[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-dysmenorrhea-pd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-dysmenorrhea-pd":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,71,100,122,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100644000","effect-of-pilates-exercises-versus-gym-exercises-on-primary-dysmenorrhea-100644000",false,"NCT07669883","Effect of Pilates Exercises Versus Gym Exercises On Primary Dysmenorrhea","dysmenorrhea","Inclusion criteria :\n\nHealthy young virgin females suffering from primary dysmenorrhea diagnosed by the gynecologist.\n\n* Their ages will be ranged from 17-25 years old\n* Their body mass index will be ranged from 20-25 kg\u002F m²\n* All females have regular menstruation\n\nExclusion Criteria:\n\n* Females will be excluded from the study if they have;\n\n  * Any gynecological problem such as irregular menstrual cycle, secondary dysmenorrhea due to endometriosis, ovarian cyst, uterine fibroid and congenital malformation or pelvic inflammation.\n  * Cardiovascular diseases\n  * Respiratory diseases.\n  * Liver and kidney dysfunctions","FEMALE","17 Weeks","25 Weeks",{"count":20,"type":21},52,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study will be conducted to assess the effect of Pilates Exercises Versus Gym Exercises On Primary Dysmenorrhea.",[27],"Primary Dysmenorrhea (PD)",[29],"Primary dysmenorrhea","NOT_YET_RECRUITING","2026-06-21",{"date":33,"type":34},"2026-06-25","ACTUAL",{"date":36,"type":21},"2026-06-11",{"date":38,"type":21},"2026-12-30",{"name":40,"class":41},"Cairo University","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":60,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100606532","effect-of-semiconductor-embedded-wearable-sleeve-on-treatment-of-primary-dysmenorrhea-symptoms-100606532","NCT07176780","Effect of Semiconductor Embedded Wearable Sleeve on Treatment of Primary Dysmenorrhea Symptoms","Effect of Semiconductor Embedded Wearable Sleeve on the Treatment and Mitigation of Primary Dysmenorrhea Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n* Self-reported primary dysmenorrhea during past three menstrual cycles\n* Age 18-45 inclusive at the time of consent\n* Self-reported typical primary dysmenorrhea symptom pain greater than 4 on a 1-10 visual analog scale (VAS)\n* History of regular menstrual cycles with a usual length of 21 to 35 days\n* Willing and able to provide informed consent and adhere to study requirements\n\nExclusion Criteria:\n\n* History of neurological conditions, including multiple sclerosis or Parkinson's disease\n* Secondary dysmenorrhea including confirmed or suspected endometriosis or fibroids or intrauterine device\n* Self-reported size not available in study device\n* Pregnant or planning to become pregnant during the study\n* Have within the past six months of enrollment, or are planning to in the next six months, start or discontinue any of the following contraceptive methods:\n\n  1. intrauterine device\n  2. oral contraceptives,\n  3. contraceptive patch,\n  4. implant (Nexplanon),\n  5. shot (Depo-Provera),\n  6. vaginal ring\n* Chronic pain conditions unrelated to primary dysmenorrhea\n* Auto-immune or auto-inflammatory diseases\n* Has used within the last 90 days or is planning to use nicotine-containing products\n* History of metabolic disorders\n* Active infection (local or systemic) that, in the opinion of the investigator, would prevent usage of the device\n* In the opinion of the investigator, any other criteria or condition that could increase the risk associated with study participation or study treatment or could interfere with the interpretation of study results\n* Have taken any investigational drug or used any investigational device within the 30 days prior to consent.",true,"18 Years","45 Years",{"count":53,"type":21},100,[24],"This study is looking to test a non-compressive semiconductor embedded body sleeve for treatment of primary dysmenorrhea symptoms. Dysmenorrhea is the lower abdominal pain (sometimes referred to as \"cramping\") experienced during menstruation (monthly \"period\"), affecting up to 94% of people aged from 10-20 years old. The semiconductor embedded fabric increases blood circulation through activation of the embedded elements with body heat while worn and releases energy waves as well as negative ions. This energy has an effect inside the body that increases oxygen and nutrient flow to tissues, and can help to decrease pain and inflammation. This study is testing this technology to see if it can be used as a non-pharmacological treatment for menstrual cramping.",[57,27,58,59],"Primary Dysmenorrhea","Menstrual Cramps","Women's Health",[58,61,57,59],"Dysmenorrhea","2026-06-12",{"date":64,"type":34},"2026-06-16",{"date":66,"type":21},"2026-12",{"date":68,"type":21},"2027-03",{"name":70,"class":41},"University of California, Davis",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":99},"100638333","graded-motor-imagery-for-primary-dysmenorrhea-100638333","NCT07618832","Graded Motor Imagery for Primary Dysmenorrhea","Effect of Graded Motor Imagery on Pressure Pain Threshold and Pain Intensity in Women With Primary Dysmenorrhea: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Female sex (aged 18-30 years)\n2. Diagnosis of primary dysmenorrhea confirmed by a physician (painful menstruation for ≥6 consecutive cycles, in the absence of identifiable pelvic pathology on clinical and\u002For ultrasound evaluation)\n3. Pain ≥4\u002F10 NRS experienced during the last period.