[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-dysmenorrhea\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-dysmenorrhea":28},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,31,0,25,[9,47,78,103,128,154,180,201,230,244,271,293,315,339,358,381,403,429,452,473,500,523,545,564,588],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100053653","phase-3-evaluation-of-the-analgesic-effect-of-intramyometrial-botulinum-toxin-injection-via-hysteroscopy-in-pelvic-pain-suggestive-of-dysmenorrhea-100053653",false,"NCT06995287","Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Pelvic Pain Suggestive of Dysmenorrhea","Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Pelvic Pain Suggestive of Dysmenorrhea: A Prospective, Multicenter, Double-Blind, Randomized Placebo-Controlled Study.","HYSTEROXINE","Inclusion Criteria:\n\n* Adult women who are not menopausal,\n* Presenting with:\n* Either severe primary dysmenorrhea, defined by an average pain intensity (VAS) ≥ 6\u002F10 over the last 3 months at the inclusion visit,\n* Or, in cases of amenorrhea under hormonal treatment, severe chronic pelvic pain (average VAS ≥ 6\u002F10 over the last 3 months), described as cramp-like, localized in the pelvic region, and similar to the initial dysmenorrhea pain.\n* Having failed optimal first-line medical treatment combining hormonal therapy and appropriate analgesics (Level I and II analgesics, and NSAIDs),\n* Having undergone a pelvic MRI within 1 year prior to the randomization visit that shows no evidence of deep infiltrating endometriosis or endometrioma, following systematic review by radiologists from the expert center managing the patient (if the pelvic MRI is deemed of insufficient quality for interpretation, a new MRI will be performed at the center),\n* Using a highly effective method of contraception (failure rate \\\u003C1%) for the entire duration of the follow-up period. Highly effective contraception methods are defined as one of the following: combined hormonal contraception (containing estrogen and progestin) with ovulation inhibition (oral, vaginal, or transdermal), progestin-only hormonal contraception with ovulation inhibition (oral, injectable, or implantable), intrauterine device (IUD), intrauterine hormonal system (IUS), condoms, bilateral tubal occlusion, vasectomized partner, or sexual abstinence,\n* Having a negative urine pregnancy test on the day of the procedure,\n* Having signed the informed consent form for the study at the M-1 visit.\n\nExclusion Criteria:\n\n* Pregnant or planning a pregnancy during the entire study period,\n* Currently breastfeeding,\n* Refusal to use effective contraception during the study and for 6 months after its completion,\n* Contraindications to botulinum toxin, including:\n* Generalized disorders of muscular activity (e.g., myasthenia gravis, Lambert-Eaton syndrome),\n* Ongoing treatment with aminoglycosides, peripheral muscle relaxants, or amino-4-quinolines,\n* Hypersensitivity to the active substance, human albumin, or sucrose,\n* Bleeding disorders or current treatment with anticoagulants,\n* Ongoing vaginal or upper genital tract infection,\n* Participation in another interventional clinical trial,\n* Inability to cooperate or understand the study requirements in a way that would allow strict adherence to the protocol,\n* Subject to legal protection measures (e.g., guardianship, curatorship, or judicial protection),\n* Not affiliated with the French social security system,\n* Unable to access the internet to complete questionnaires at Month 1 and Month 6.","FEMALE","18 Years",{"count":21,"type":22},222,"ESTIMATED","INTERVENTIONAL",[25],"PHASE3","The objective of the study is to evaluate the global impression of improvement at 3 months following intramyometrial botulinum toxin injections via hysteroscopy in women with severe primary dysmenorrhea who have failed first-line medical treatment, compared to intramyometrial placebo injections.",[28,29],"Primary Dysmenorrhea","Chronic Pelvic Pain",[31,32,33],"Primary dysmenorrhea","injection","Botulimum toxin, Type A","RECRUITING","2026-07-09",{"date":37,"type":38},"2026-07-13","ACTUAL",{"date":40,"type":38},"2026-02-09",{"date":42,"type":22},"2028-09-09",{"name":44,"class":45},"Nantes University Hospital","OTHER",8,{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":12,"sex":18,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100546749","the-effect-of-cognitive-exercise-therapy-approach-and-yoga-in-adolescents-with-dysmenorrhoea-100546749","NCT06398990","The Effect of Cognitive Exercise Therapy Approach and Yoga in Adolescents With Dysmenorrhoea","The Effect of Telerehabilitation-Based Cognitive Exercise Therapy Approach and Yoga on Pain, Physical Function and Quality of Life in Adolescents With Dysmenorrhoea","Inclusion Criteria:\n\n* Between the ages of 10 and 19,\n* Having had a menstrual cycle for at least 6-12 months (ACOG, 2018),\n* Having menstrual pain intensity of ≥4 cm according to the Visual Analog Scale (VAS, 0-10 cm) (Kannan, P. 2015; Yonglitthipagon, P. 2017),\n* To have been diagnosed with primary dysmenorrhea according to the clinical characteristics and diagnostic approach defined in international dysmenorrhea guidelines (ACOG 2018; JOGC 2017),\n* Nulliparous (having never given birth),\n* Able to read and write in Turkish,\n* Willing to participate in the study and having provided informed consent.\n\nExclusion Criteria:\n\n* History or clinical findings suggestive of secondary dysmenorrhea,\n* Presence of serious comorbidities, including neurological, cardiovascular, musculoskeletal, psychiatric, gastrointestinal, or autoimmune disorders,\n* History of surgery involving the abdominal, pelvic, or spinal regions within the past 12 months,\n* Current pregnancy or suspected pregnancy,\n* Use of intrauterine devices (IUDs),\n* Having participated in a regular exercise, sports, or physiotherapy program within the last 6 months,\n* Concurrent participation in another clinical study.","10 Years","19 Years",{"count":57,"type":22},42,[59],"NA","Dysmenorrhoea is a condition that negatively affects the quality of life in women of many age groups. In girls with dysmenorrhoea in adolescence, there is an effect on school performance, self-confidence-depression problems and a decrease in quality of life due to pain. In order to eliminate these negative effects, they should receive a good treatment. Medical treatment usually tries to minimise and balance this situation. Considering the fact that families do not want to use drugs such as oral contraceptives in their children at this age and the risks of oral contraceptives, parents are in different searches. Considering that the approach to pain should always be from a holistic perspective, yoga and cognitive exercise therapy approaches are both biopsychosocial treatment methods within the scope of mind-body integrity. Yoga and cognitive exercise therapy approach is thought to reduce symptoms, improve physical functions and quality of life in adolescent girls. With these positive effects, school absenteeism decreases, depression and self-confidence improve. Health costs will also be reduced to some extent.",[62,28],"Dysmenorrhea",[64,65,66,67],"dysmenorrhea","mind-body exercises","cognitive exercise therapy approach","yoga","2026-06-30",{"date":70,"type":38},"2026-07-02",{"date":72,"type":38},"2025-12-01",{"date":74,"type":22},"2026-12",{"name":76,"class":45},"Acibadem University",1,{"id":79,"slug":80,"hasResults":12,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":77},"100642780","connective-tissue-massage-and-music-based-progressive-muscle-relaxation-in-primary-dysmenorrhea-100642780","NCT07647276","Connective Tissue Massage and Music-Based Progressive Muscle Relaxation in Primary Dysmenorrhea","The Effects of Connective Tissue Massage and Music-Based Progressive Muscle Relaxation on Pain Intensity, Pressure Pain Threshold, and Menstruation-Related Symptoms in Women With Primary Dysmenorrhea: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Having a diagnosis of primary dysmenorrhea made by a Gynecology and Obstetrics specialist\n* Being between 18-30 years of age\n* Being nulliparous\n* Having a regular menstrual cycle (28 ± 7 days)\n* Having menstrual pain intensity greater than 4 cm on the Visual Analog Scale for the last 6 months\n* Voluntarily agreeing to participate in the study\n\nExclusion Criteria:\n\n* Having been diagnosed at least 6 months prior with gastrointestinal, urogynecological, autoimmune, or psychiatric diseases and\u002For chronic pain syndromes\n* Having any neurological or systemic disease\n* Having a history of childbirth or previous pregnancy\n* Being pregnant\n* Using an intrauterine device (IUD)\n* Having any pelvic pathology or history of pelvic surgery\n* Chronic use of medications, including oral contraceptives or antidepressants\n* Currently receiving anti-inflammatory, analgesic, or psychotherapeutic drug treatment\n* Having irregular