarction (MI). This diagnostic uncertainty has resulted in chest pain being the second most common cause for acute hospital referrals from Norwegian emergency primary care, even though chest pain is frequently non-cardiac in origin.\n\nIn acute MI events, cardiac troponins are released into the bloodstream from the damaged myocardium, where low values are used to exclude MI. Until recently, such testing has necessitated using high-sensitivity cardiac troponin (hs-cTn) assays, which have been limited to hospital laboratories. However, recent technological advancements in point-of-care (POC) testing allow access to whole-blood assays that meet high-sensitivity criteria.\n\nIn this upcoming project, the investigators will evaluate the implementation of a whole-blood POC assay (QuidelOrtho TriageTrue hs-cTnI) across six Norwegian emergency primary care clinics. The study plans to enrol 2,500 patients over a period of 1.5 years. The clinical performance of the novel strategy will be investigated, as well as its impact on healthcare utilization and hospital referrals compared to standard care. Additionally, the investigators will assess the prevalence of persistent chest pain and its effects on quality of life, alongside psychological stress and anxiety, through validated questionnaires.\n\nThis project aims to offer better and more comprehensive management of the large group of emergency primary care patients with acute chest pain, contributing to reduced hospital referrals, improved quality of life, and more sustainable use of healthcare services.",[406,407,408,409,410,411,412,27],"Acute Myocardial Infarction (AMI)","Chest Pain","Acute Coronary Syndromes (ACS)","Non-cardiac Chest Pain","Troponin","Point of Care Testing","Out-of-hours Medical Care",[414,415,416,417,418,419,335,420,421,422,423,399,424],"TriageTrue","POC","hs-cTnI","0\u002F1-hour algorithm","troponin","chest pain","OOH","out-of-hours","acute myocardial infarction","point-of-care","QuidelOrtho","2025-12-09",{"date":427,"type":44},"2025-12-10",{"date":429,"type":44},"2025-06-27",{"date":431,"type":21},"2029-12-31",{"name":433,"class":51},"University of Oslo",6,{"id":436,"slug":437,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":440,"acronym":4,"eligibilityCriteria":441,"healthyVolunteers":86,"sex":17,"minAge":60,"maxAge":191,"enrollmentInfo":442,"targetDuration":4,"studyType":22,"phases":443,"briefSummary":444,"conditions":445,"keywords":446,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":458,"leadSponsor":460,"locationsCount":52},"100602974","project-care-cancer-risk-evaluation-100602974","NCT07130487","Project CARE: CAncer Risk Evaluation","Project CARE: CAncer Risk Evaluation (CARE)","Inclusion Criteria\n\n1. Age 18 to 70 years\n2. Able to read and speak English\n3. Have an email address or mobile phone number in EPIC and\u002For are enrolled in MyChart\n4. Receiving health care in Family Medicine or General Internal Medicine at Rutgers Health within the past 2 years\n5. Have not opted out of receiving research-related communications\n6. Have internet access (via smartphone, tablet, or computer)\n\nExclusion Criteria\n\n1. Dementia (e.g., Alzheimer's disease) as indicated in EPIC\n2. Unable to access the Internet (via smartphone, tablet, or computer)\n3. Previous germline genetic testing for hereditary cancer risk\n4. Opted out of research participation in EPIC\n5. Have a personal history of cancer",{"count":219,"type":21},[24],"The purpose of Project CARE (cancer risk assessment and evaluation) research study is to explore the acceptance and feasibility of a study-initiated proactive outreach and digital care delivery model for conducting hereditary cancer risk assessment in primary care settings and facilitating genetic risk evaluation for patients flagged as high risk. Potential participants will be recruited from Rutgers Health primary care sites (family practice and general internal medicine). EPIC will be used to identify all potential participants and they will be invited to participate in the study. Consented participants will be provided a link via email, and or text message to engage with a Relational Agent (RA, chatbot), through the patient portal for cancer risk assessment and genetic education. Those identified as high risk will be offered genetic counseling and testing.