[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"progressive-chronic-lymphocytic-leukemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:progressive-chronic-lymphocytic-leukemia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100458186","venetoclax-resistance-landscape-in-chronic-lymphocytic-leukemia-100458186",false,"NCT05246345","Venetoclax Resistance Landscape in Chronic Lymphocytic Leukemia","RAVEN","Inclusion Criteria:\n\n* Age greater than or equal to 18 years old;\n* chronic lymphocytic leukemia diagnosis according to iwCLL criteria;\n* refractory and\u002For relapsed disease during or after venetoclax treatment;\n* tumor samples available.\n* Relapse might be progressive chronic lymphocytic leukemia or transformation into Richter syndrome.\n* Patients must be able to express their opposition to be enrolled in this study, if need be.\n* Patients must be affiliated at the French Social Security system\n\nExclusion Criteria:\n\nPatients of their legal guardians refusing to participate\n\n\\-","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to collect medical informations and samples from refractory and\u002For relapsed chronic lymphocytic leukemia during or after venetoclax treatment, in order to evaluate the frequency of resistance mechanisms.",[24,25,26,27,28],"Chronic Lymphocytic Leukemia","CLL","Progressive Chronic Lymphocytic Leukemia","Refractory Chronic Lymphocytic Leukemia","Relapsed Chronic Lymphocytic Leukemia",[30,31,32],"Venetoclax","Venetoclax resistance","Resistance mechanism","RECRUITING","2024-01-08",{"date":36,"type":37},"2024-01-09","ACTUAL",{"date":39,"type":37},"2022-03-07",{"date":41,"type":20},"2027-03",{"name":43,"class":44},"University Hospital, Clermont-Ferrand","OTHER",14]