menstrual cycles (\\\u003C21 or \\>35 days and\u002For cycle variation \\>4 days)\n* Presence of pathology indicating secondary dysmenorrhea","30 Years",{"count":87,"type":22},36,[59],"This randomized controlled clinical trial aims to investigate the effects of Connective Tissue Massage (CTM) and music-based Progressive Muscle Relaxation Training (PMRT) on pain intensity, pressure pain threshold, analgesic use, and menstruation-related symptoms in women with primary dysmenorrhea. Participants will be randomly assigned to one of three groups: CTM, music-based PMRT, or control. Baseline assessment will be conducted during menstrual days 1-2 of Cycle 0. The interventions will be applied during the premenstrual intervention window of Cycle 0, from the estimated ovulation day, calculated as cycle length minus 14 days, until Cycle 1 Day 1. Post-intervention assessment will be conducted during menstrual days 1-2 of Cycle 1. No intervention will be applied after the post-intervention assessment, and follow-up assessment will be conducted during menstrual days 1-2 of Cycle 2. Outcomes including pain intensity, pressure pain threshold, analgesic use, menstrual symptoms, attitudes toward menstruation, functional and emotional impact of dysmenorrhea, and pain catastrophizing will be evaluated across menstrual cycles. Participant satisfaction and adherence to the interventions will also be assessed.",[28],[31,92,93,94],"Connective tissue massage","Progressive muscle relaxation training","Pain","2026-06-26",{"date":68,"type":38},{"date":98,"type":38},"2026-06-22",{"date":100,"type":22},"2026-11-15",{"name":102,"class":45},"Pamukkale University",{"id":104,"slug":105,"hasResults":12,"nctId":106,"briefTitle":107,"officialTitle":108,"acronym":4,"eligibilityCriteria":109,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":23,"phases":112,"briefSummary":113,"conditions":114,"keywords":116,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100642135","emotional-freedom-techniques-in-nursing-students-with-primary-dysmenorrhea-100642135","NCT07658859","Emotional Freedom Techniques in Nursing Students With Primary Dysmenorrhea","Effect of Emotional Freedom Techniques on Pain Intensity, Pain Catastrophizing, and Functional-Emotional Impact in Nursing Students With Primary Dysmenorrhea","Inclusion Criteria:\n\n* Being enrolled in a nursing program,\n* Being 18 years of age or older\n* Having had a regular menstrual cycle within the last six months\n* Experiencing primary dysmenorrhea during the last three menstrual cycles\n* Reporting moderate to severe pain according to the Visual Analog Scale (VAS: 4-10)\n* Voluntary participation in the study\n* Providing written informed consent\n\nExclusion Criteria:\n\n* Having a diagnosed gynecological disease that may cause secondary dysmenorrhea (endometriosis, adenomyosis, uterine fibroids, pelvic inflammatory disease, etc.)\n* Having chronic pain syndrome\n* Receiving regular treatment or taking psychiatric medication due to a psychiatric diagnosis\n* Applying another pharmacological or non-pharmacological intervention that may affect pain perception during the research process,\n* Taking the course Obstetrics, Gynecology and Women's Health Nursing • Receiving\u002Fhaving received emotional freedom technique training,\n* Having previously received training in this technique or regularly using it\n* Having a cognitive or sensory problem that prevents communication or completing data collection forms\n* Not completing the application protocol\n* Incomplete completion of data collection forms\n* Wishing to withdraw from the research",{"count":111,"type":22},92,[59],"This study will examine whether Emotional Freedom Techniques (EFT) can reduce pain intensity, pain catastrophizing, and functional-emotional impact in nursing students with primary dysmenorrhea. Eligible participants will be randomly assigned to an intervention group or a control group. The intervention group will receive EFT-based support, and the control group will continue their usual coping practices. Study outcomes will be measured before the intervention, after the intervention, and at follow-up. This study may provide evidence for a safe, non-pharmacological approach to support students with primary dysmenorrhea.",[115],"PRIMARY DYSMENORRHEA",[115,117,118],"EMOTIONAL FREEDOM TECHNIQUES","NURSING STUDENTS","NOT_YET_RECRUITING","2026-06-17",{"date":98,"type":38},{"date":123,"type":22},"2026-06-19",{"date":125,"type":22},"2026-12-19",{"name":127,"class":45},"Ataturk University",{"id":129,"slug":130,"hasResults":12,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":4,"eligibilityCriteria":134,"healthyVolunteers":135,"sex":18,"minAge":19,"maxAge":136,"enrollmentInfo":137,"targetDuration":4,"studyType":23,"phases":139,"briefSummary":140,"conditions":141,"keywords":145,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":150,"leadSponsor":152,"locationsCount":4},"100606532","effect-of-semiconductor-embedded-wearable-sleeve-on-treatment-of-primary-dysmenorrhea-symptoms-100606532","NCT07176780","Effect of Semiconductor Embedded Wearable Sleeve on Treatment of Primary Dysmenorrhea Symptoms","Effect of Semiconductor Embedded Wearable Sleeve on the Treatment and Mitigation of Primary Dysmenorrhea Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial","Inclusion Criteria:\n\n* Self-reported primary dysmenorrhea during past three menstrual cycles\n* Age 18-45 inclusive at the time of consent\n* Self-reported typical primary dysmenorrhea symptom pain greater than 4 on a 1-10 visual analog scale (VAS)\n* History of regular menstrual cycles with a usual length of 21 to 35 days\n* Willing and able to provide informed consent and adhere to study requirements\n\nExclusion Criteria:\n\n* History of neurological conditions, including multiple sclerosis or Parkinson's disease\n* Secondary dysmenorrhea including confirmed or suspected endometriosis or fibroids or intrauterine device\n* Self-reported size not available in study device\n* Pregnant or planning to become pregnant during the study\n* Have within the past six months of enrollment, or are planning to in the next six months, start or discontinue any of the following contraceptive methods:\n\n  1. intrauterine device\n  2. oral contraceptives,\n  3. contraceptive patch,\n  4. implant (Nexplanon),\n  5. shot (Depo-Provera),\n  6. vaginal ring\n* Chronic pain conditions unrelated to primary dysmenorrhea\n* Auto-immune or auto-inflammatory diseases\n* Has used within the last 90 days or is planning to use nicotine-containing products\n* History of metabolic disorders\n* Active infection (local or systemic) that, in the opinion of the investigator, would prevent usage of the device\n* In the opinion of the investigator, any other criteria or condition that could increase the risk associated with study participation or study treatment or could interfere with the interpretation of study results\n* Have taken any investigational drug or used any investigational device within the 30 days prior to consent.",true,"45 Years",{"count":138,"type":22},100,[59],"This study is looking to test a non-compressive semiconductor embedded body sleeve for treatment of primary dysmenorrhea symptoms. Dysmenorrhea is the lower abdominal pain (sometimes referred to as \"cramping\") experienced during menstruation (monthly \"period\"), affecting up to 94% of people aged from 10-20 years old. The semiconductor embedded fabric increases blood circulation through activation of the embedded elements with body heat while worn and releases energy waves as well as negative ions. This energy has an effect inside the body that increases oxygen and nutrient flow to tissues, and can help to decrease pain and inflammation. This study is testing this technology to see if it can be used as a non-pharmacological treatment for menstrual cramping.",[28,142,143,144],"Primary Dysmenorrhea (PD)","Menstrual Cramps","Women's Health",[143,62,28,144],"2026-06-12",{"date":148,"type":38},"2026-06-16",{"date":74,"type":22},{"date":151,"type":22},"2027-03",{"name":153,"class":45},"University of California, Davis",{"id":155,"slug":156,"hasResults":12,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":135,"sex":18,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":23,"phases":166,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":77},"100633659","efficacy-of-cl25216-on-hormonal-balance-and-menstrual-health-in-women-with-primary-dysmenorrhea-100633659","NCT07529561","Efficacy of CL25216 on Hormonal Balance and Menstrual Health in Women With Primary Dysmenorrhea.","The Effect of CL25216 on Hormonal Balance and Menstrual Health in Women With Primary Dysmenorrhea: A Randomized, Double-blind, Placebo Controlled Clinical Trial","PD","Inclusion Criteria:\n\n* Healthy females aged between 25-40 years with a Body Mass Index (BMI) of approximately 25 to 29 kg\u002Fm2.