\n\nThe research questions the study aims to answer are:\n\n1. What percent of patients who completed the RA are identified as high risk?\n2. What percent of patients who engaged with the risk assessment were identified as high risk?\n3. What percent of high-risk patients had genetic counseling or genetic testing within 4 months of completing the risk assessment?",[27],[447,448,449,450,451,452,453],"Genetic Counseling","Genetic Testing","Primary Care Provider","High-risk patients in primary care settings","Genetic Education","Relational Agent","Chatbot","2025-11-19",{"date":456,"type":44},"2025-11-25",{"date":454,"type":44},{"date":459,"type":21},"2026-11",{"name":461,"class":51},"Anita Y. Kinney, PhD, RN",{"id":463,"slug":464,"hasResults":11,"nctId":465,"briefTitle":466,"officialTitle":466,"acronym":4,"eligibilityCriteria":467,"healthyVolunteers":86,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":468,"targetDuration":4,"studyType":22,"phases":470,"briefSummary":471,"conditions":472,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":474,"lastUpdatePostDateStruct":475,"startDateStruct":477,"completionDateStruct":479,"leadSponsor":481,"locationsCount":52},"100611233","improving-the-accuracy-of-artificial-intelligence-triage-in-primary-care-100611233","NCT07237919","Improving the Accuracy of Artificial Intelligence Triage in Primary Care","Inclusion Criteria:\n\n* GP practices using the Patchs system\n\nExclusion Criteria:\n\n* N\u002FA",{"count":469,"type":21},226821,[24],"WHY ARE WE DOING THIS? When patients contact their GP practice, the first step is to work out what kind of help they need and how quickly it's needed. This is called 'triage' and is important for patient safety.\n\nArtificial Intelligence (AI) can help make triage faster. While AI is already being used in the NHS, we don't know how accurate it is or if it treats all patients fairly.\n\nWHAT WILL WE DO?\n\nWe will collect anonymised data from patients that use an AI triage system called Patchs in GP practices in England. The project will last four years. We will analyse the data in four steps:\n\n1. Look at data from GP practices using Patchs without AI triage to see how they currently triage patients and what problems they face.\n2. Use data from GP practices using Patchs (both with AI on and off) to make the AI triage more accurate.\n3. Check data from GP practices using Patchs with AI triage off to measure how well the updated AI system works.\n4. Give the improved AI triage system to GP practices already using AI.\n\nAt each step, we will check whether patients from different backgrounds are treated fairly.\n\nHOW WILL WE ANALYSE THE DATA? We will use statistical methods to compare the triage decisions made by the AI with those made by clinical staff. This analysis will also be used to check that the AI works fairly for patients from different backgrounds.\n\nWHAT DIFFERENCE WILL WE MAKE? Our research will show the problems with triage and explain how an improved AI system could help patients get the care they need more quickly.",[27,473],"Artificial Intelligence (AI)","2025-11-14",{"date":476,"type":44},"2025-11-20",{"date":478,"type":44},"2025-04-01",{"date":480,"type":21},"2029-07",{"name":482,"class":51},"University of Manchester",{"id":484,"slug":485,"hasResults":11,"nctId":486,"briefTitle":487,"officialTitle":488,"acronym":489,"eligibilityCriteria":490,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":18,"enrollmentInfo":491,"targetDuration":4,"studyType":22,"phases":493,"briefSummary":494,"conditions":495,"keywords":499,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":516,"locationsCount":52},"100595389","validation-of-a-composite-medical-device-using-a-blood-biomarker-based-algorithm-and-mdq-for-the-diagnosis-of-bipolar-disorder-100595389","NCT07031817","Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder","Validation of a Composite Medical Device Using a Blood Biomarker-based Algorithm and MDQ for the Diagnosis of Bipolar Disorder in Patients With a Characterized Depressive Episode in Primary Care","BIPOVITE","Inclusion Criteria :\n\n* Cis man, cis woman, trans man, trans woman or non-binary,\n* Aged 18 to 65 years old,\n* Meets the DSM-5 criteria for the diagnosis of moderate to severe EDC and is eligible for antidepressant treatment.