[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"procedural-sedation-and-analgesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:procedural-sedation-and-analgesia":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,76,104],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100645186","consent-understanding-and-propofol-requirement-during-endobronchial-ultrasound-100645186",false,"NCT07677982","Consent Understanding and Propofol Requirement During Endobronchial Ultrasound","Association of Preoperative Consent Understanding With Propofol Requirement During Endobronchial Ultrasound: A Prospective Observational Study","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective endobronchial ultrasound\n* ASA physical status I to III\n* Ability to read and understand Turkish\n* Provision of written informed consent for study participation\n\nExclusion Criteria:\n\n* Active psychiatric disease that may affect the informed consent process, anxiety assessment, or communication\n* Cognitive impairment, including dementia or delirium\n* Contraindication or known allergy to propofol, midazolam, or remifentanil\n* Emergency EBUS procedure\n* Regular anxiolytic or sedative drug use within the last month\n* Illiteracy\n* Turkish language barrier\n* Advanced organ failure or decompensated systemic disease that may significantly affect sedative drug response, hemodynamic stability, communication, or consent assessment","ALL","18 Years",{"count":19,"type":20},75,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether a participant's understanding of the informed consent information is related to the amount of propofol needed during endobronchial ultrasound (EBUS). EBUS is a procedure that uses a thin camera and ultrasound to look at lymph nodes and other areas inside the chest. Propofol is a sedative medicine used to help participants stay comfortable during the procedure.\n\nBefore EBUS, all participants will receive the usual information about the procedure as part of routine care. After this routine consent process, participants will answer short questions about what they understood. They will also answer questions about their anxiety before the procedure. The study will not change the usual consent process, sedation plan, or medical care.\n\nDuring EBUS, participants will receive usual sedation and monitoring according to routine clinical practice. The research team will record how much sedative medicine is used, whether extra sedation is needed, whether any important clinical events occur, and how participants recover after sedation. The main question is whether participants who understand the consent information better need less propofol during EBUS.",[24,25,26],"ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION","Procedural Sedation and Analgesia","Informed Consent",[28,29,30,31,32,33],"EBUS-TBNA","Informed consent understanding","Procedural sedation","Preoperative anxiety","Sedative requirement","Propofol consumption","NOT_YET_RECRUITING","2026-06-30",{"date":37,"type":38},"2026-07-01","ACTUAL",{"date":37,"type":20},{"date":41,"type":20},"2027-07-01",{"name":43,"class":44},"Uludag University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100631065","predictors-of-maladaptive-behaviors-in-children-undergoing-procedural-sedation-100631065","NCT07495826","PRedictors Of Maladaptive Behaviors in Children Undergoing Procedural SEDation","Predictors of Maladaptive Behaviors in Children Undergoing Procedural Sedation","PRoSEED","Inclusion Criteria:\n\n* Children and adolescents 1-17 years undergoing procedural sedation or anxiolysis with any agent for any indication in the ED and dental clinics\n\nExclusion Criteria:\n\n* Patients where the primary caregiver lacks English or French (if applicable to site) comprehension in the absence of a native language interpreter\n* Lack a smartphone able to receive SMS text messages\n* Caregiver and\u002For patient are not available for all of the planned follow-up dates\n* Previously enrolled in the study","1 Year","17 Years",{"count":57,"type":20},2145,"Procedural sedation for children outside of the operating room is a common practice in emergency departments, outpatient clinics, radiology suites, and dental offices for painful and anxiety-provoking procedures. However, there is emerging evidence that so-called \"delayed maladaptive behaviors\" (disordered sleep, anxiety, and aggression) affect nearly a quarter of children for up to 2 weeks following sedation. This can lead to poor school attendance, reduced extracurricular involvement, disruptions to caregivers' employment obligations, and poor patient satisfaction. As this phenomenon has only recently been identified, very little is known about what factors predispose children to delayed maladaptive behaviors, however, small studies suggest younger age and pre-procedural anxiety may be involved. The aim of our study is to characterize risk factors for delayed maladaptive behavior in a large multicentre study involving emergency departments, dental offices, and hospital sedation services. Understanding these risk factors may help healthcare workers prevent delayed maladaptive behaviors and provide patients with anticipatory guidance, akin to post-operative recovery instructions.