\n* Healthy women with primary dysmenorrhea Grade 2 (measured using Verbal Multi-dimensional scoring system (VMSS)) at least for 1 day in 50 % of menstrual cycles and maximum pain intensity score ≥4 on a 10 cm VAS for at least 3 menstrual cycles before participating in the study.\n* Subjects with regular menstrual cycles that typically occur between every 21-35 days (menstrual period 3-7 days) in last 6 months.\n* Subjects with normal pelvic TVS and breast mammogram.\n* Subjects without any chronic diseases having symptoms such as burning, itching, abnormal vaginal discharge.\n* Subjects willing to provide their age of menarche and regularity in menstrual cycle.\n* Subjects without any clinical history of Gynaecological disorders or ovarian pathology, pelvic pathology like pelvic inflammatory disease, tumour and fibroma or without any history of pelvic surgery (screened using pelvic transvaginal sonography (TVS))\n* Subjects with normal thyroid profile\n* Subjects willing not to use any analgesics 24 hrs. prior screening and throughout the study.\n* Females of childbearing potential who are sexually active must agree to use adequate non-hormonal contraception during the study.\n* Normal vital signs, including electrocardiogram (ECG) and laboratory evaluations (including clinical chemistry, haematology, and complete urinalysis) within the reference range for the testing laboratory or the results are deemed not clinically significant for inclusion into this study by the investigator.\n* Subject understands the study procedures and provides signed informed consent to participate in the study\n\nExclusion Criteria:\n\n* Subjects with irregular menstrual cycle (shorter than 21 and longer than 35 days) affecting the treatment and efficacy judgment.\n* Subjects with secondary dysmenorrhea (menstrual pain associated with conditions such as endometriosis, pelvic inflammatory disease, leiomyomas, Mullerian anomalies, and adenomyosis and interstitial cystitis).\n* Subjects who are on related medications such as NSAIDs or hormonal contraceptive pills or intrauterine contraceptive devices in the past 3 months.\n* History of cerebrovascular disease, thrombo-embolic disorders, heart attack, or angina at any time or thrombophlebitis within the last 5 years, on anti-coagulant or anti-platelet drugs daily for any conditions.\n* Subjects with a high blood pressure (systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥ 90 mmHg) and Fasting blood glucose level \\>125 mg\u002Fdl at screening.\n* Subjects who had any hormonal therapy or any other herbal products in the past 3 months.\n* Hypothyroidism, hyperthyroidism, hyperprolactinemia, Cushing's syndrome and congenital adrenal hyperplasia, following a special diet for the past 3 months, taking drugs affecting insulin sensitivity or lipid and hormonal profiles, including glucocorticoids, ovulation-stimulating drugs, anti-obesity, anti-diabetes, anti-hypertensive, anti-estrogenic, anti-androgenic during the last 3 months.\n* Active gall bladder disease, gynaecological or breast surgery in the last 6 months.\n* Subjects underwent hysterectomy or bilateral oophorectomy.\n* History of breast, endometrial, other gynaecological cancer at any time or other cancer within the last 5 years.\n* Smokers or tobacco users.\n* Alcohol intake (\\>2 standard drinks per day), or recreational drugs (such as cocaine, methamphetamine, marijuana, etc.) or psychiatric drug users.\n* Pregnant and lactating mothers.\n* History of hypersensitivity reactions attributed to investigational product (IP) or its components or related products.\n* History of positive hepatitis screening including Hepatitis B surface antigen or Hepatitis C virus (HCV) antibodies or subjects with human immunodeficiency virus (HIV) and \u002For syphilis.\n* History of clinically significant illness or any other medical disorder that may interfere with subject treatment, assessment or compliance with the protocol.\n* Any condition that in opinion of the Investigator, does not justify the subjects' participation in the study.\n* Subjects with a systemic disease including tuberculosis, leucosis, collagenosis, multiple sclerosis or other autoimmune diseases.\n* Subject consumes significant amounts of soya products in the diet or any products containing red clover, black cohosh, omega 3 or omega 6 fatty acids or any other Ayush or homeopathic preparations that can interfere with the study","25 Years","40 Years",{"count":165,"type":22},80,[59],"This study is to evaluate the effects of CL25216 on hormonal balance and menstrual health in women with primary dysmenorrhea. Enrolled subjects will receive either CL25216 - 250 mg\u002Fday or placebo.",[28,169],"Menstural Cramps","2026-04-08",{"date":172,"type":38},"2026-04-14",{"date":174,"type":22},"2026-04-13",{"date":176,"type":22},"2026-09-10",{"name":178,"class":179},"ApexCPG LLC","INDUSTRY",{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":162,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":189,"briefSummary":190,"conditions":191,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":4},"100632934","evaluation-of-the-effect-of-a-structured-yoga-exercise-in-young-women-with-primary-dysmenorrhea-100632934","NCT07520136","Evaluation of the Effect of a Structured Yoga Exercise in Young Women With Primary Dysmenorrhea","Evaluation of the Effect of a Structured Yoga Exercise Program on Pain, Menstrual Symptoms, and Quality of Life in Young Women With Primary Dysmenorrhea","Inclusion Criteria:\n\n* Healthy young women with primary dysmenorrhea\n* Aged between 18-25 years\n* Having a regular menstrual cycle (30-35 days)\n* Menstrual bleeding duration of 3-10 days\n\nExclusion Criteria:\n\n* Having secondary dysmenorrhea\n* Participation in regular physical activity or other exercise programs\n* Use of medication\n* Diagnosed with polycystic ovary syndrome\n* Having bleeding disorders\n* Positive pregnancy test\n* Being in the breastfeeding period\n* Primary dysmenorrhea attributed to medical disorders or other causes\n* Participants who miss three consecutive sessions or four alternating sessions during the study will be excluded from the research",{"count":188,"type":22},30,[59],"Abstract\n\nPrimary dysmenorrhea is a common gynecological condition affecting women of reproductive age and negatively impacting quality of life. It is characterized by cramping pain in the lower abdomen that may radiate to the lower back and thighs, leading to decreased daily functioning, academic performance, and psychological well-being. In addition to pharmacological treatments, complementary approaches are increasingly used in the management of dysmenorrhea. Yoga, a mind-body exercise that combines physical movement with mental focus, has been suggested as an effective method for reducing stress and pain associated with dysmenorrhea.\n\nThe aim of this study is to evaluate the level of awareness about dysmenorrhea in young women with primary dysmenorrhea and to investigate the effects of a yoga program on pain, quality of life, and menstrual attitudes following an educational session provided to all participants. Pain severity, quality of life, and menstrual attitudes will be assessed using validated questionnaires and scales, including the Visual Analog Scale (VAS), awareness questionnaire, functional and emotional dysmenorrhea scale, Menstrual Attitude Scale, and quality of life questionnaire.\n\nThis study aims to determine whether yoga exercises reduce dysmenorrhea symptoms and improve quality of life in young women with primary dysmenorrhea. Additionally, the study is expected to increase awareness about dysmenorrhea and provide evidence for the effectiveness of yoga as a non-pharmacological intervention.",[28],"2026-04-02",{"date":194,"type":38},"2026-04-09",{"date":196,"type":22},"2026-04",{"date":198,"type":22},"2026-11",{"name":200,"class":45},"Ankara University",{"id":202,"slug":203,"hasResults":12,"nctId":204,"briefTitle":205,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":135,"sex":18,"minAge":19,"maxAge":85,"enrollmentInfo":208,"targetDuration":4,"studyType":23,"phases":210,"briefSummary":211,"conditions":212,"keywords":215,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":77},"100624415","self-acupressure-for-primary-dysmenorrhea-and-premenstrual-symptoms-100624415","NCT07409337","Self-Acupressure for Primary Dysmenorrhea and Premenstrual Symptoms","Effects of Self-Acupressure on Primary Dysmenorrhea and Premenstrual Symptoms in Women Aged 18-30: A Randomized, Sham-Controlled, 6-Month Trial","Inclusion Criteria:\n\n* Female participants aged 18 to 30 years\n* Regular menstrual cycles (21-35 days)\n* Diagnosis of primary dysmenorrhea with moderate to severe menstrual pain\n* Presence of premenstrual symptoms consistent with premenstrual syndrome\n* Currently enrolled as a university student\n* Willingness to perform self-acupressure as instructed for approximately six menstrual cycles\n* Ability to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Secondary dysmenorrhea (e.g., endometriosis, uterine fibroids, pelvic