\n\nNon-Inclusion Criteria :\n\n* Patients under guardianship or trusteeship,\n* Patients with schizophrenia according to DSM-5 criteria,\n* Patients who have received psychotropic treatment in the 5 days prior to inclusion (or 21 days for fluoxetine or aripiprazole), with the exception of benzodiazepines and hydroxyzine at the doses and in compliance with the indications of the Marketing Authorisations,\n* Patients with an unstable physiological state or a serious and symptomatic medical condition in the opinion of the investigator,\n* Pregnant or breast-feeding patients,\n* Patients with a known autoimmune disease, in particular Crohn's disease or thyroiditis, or any other pathology which could, in the opinion of the investigator, modify the blood concentration of immune biomarkers,\n* Patients unable to give informed consent to participate in the study or who cannot be given informed information,\n* Patients not covered by a social security scheme,\n* Patients participating in another interventional study on the day of inclusion,\n* Patients under court protection,\n* Patients vaccinated less than 30 days ago,\n* Patients with difficulties reading, understanding or speaking French.\n\nExclusion Criteria :\n\n* Participants will have the right to withdraw their consent at any time for any reason whatsoever without any prejudice to them,\n* The investigator may prematurely exclude a subject from the study, in agreement with the sponsor, if the subject presents one or more exclusion criteria,\n* Diagnosis of schizophrenia during follow-up or any other diagnosis that would lead to a change in the initial EDC diagnosis,\n* Any condition or situation which, in the opinion of the investigator, would be incompatible with the continuation of the study or which would lead to a bias in the management of the data.",{"count":492,"type":21},623,[24],"The goal of this interventional clinical trial is to assess the diagnostic performance of a composite diagnostic medical devise based on blood-based in vitro diagnostic device and Mood Disorder Questionnaire (MDQ) in identifying bipolar disorder among adult patients presenting with a current major depressive episode in primary care. The study will compare the results of the medical device diagnostic test to those of standardized psychiatric clinical evaluation, to evaluate its sensitivity, specificity, and overall clinical utility.\n\nThe main research questions are :\n\n* Can the investigational medical device accurately distinguish bipolar disorder from unipolar depression ?\n* How does its diagnostic accuracy compare with validated psychiatric questionnaires commonly used in clinical practice ?\n\nParticipants will :\n\n* Provide a blood sample for biomarker analysis using the investigational diagnostic device.\n* Complete a few validated psychiatric assessment tools (e.g., MDQ, MINI).\n* Share sociodemographic and clinical data relevant to psychiatric evaluation.",[496,497,27,498],"Bipolar Disorder (BD)","Major Depressive Episode (MDE)","Major Depression",[500,501,335,502,503,504,505,506,507,508],"bipolar disorder","major depressive episode","composite medical device","blood biomarkers","mood depression questionnaire","diagnosis","composite diagnostic tool","in vitro diagnostic test","blood biomarker-based algorithm","2025-10-02",{"date":511,"type":44},"2025-10-07",{"date":513,"type":44},"2025-09-30",{"date":515,"type":21},"2028-07-01",{"name":517,"class":51},"University Hospital, Montpellier",{"id":519,"slug":520,"hasResults":11,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":524,"eligibilityCriteria":525,"healthyVolunteers":86,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":528,"conditions":529,"keywords":531,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":52},"100604131","social-skills-in-chronic-pain-addiction-intimate-partner-violence-and-primary-care-100604131","NCT07145528","Social Skills in Chronic Pain, Addiction, Intimate Partner Violence and Primary Care","Social Skills in Adult Patients Followed for Chronic Pain, Addiction, Intimate Partner Violence or Followed in Primary Care: A Comparative Observational Study","Skills-PAVIP","Inclusion Criteria:\n\nPatients aged 18 and over Suicidal: Patients at risk of suicide, or Suicidal : Patients who have attempted suicide, or Primary care patients\n\nExclusion Criteria:\n\nPatients not fluent in French, Patients with an unstabilized psychiatric disorder, Patients refusing to participate in the study. Persons not affiliated to a social security scheme or beneficiaries of a similar scheme, Pregnant and breast-feeding women",{"count":527,"type":21},600,"Context: psychosocial competencies (CPS) are higher cognitive functions defined by the ability to interact with others by adopting appropriate and positive behavior. They are defined among three axes: emotional skills, cognitive skills and social skills. Dysfunctions in social skills in adults are linked to substance use and abuse, sensitivity to pain, control of violence, and being a victim of violence. The links are bidirectional: both causes and consequences.