[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"progestins-primed-ovarian-stimulation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:progestins-primed-ovarian-stimulation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100624427","ivf-outcomes-with-time-lapse-culture-comparison-between-ppos-and-gnrh-antagonist-protocols-100624427",false,"NCT07409493","IVF Outcomes With Time-Lapse Culture: Comparison Between PPOS and GnRH Antagonist Protocols","Inclusion Criteria:\n\n* Women aged 20-45 years\n* Indicated for in vitro fertilization (IVF) treatment\n* Planned freeze-all embryo strategy\n* Voluntary participation in research.\n\nExclusion Criteria:\n\n* Systemic diseases\n* Use of hormonal medications within 3 months prior to enrollment\n* Oocyte donation cycles\n* Unwilling or unable to participate in research","FEMALE","20 Years","45 Years",{"count":19,"type":20},148,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to compare two ovarian stimulation protocols used in in vitro fertilization (IVF): the fixed Progestin-Primed Ovarian Stimulation (PPOS) protocol and the GnRH Antagonist protocol. The study will evaluate IVF outcomes and embryo development patterns using time-lapse embryo monitoring technology. The main questions the study aims to answer are:\n\n* Does the fixed - PPOS protocol achieve similar numbers of mature eggs, good-quality embryos, and clinical outcomes compared to the GnRH Antagonist protocol?\n* Are there differences in embryo development patterns (morphokinetics) between the two protocols when monitored by time-lapse imaging?\n* How does embryo quality (KIDScore) compare between the two protocols?\n\nStudy Design:\n\nResearchers will randomly assign 148 women undergoing IVF to two groups:\n\n* PPOS group (n=74): Will receive FSH injections (oral Duphaston 20mg daily) starting from day 2-3 of the menstrual cycle\n* GnRH Antagonist group (n=74): Will receive FSH injections (Orgalutran 0.25mg injections) when follicles reach ≥14mm\n\nParticipants will:\n\n* Undergo controlled ovarian stimulation with their assigned protocol for approximately 10-12 days\n* Have regular ultrasound monitoring and blood tests to track follicle development\n* Undergo egg retrieval procedure when follicles are mature\n* Have all embryos cultured in the EmbryoScope time-lapse incubator with continuous monitoring\n* Have embryos frozen on Day 5\u002F6 for future transfer\n\nStudy Location:\n\nDepartment of Assisted Reproduction and Andrology, Hanoi Obstetrics and Gynecology Hospital\n\nStudy Duration: January 2026 - June 2028",[26,27,28],"Infertility (IVF Patients)","Embryo Morphokinetics","Progestins Primed Ovarian Stimulation",[30,31,32],"IVF","PPOS","Embryo morphokinetics","RECRUITING","2026-02-12",{"date":36,"type":37},"2026-02-13","ACTUAL",{"date":39,"type":37},"2026-01-21",{"date":41,"type":20},"2028-10",{"name":43,"class":44},"Hanoi Medical University","OTHER"]