inflammatory disease)\n* Current use of hormonal contraceptives or hormonal therapy within the past 3 months\n* Pregnancy or breastfeeding\n* Chronic gynecological, endocrine, or systemic disease that may affect menstrual pain or symptoms\n* Regular use of analgesic or anti-inflammatory medications outside menstruation\n* Prior formal training or regular practice of acupuncture or acupressure\n* Inability to comply with study procedures or follow-up schedule",{"count":209,"type":22},120,[59],"This randomized, sham-controlled trial aims to evaluate the effects of self-administered acupressure on menstrual pain severity and premenstrual symptoms in women aged 18-30 years with primary dysmenorrhea. Participants will be randomly assigned to either a self-acupressure intervention group or a sham self-acupressure control group. The intervention will be applied during the premenstrual and menstrual periods over approximately six months. The primary outcome is the change in menstrual pain severity, and secondary outcomes include changes in premenstrual symptom severity, analgesic use, and menstruation-related activity limitation.",[28,213,214],"Premenstrual Syndrome","Menstrual Pain",[216,62,217,218,219,220],"Self-acupressure","Premenstrual symptoms","Menstrual pain","Non-pharmacological treatment","Sham-controlled trial","2026-02-14",{"date":223,"type":38},"2026-02-18",{"date":225,"type":38},"2026-02-15",{"date":227,"type":22},"2026-08-15",{"name":229,"class":45},"Nigde Omer Halisdemir University",{"id":231,"slug":4,"hasResults":12,"nctId":13,"briefTitle":232,"officialTitle":233,"acronym":16,"eligibilityCriteria":234,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":235,"targetDuration":4,"studyType":23,"phases":236,"briefSummary":26,"conditions":237,"keywords":238,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":239,"startDateStruct":241,"completionDateStruct":242,"leadSponsor":243,"locationsCount":46},"100592581","Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Severe Primary Dysmenorrhea","Evaluation of the Analgesic Effect of Intramyometrial Botulinum Toxin Injection Via Hysteroscopy in Severe Primary Dysmenorrhea: a Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Study","Inclusion Criteria:\n\n* Adult women who are not menopausal,\n* Experiencing severe dysmenorrhea, defined as an average pain intensity score ≥ 6\u002F10 on a Numerical Rating Scale (NRS) over the past 3 months at the inclusion visit,\n* Having failed optimal first-line medical treatment combining hormonal therapy and appropriate analgesics (Level I and II analgesics, and NSAIDs),\n* Having undergone a pelvic MRI within 6 months prior to the inclusion visit that shows no evidence of deep infiltrating endometriosis or endometrioma, following systematic review by radiologists from the expert center managing the patient (if the pelvic MRI is deemed of insufficient quality for interpretation, a new MRI will be performed at the center),\n* Using a highly effective method of contraception (failure rate \\\u003C1%) for the entire duration of the follow-up period. Highly effective contraception methods are defined as one of the following: combined hormonal contraception (containing estrogen and progestin) with ovulation inhibition (oral, vaginal, or transdermal), progestin-only hormonal contraception with ovulation inhibition (oral, injectable, or implantable), intrauterine device (IUD), intrauterine hormonal system (IUS), condoms, bilateral tubal occlusion, vasectomized partner, or sexual abstinence,\n* Having a negative urine pregnancy test on the day of the procedure,\n* Having signed the informed consent form for the study at the M-1 visit.\n\nExclusion Criteria:\n\n* Pregnant or planning a pregnancy during the entire study period,\n* Currently breastfeeding,\n* Refusal to use effective contraception during the study and for 6 months after its completion,\n* Contraindications to botulinum toxin, including:\n* Generalized disorders of muscular activity (e.g., myasthenia gravis, Lambert-Eaton syndrome),\n* Ongoing treatment with aminoglycosides, peripheral muscle relaxants, or amino-4-quinolines,\n* Hypersensitivity to the active substance, human albumin, or sucrose,\n* Bleeding disorders or current treatment with anticoagulants,\n* Ongoing vaginal or upper genital tract infection,\n* Participation in another interventional clinical trial,\n* Inability to cooperate or understand the study requirements in a way that would allow strict adherence to the protocol,\n* Subject to legal protection measures (e.g., guardianship, curatorship, or judicial protection),\n* Not affiliated with the French social security system,\n* Unable to access the internet to complete questionnaires at Month 1 and Month 6.",{"count":21,"type":22},[25],[28,29],[31,32,33],{"date":240,"type":38},"2026-02-12",{"date":40,"type":38},{"date":42,"type":22},{"name":44,"class":45},{"id":245,"slug":246,"hasResults":12,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":23,"phases":252,"briefSummary":253,"conditions":254,"keywords":255,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":262,"lastUpdatePostDateStruct":263,"startDateStruct":265,"completionDateStruct":267,"leadSponsor":269,"locationsCount":4},"100621910","primary-dysmenorrhea-and-comfort-theory-100621910","NCT07376759","Primary Dysmenorrhea and Comfort Theory","Effects of Comfort Theory-Based Education on Dysmenorrhea, Menstrual Symptoms, Premenstrual Syndrome and General Well-Being Levels in University Students With Primary Dysmenorrhea","Inclusion Criteria:\n\n* Female students aged 18 and over\n* Single\n* Having a menstrual pain intensity of 3 or higher according to the Visual Analog Scale\n* Having had a regular menstrual cycle for the last 6 months\n* Volunteering to participate in the study\n\nExclusion Criteria:\n\n* Women diagnosed with a psychiatric illness\n* Women diagnosed with a gynecological illness\n* Women diagnosed with a chronic illness\n* Women using a pharmacological or non-pharmacological method for primary dysmenorrhea\n* Women using hormonal birth control methods",{"count":165,"type":22},[59],"Dysmenorrhea is defined as lower abdominal pain experienced during menstruation. It is divided into two types: primary dysmenorrhea and secondary dysmenorrhea. In young women, the majority of dysmenorrhea cases are primary dysmenorrhea. Primary dysmenorrhea has a physical, psychological, and social impact on young women. Pharmacological and non-pharmacological methods are used to treat primary dysmenorrhea. Education is important in increasing the effectiveness of primary dysmenorrhea treatment. An effective education process takes place in accordance with nursing theories and models. There are a limited number of studies on the effect of comfort theory-based education in the management of primary dysmenorrhea. In this research, planned as a randomized controlled trial, the intervention group will receive comfort theory-based education, while the control group will receive no intervention. This study aims to contribute to the literature by investigating the effect of comfort theory-based education on dysmenorrhea, menstrual symptoms, premenstrual syndrome, and general well-being in university students with primary dysmenorrhea.",[28],[256,257,258,259,260,261],"primary dysmenorrhea","comfort theory","menstrual symptoms","premenstrual syndrome","general wellbeing","nursing","2026-01-21",{"date":264,"type":38},"2026-01-29",{"date":266,"type":22},"2026-02",{"date":268,"type":22},"2026-06",{"name":270,"class":45},"Ordu University",{"id":272,"slug":273,"hasResults":12,"nctId":274,"briefTitle":275,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":12,"sex":18,"minAge":278,"maxAge":162,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":289,"leadSponsor":291,"locationsCount":77},"100620081","transcutaneous-tibial-nerve-stimulation-on-women-with-primary-dysmenorrhea-100620081","NCT07352982","Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea","Effect of Transcutaneous Tibial Nerve Stimulation on Women With Primary Dysmenorrhea","Inclusion Criteria:\n\n* Age ranges from 20-25 years old.\n* Body mass index (BMI) doesn't exceed 30 kg\u002Fm2.\n* Patients referred from a Gynecologist with a diagnosis of Primary Dysmenorrhea (PD).\n* Patients have regular menstrual cycles.\n* Patients suffer from pain located in the suprapubic area, abdomen, lower lumbar area, perineum, and\u002For medial aspect of the thighs during at least half of their annual menstrual cycles and\u002For in the last 3 cycles.\n\nExclusion Criteria:\n\n* Patients diagnosed with gynecological pathology.\n* Patients taking oral contraceptives or had an intrauterine device implanted.\n* Patients had bad obstetric situations or diseases that could interfere with participation.\n* Patients have certain disorders including uncorrected coagulopathies, severe comorbid disorder, cancer in the last 5 years or at present, presence of erosions on the inner aspect of the ankle, severe mental disorders, or neuropathies affecting the lower limb.