\n\nThere is emerging evidence that maladaptive behaviors, including significant negative behavioral changes, can occur in children following procedural sedation. These include disordered sleep, anxiety, and aggression)1,2 and affect up to 24% of children following inhalational anesthetics3 and intravenous sedatives such as ketamine.1 Moreover, these appear to be more pronounced in children \\\u003C4 years4 and can persist for up to 2 weeks post-sedation. Unfortunately, only two trials have reported delayed maladaptive behaviors.1,2 Data on immediate and delayed AEs are urgently needed for safe clinical decision-making and anticipatory guidance surrounding ED anxiolytics. In a prospective cohort study of children undergoing emergency department procedural sedation with intravenous ketamine, 22% exhibited significant negative behavioral changes 1-2 weeks after discharge, as measured by the Post-Hospitalization Behavior Questionnaire. High pre-procedure anxiety have been identified as independent predictors of these maladaptive behaviors.5 Additionally, irritability, hyperactivity, and hallucinations during recovery have been reported and are associated with lower parental satisfaction.6",[25],[61,62,63,64],"procedural sedation","pediatrics","maladaptive behavior","pain","RECRUITING","2026-03-24",{"date":68,"type":38},"2026-03-27",{"date":70,"type":38},"2026-03-18",{"date":72,"type":20},"2030-05-30",{"name":74,"class":44},"London Health Sciences Centre Research Institute",2,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":17,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":45},"100582744","study-of-the-efficacy-of-moderate-sedation-with-intra-nasal-dexmedetomidine-monitored-by-eeg-monitoring-100582744","NCT06867289","Study of the Efficacy of Moderate Sedation With Intra-NAsal Dexmedetomidine Monitored by EEG MOnitoring","DINAMO","Inclusion Criteria:\n\n* Indication of DEX sedation for brain NMRI at the CHR de Metz-Thionville\n\n  * in a patient aged between 12 months and 5 years or\n  * for a patient aged between 5 and 18 whose cooperation during the examination appears compromised (previous failure, autism spectrum disorders, etc.).\n* Membership of a social security scheme\n* Free and informed consent obtained from the patient's legal guardian(s).\n\nExclusion Criteria:\n\n* Weight \\\u003C 10 kg\n* Patients with contraindications to the use of DEX\n\n  * Hypersensitivity to the active ingredient or to any of the excipients listed in the section on \"Hypersensitivity\".\n  * Advanced heart block (level 2 or 3), unless pacemaker implanted\n  * Uncontrolled hypotension\n  * Acute cerebrovascular pathologies\n* Patients with nasal obstruction\n* Parental refusal of DEX administration\n* Minors under guardianship\n* Minors under judicial sanction",{"count":84,"type":20},50,"INTERVENTIONAL",[87],"NA","This is a prospective, monocentric diagnostic study aiming to evaluate whether a sedation score obtained by a per-procedural electroencephalogram (EEG), the PSI score, could identify patients for whom a 2 μg\u002Fkg dose of DEX would not be sufficient for the successful performance of cerebral NMRI, and who could therefore benefit from a higher dosage of DEX (4 μg\u002Fkg).",[25,90],"Pediatric ALL",[92,93,94],"MRI","dexmedetomidine","EEG","2026-03-11",{"date":97,"type":38},"2026-03-12",{"date":99,"type":38},"2025-04-08",{"date":101,"type":20},"2027-04-08",{"name":103,"class":44},"Centre Hospitalier Régional Metz-Thionville",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":112,"targetDuration":114,"studyType":21,"phases":4,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":45},"100624762","qnox-response-to-nociceptive-motor-events-during-procedural-sedation-100624762","NCT07413848","qNOX Response to Nociceptive Motor Events During Procedural Sedation","Performance of the CONOX Monitor Without Neuromuscular Blockade: qCON and qNOX Responses to Nociceptive Motor Events During Procedural Sedation","MO-NOX","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective diagnostic or therapeutic urological procedures (cystoscopy, ureteroscopy, prostate biopsy, intradetrusor botulinum toxin injection) under monitored anesthesia care\n* Able to provide written informed consent\n\nExclusion Criteria:\n\n* Known central neurological disease (epilepsy, Alzheimer's disease, Parkinson's disease, stroke) or history of brain surgery\n* Body Mass Index (BMI) ≥35 kg\u002Fm²\n* Known allergy to anesthetic agents used in the study (propofol, fentanyl, lidocaine)",{"count":113,"type":20},120,"1 Day","The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures. The main questions it aims to answer are:\n\nDoes the qNOX index respond to pain-related motor responses during urological procedural sedation? Does the qNOX index show greater responsiveness to painful episodes compared to blood pressure and heart rate? Participants undergoing urological procedures (such as cystoscopy) under sedation as part of their regular medical care will have continuous brain activity monitoring with the CONOX device. All monitoring displays (CONOX monitor, vital signs monitor, and target-controlled infusion pump) will be video-recorded throughout the procedure to capture synchronized data including qCON, qNOX, EMG, heart rate, blood pressure, oxygen saturation, and drug concentrations. Researchers will analyze the relationship between these indices and spontaneous movements triggered by painful stimulation to evaluate the monitor's performance compared to traditional vital signs.",[117,25,118],"Monitoring Noxious Events Using EEG-Derived Pain Indices","Monitored Anesthesia Care",[120,121,122,123,124,125,126],"EEG Monitoring","CONOX Monitor","qNOX Index","qCON Index","Target Controlled Infusion","Procedural Sedation","Propofol","2026-02-15",{"date":129,"type":38},"2026-02-18",{"date":131,"type":38},"2026-01-14",{"date":133,"type":20},"2026-05-30",{"name":135,"class":44},"Ankara University"]