[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"primary-teeth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:primary-teeth":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,63,98,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":38,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":4},"100634665","early-phase-1-chloramphenicol-tetracycline-zinc-oxide-and-eugenol-paste-ctz-paste-for-emergency-dental-treatment-in-public-health-settings-a-randomized-trial-100634665",false,"NCT07542639","Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial","Clinical and Radiographic Efficacy of Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) in the Context of Emergency Dental Treatments in Brazilian Public Health: Randomized Clinical Trial","CTZ- emergency","Inclusion Criteria:\n\n* Pediatric patients presenting with:\n* Irreversible pulpitis in primary molars;\n* Pulp necrosis, with or without abscess, in primary molars.\n* Primary molars with sufficient remaining tooth structure to allow endodontic treatment.\n* Primary teeth in which the permanent successor tooth germ presents developmental stages compatible with Nolla stages 1 to 7, defined as:\n\nStage 1: Presence of bony crypt with no evidence of calcification; Stage 2: Initial calcification, with appearance of radiopaque points in the crown region; Stage 3: Approximately one-third of crown formation; Stage 4: Approximately two-thirds of crown formation; Stage 5: Crown almost complete, without full calcification; Stage 6: Crown completely formed, without initiation of root formation; Stage 7: Initial root formation.\n\n* Clinical and radiographic conditions indicating feasibility of tooth maintenance through endodontic treatment, including:\n* Permanent successor in developmental stages prior to Nolla Stage 8;\n* Preservation of the bony crypt.\n\nExclusion Criteria:\n\n* Pediatric patients presenting with:\n* Reversible pulpitis;\n* Indication for endodontic treatment in permanent teeth.\n* History of allergy or hypersensitivity to any components of the obturation materials (e.g., CTZ paste or zinc oxide-eugenol).\n* Clinical conditions that prevent adequate management in an outpatient setting.\n* Primary teeth in which the permanent successor:\n* Is in advanced developmental stages (Nolla Stage 8 or higher), and\u002For\n* Presents disruption of the bony crypt, contraindicating endodontic treatment.\n* Teeth presenting internal root resorption that compromises the feasibility of endodontic treatment.","ALL","2 Years","11 Years",{"count":21,"type":22},110,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and structural constraints directly impact treatment effectiveness. In these contexts, conventional pulpectomy using zinc oxide-eugenol (ZOE), although effective, may present operational limitations that restrict its large-scale applicability in public health systems.\n\nIn this scenario, non-instrumental endodontic treatment (NIET), based on the concept of Lesion Sterilization and Tissue Repair (LSTR), has emerged as a simplified alternative. Among the available options, CTZ paste shows potential for single-visit application, reducing clinical time and technical complexity.\n\nThis study aims to evaluate the clinical and radiographic non-inferiority of CTZ paste compared to conventional pulpectomy with ZOE in primary molars with pulp necrosis, with or without abscess or fistula, treated in emergency dental care settings.\n\nThis is a randomized, pragmatic, controlled, non-inferiority clinical trial conducted at a single center, with clinical and radiographic follow-up at 3, 6, and 12 months. Participants will be allocated into two groups: (1) NIET with CTZ paste and (2) conventional pulpectomy with ZOE.\n\nPrimary outcomes include pain resolution and absence of clinical signs of infection. Secondary outcomes include radiographic success, clinical time, child behavior (Frankl Scale), need for retreatment, and oral health-related quality of life.\n\nThe findings are expected to provide robust evidence regarding the effectiveness of CTZ paste under real-world clinical conditions, contributing to the development of more accessible and effective protocols within public health systems, with the potential to expand access to conservative treatment and reduce early tooth extractions in pediatric dentistry.",[28,29,30,31,32,33,34,35,36,37],"Pulp Disease, Dental","Pulp Necrosis","Pulp Therapy in Primary Molars","Primary Teeth","Pulpectomy","Endodontics","Dental Care for Children","Treatment Outcome","Quality of Life","Health Services Accessibility",[39,40,41,42,43,44,45,46,47,48,49,50],"pulpectomy","pulpotomy","CTZ paste","NIET","Non-instrumental endodontic treatment","LSTR","Lesion sterilization and tissue repair","Endodontic infection","dental abscess","Fistula","Emergency dental treatment","Public health dentistry","NOT_YET_RECRUITING","2026-05-07",{"date":54,"type":55},"2026-05-12","ACTUAL",{"date":57,"type":22},"2026-06-08",{"date":59,"type":22},"2028-02-28",{"name":61,"class":62},"University of Sao Paulo","OTHER",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":11,"sex":17,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":23,"phases":74,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100614226","digital-occlusal-analysis-and-bite-force-evaluation-of-primary-molars-restored-with-zirconia-crowns-using-t-scan-100614226","NCT07276841","Digital Occlusal Analysis and Bite Force Evaluation of Primary Molars Restored With Zirconia Crowns Using T-Scan","Digital Occlusal Analysis and Bite Force Evaluation of Pulp Treated Primary Molars Restored With Zirconia Crowns Using T-Scan: An Experimental Before-and-After Study","Inclusion Criteria:\n\n* Children aged 6 to 9 years.\n* Both boys and girls can participate.\n* A pulp-treated primary molar (pulpotomy) that is healthy and shows no pain, no swelling, no mobility, and no radiographic problems (such as internal resorption or infection).\n* The lower first permanent molar must be erupted.