\n\nObjectives: Compare the level of psychosocial skills in patients presenting with a use disorder or chronic pain or being victims or perpetrators of domestic violence or patients followed in a primary care center without any of these histories, using the score obtained after passing a scale currently being validated in an adult population.\n\nSecondary objectives Describe profiles of social skills dysfunction within each population Evaluate the link between alterations in CPS in the different populations and different sociodemographic, intrinsic or environmental criteria\n\nType of study: multicenter comparative cross-sectional study\n\nNumber of centers: twelve (6 multi-professional primary care health centers - 6 hospital centers)\n\nStudy description: Cross-sectional, multicenter study. The patients will be included consecutively over a one-year period at the time of their visit to the inclusion center.\n\nPrimary endpoint: score obtained for each of the 4 axes on the ad hoc psychosocial skills assessment test.\n\nNumber of subjects: 600 patients (60 in each group)\n\nInclusion criteria\n\n* Patients aged 18 and over,\n* Patients with chronic pain lasting at least 6 months,\n* Patients with alcohol dependence,\n* Patients victims of intra-family violence,\n* Patients who commit intra-family violence,\n* Patients followed in primary care and not presenting any of the 4 previous items,\n\nStudy procedure: each participant, regardless of population, will receive a single 45-minute interview consisting of a validated psychosocial skills assessment test, and a record of consumption status and medico-socio-economic history.\n\nData will be collected directly online, and the main analysis will be based on a comparative analysis of the level of social skills between the different groups for each of the four axes of the social skills assessment test.",[530,27],"Social Skills",[532,533,534],"intimate partner violence","addiction","chronic pain","2025-08-20",{"date":537,"type":44},"2025-08-28",{"date":539,"type":21},"2025-09-01",{"date":541,"type":21},"2026-09-01",{"name":543,"class":51},"University Hospital, Clermont-Ferrand",{"id":545,"slug":546,"hasResults":11,"nctId":547,"briefTitle":548,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":86,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":551,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":553,"conditions":554,"keywords":556,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":565,"locationsCount":208},"100581593","designing-a-tailored-primary-care-intervention-to-manage-the-burden-of-caring-for-patients-living-with-alzheimers-disease-or-a-related-dementia-100581593","NCT06852326","Designing a Tailored Primary Care Intervention to Manage the Burden of Caring for Patients Living with Alzheimer's Disease (or a Related Dementia)","ISAMA-PP","Inclusion Criteria:\n\n* Healthcare professionals who are members of the 3 CPTSs included and who agree to participate\n* Adult informal carers of patients living with Alzheimer's disease or a related dementia from the 3 CPTS who agree to participate\n* University experts: general practitioners, geriatric mobile team doctor, advanced practice nurse, clinical psychologist, biostatistical methodologist. Some of them had already taken part in the steering committee for ISAMA's exploratory qualitative and quantitative studies.