[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"progressive-aphasia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:progressive-aphasia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,58,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":57},"100612951","remotely-supervised-neuromodulation-in-ppa-100612951",false,"NCT07260253","Remotely-supervised Neuromodulation in PPA","Investigating the Benefits of Remotely-Supervised Neuromodulation In Primary Progressive Aphasia","Inclusion Criteria:\n\n* Meets diagnostic criteria for primary progressive aphasia (PPA)\n* Meets diagnostic criteria for logopenic variant PPA\n* Attains score of 15 or higher on the Mini-Mental State Examination\n* Has adequate hearing and vision (with hearing or vision aids, if needed)\n* Is able to travel to research site and undergo MRI brain scan\n* Has access to high speed internet and basic experience using a computer and the internet\n* Is a fluent speaker of English\n* Has a study partner who can co-enroll in the study, attend pre-treatment training at the research site, and be present for teleconference meetings, as needed\n\nExclusion Criteria:\n\n* Speech and language deficits better accounted for by another neurological disorder\n* Does not meet diagnostic criteria for logopenic variant PPA\n* Scores less than 15 on the Mini-Mental State Examination\n* Does not have a study partner who can co-enroll in the study\n* Has contraindications for tDCS or MRI scan (History of seizures, head injury, craniotomy, skull surgery or fracture; History of severe or frequent migraines; Metallic implant in head or any metal in head; Pacemaker or cardioverter-defibrillator or any other stimulator; Chronic skin problems; Pregnancy)\n* Has a history of stroke, epilepsy, or significant brain injury","ALL","40 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn whether home-based brain stimulation combined with virtual speech-language therapy can improve communication abilities in adults with logopenic variant primary progressive aphasia (lvPPA), a language disorder most often caused by Alzheimer's disease.\n\nThe main questions the study aims to answer are:\n\n* Is combining remotely supervised transcranial direct current stimulation (tDCS) with virtual speech-language therapy feasible and acceptable for people with lvPPA?\n* Does this combined treatment lead to improvements in communication compared to speech-language therapy with sham (placebo) stimulation?\n* Do individual brain characteristics help predict who benefits most from this treatment?\n\nResearchers will compare participants who receive active tDCS plus virtual speech-language therapy to participants who receive sham (placebo) tDCS plus virtual speech-language therapy to see if active brain stimulation enhances communication outcomes.\n\nParticipants will:\n\n* Complete speech-language therapy sessions delivered by video visit.\n* Receive either active or sham tDCS that is remotely supervised and completed at home.\n* Complete language and cognitive testing before and after treatment.\n* Undergo brain imaging and other assessments to help understand treatment response.",[26,27,28,29,30,31],"Primary Progressive Aphasia(PPA)","Progressive Aphasia","Progressive Aphasia in Alzheimer's Disease","Logopenic Progressive Aphasia (LPA)","Logopenic Variant Primary Progressive Aphasia","Logopenic Variant of Primary Progressive Aphasia (LPA)",[33,34,35,36,37,38,39,40,41,42,43,44],"lvPPA","PPA","logopenic variant PPA","transcranial direct-current stimulation","tDCS","neuromodulation","speech therapy","speech-language pathology","logopenic","teletherapy","remote","virtual","RECRUITING","2026-06-24",{"date":48,"type":49},"2026-06-29","ACTUAL",{"date":51,"type":49},"2026-04-15",{"date":53,"type":20},"2029-08",{"name":55,"class":56},"Maya Henry","OTHER",2,{"id":59,"slug":60,"hasResults":11,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":16,"minAge":66,"maxAge":4,"enrollmentInfo":67,"targetDuration":4,"studyType":21,"phases":69,"briefSummary":71,"conditions":72,"keywords":77,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100555412","early-phase-1-educational-support-group-program-for-bilingual-and-spanish-speaking-carepartners-and-people-with-progressive-aphasia-100555412","NCT06511752","Educational Support Group Program for Bilingual and Spanish-speaking Carepartners and People With Progressive Aphasia","Educational Support Group Program for Carepartners of Bilingual and Spanish-speaking Persons With Progressive Forms of Aphasia and for Persons With Progressive Forms of Aphasia","Inclusion Criteria:\n\nAll participants must:\n\n* speak Spanish and\u002For English (although participants may speak other languages in addition to Spanish and\u002For English)\n* identify as Hispanic and\u002For Latinx,\n* or their spouse\u002Ffamily member with PA identifies as Hispanic and\u002For Latinx\n* see and hear well enough to participate\n* have access to a computer or mobile device with video capability\n* have an internet connection\n\nAdditional inclusion criteria for PA\u002F language-led dementia support group participants:\n\n* Individuals with PA:\n* Has a diagnosis of PA, or language-led dementia, and aphasia is one of the primary causes of difficulty with activities of daily living\n* Aware of language difficulties and willing to discuss them\n* Able to actively engage in group discussion and complete activities with minimal support\n* Able to regularly attend meetings\n* Willing to follow the rules of the support group for interacting with others respectfully\n\nAdditional inclusion criteria for care partner support group plus implementation phase participants:\n\n* Individuals with PA:\n* Diagnosis of aphasia or dementia that is progressive in nature, and aphasia is one of the primary causes of difficulty with activities