[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-nocturnal-enuresis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-nocturnal-enuresis":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,50,77,101,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100632009","causes-and-types-of-nocturnal-enuresis-in-children-100632009",false,"NCT07508111","Causes and Types of Nocturnal Enuresis in Children","A Descriptive Study on the Causes and Types of Nocturnal Enuresis Among Children Attending Assiut University Children's Hospital","Inclusion Criteria:\n\n* Male and female children aged above 5 years.\n* Presenting with nocturnal enuresis, defined as involuntary voiding during sleep for ≥2 nights\u002Fweek for ≥3 months.\n* Parents or caregivers providing informed consent, including child assent where applicable.\n\nExclusion Criteria:\n\n* Children with known neurological disorders, such as epilepsy or cerebral palsy.\n* Presence of an acute urinary tract infection (indicated by a positive urine culture requiring treatment).\n* Children diagnosed with diabetes mellitus.\n* Structural anomalies of the urinary system requiring immediate surgery, such as severe hypospadias.\n* Families unwilling to participate or complete follow-up data collection.","ALL","5 Years","18 Years",{"count":20,"type":21},80,"ESTIMATED","OBSERVATIONAL","Nocturnal enuresis, commonly known as bedwetting, is a frequent condition that affects many children and can have a significant impact on their self-esteem, social life, and family stress. The causes of bedwetting can vary widely, ranging from deep sleep patterns and excess nighttime urine production to underlying medical conditions like constipation, urinary tract infections, or enlarged tonsils and adenoids (which can affect breathing during sleep).The main goal of this descriptive study is to understand the different types and the underlying causes of bedwetting among children attending the pediatric outpatient clinics at Assiut University Children's Hospital. By identifying these specific causes in the local population, healthcare providers can offer better, more targeted treatments and help reduce the stigma surrounding this condition.\n\nDuring a single clinic visit, researchers will collect information through a structured interview with the parents and the child. The study involves a routine physical examination, including checking weight, height, and looking for physical signs of constipation or enlarged tonsils. Participants will also undergo standard tests to help pinpoint any medical causes, such as a urine test (urinalysis and culture), a basic ultrasound of the abdomen and pelvis, and potentially plain X-rays if issues like severe constipation or airway blockages are suspected.\n\nThe study aims to include at least 80 male and female children aged 5 years and older who have been experiencing bedwetting at least twice a week for three months or more.",[25,26,27,28,29,30],"Nocturnal Enuresis","Nocturnal Enuresis in Children","Primary Nocturnal Enuresis","Secondary Nocturnal Enuresis","Monosymptomatic Enuresis Nocturna","Polysymptomatic Enuresis",[25,32,33,34,35,36,37],"Bedwetting","Urinary Incontinence","Pediatrics","Primary Enuresis","Secondary Enuresis","Monosymptomatic Enuresis","NOT_YET_RECRUITING","2026-03-27",{"date":41,"type":42},"2026-04-02","ACTUAL",{"date":44,"type":21},"2026-05",{"date":46,"type":21},"2027-06",{"name":48,"class":49},"Assiut University","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":64,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100593183","a-cohort-study-on-treating-primary-nocturnal-enuresis-by-regulating-central-peripheral-circadian-rhythm-100593183","NCT07003126","A Cohort Study on Treating Primary Nocturnal Enuresis by Regulating Central-Peripheral Circadian Rhythm","Inclusion Criteria:\n\n1. Diagnosis according to the ICCS criteria:\n\n   At least one episode of involuntary nighttime urination per month for more than 3 months.\n\n   No abnormalities in routine urinalysis. No period of bedwetting-free days lasting more than 6 months, except for organic diseases.\n2. Age: 5 to 15 years (inclusive), regardless of gender.\n3. Right-handedness (as assessed by the Annett Hand Preference Questionnaire)\n\nExclusion Criteria:\n\n1. Secondary nocturnal enuresis;\n2. History of head trauma, neurological disorders, psychosurgery, or major physical conditions (including autism spectrum disorder, epilepsy, cerebral palsy);\n3. Contraindications to fMRI.