\n\nExclusion Criteria:\n\n\\- Professional carers",{"count":552,"type":21},30,"The design of the intervention is an ongoing process which will consist of two phases: a determination of the intervention using the Delphi-modified consensus method and an assessment of its acceptability, as described in the methodological recommendations of the Medical Research Council Guidance.",[27,555],"Alzheimer Disease",[557,558],"care","caregiver","2025-02-27",{"date":561,"type":44},"2025-02-28",{"date":563,"type":44},"2024-11-21",{"date":152,"type":21},{"name":566,"class":51},"University Hospital, Tours",{"id":568,"slug":569,"hasResults":11,"nctId":570,"briefTitle":571,"officialTitle":571,"acronym":572,"eligibilityCriteria":573,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":22,"phases":576,"briefSummary":577,"conditions":578,"keywords":579,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":585,"lastUpdatePostDateStruct":586,"startDateStruct":588,"completionDateStruct":590,"leadSponsor":592,"locationsCount":52},"100568260","physical-inactivity-and-sedentary-behavior-screening-and-intervention-in-ambulatory-primary-care-100568260","NCT06678906","Physical Inactivity and Sedentary Behavior: Screening and Intervention in Ambulatory Primary Care","IPSEDI","Inclusion Criteria:\n\n* Adult patients\n* Not benefiting from Long-Term Illness coverage\n* Followed in primary outpatient care by one of the participating centers\n* Patients identified as \"inactive\" by the ONAPS-PAQ questionnaire during an appointment with a general practitioner in the partner Multi-Professional Health Centers, whether sedentary or not\n* Patient having signed informed consent to participate in the study\n* Patients who understand and speak French\n* Persons affiliated with a social security scheme or beneficiaries of a similar scheme\n* Patients classified as \"inactive\" (\\\u003C 600 MET.min\u002Fweek) after 7-day actimetry analysis\n\nExclusion Criteria:\n\n* Patient receiving follow-up for another reason with physiotherapists participating in the protocol\n* Persons referred to in articles L1121-5 to L1121-8 of the Public Health Code\n* Patient participating in another interventional research study with an exclusion period still ongoing at pre-inclusion",{"count":575,"type":21},160,[24],"Physical inactivity and sedentary behaviors are among the leading modifiable risk factors for chronic diseases. In France, despite the national Sport Health strategy, awareness campaigns physical inactivity and sedentary behavior worsened between 2005 and 2015. Primary healthcare professionals, including general practitioners and physiotherapists already involved in tertiary prevention, can act for primary and secondary prevention.",[27],[580,581,582,583,584],"Physical inactivity","Sedendary behavior","Innovative personalized support by physiotherapist","Ambulatory primary care","Healthcare pathway","2025-02-05",{"date":587,"type":44},"2025-02-10",{"date":589,"type":21},"2025-05",{"date":591,"type":21},"2027-01",{"name":593,"class":51},"University Hospital, Grenoble",{"id":595,"slug":596,"hasResults":11,"nctId":597,"briefTitle":598,"officialTitle":599,"acronym":600,"eligibilityCriteria":601,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":602,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":604,"conditions":605,"keywords":607,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":616,"locationsCount":208},"100560715","problematic-use-and-addiction-in-primary-care-100560715","NCT06580756","Problematic Use and Addiction in Primary Care","Development and Validation of a Short Training Course to Help Primary Care Healthcare Professionals Identify Addictive Disorders","PAPRICA","Inclusion Criteria:\n\n* be a primary care professional (physiotherapists, nurses, midwives, dentists, pharmacists, General practitioner)\n* in ambulatory practice. Recruitment will be carried out with the help of territorial professional health communities, to include practitioners practicing in conditions representative of the diversity of primary care practice.\n\nGPs agreeing to take part will be divided into a control group and an intervention group, by drawing lots.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* The same participant may not be included in more than one stage.",{"count":603,"type":21},200,"The morbi-mortality and social cost of addictive disorders led the French authorities to set up a government plan in 2018 to combat drugs and addictive behavior (Interministerial mission to combat drugs and addictive behaviour - (MILDECA)). In particular, it encourages early detection, which is the first stage in a validated global approach to the management of addictive disorders. Improving early identification of addictive disorders in primary care would reduce morbidity and mortality and improve quality of life for patients with addictive disorders. The identification of use disorders should be systematic in primary care and was the subject of a recommendation in 2015. Numerous tests are cited in these recommendations, but few have actually been validated in primary care, and none has been shown to be feasible. For example, only 23% of GPs claim to systematically identify alcohol consumption.