\n4. Confirmed altered pressure pain threshold: PPT ≥2 standard deviations below published norms for age-matched healthy women, measured at baseline assessment\n5. Regular menstrual cycle (21-35 days)\n6. Capable of engaging in virtual video sessions and taking online tests.\n7. Consent to withhold new analgesic or hormonal treatments during the study period.\n\nExclusion Criteria:\n\n1. Secondary dysmenorrhea (endometriosis, adenomyosis, fibroids, pelvic inflammatory disease, ovarian cysts ≥3 cm confirmed on imaging)\n2. Current use of hormonal contraceptives (which alter prostaglandin levels and pain processing)\n3. Pregnancy or lactation\n4. Concurrent chronic pain condition (fibromyalgia, CRPS, chronic low back pain, chronic pelvic pain unrelated to menstruation)\n5. Neurological or psychiatric disorder that would impair motor imagery ability (stroke, schizophrenia, active psychosis)\n6. Cognitive impairment affecting informed consent capacity\n7. Participation in another clinical trial within 4 weeks before enrollment\n8. Previous exposure to graded motor imagery or mirror therapy\n9. Regular use of NSAIDs or opioids for non-menstrual indications","30 Years",{"count":80,"type":21},81,[24],"The goal of this clinical trial is to learn if graded motor imagery can reduce pain sensitivity and period pain in women with primary dysmenorrhea (painful periods with no medical cause).\n\nThe main questions it aims to answer are:\n\n1. Is there a decrease in pressure pain threshold (increased pain sensitivity) with graded motor imagery?\n2. Is the intensity of menstrual pain reduced by graded motor imagery?\n3. Is GMI helpful to reduce menstrual symptoms and pain catastrophizing (negative thinking about pain)?\n\nResearchers will compare full GMI (active intervention), a sham GMI(inactive intervention), and a wait-list (no intervention) to see if GMI works better than the alternatives.\n\nParticipants will:\n\n1. Take part in a 6-week graded motor imagery program, sham program, or no intervention control.\n2. Do laterality recognition, motor imagery, and mirror therapy exercises in the graded motor imagery group.\n3. Complete pain and symptom assessments before and after the program, and again at follow-up.",[27],[85,57,86,87,88],"Graded Motor Imagery","Primary dysmenorrhea and pressure pain threshold","Primary dysmenorrhea and altered pain sensitivity","Non-pharmacological intervention for primary dysmenorrhea","RECRUITING","2026-05-30",{"date":92,"type":34},"2026-06-02",{"date":94,"type":34},"2026-04-06",{"date":96,"type":21},"2026-08",{"name":98,"class":41},"Dr. Mehak Naeem",1,{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":78,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":99},"100620194","pelvic-nerve-mobilization-for-primary-dysmenorrhea-100620194","NCT07354451","Pelvic Nerve Mobilization for Primary Dysmenorrhea","Efficacy of Pelvic Nerve Mobilization in Reducing Symptoms of Primary Dysmenorrhea: A Randomized Controlled Trial","PNM-PD","Inclusion Criteria:\n\n* Female university students aged 18-30 years\n* Regular menstrual cycles (24-35 days)\n* Clinically diagnosed primary dysmenorrhea\n* Average menstrual pain intensity ≥ 5 on Visual Analog Scale\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Secondary dysmenorrhea (e.g., endometriosis, fibroids, pelvic inflammatory disease)\n* History of pelvic or spinal surgery\n* Neurological disorders\n* Current pregnancy or lactation\n* Current physiotherapy or manual therapy treatment\n* Contraindications to manual therapy",{"count":109,"type":21},60,[24],"Primary dysmenorrhea is a highly prevalent condition among young women and is associated with significant pain, reduced quality of life, and academic absenteeism. Although non-steroidal anti-inflammatory drugs are commonly used, many women seek non-pharmacological alternatives due to limited effectiveness or adverse effects. Emerging evidence suggests that altered pelvic neurodynamics may contribute to dysmenorrheic pain.\n\nThis randomized controlled trial aims to evaluate the effectiveness of external pelvic nerve mobilization in reducing menstrual pain and associated symptoms among university women with primary dysmenorrhea. Participants aged 18-30 years will be randomly allocated to receive either external pelvic nerve mobilization or a sham manual therapy intervention across three consecutive menstrual cycles. Outcomes will include pain intensity, menstrual distress, quality of life, pelvic tenderness, analgesic consumption, and academic absenteeism.",[27],"2026-04-27",{"date":115,"type":34},"2026-04-29",{"date":117,"type":34},"2025-10-20",{"date":119,"type":21},"2026-07-30",{"name":121,"class":41},"University of Hail",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":78,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":135,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":99},"100592980","effect-of-yoga-training-on-nausea-and-pain-100592980","NCT07000487","Effect of Yoga Training on Nausea and Pain","Effect of Yoga Training on Nausea and Pain Symptoms in Young Women With Primary Dysmenorrhea: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Having a regular menstrual cycle\n* Being single\n* Not having any psychiatric diagnosis or gynecological disease (abnormal uterine bleeding, myoma, ovarian cysts, etc.) extremities and any health problems that may prevent physical exercise\n* Not having any systemic disease (heart, diabetes, epilepsy, rheumatoid arthritis, etc.)