\n* Patients who are smoking or taking oral sedatives.\n* Patients had undergone surgery or childbirth in the last 6 months.\n* Patients who are pregnant.","20 Years",{"count":280,"type":22},32,[59],"This study aims to investigate the effects of transcutaneous tibial nerve stimulation (TTNS) on women with primary dysmenorrhea (PD).",[284,285,28],"Transcutaneous Tibial Nerve Stimulation","Women","2026-01-19",{"date":262,"type":38},{"date":286,"type":38},{"date":290,"type":22},"2026-07-01",{"name":292,"class":45},"Kafrelsheikh University",{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":297,"acronym":4,"eligibilityCriteria":298,"healthyVolunteers":135,"sex":18,"minAge":55,"maxAge":162,"enrollmentInfo":299,"targetDuration":4,"studyType":301,"phases":4,"briefSummary":302,"conditions":303,"keywords":304,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":77},"100619921","impact-of-primary-dysmenorrhea-on-academic-performance-and-quality-of-life-among-medical-students-at-sohag-university-100619921","NCT07350902","Impact of Primary Dysmenorrhea on Academic Performance and Quality of Life Among Medical Students at Sohag University","Inclusion Criteria:\n\n* • Undergraduate females from the 3 selected faculties in Sohag University\n\nExclusion Criteria:\n\n* • Students who will refuse to participate in this study.\n\n  * Pregnant females \\\\ females with amenorrhea.\n  * Females with gynecological problems as adenomyosis, uterine fibroids and others to exclude secondary dysmenorrhea",{"count":300,"type":22},402,"OBSERVATIONAL","Pain is an unpleasant sensation that negatively affects individual experiencing it, depending on its quality, intensity, location, and duration. One of the causes of pain among females is dysmenorrhea. Dysmenorrhea is defined as pain during menstruation. A significant population of females experience mild, moderate or severe pain during menstruation. Primary dysmenorrhea is defined as dysmenorrhea with the absence of any organic pathology starting 6-12 months after the menarche and frequently continuing till menopause, while secondary dysmenorrhea results from gynecologic problems such as adenomyosis, endometriosis, uterine fibroid and others.",[28],[62,305],"Academic performance","2026-01-09",{"date":308,"type":38},"2026-01-20",{"date":310,"type":22},"2026-01-01",{"date":312,"type":22},"2027-12-01",{"name":314,"class":45},"Sohag University",{"id":316,"slug":317,"hasResults":12,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":135,"sex":18,"minAge":19,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":325,"briefSummary":326,"conditions":327,"keywords":328,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":335,"leadSponsor":337,"locationsCount":4},"100619212","comparison-of-pain-physical-and-psychosocial-parameters-in-women-with-and-without-primary-dysmenorrhea-100619212","NCT07341685","Comparison of Pain, Physical, and Psychosocial Parameters in Women With and Without Primary Dysmenorrhea","Comparison of Women With andWithout Primary Dysmenorrhea in Terms of Pain Threshold, Joint Mobility, PhysicalActivity Habit Level, Respiratory Muscle Strength, Menstruation Attitudes andDepressive Symptoms","Inclusion Criteria:\n\n* Be between 18 and 35 years of age\n* Have a history of menstrual pain since the first few years after menarche\n* Have a menstrual pain intensity of 4 or higher on the VAS in the last 6 months\n* Have no pelvic or uterine pathology (e.g., cysts, infections, fibroids)\n* Have a regular menstrual cycle\n* Be willing to voluntarily participate in the study\n\nExclusion Criteria:\n\n* Having a neurological, orthopedic, rheumatologic, cardiac, or pulmonary disease\n* Being pregnant or suspected of pregnancy\n* Having given birth\n* Having undergone abdominal, pelvic, or spinal surgery within the past year\n* Having a malignant disease","35 Years",{"count":324,"type":22},70,[59],"Dysmenorrhea is a common gynecological condition that negatively affects women's physical, psychological, and social well-being. Primary dysmenorrhea (PD) has been associated with reduced pain thresholds in various body regions; however, evidence regarding its relationship with joint mobility, respiratory muscle strength, and psychosocial factors remains limited. In addition, the influence of menstrual attitudes, physical activity habits, and depressive symptoms in women with PD has not been sufficiently explored. Therefore, this study aims to compare women with and without primary dysmenorrhea in terms of pain threshold, joint mobility, physical activity level, respiratory muscle strength, menstrual attitudes, and depressive symptoms. Identifying the parameters affected by PD is essential for developing effective management strategies and may contribute to increased awareness and improved clinical approaches for primary dysmenorrhea.",[28],[62,329,330],"Joint Mobility","Physical Activity","2026-01-06",{"date":333,"type":38},"2026-01-14",{"date":225,"type":22},{"date":336,"type":22},"2027-02-15",{"name":338,"class":45},"Izmir Democracy University",{"id":340,"slug":341,"hasResults":12,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":322,"enrollmentInfo":345,"targetDuration":4,"studyType":23,"phases":346,"briefSummary":347,"conditions":348,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":77},"100616562","effect-of-transcutaneous-tibial-nerve-stimulation-on-primary-dysmenorrhea-100616562","NCT07307222","Effect of Transcutaneous Tibial Nerve Stimulation on Primary Dysmenorrhea","Inclusion Criteria:\n\n* Females with a regular menstrual cycle, experiencing primary dysmenorrhea, confirmed by history and clinical diagnosis.\n* Females aged between 18 and 35 years.\n* Their BMI ranging from 20 to 29.9 kg\u002Fm².\n\nExclusion Criteria:\n\n* Females engaging in regular physical exercises prior to the study course.\n* A history of abdominal or pelvic surgery.\n* Pelvic pathologies or diseases (e.g., polycystic ovary syndrome, endometriosis, adenomyomas, or uterine fibroids).\n* Malignant or benign neoplasms in the uterus.\n* Chronic diseases, including diabetes and\u002For rheumatoid arthritis.\n* Presence of metal implants or pacemakers.\n* Any contraindications to the use of electrical stimulation (e.g., open wounds, some skin conditions…. etc.).",{"count":87,"type":22},[59],"This study will be conducted to evaluate the effect of Transcutaneous Tibial Nerve Stimulation (TTNS) on primary dysmenorrhea.",[28],"2025-12-14",{"date":351,"type":38},"2025-12-29",{"date":353,"type":22},"2025-12-21",{"date":355,"type":22},"2026-03-31",{"name":357,"class":45},"Cairo University",{"id":359,"slug":360,"hasResults":12,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":135,"sex":18,"minAge":19,"maxAge":162,"enrollmentInfo":365,"targetDuration":4,"studyType":301,"phases":4,"briefSummary":367,"conditions":368,"keywords":369,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":373,"lastUpdatePostDateStruct":374,"startDateStruct":376,"completionDateStruct":378,"leadSponsor":380,"locationsCount":77},"100611334","knee-joint-position-sense-and-dynamic-balance-in-females-with-primary-dysmenorrhea-100611334","NCT07239232","\"Knee Joint Position Sense and Dynamic Balance in Females With Primary Dysmenorrhea","Assessment Of Knee Joint Position Sense And Dynamic Balance IN Female With Primary Dysmenorrhea","Inclusion Criteria:\n\n* They should be virgin, healthy female students\n* They have regular menstruation (3-8 days in duration, with 21-35 days in-between).\n* They should have the same activity level mild active female.\n* Their ages will range from 18 to 25 years old.\n* Their body mass index (BMI) will range from 18 to 24.9 Kg\u002Fm2.\n\nExclusion Criteria:\n\n* History of knee injury, surgery in the knee or spinal vertebrae.\n* Females having any vestibular problems, otitis media, labyrinthitis or any inner ear problems that affect balance\n* Women with any cognitive deficits\n* History of neuromuscular or spinal disease.\n* History of pelvic pathology or any gynecological disease.",{"count":366,"type":22},62,"The purpose of the study is to assess knee joint position sense, pain and dynamic balance in female with primary dysmenorrhea.",[28],[370,371,372,28],"Knee","Position sense","Balance","2025-12-05",{"date":375,"type":38},"2025-12-12",{"date":377,"type":38},"2025-11-18",{"date":379,"type":22},"2026-01-30",{"name":357,"class":45},{"id":382,"slug":383,"hasResults":12,"nctId":384,"briefTitle":385,"officialTitle":386,"acronym":387,"eligibilityCriteria":388,"healthyVolunteers":12,"sex":18,"minAge":389,"maxAge":322,"enrollmentInfo":390,"targetDuration":4,"studyType":23,"phases":392,"briefSummary":393,"conditions":394,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":77},"100488447","phase-3-efficacy-and-safety-of-cde100-in-the-treatment-of-menstrual-cramp-pain-associated-with-primary-dysmenorrhea-100488447","NCT05640232","Efficacy and Safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea","A National, Multicenter, Randomized, Double-blind, Double-dummy, Phase III, Crossover Study to Assess the Efficacy and Safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea.","ASTRAL","Inclusion Criteria:\n\n* Patient has given written informed consent to participate in the study prior to admission to the study;\n* Female patients aged between 16 and 35 years old, inclusive;\n* History of regular menstrual cycles, occuring between every 21 to 35 days;\n* Clinical history compatible with the diagnosis of primary dysmenorrhea;\n* Self-reported history of ≥ 4 painful cycles, with moderate or severe menstrual cramps, in the six (06) months prior to selection for the study.