\n4. Note: Mild comorbidities commonly associated with primary nocturnal enuresis (e.g., ADHD) are permitted but must be included as covariates in statistical analyses.","15 Years",{"count":58,"type":21},200,"INTERVENTIONAL",[61],"NA","Primary nocturnal enuresis (PNE), a prevalent pediatric disorder, suffers from therapeutic limitations characterized by low efficacy and high relapse rates. Targeting its core pathophysiology could significantly improve treatment outcomes. Growing evidence implicates circadian dysregulation in PNE pathogenesis. Our preliminary fMRI cohort identified abnormal functional connectivity between the suprachiasmatic nucleus (SCN, the central circadian pacemaker) and superior temporal gyrus in PNE patients, with clinical data confirming circadian realignment correlates with symptom remission. Small-scale pilot studies and clinical observations indicate that modulating central and peripheral circadian rhythms significantly alleviates PNE symptoms. This study will establish a circadian-focused PNE cohort to quantify therapeutic efficacy and elucidate underlying mechanisms, ultimately driving the development of mechanism-based therapies for PNE.",[27],[27,65,66],"Circadian Rhythm","Treatment","2025-06-03",{"date":69,"type":42},"2025-06-04",{"date":71,"type":21},"2025-07-01",{"date":73,"type":21},"2028-06-01",{"name":75,"class":49},"Shanghai Children's Medical Center",1,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":85,"targetDuration":4,"studyType":59,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":76},"100592993","micturition-desire-relaxation-training-device-for-lower-urinary-tract-dysfunction-in-children-100592993","NCT07000656","Micturition Desire-Relaxation Training Device for Lower Urinary Tract Dysfunction in Children","Prospective Evaluation of Micturition Desire-Relaxation Training Device for Treating Lower Urinary Tract Dysfunction in Children: A Randomized Controlled Pilot Study","ICCS，LUTD，PNE","Inclusion Criteria:\n\n1. Diagnosis according to the ICCS criteria:\n\n   For nocturnal enuresis:\n\n   At least one episode of involuntary nighttime urination per month for more than 3 months.\n\n   No abnormalities in routine urinalysis. No period of bedwetting-free days lasting more than 6 months, except for organic diseases.\n\n   For daytime urinary incontinence:\n\n   At least one episode of intermittent urinary leakage during wakefulness per month for more than 3 months.\n\n   No anatomical or neurological causes of urinary incontinence.\n\n   For urinary frequency:\n\n   The child experiences only urinary frequency and urgency, occurring during the day and before sleep, with intervals ranging from a few minutes to 1 hour. Each urination involves a small volume, less than 50% of the estimated bladder capacity \\[EBC (mL) = 30 + (age × 30)\\], typically less than 30 mL, sometimes just a few drops, while total daily urine volume remains within normal limits. When the child is engaged in play or focused, the intervals between urination are extended, and urinary frequency symptoms disappear after falling asleep.\n2. Age: 5 to 18 years (inclusive), regardless of gender.\n3. Voluntary participation: The child and their guardian must voluntarily participate in the trial and sign the informed consent form.\n\nExclusion Criteria:\n\n1. Exclude enuresis caused by urinary tract infections, pinworms, myelitis, spinal cord injuries, epilepsy, cerebral developmental disorders, diabetes, and other neurological, urinary, or endocrine diseases, as well as transient enuresis due to excessive activity, mental fatigue, or excessive fluid intake before bedtime.\n2. Exclude conditions causing urinary frequency such as neurogenic bladder, urinary tract infections, urethral syndrome, hypercalciuria, or metabolic diseases.\n3. Patients who have participated in or are currently participating in other clinical trials within the past month.\n4. Patients deemed unsuitable for participation in the clinical trial by the investigator.",{"count":58,"type":21},[61],"Urine storage and voiding are fundamental physiological processes. In clinical settings, many cases of lower urinary tract dysfunction (LUTD) are closely associated with abnormal conditioned reflexes formed in the central nervous system during the urine storage or voiding phases. Relaxation, as a core physiological and psychological state, has been shown to promote effective urine storage and facilitate smooth voiding. By repeatedly training individuals to establish a new conditioned reflex linking the sensation of urinary urgency with a state of relaxation, it may be possible to improve bladder storage capacity and voiding function. Based on this concept, the investigators have developed the world's first Micturition Desire-Relaxation Training Device (Chinese Patent No.: ZL 2020 1 0397789.4). This study aims to evaluate the clinical efficacy of this device in treating LUTD in children.",[89,90,91,27],"Daytime Urinary Incontinence","Urinary Frequency","Lower Urinary Tract Dysfunction","RECRUITING","2025-06-02",{"date":95,"type":42},"2025-06-05",{"date":97,"type":42},"2024-11-20",{"date":99,"type":21},"2026-05-31",{"name":75,"class":49},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":59,"phases":112,"briefSummary":113,"conditions":114,"keywords":115,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":134},"100584016","effectiveness-of-pelvic-floor-muscle-rehabilitation-combined-with-desmopressin-in-children-with-primary-monosymptomatic-nocturnal-enuresis-100584016","NCT06883851","Effectiveness of Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in Children With Primary Monosymptomatic Nocturnal Enuresis","Evaluating the Efficacy of Structured Pelvic Floor Muscle Rehabilitation Combined With Desmopressin in the Management of Primary Monosymptomatic Nocturnal Enuresis in Children","Inclusion Criteria:\n\n* Being between 7 and 13 years old\n* Diagnosed with primary MNE by a pediatric urology department within the last 6 months\n* No urinary tract infection verified by laboratory tests\n* Ability to communicate in Turkish and absence of mental deficit\n* No diagnosed psychiatric problems\n* Willingness to participate in the study (child and family)\n\nExclusion Criteria:\n\n* Presence of orthopedic conditions preventing evaluation\n* Anatomical anomalies in the urinary system\n* History of urinary system surgery\n* Neurological disorders\n* Presence of mental retardation\n* History of orthopedic surgery that could alter pelvic or lower extremity integrity\n* Receiving PFM rehabilitation in the last 6 months\n* Using nighttime alarm therapy in the last 6 months\n* Receiving any treatment for enuresis in the last 6 months","7 Years","13 Years",{"count":111,"type":21},40,[61],"The aim of this randomized controlled trial is to evaluate the effects of Structured Pelvic Floor Muscle Rehabilitation (SPFMR) in children with Primary Monosymptomatic Nocturnal Enuresis (PMNE) who are undergoing desmopressin asetat (DDAVP) treatment prescribed by a pediatric urologist. The study aims to investigate whether SPFMR can reduce the frequency and severity of enuresis episodes and whether it can also reduce relapse rates in the short- and long-term follow-up. The main questions the study seeks to answer are:\n\n* Does SPFMR reduce the frequency and severity of enuresis episodes in children with PMNE?\n* Does SPFMR treatment reduce relapse rates in children with PMNE in the long term? Researchers will compare the group receiving SPFMR in addition to DDAVP treatment with a control group receiving only DDAVP treatment. This comparison will help evaluate the effect of SPFMR on the severity of enuresis episodes and relapse rates.\n\nParticipants will:\n\n* Receive DDAVP treatment (SPFMR group and Control group)\n* Participate in SPFMR sessions ( SPFMR group)\n* Keep a diary of enuresis frequency and severity\n* Assess relapse during short- and long-term follow-up\n\nThe hypotheses of the study are:\n\nH0: Adding SPFMR to desmopressin treatment for children with PMNE has no short-term effect on the severity of enuresis episodes.\n\nH1: Adding SPFMR to desmopressin treatment for children with PMNE has a short-term effect on the severity of enuresis episodes.\n\nH0: Adding SPFMR to desmopressin treatment for children with PMNE has no long-term effect on the severity of enuresis episodes.\n\nH2: Adding SPFMR to desmopressin treatment for children with PMNE has a long-term effect on the severity of enuresis episodes.",[27,26],[116,117,118,119,120,121,122,123,124],"biofeedback","core stabilization","exercise","urinary incontinence","management","treatment","enuresis","pelvic floor rehabilitation","desmopressin","2025-03-16",{"date":127,"type":42},"2025-03-19",{"date":129,"type":42},"2025-03-11",{"date":131,"type":21},"2027-08-30",{"name":133,"class":49},"Bahçeşehir University",2,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":4,"eligibilityCriteria":141,"healthyVolunteers":142,"sex":16,"minAge":143,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":59,"phases":147,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":4},"100580773","early-phase-1-evaluating-the-efficacy-of-atomoxetine-in-reducing-primary-nocturnal-enuresis-in-children-with-adhd-a-randomized-placebo-controlled-study-100580773","NCT06841666","Evaluating the Efficacy of Atomoxetine in Reducing Primary Nocturnal Enuresis in Children With ADHD: A Randomized, Placebo-Controlled Study","Evaluating the Efficacy of Atomoxetine in Reducing Primary Nocturnal Enuresis in Children With ADHD","Inclusion Criteria:\n\n* Children aged 6-12 years diagnosed with ADHD per Conners-48 scale. Children experiencing primary nocturnal enuresis.\n\nExclusion Criteria:\n\n* Secondary causes of enuresis (e.g., urinary tract infections, diabetes). Use of other enuresis treatments. Known contraindications to atomoxetine.",true,"6 Years","12 Years",{"count":146,"type":21},100,[148],"EARLY_PHASE1","1. Primary Aim: To evaluate the efficacy of atomoxetine in reducing the frequency of primary nocturnal enuresis episodes in children with ADHD.\n2. Secondary Aim: To determine if improvements in attention symptoms correlate with reductions in nocturnal enuresis episodes.",[151,27],"ADHD",[27,151,153],"Atomoxetine","2025-02-25",{"date":156,"type":42},"2025-02-27",{"date":158,"type":21},"2025-02-28",{"date":160,"type":21},"2025-09-05",{"name":162,"class":49},"Tanta University"]