\n* The child is cooperative during dental treatment (positive behavior on the Frankl scale).\n* The child has no missing teeth.\n* The child has a normal bite (normal overjet and overbite).\n* The child is generally healthy with no systemic diseases, to ensure they can attend follow-ups.\n\nExclusion Criteria:\n\n* Children with medical conditions or who are uncooperative during dental care.\n* Children with parafunctional habits, such as teeth grinding (bruxism), thumb-sucking, or other habits that may affect bite-force measurements.\n* Teeth that are close to falling out, have severe root resorption, or need extraction.\n* Teeth with deep cavities below the gum line that prevent proper crown placement.\n* Teeth that are mobile (Miller's Grade 2 or higher).\n* Teeth that have had previous pulp therapy other than the included pulpotomy.\n* Children who are unable to attend follow-up visits or whose parents do not agree to participate.","6 Years","9 Years",{"count":73,"type":22},11,[75],"NA","The goal of this observational study is to evaluate the adaptation of occlusion and bite force after zirconia crown restoration in children with pulp-treated primary molars. The main questions it aims to answer are:\n\nHow does occlusion adapt after placement of zirconia crowns?\n\nDoes bite force change following crown restoration?\n\nParticipants will:\n\nUndergo routine pulp treatment and restoration of primary molars with zirconia crowns.\n\nHave bite force and occlusal contacts measured using the T-Scan digital occlusal analysis system before and after crown placement.",[78,31,79,80],"Dental Occlusion","Pulp-treated Primary Molars","Zirconia Crowns",[82,83,84,85,86,31,87],"Occlusion","Bite Force","Pediatric Dentistry","Zirconia Crown","T-Scan","Restorative Dentistry","2025-11-30",{"date":90,"type":55},"2025-12-11",{"date":92,"type":22},"2026-01",{"date":94,"type":22},"2026-03",{"name":96,"class":62},"Cairo University",1,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":105,"sex":17,"minAge":106,"maxAge":71,"enrollmentInfo":107,"targetDuration":4,"studyType":23,"phases":109,"briefSummary":111,"conditions":112,"keywords":114,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":4},"100587215","phase-1-comparison-of-3mixtatin-pulpotomy-and-metapex-pulpectomy-in-primary-molars-with-irreversible-pulpitis-100587215","NCT06925490","Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis","Clinical and Radiographic Evaluation of Pulpotomy Using 3Mixtatin Versus Pulpectomy Using Metapex in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis in Children Aged 4 to 9 Years: A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Children aged from 4 to 9 years with vital primary molars showing signs of irreversible pulpitis.\n* Children with spontaneous pain lasting a few seconds to several hours.\n* Pain is intensified by thermal stimulus and persists after its removal.\n* Pulp hemorrhage after performing access cavity and deroofing of pulp chamber showing reddish pink healthy pulp tissue.\n* Radicular pulp health is verified by achieving hemostasis within eight minutes of compression using a cotton pellet with 5% sodium hypochlorite.\n* Absence of peri-apical or inter-radicular radiolucency, widening of periodontal ligament space, internal or external root resorption.\n\nExclusion Criteria:\n\n* Unrestorable primary molars.\n* Primary molars with uncontrolled pulp hemorrhage or pulp necrosis.\n* Medically compromised patients who have systemic disease.\n* Uncooperative children who refuse treatment.\n* Children whose parents are unwilling to place stainless steel crowns.\n* Children whose parents or caregivers refuse to participate in the study or are unable to attend follow-up visits.",true,"4 Years",{"count":108,"type":22},50,[110],"PHASE1","The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.",[113,31,28],"Irreversible Pulpitis",[115,116,117,39,40],"3Mixtatin","irreversible pulpitis","metapex","2025-04-25",{"date":120,"type":55},"2025-04-27",{"date":122,"type":22},"2025-06",{"date":124,"type":22},"2026-10",{"name":96,"class":62},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":105,"sex":17,"minAge":106,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":154},"100581779","zinc-oxide-ozonated-olive-oil-in-lstr-100581779","NCT06854744","Zinc Oxide Ozonated Olive Oil in LSTR","Zinc Oxide Ozonated Oil Versus Modified Triple Antibiotic Paste as a Lesion Sterilization and Tissue Repair Technique in Primary Molars","Zn-OO\u002FMTAP","Inclusion Criteria: 1- Cooperative patients in the age group of (4-7) years with no associated systemic illness.\n\n2- Bilateral mandibular primary molars showing signs and symptoms of pulp necrosis or chronic pulp infection with\u002Fwithout hemorrhage, suppuration, or purulence.\n\n3- Spontaneous pain or tenderness to percussion. 4- Presence of chronic apical abscess, sinus tract, or grade I mobility. 5-The tooth should be restorable. 6- Radiographic characteristics are:\n\n1. Widening of Periodontal ligament space.\n2. Radicular involvement.\n3. Furcation involvement less than or equal to half of the shortest root in the vertical dimension\n\n   \\-\n\n   Exclusion Criteria: Exclusion criteria :\n   1. Physiologic root resorption is more than one-third of its length.\n   2. Excessive internal resorption.\n   3. Non-restorable teeth exhibiting greater than grade I mobility.\n   4. Perforation into the bifurcation.\n   5. Any underlying pathological lesion.\n   6. Any previous history of allergy to the antibiotics used in the study. -","7 Years",{"count":136,"type":22},30,[75],"This study will be carried out to evaluate and compare the clinical and radiographic effect of zinc oxide-ozonated olive oil (ZnO-OO) versus Modified Triple Antibiotic Paste (MTAP) as a Lesion Sterilization and Tissue Repair Technique in Primary Molars",[140,141,28,31],"Pulpitis - Irreversible","Ozone",[143],"ZnOO \u002FMTAP","RECRUITING","2025-02-25",{"date":147,"type":55},"2025-03-03",{"date":149,"type":55},"2024-01-15",{"date":151,"type":22},"2025-04",{"name":153,"class":62},"Tanta University",2]