[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-percutaneous-coronary-intervention\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-percutaneous-coronary-intervention":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,37,56,76,113,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":26,"lastUpdatePostDateStruct":27,"startDateStruct":30,"completionDateStruct":32,"leadSponsor":34,"locationsCount":4},"100608593","prognostic-value-of-the-cally-index-in-patients-undergoing-primary-pci-100608593",false,"NCT07203573","Prognostic Value of the CALLY Index in Patients Undergoing Primary PCI","Prognostic Value of the C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index on Patients Undergoing Primary Percutaneous Coronary Intervention","Inclusion Criteria:\n\nAge ≥ 18 years\n\n* Diagnosis of STEMI based on 4th universal definition of myocardial infarction\n* Undergoing Primary PCI within guideline-recommended timeframes\n* Provided informed consent to participate in the study\n\nExclusion Criteria:\n\n* Active infection (as detected by baseline leukocytosis on admission), autoimmune or inflammatory disease affecting CRP, albumin, or lymphocyte counts\n* Chronic liver disease or advanced malignancy\n* Patients receiving immunosuppressive therapy\n* Refusal to participate","ALL","18 Years",{"count":19,"type":20},140,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the relationship between the admission CALLY index and short-term adverse outcomes in STEMI patients undergoing PPCI. Specifically, it seeks to determine whether the CALLY index is associated with in-hospital and 30-day complications, including heart failure, arrhythmias, reinfarction, or death. Additionally, the study will assess the association between the CALLY index and procedural success, defined by post-intervention TIMI flow, as well as the complexity of coronary artery disease using the SYNTAX score.",[24],"Primary Percutaneous Coronary Intervention","NOT_YET_RECRUITING","2025-09-24",{"date":28,"type":29},"2025-10-02","ACTUAL",{"date":31,"type":20},"2025-09-25",{"date":33,"type":20},"2026-10-25",{"name":35,"class":36},"Assiut University","OTHER",{"id":38,"slug":39,"hasResults":11,"nctId":40,"briefTitle":41,"officialTitle":41,"acronym":4,"eligibilityCriteria":42,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":43,"enrollmentInfo":44,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":46,"conditions":47,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":4},"100606409","impact-of-gut-microbiota-on-clinical-outcomes-and-left-ventricular-remodeling-after-primary-percutaneous-coronary-intervention-100606409","NCT07175181","Impact of Gut Microbiota on Clinical Outcomes and Left Ventricular Remodeling After Primary Percutaneous Coronary Intervention","Inclusion Criteria:\n\n* Age ≥ 18 years .\n* Confirmed diagnosis of ST-elevation myocardial infarction (STEMI) and indication for PCI based on clinical guidelines.\n* Patients scheduled to undergo primary PCI for STEMI.\n* Ability and willingness to provide informed consent for participation and for the collection of stool samples.\n* No significant comorbidities that may confound the results (e.g., chronic kidney disease, liver cirrhosis).\n* No prior use of antibiotics, probiotics, or prebiotics within the last 3 months, as these may significantly alter gut microbiota composition.\n* Willingness and ability to complete follow-up assessments as required by the study protocol.\n* Absence of major gastrointestinal disorders (e.g., inflammatory bowel disease, gastrointestinal infections) that could affect gut microbiota.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years.\n* Chronic Diseases:\n\n  * Chronic kidney disease (stage 3 or higher).\n  * Chronic liver disease (e.g., cirrhosis).\n  * Active malignancies.\n* Acute infections or active inflammatory conditions at the time of PCI.\n* Gastrointestinal Disorders:\n\n  * Inflammatory bowel disease.\n  * Celiac disease.\n  * Diverticulitis.\n* Recent use of antibiotics, probiotics, or prebiotics within the last 3 months.\n* Use of immunosuppressive medications or chemotherapy.