\n\nExclusion Criteria:\n\n* Diagnosis of secondary dysmenorrhea;\n* History of non-response to treatment with non-steroidal anti-inflammatory drugs (NSAIDs) to relieve menstrual cramps;\n* Onset of primary dysmenorrhea after starting to use oral contraceptives;\n* Use of oral contraceptives for \\\u003C 3 months prior to study selection;\n* Use of an intrauterine device (IUD), hormonal implants or contraceptive injections in the last six (06) months;\n* Previous diagnosis or physical examination findings and\u002For clinical and\u002For surgical history that may indicate the presence of endometriosis, pelvic inflammatory disease, adenomyosis, mullerian duct malformation, uterine fibroma, cystic ovary and\u002For pelvic varicocele;\n* History of recurrent pelvic and\u002For lower abdominal pain outside the menstrual period;\n* Presence of known allergy or hypersensitivity to the components of the drugs used during the clinical trial;\n* History of hypersensitivity reactions, such as asthma attacks or other types of allergic reactions, to acetylsalicylic acid or other NSAIDs;\n* History or diagnosis of peptic\u002Fhemorrhagic ulcer;\n* History of gastrointestinal bleeding or perforation related to the use of NSAIDs;\n* Presence of compromised bone marrow function or diseases of the hematopoietic system;\n* Diagnosis of acute intermittent hepatic porphyria;\n* Diagnosis of congenital deficiency of glucose-6-phosphate dehydrogenase (G6PD);\n* Diagnosis of untreated angle-closure glaucoma;\n* Presence of mechanical stenosis in the gastrointestinal tract;\n* Diagnosis of megacolon and\u002For paralytic or obstructive ileus;\n* Diagnosis of myasthenia gravis;\n* Treatment with psychoactive drugs (such as, for example, antidepressants, antipsychotics, etc.) in the 30 days prior to selection for the study;\n* Participants with a history of alcohol or illicit drug use disorder in the last two (02) years;\n* Participants with a current medical history of cancer and\u002For cancer treatment in the last five (05) years;\n* Presence of any serious illness, at the discretion of the investigator;\n* Any finding of clinical observation (clinical\u002Fphysical evaluation) or laboratory condition that is interpreted by the investigating physician as a risk to the participation of the research participant in the clinical trial or presence of uncontrolled chronic disease(s);\n* Participants who are pregnant, nursing or planning to become pregnant;\n* Disagreement with the use of a known effective barrier contraceptive method, unless using a stable oral contraceptive for three months or more (which must be maintained throughout the study), or surgically sterile or who expressly declare themselves exempt from risk of pregnancy for not exercising sexual practices or exercising them in a non-reproductive manner;\n* Participation in a clinical research protocol in the last 12 months (CNS Resolution 251, of August 7, 1997, item III, subitem J), unless the investigator judges that there may be a direct benefit to it;\n* Presence of any condition that, at the discretion of the investigator, makes the patient unfit to participate in the study.","16 Years",{"count":391,"type":22},238,[25],"The purpose of this study if to evaluate the efficacy and safety of CDE100 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea.",[28],{"date":396,"type":38},"2025-12-08",{"date":398,"type":38},"2025-06-11",{"date":400,"type":22},"2027-01-30",{"name":402,"class":179},"EMS",{"id":404,"slug":405,"hasResults":12,"nctId":406,"briefTitle":407,"officialTitle":408,"acronym":4,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":162,"enrollmentInfo":410,"targetDuration":4,"studyType":23,"phases":412,"briefSummary":413,"conditions":414,"keywords":415,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":77},"100608022","exercise-motor-imagery-and-pain-neuroscience-education-for-primary-dysmenorrhea-a-randomized-trial-100608022","NCT07196150","Exercise, Motor Imagery, and Pain Neuroscience Education for Primary Dysmenorrhea: A Randomized Trial","Comparison of the Effects of Exercise, Motor Imagery Training, and Pain Neuroscience Education on Pain, Menstrual Symptoms, and Cognitive Flexibility in Women With Primary Dysmenorrhea: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Female, aged 18-25 years\n* Gynecological examination and ultrasound confirming absence of pelvic pathology\n* History of primary dysmenorrhea for at least 6 months, with pain intensity ≥4 on the Numeric Rating Scale (0-10) during the first 3 days of menstruation\n* Regular menstrual cycles (21-35 days)\n* Nulliparous (no history of pregnancy or childbirth)\n* No systemic, metabolic, rheumatologic, or lumbar pathology\n* Willingness to participate in the 8-week intervention program and attend follow-up assessments\n\nExclusion Criteria:\n\n* Diagnosis of secondary dysmenorrhea (e.g., endometriosis, pelvic inflammatory disease, uterine fibroids, ovarian cysts)\n* Current pregnancy or planning to become pregnant during the study period\n* History of pelvic or abdominal surgery\n* History of sexually transmitted diseases\n* Current use of antidepressants, anxiolytics, or hormonal therapy (e.g., oral contraceptives, intrauterine device)\n* Known neurological, psychiatric, or systemic musculoskeletal disorders\n* Cognitive impairment or attention deficit that may interfere with participation\n* Participation in regular exercise in the last 6 months\n* Use of alternative therapies for dysmenorrhea (e.g., acupuncture, massage)",{"count":411,"type":22},51,[59],"The goal of this clinical trial is to find out whether exercise, motor imagery training, and pain neuroscience education can help reduce menstrual pain and improve well-being in young women with primary dysmenorrhea. The study will also look at how these approaches affect menstrual symptoms, movement control, and cognitive flexibility.\n\nThe main questions it aims to answer are:\n\n* Does adding motor imagery or pain neuroscience education to an exercise program reduce pain and menstrual symptoms more than exercise alone?\n* Do these approaches improve movement control, thinking flexibility, and knowledge about pain?\n\nResearchers will compare three groups:\n\n* Exercise only\n* Exercise plus motor imagery training\n* Exercise plus pain neuroscience education\n\nParticipants will:\n\n* Attend supervised exercise sessions twice a week for 8 weeks\n* Practice either motor imagery or receive short pain neuroscience education, depending on their group\n* Complete questionnaires and tests before and after the program, during the first three days of menstruation",[28],[31,218,416,417,418,419],"Exercise","Motor imagery","Pain education","Cognition","2025-09-19",{"date":422,"type":38},"2025-09-29",{"date":424,"type":38},"2025-02-25",{"date":426,"type":22},"2026-09",{"name":428,"class":45},"Muge Dereli",{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":162,"enrollmentInfo":436,"targetDuration":4,"studyType":301,"phases":4,"briefSummary":438,"conditions":439,"keywords":440,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":77},"100600302","effect-of-primary-dysmenorrhea-on-muscle-activity-in-young-adult-females-100600302","NCT07095725","Effect of Primary Dysmenorrhea on Muscle Activity in Young Adult Females","Effect of Primary Dysmenorrhea on Abdominal and Back Muscles Activity in Young Adult Females","Inclusion Criteria:\n\n* All females clinically diagnosed with PD, as confirmed and referred by a gynecologist.\n* Age ranges from 18 to 25 years.\n* BMI ranges from 20 to 25 kg\u002Fm2 .\n* Onset of menstrual pain 6-24 months after menarche.\n* Having a regular menstrual cycle (28 ± 7 days with no intermittent bleeding).\n* Their PD symptoms will be determined according to the WaLLID questionnaire and will be classified into mild PD (1-4), moderate PD (5-7), severe PD (8-12).\n* All participants are virgins.\n\nExclusion Criteria:\n\n* Menstrual irregularity.\n* Use of antidepressant or steroid drugs.\n* Secondary dysmenorrhea.\n* Musculoskeletal problems in the abdominal region, pelvic region, or spine.\n* Surgical history involving the abdominal region, pelvic region, or spine in the last year.