of daily living\n* Have some ability to communicate and understand communication in order to participate in training sessions\n* Are functionally able to engage in training sessions (e.g., able to maintain some attention, minimal challenging behavior that would cause disruption)\n* Have a care partner who also consents to participating in the project\n* Care partners:\n* Self-identification as a caregiver of an individual with a diagnosis of PA or language-led dementia\n* Willing to discuss caregiving for individuals with PA\u002F language-led dementia\n* Able to regularly attend meetings\n* Willing to follow the rules of the support group for interacting with others respectfully\n\nExclusion Criteria:\n\n• Beyond the inclusion criteria included above, no additional exclusion criteria apply",true,"18 Years",{"count":68,"type":20},120,[70],"EARLY_PHASE1","The current study aims to examine the benefits of an education\u002Fsupport group program for individuals with progressive aphasia (caused by various etiologies, diagnoses) and their carepartners. The current study utilizes pre-, post-treatment, and follow-up assessments to measure effects of a psychoeducational support group and an implementation\u002Fcommunication skills training phase on measures of psychosocial function, communicative effectiveness and speech\u002Flanguage function. Analysis of study-specific surveys and semi-structured interviews will provide qualitative data regarding outcomes. Before beginning the education and support group, focus groups will be run in order to set priorities for the themes to be included in the education program. Participants will join via tele-based means if preferred and these participants may reside in the United States, or internationally including Mexico and Spain.",[73,74,75,76,27,28],"Alzheimer Disease","Dementia","Primary Progressive Aphasia","Aphasia",[78,79,80,81,82],"bilingual","Spanish","Castellano","multicultural","multilingual","2026-06-08",{"date":85,"type":49},"2026-06-10",{"date":87,"type":49},"2024-05-21",{"date":89,"type":20},"2030-12",{"name":91,"class":56},"University of Texas at Austin",1,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":113,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":92},"100609830","intervention-for-communication-quality-of-life-in-primary-progressive-aphasia-100609830","NCT07219680","Intervention for Communication Quality of Life in Primary Progressive Aphasia","Intervention to Promote Communication Quality of Life for Persons With Language-Led Dementia and Their Partners: A Randomized Pilot Trial","Multi-PA","Inclusion Criteria for Persons with PPA:\n\n* A PPA (Gorno-Tempini et al., 2011) or \"PPA-plus\" (Mesulam et al., 2001) diagnosis\n* MMSE score of 15 or higher and must be able to produce single monosyllabic words intelligibly\n* Must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)\n* Hearing and vision adequate for participation in teleconference meetings\n* Must have a study partner available (someone who will commit to attending teleconference sessions, as needed, during assessment and treatment phases)\n\nInclusion criteria for Care Partners:\n\n* Partners must express willingness to attend and participate in assessment and treatment sessions, including those targeting dyadic communication goals\n* Partners must speak English, Spanish or both languages (i.e., bilingual speakers of English or Spanish)\n* Partner's hearing and vision should be adequate for participation in teleconference meetings\n\nThe participant and\u002For study partner must have basic experience using a computer.\n\nExclusion criteria for persons with PPA:\n\n* Other central nervous system or medical diagnosis that can account for symptoms\n* Psychiatric diagnosis that can account for symptoms",{"count":102,"type":20},30,[23],"The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and their primary communication partners. The study will enroll participants who speak English and\u002For Spanish.\n\nThe main questions the study aims to answer are:\n\n* Is the telerehabilitation program feasible and acceptable for people with PPA and their study partners?\n* Do participants with PPA and study partners find treatment beneficial?\n* What patterns of treatment response are seen in participants?\n* Which outcome measures are most useful for evaluating changes in communication and quality of life?\n\nResearchers will compare participants who receive intervention immediately to participants assigned to a waitlist control group (who will receive treatment after a delay) to see whether participation in the treatment program is associated with improvements in communication and quality of life.\n\nParticipants will:\n\n* Take part in speech language therapy sessions delivered by video visit that combine restorative, compensatory, and partner-focused communication strategies. Treatment may take place after a waiting period.\n* Receive education and communication training together with their partner.\n* Complete speech, language, and cognitive assessments.\n* Complete questionnaires about communication abilities, daily functioning, and quality of life.",[26,106,29,107,27,108,109,30,31,110,111,112],"Semantic Dementia","Nonfluent Aphasia, Progressive","Semantic Variant Primary Progressive Aphasia (svPPA)","Semantic Aphasia","Logopenic Progressive Aphasia","Nonfluent Variant Primary Progressive Aphasia (nfvPPA)","Nonfluent Progressive Aphasia",[40,114,41,115,116,117,42,43,118,119,120,121,122,78,79,123,124],"neurodegenerative disease","nonfluent","semantic","script training","multimodal communication training","partner training","augmentative and alternative communication","AAC","Communication Book","Hispanic","Latino",{"date":126,"type":49},"2026-04-21",{"date":128,"type":49},"2026-04-01",{"date":130,"type":20},"2027-08",{"name":55,"class":56}]