\n* Young women who agree to participate in the study and can speak and understand Turkish\n\nExclusion Criteria:\n\n* Wanting to leave the study, primary dysmenorrhea severity and nausea level below 4 points.",{"count":130,"type":21},70,[24],"This study was planned to determine the effect of yoga training on reducing nausea and pain symptoms in young women with primary dysmenorrhea. As a result of this study, evaluating the extent to which women with dysmenorrhea experience pain and nausea and the extent to which yoga has a positive effect on these symptoms may shed light on women experiencing these symptoms and developments in the literature, and may increase the use of non-pharmacological approaches. The results of the study will contribute to the literature on dysmenorrhea, one of the important gynecological problems in women. In addition, although there are many results in the literature on the effectiveness of yoga in the management of nausea symptoms with cancer patients, there are not many studies on nausea on dysmenorrhea. In this respect, it will provide important evidence to the literature.",[27,134],"Yoga",[136,137,138,139,140],"primary dysmenorrhea","yoga","pain","nausea","young woman","2025-05-24",{"date":143,"type":34},"2025-06-03",{"date":145,"type":21},"2025-06-01",{"date":147,"type":21},"2025-10-31",{"name":149,"class":41},"Çankırı Karatekin University",{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":4,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":156,"maxAge":51,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":163,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":99},"100572208","a-preliminary-study-on-the-efficacy-of-danggui-shaoyao-san-and-cuscuta-chinensis-in-patients-with-primary-dysmenorrhea-100572208","NCT06730282","A Preliminary Study on the Efficacy of Danggui Shaoyao San and Cuscuta Chinensis in Patients with Primary Dysmenorrhea","Inclusion Criteria:\n\n1. Female participants aged 20 to 45 years.\n2. Regular menstrual cycles (21 to 42 days).\n3. History of moderate to severe primary dysmenorrhea (Visual Analogue Scale (VAS) score \\> 3) persisting for at least three consecutive menstrual cycles.\n4. Able to understand and complete the study questionnaires (e.g., MSQ).\n5. Willing to comply with study protocols, including taking study medications and attending follow-up visits.\n\nExclusion Criteria:\n\n1. Secondary dysmenorrhea caused by conditions such as endometriosis, pelvic inflammatory disease, or uterine fibroids.\n2. Current use of an intrauterine contraceptive device (IUD).\n3. Irregular menstrual cycles.\n4. Pregnant, breastfeeding, or planning pregnancy within the study period.\n5. Use of anticoagulant medications (e.g., aspirin, warfarin, or heparin).\n6. Known allergies to any components of the study medications.\n7. Severe uncontrolled systemic diseases (e.g., neurological disorders, immunodeficiency, or bleeding disorders).\n8. Concurrent use of other herbal medicines or alternative treatments for premenstrual syndrome or dysmenorrhea.\n9. Participation in another clinical trial during the study period.\n\n   \\-","20 Years",{"count":158,"type":21},200,[24],"This study aims to evaluate the efficacy of two traditional Chinese medicine (TCM) formulas, Danggui Shaoyao San (DSS) and Cuscuta Chinensis (Tu Si Zi), in treating primary dysmenorrhea (PD). Primary dysmenorrhea, a common condition characterized by painful menstrual cramps, affects many women of reproductive age and significantly impacts their quality of life. Conventional treatments, such as NSAIDs and oral contraceptives, often have limited efficacy or side effects, underscoring the need for alternative therapeutic options.\n\nIn this randomized, double-blind study, participants will be divided into four groups: DSS, Tu Si Zi, a combination of DSS and Tu Si Zi, and a placebo group. The study will measure treatment outcomes using the Visual Analogue Scale (VAS) for pain and the Menstrual Symptom Questionnaire (MSQ), which captures physical and emotional symptoms. Additionally, TCM-based tools like pulse diagnosis and constitution questionnaires will be employed to explore personalized treatment strategies.\n\nThis research seeks to determine whether these TCM formulas can alleviate pain and improve other menstrual symptoms, potentially providing broader benefits than conventional painkillers. The findings aim to support evidence-based integration of TCM in managing dysmenorrhea and inform clinicians and patients about effective therapeutic choices.",[27,162],"Traditional Chinese Medicine (TCM) Approaches",[57,164,165,166,167],"Traditional Chinese Medicine (TCM)","Danggui Shaoyao San (DSS)","Cuscuta Chinensis (Tu Si Zi)","Herbal Medicine","2024-12-11",{"date":170,"type":34},"2024-12-12",{"date":172,"type":21},"2024-12-01",{"date":174,"type":21},"2026-06-30",{"name":176,"class":41},"Taichung Tzu Chi Hospital"]