\n* Uncontrolled diabetes or hypertension.","80 Years",{"count":45,"type":20},144,"Left ventricular remodeling (LVR) refers to the structural and functional changes that occur in the left ventricle following myocardial injury. These changes can include alterations in left ventricular shape, size, wall thickness, and volume, which can ultimately lead to decreased cardiac function and increased risk of heart failure. The remodeling process is often maladaptive and can worsen the prognosis of patients with CAD. Recent advances in microbiome research have unveiled the critical role of gut microbiota in modulating systemic health, including cardiovascular health. The gut microbiome consists of trillions of microorganisms that engage in complex interactions with the host, influencing various physiological processes. Among these interactions is the production of metabolites that can directly affect cardiovascular physiology. Notably, Trimethylamine N-oxide (TMAO). Elevated TMAO levels have been associated with increased risk of atherosclerosis and cardiovascular events, including those following PCI. Data suggest that TMAO may promote endothelial dysfunction and enhance inflammatory pathways, thereby exacerbating vascular injury and LV remodeling. These findings indicate that the interaction between gut microbiota composition, TMAO production, and cardiovascular risk could represent a novel therapeutic target for improving patient outcomes after PCI . Understanding the dynamics of these relationships can provide critical insights into individualized treatment strategies and dietary interventions that may mitigate cardiovascular risk.",[24],"2025-09-15",{"date":50,"type":29},"2025-09-17",{"date":52,"type":20},"2025-10-01",{"date":54,"type":20},"2026-12-01",{"name":35,"class":36},{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100606415","relation-of-total-ischemic-time-to-repolarization-indices-and-their-impact-on-outcomes-among-stemi-patients-undergoing-primary-pci-100606415","NCT07175259","Relation of Total Ischemic Time to Repolarization Indices and Their Impact on Outcomes Among STEMI Patients Undergoing Primary PCI","Inclusion Criteria:\n\n\\- Patients presenting with acute STEMI undergoing primary PCI\n\nExclusion Criteria:\n\n\\- 1. Prior myocardial infarction or CABG. 2. Left or right bundle branch block. 3. Atrial fibrillation. 4. Cardiac arrest or cardiogenic shock 5. Valvular heart disease (severe). 6. Use of QT-prolonging medications as anti-arrhythmic, anti-psychotic, anti-depressant and some types of antibiotics.\n\n7\\. Poor quality ECG tracings. 8. Chronic kidney disease stage ≥3. 9. Electrolyte abnormalities at admission 10. Undetermined date of pain",{"count":63,"type":20},500,"1. Evaluate The impact of early versus late presentation on electrocardiographic ventricular repolarization indices.\n2. To assess the association between repolarization indices among early, late presentation in relation to in-hospital ventricular arrhythmias, in-hospital MACE, and 6 months MACE.",[66,67,68,24],"ST Elevation (STEMI) Myocardial Infarction of Other Sites","Repolarization Indices","Total Ischemic Time","2025-09-09",{"date":71,"type":29},"2025-09-16",{"date":52,"type":20},{"date":74,"type":20},"2026-12-31",{"name":35,"class":36},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":93,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100604931","the-effect-of-cardiac-rehabilitation-on-left-ventricular-remodeling-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-acute-myocardial-infarction-100604931","NCT07155928","The Effect of Cardiac Rehabilitation on Left Ventricular Remodeling in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction","Inclusion Criteria:\n\n1. Underwent successful primary PCI within 24 hours of symptom onset.\n2. Hemodynamically stable and able to participate in rehabilitation.\n\nExclusion Criteria:\n\n1. Stage IV Heart failure, LVEF \\\u003C 30%\n2. Life-threatening arrhythmias\n3. Unstable Angina\n4. Severe Valvular Diseases\n5. Uncontrolled Hypertension\n6. CKD Stages IV and V\n7. Hypothyroidism\n8. Cardiomyopathy\n9. Inability to ambulate or consent",{"count":83,"type":20},100,"INTERVENTIONAL",[86],"NA","Cardiac rehabilitation has proven to improve the functional capacity of patients who had acute myocardial infarction. However, its effect on Left ventricular remodeling following an MI event treated with Primary PCI is not yet fully understood. So, for this randomized controlled trial our objectives are as follows:\n\n* Primary: To assess the effect of a structured CR program on LV remodeling parameters (LVEF, LVESV, LVEDV, LVESD, LVEDD + SWMA) in STEMI patients treated with primary PCI.