\n* Any psychiatric or gynecological problems.",{"count":437,"type":22},72,"This study aims to investigate the effect of primary dysmenorrhea on the activity of the abdominal and back muscles in young adult females.",[28],[441,442,443,28],"Muscle Activity","Maximum Voluntary Contraction","EMG","2025-07-31",{"date":446,"type":38},"2025-08-05",{"date":448,"type":38},"2025-07-01",{"date":450,"type":22},"2025-11-20",{"name":357,"class":45},{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":456,"acronym":4,"eligibilityCriteria":457,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":85,"enrollmentInfo":458,"targetDuration":4,"studyType":23,"phases":459,"briefSummary":460,"conditions":461,"keywords":462,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":466,"startDateStruct":468,"completionDateStruct":470,"leadSponsor":471,"locationsCount":77},"100600083","effects-of-chamomile-with-l-theanine-beverage-among-young-women-experiencing-primary-dysmenorrhea-100600083","NCT07092878","Effects of Chamomile With L-theanine Beverage Among Young Women Experiencing Primary Dysmenorrhea","Inclusion Criteria:\n\n* A VAS score of ≥4 cm for the past three consecutive menstrual cycles\n* Regular monthly menstruation\n* No history of allergies or psychological\u002Fgynecological illnesses\n* Absence of secondary dysmenorrhea\n* No current use of any medications\n* No ongoing non-pharmacological management for dysmenorrhea.\n\nExclusion Criteria:\n\n* Pregnant\n* Breastfeeding",{"count":188,"type":22},[59],"This study aims to evaluate the effects of a beverage containing chamomile and L-theanine on menstrual symptoms, pain intensity, mood, and sleep quality among young adult females with primary dysmenorrhea.",[28],[256,463,464],"sleep","mood","2025-07-21",{"date":467,"type":38},"2025-07-30",{"date":469,"type":38},"2025-03-01",{"date":444,"type":22},{"name":472,"class":45},"Universiti Tunku Abdul Rahman",{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":85,"enrollmentInfo":480,"targetDuration":4,"studyType":23,"phases":482,"briefSummary":483,"conditions":484,"keywords":487,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":499},"100540418","clinical-study-on-dry-needling-for-primary-dysmenorrhea-and-its-preliminary-correlation-with-acupoints-100540418","NCT06316583","Clinical Study on Dry Needling for Primary Dysmenorrhea and Its Preliminary Correlation With Acupoints","Clinical Study of Dry Needling on Myofascial Trigger Points Treatment for Primary Dysmenorrhea and Preliminary Investigation of Its Relevance to Acupoints","Inclusion Criteria:\n\n1. All participants diagnosed explicitly by a gynecologist as having primary dysmenorrhea without pelvic organic lesions.\n2. Aged between 18 and 30 years.\n3. A history of cyclical menstrual pain for more than 2 years.\n4. Pain greater than 30mm on the Visual Analog Scale (VAS, 0-100mm).\n5. Participants must sign an informed consent form and be willing to undergo acupuncture treatment and cooperate to complete the relevant procedures of this trial.\n\nExclusion Criteria:\n\n1. Those suffering from secondary dysmenorrhea or any other reproductive and urinary system diseases, such as endometriosis.\n2. A history of pregnancy, miscarriage, or planning for pregnancy. Individuals with skin infections on the abdomen and lower back.\n3. Past use of acupuncture therapy or other needling treatments.\n4. Those with a history of mental illness and severe diseases of the heart, liver, brain, kidneys, hematopoietic system, etc.\n5. Within the past 6 months, individuals referred to pain clinics, those who have used pain relievers like morphine or pethidine, or those allergic to NSAIDs. Also, those currently taking or receiving anticoagulant medications.\n6. Individuals who have had adverse reactions to acupuncture (e.g., fainting).",{"count":481,"type":22},150,[59],"Primary dysmenorrhea refers to menstrual pain not caused by pelvic organic lesions, commonly seen in young women, significantly affecting patients' quality of life. Dry needling therapy targeting myofascial trigger points for primary dysmenorrhea has been preliminarily applied in clinical settings. However, related research is limited with questionable quality, hindering its widespread clinical application. Furthermore, is there a connection between myofascial trigger points in dry needling and acupuncture acupoints in terms of selection and mechanism of action? Could this be a new interpretation of acupuncture theory? These are important questions that have garnered widespread attention. This study employs a randomized patient-blinded controlled design, enrolling primary dysmenorrhea patients aged 18 to 30 years. They are randomly divided into three groups: the trigger point dry needling group, traditional acupuncture treatment group, and trigger point sham needle (placebo) group. Changes in pain levels, quality of life scores, inflammatory factor levels, and local blood flow before and after treatment among the three groups are observed. The aim is to assess the therapeutic effects of dry needling trigger points and acupuncture treatments on primary dysmenorrhea and explore their potential mechanisms of action. By comparing the differences and similarities between dry needling trigger points and acupuncture treatments in terms of acupoint selection, treatment effects, and potential mechanisms of action, this study seeks to preliminarily explore the feasibility of integrating trigger point theory into the meridian 'acupoint' theory, laying the foundation for a modern interpretation of acupuncture",[485,486,28],"Trigger Point Pain, Myofascial","Acupuncture",[488],"trigger points, dry-needling, primary dysmenorrhea","2025-05-17",{"date":491,"type":38},"2025-05-21",{"date":493,"type":38},"2024-04-01",{"date":495,"type":22},"2026-12-31",{"name":497,"class":498},"Beijing Hospital","OTHER_GOV",2,{"id":501,"slug":502,"hasResults":12,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":12,"sex":18,"minAge":507,"maxAge":508,"enrollmentInfo":509,"targetDuration":4,"studyType":23,"phases":511,"briefSummary":512,"conditions":513,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":514,"lastUpdatePostDateStruct":515,"startDateStruct":517,"completionDateStruct":519,"leadSponsor":521,"locationsCount":77},"100592008","effect-of-virtual-reality-on-prostaglandin-levels-in-adolescent-females-with-primary-dysmenorrhea-100592008","NCT06987838","Effect of Virtual Reality on Prostaglandin Levels in Adolescent Females With Primary Dysmenorrhea","Effect of Virtual Reality on Prostaglandin Levels in Adolescent Females With Primary Dysmenorrhea: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 17- 21 years old.\n* The body mass index (BMI) \\\u003C 30 kg\u002Fm2.\n* Unmarried females.\n* Females with dysmenorrhea pain.\n* Females with regular menstrual cycles.\n* Females with normal gynecology.\n\nExclusion Criteria:\n\n* Have a pathological disease related to reproduction.\n* Students who use analgesic drugs for 3 months\u002F3 menstrual cycles.\n* Students with menstrual pain secondary to diagnosed organic or inflammatory causes.","17 Years","21 Years",{"count":510,"type":22},50,[59],"This study will be conducted to study the effect of virtual reality therapy on prostaglandin levels in adolescent females with primary dysmenorrhea.",[28],"2025-05-16",{"date":516,"type":38},"2025-05-23",{"date":518,"type":22},"2025-05-25",{"date":520,"type":22},"2025-09-01",{"name":522,"class":45},"Benha National University",{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":4,"eligibilityCriteria":529,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":162,"enrollmentInfo":530,"targetDuration":4,"studyType":23,"phases":532,"briefSummary":533,"conditions":534,"keywords":535,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":537,"lastUpdatePostDateStruct":538,"startDateStruct":540,"completionDateStruct":541,"leadSponsor":543,"locationsCount":77},"100582203","different-exercise-training-programs-in-university-students-with-primary-dysmenorrhea-100582203","NCT06860256","Different Exercise Training Programs in University Students with Primary Dysmenorrhea","Comparison of the Effects of Different Exercise Training Programs on Dysmenorrhea Symptoms, Sleep and Quality of Life in University Students with Primary Dysmenorrhea","Inclusion Criteria:\n\n* Nulliparous female university students aged 18-25 years who volunteered to participate in the study, met the criteria specified in the PD Consensus Guidelines and were diagnosed with PD by a gynecologist\n* Individuals with a body mass index (BMI) between 18-35\n* Individuals with a regular menstrual cycle (28 ± 7 days)\n* Individuals with menstrual pain Visual Analog Scale (VAS) score of 4 cm or higher for the last 6 months\n\nExclusion Criteria:\n\n* Gastrointestinal, urogynecologic, autoimmune, psychiatric, neurological diseases or other chronic pain syndromes\n* Having given birth and\u002For being pregnant\n* Intrauterine device users\n* Pelvic surgery patients\n* Taking oral contraceptives or medication, including