\n\nOther primary care professionals (physiotherapists, nurses, midwives, dentists, pharmacists) also have a role to play in identifying addictive disorders. The evolution of their respective professions (delegation of tasks, creation of the profession of advanced practice nurse, medical assistants) and the recent reorganization of the practice framework, both in terms of practice structures and professional community organizations, involve them in a global multidisciplinary collaboration on patient care, particularly in the early identification of addictive disorders.\n\nThe hypothesis is that the difficulties in implementing tests to identify addictive disorders in primary care are linked to the lack of specific consideration of the needs of primary care patients and caregivers.\n\nThe overall aim of the study is to improve the early detection of addictive disorders through brief training for primary care healthcare professionals.",[606,27],"Addiction Disorders",[608],"short training program","2024-12-04",{"date":611,"type":44},"2024-12-09",{"date":613,"type":21},"2025-09",{"date":615,"type":21},"2028-08",{"name":566,"class":51},{"id":618,"slug":619,"hasResults":11,"nctId":620,"briefTitle":621,"officialTitle":622,"acronym":623,"eligibilityCriteria":624,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":625,"enrollmentInfo":626,"targetDuration":4,"studyType":121,"phases":4,"briefSummary":627,"conditions":628,"keywords":629,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":639,"locationsCount":52},"100553349","risk-management-in-primary-care-100553349","NCT06484933","Risk Management in Primary Care","Assessing Risk Management in Primary Care Teams","eGERISSEP","Inclusion Criteria:\n\nHealthcare professional\n\n* Healthcare professional over 18 years of age, registered with the professional association on which he\u002Fshe depends and holding an RPPS identification number with care activity as part of a coordinated practice, within a legally formalised care team working on a territorial health project, or care activity within a care team that is not legally formalized but defined as an entity bringing together ≥ 4 different professionals to care for the same patient.\n* Most care provided on an outpatient basis\n* Care activity in the AURA region\n* Agreement to participate in the focus group Users\n* Any user of the healthcare system over the age of 18\n* Consulting a healthcare professional from a team included in the research\n* Agreement to participate in the focus group\n\nExclusion Criteria:\n\nHealthcare professional\n\n* Primary care healthcare professional with a specific exclusive practice that does not form part of the overall management of a patient (e.g. homeopathy, mesotherapy, acupuncture, etc.) Users\n* Persons deprived of their liberty by a judicial or administrative decision\n* Adults under legal protection (guardianship, curatorship)\n* Persons not affiliated to a social security scheme or beneficiaries of a similar scheme","100 Years",{"count":120,"type":21},"The proposed research is a prospective, non-comparative study based on a qualitative method, comprising a literature review followed by 2 successive series of Focus Groups with users and healthcare professionals of primary care in the French AURA region. The 2 Focus Group phases will make it possible to :\n\n* propose an operational definition of the notion of a professional team in primary care (validation by consensus between the participants of the first 4 Focus Groups based on the definitions in the literature)\n* describe the ways in which risks are managed in primary care teams (qualitative analysis of the contributions made by the participants in the next 12 Focus Groups organized in 12 primary care teams)",[27],[34,630,631],"Risk management","Teamwork","2024-07-01",{"date":634,"type":44},"2024-07-03",{"date":636,"type":21},"2024-07-05",{"date":638,"type":21},"2026-06-01",{"name":235,"class":51}]