\n* Secondary: To evaluate changes in exercise capacity, heart rate recovery and clinical outcomes such as major adverse cardiovascular events and the effect of CR on the patients' Quality of Life.\n\nThese results will be compared to the same parameters in a control group that will not undergo cardiac rehabilitation to properly assess the effect of cardiac rehab.\n\nParticipants in the intervention group will be asked to undergo a supervised CR program based on published guidelines (FITT principle). The core will be a moderate-intensity aerobic exercise regimen (e.g. treadmill or cycle ergometer) 2-3 times per week for 12 weeks. Each session will last \\~20-60 minutes of exercise followed by cool-down, with intensity gradually increased to High intensity interval training (HIIT) in low-moderate risk individuals, as it has shown better improvement in cardiovascular health while being safe in MI patients. Resistance exercises (e.g. light weights or band exercises) will also be included twice weekly. Exercise dose (frequency, intensity, time) will be tracked. Physical therapists will supervise all sessions in an outpatient CR facility or affiliated gym. Patients' vitals and ECG will be monitored during initial sessions for safety.",[89,90,91,24,92],"Acute Myocardial Infarction (AMI)","PCI Patients","Percutaneous Coronary Intervention (PCI)","Left Ventricle Remodeling",[94,95,24,96,97,98,99,100,101,102,103,104],"Cardiac Rehabilitation","Acute Myocardial Infarction","Left Ventricular Remodeling","Ejection fraction","End-systolic volume","End-systolic diameter","End-diastolic volume","End-diastolic diameter","Functional capacity","Aerobic exercise","Resistance Training","2025-08-26",{"date":107,"type":29},"2025-09-04",{"date":109,"type":20},"2025-11",{"date":111,"type":20},"2027-12",{"name":35,"class":36},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},"100601783","prognostic-value-of-the-lvot-vti-in-stemi-patients-undergoing-ppci-100601783","NCT07114978","Prognostic Value of the LVOT VTI in STEMI Patients Undergoing PPCI","Prognostic Value of the Left Ventricular Outflow Tract Velocity-time Integral in Predicting In-hospital Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention","Inclusion Criteria:\n\n1. Adult patients (≥18 years), diagnosed with acute STEMI according to current ESC guidelines(3) and undergoing primary PCI within 24 hours of symptom onset.\n2. Patients undergo transthoracic echocardiography within 24 hours of admission.\n\nExclusion Criteria:\n\n1. Presence of significant aortic valve disease (e.g., severe aortic stenosis or regurgitation).\n2. LVOT obstruction or hypertrophic cardiomyopathy.\n3. Poor echocardiographic window.\n4. Refusal to participate.",{"count":121,"type":20},125,"* To determine whether LVOT VTI \\\u003C 15 cm predicts the development of in-hospital cardiogenic shock or need for vasopressors in STEMI patients undergoing primary PCI.\n* To assess association of LVOT VTI with other adverse outcomes (in-hospital death, heart failure, arrhythmias, need for mechanical ventilation, prolonged hospital stay).",[124,125,24],"LVOT VTI","STEMI - ST Elevation Myocardial Infarction (MI)","2025-08-04",{"date":128,"type":29},"2025-08-11",{"date":130,"type":20},"2025-08-01",{"date":132,"type":20},"2026-10",{"name":35,"class":36},1,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":4,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":141,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":25,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":134},"100579552","short-term-outcomes-of-primary-percutaneous-coronary-intervention-pci-patients-presented-with-acute-heart-failure-in-assuit-university-heart-hospital-100579552","NCT06825780","Short Term Outcomes of Primary Percutaneous Coronary Intervention (PCI) Patients Presented With Acute Heart Failure in Assuit University Heart Hospital","Inclusion Criteria:\n\n* age more than 18 years\n* acute heart failure\n* PCI\n\nExclusion Criteria:\n\n* NSTEMI\n* end stage renal disease",{"count":142,"type":20},200,"Observational study outcome of PCI in patients presented with acute heart failure",[24],"2025-02-08",{"date":147,"type":29},"2025-02-13",{"date":149,"type":20},"2025-03-03",{"date":151,"type":20},"2026-01-01",{"name":35,"class":36}]