antidepressants, for at least 6 months before the study\n* Those with a pathological history or ultrasonography result indicating secondary dysmenorrhea\n* Those who use alternative treatment methods and exercise regularly\n* Serious traumatic life events that occurred in the three months prior to the start of the study\n* Communication problems that may interfere with the implementation of assessments and\u002For treatment program",{"count":531,"type":22},90,[59],"Dysmenorrhea is severe lower abdominal pain in women during menstruation. The pain is usually cramping and can radiate to the thighs or lower spine. Lower abdominal pain may be accompanied by vomiting, headache, back pain, diarrhea, fatigue, etc. Depending on the pathophysiology, dysmenorrhea is classified into two types: primary and secondary. Primary dysmenorrhea (PD) is menstrual pain associated with normal ovulatory cycles in the absence of pelvic pathology and a clear physiologic etiology and is most commonly seen in adolescents and young adults. There are numerous studies on PD in the literature, but there is still a lack of studies on which of the non-pharmacologically recommended exercise and other methods is more effective on dysmenorrhea symptoms, sleep and quality of life for individuals with this problem. Different exercise intensities may affect PD symptoms through different mechanisms. Moderate to high intensity exercise may reduce pain by increasing anti-inflammatory cytokines, whereas less intense exercise, such as yoga, affects pain levels by decreasing cortisol levels. The lack of research on which exercise training is more effective in PD individuals was considered as a limitation. In the light of this information, the aim of the investigators study is to compare the effects of different training techniques on dysmenorrhea symptoms, sleep and quality of life in PD treatment and to present the preferability of these techniques based on evidence.",[416,28],[256,536],"exercises","2025-02-28",{"date":539,"type":38},"2025-03-06",{"date":424,"type":22},{"date":542,"type":22},"2025-10-25",{"name":544,"class":45},"Hasan Kalyoncu University",{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":549,"acronym":4,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":18,"minAge":55,"maxAge":551,"enrollmentInfo":552,"targetDuration":4,"studyType":301,"phases":4,"briefSummary":554,"conditions":555,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":557,"startDateStruct":559,"completionDateStruct":561,"leadSponsor":563,"locationsCount":77},"100577813","pelvic-floor-muscle-activity-in-primary-dysmenorrhea-100577813","NCT06803173","Pelvic Floor Muscle Activity in Primary Dysmenorrhea","Inclusion Criteria:\n\n* They should be virgin, healthy female physiotherapy students with PD.\n* They have regular menstruation (3-8 days in duration, with 21-35 days in between).\n* Their ages will range from 18 to 25 years old.\n* Their body mass index (BMI) will range from 18 to 24.9 kg\u002Fm2.\n* Their waist-to-hip ratio will be less than 0.8.\n\nExclusion Criteria:\n\n* Any urological or gynecological disorders in the previous 12 weeks (e.g., endometriosis, fibroids).\n* Fibromyalgia.\n* Severe psychiatric or psychological disorders.\n* Those who had taken analgesics in the 12 hours before the assessment.\n* Abdominal or pelvic surgery within the past six months.","24 Years",{"count":553,"type":22},77,"This study will be conducted to assess the pelvic floor muscle (PFM) activity in primary dysmenorrhea (PD).",[28],"2025-01-27",{"date":558,"type":38},"2025-01-31",{"date":560,"type":22},"2025-02-01",{"date":562,"type":22},"2025-04-15",{"name":357,"class":45},{"id":565,"slug":566,"hasResults":12,"nctId":567,"briefTitle":568,"officialTitle":568,"acronym":569,"eligibilityCriteria":570,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":571,"enrollmentInfo":572,"targetDuration":4,"studyType":23,"phases":574,"briefSummary":575,"conditions":576,"keywords":577,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":556,"lastUpdatePostDateStruct":581,"startDateStruct":583,"completionDateStruct":584,"leadSponsor":586,"locationsCount":4},"100577913","effect-of-aerobic-exercise-on-clinical-symptoms-during-the-ovarian-cycle-100577913","NCT06804473","Effect of Aerobic Exercise on Clinical Symptoms During the Ovarian Cycle","OVARIANEXERCYC","Inclusion Criteria\n\n* Age between 18 and 26 years.\n* Sedentary lifestyle.\n* Body Mass Index (BMI) between 18.5 and 26 kg\u002Fm².\n* Regular menstrual cycle (24-38 days).\n* Menstrual pain intensity ≥ 4 mm on the Visual Analog Scale (VAS).\n* Presence of anxiety or stress.\n\nExclusion Criteria\n\n* Pregnancy or breastfeeding within the last 3 months.\n* Amenorrhea.\n* Use of oral contraceptives in the last 3 months.\n* Presence of an intrauterine device (IUD).\n* Regular alcohol consumption.\n* Active smoking.\n* Chronic endocrine, digestive, neurological, or uncontrolled cardiovascular diseases, and\u002For psychiatric disorders.\n* Any medical diagnosis contraindicating physical exercise.","26 Years",{"count":573,"type":22},44,[59],"This study aims to evaluate the effects of moderate-to-high intensity aerobic exercise on primary dysmenorrhea, a common condition characterized by painful menstrual cramps.\n\nThe study will involve women diagnosed with primary dysmenorrhea, who will be randomly assigned to one of two groups:\n\nExperimental Group: Participants will perform a supervised aerobic exercise program tailored to their fitness level.\n\nControl Group: Participants will continue their usual care without any additional interventions.\n\nThe study will run from February 2025 to April 2025 in Madrid, Spain. Before starting, all participants will complete a questionnaire to gather information about their demographics, menstrual cycle characteristics, medical history, and physical activity levels. This will help ensure an accurate diagnosis of primary dysmenorrhea and provide baseline data for comparison.\n\nParticipants will be randomly assigned to their groups using a computer-generated sequence, with allocation managed confidentially to avoid bias. The study's single-blind design ensures that the evaluators will not know the group assignments.\n\nThe goal of this research is to determine whether regular aerobic exercise can serve as an effective, non-pharmacological intervention to reduce the severity of menstrual pain and improve the quality of life for women with primary dysmenorrhea. The findings will inform patients, families, and healthcare providers about potential lifestyle strategies to manage this condition.",[28],[64,578,579,580],"exercise","pain","aerobic exercise",{"date":582,"type":38},"2025-02-03",{"date":469,"type":22},{"date":585,"type":22},"2025-06-30",{"name":587,"class":45},"Universidad Francisco de Vitoria",{"id":589,"slug":590,"hasResults":12,"nctId":591,"briefTitle":592,"officialTitle":593,"acronym":4,"eligibilityCriteria":594,"healthyVolunteers":12,"sex":18,"minAge":507,"maxAge":162,"enrollmentInfo":595,"targetDuration":4,"studyType":23,"phases":596,"briefSummary":597,"conditions":598,"keywords":599,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":499},"100575873","effects-of-kegel-exercises-and-myokinetic-release-of-trigger-points-in-primary-dysmenorrhea-100575873","NCT06777940","Effects of Kegel Exercises and Myokinetic Release of Trigger Points in Primary Dysmenorrhea","Effects of Kegel Exercises With and Without Myokinetic Active Release of Trigger Points on Pain, Fatigue and Quality of Life in Primary Dysmenorrhea","Inclusion Criteria:\n\n* Age 17-25 years\n* Diagnosed cases of dysmenorrhea\n* Subject having trigger point in rectus abdominins, quadratus lumborum and gluteus medius\n* With regular cycles 21-35 days lasting 3-7 days\n\nExclusion Criteria:\n\n* Oral contraceptives used for menstrual irregularity\n* Other gynecological disease like fibroids, endometriosis\n* Who take analgesia\n* Endometrial polyp, having pelvic infection using IUD, having venous congestion in internal genital organs.",{"count":510,"type":22},[59],"The rationale of this study is despite the widespread belief that exercise can reduce dysmenorrhea, evidence-based studies are limited. Studies are therefore required to evaluate the association between quality of life and the primary dysmenorrheal females, the functional impact on the quality of life and primary dysmenorrhea females also it's a crucial time for females to focus on their studies and dysmenorrhea can add to the fatigue levels and cause distress in this age group thus the purpose of this study is to determine whether myokinetic active release of trigger points in the rectus abdominis, gluteus medius and quadratus lumborum is a more effective way to reduce dysmenorrhea than kegel exercises",[28],[600],"trigger points","2025-01-10",{"date":603,"type":38},"2025-01-16",{"date":605,"type":38},"2023-12-23",{"date":607,"type":22},"2025-02",{"name":609,"class":45},"Riphah International University"]