[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prolonged-disorders-of-consciousness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prolonged-disorders-of-consciousness":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100614060","stellate-ganglion-block-on-postoperative-sleep-status-in-patients-with-prolonged-disorders-of-consciousness-100614060",false,"NCT07274683","Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness","Effect of Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness: a Single--Centre Cohort Study","Inclusion Criteria:\n\n* Aged 18-65 years;\n* Prolonged disorders of consciousness after acquired brain injury;\n* Scheduled to undergo spinal cord electronic stimulator implantation under general anesthesia;\n* The skull is intact;\n* Informed consent is obtained;\n\nExclusion Criteria:\n\n* Continuous sedation therapy is performed within 72 hours prior to the study;\n* The integrity of brain structure is disrupted due to causes such as open head injury and cerebral parenchymal resection;\n* Decreased intracranial compliance caused by hydrocephalus and other reasons;\n* Airway stenosis or severe dysfunction of ventilation or gas exchange due to various causes;\n* Known or suspected severe cardiac, pulmonary, and renal dysfunction;\n* History of sedative drug allergy;\n* Complicated by other mental or neurological disorders;\n* Local anesthetic allergy;\n* Other reasons for ineligibility in this study;\n* Informed consent is not obtained;","ALL","18 Years","65 Years",{"count":20,"type":21},25,"ESTIMATED","6 Months","OBSERVATIONAL","The goal of this clinical trial is to learn about the effect of preoperative administration of stellate ganglion block on postoperative sleep status in patients with prolonged disorders of consciousness. The main aims to answer are: • To explore the effect of preoperative administration of stellate ganglion block on postoperative polysomnography and total sleep time in patients with prolonged disorders of consciousness. • To explore the effect of preoperative administration of stellate ganglion block on postoperative cerebral oxygen saturation, cerebral hemodynamic parameters and recovery of consciousness. Participants will be pDoC patients with intact skulls after acquired brain injury who will undergo spinal cord electronic stimulator implantation under general anesthesia at Beijing Tiantan Hospital. Stellate ganglion block will be administrated before the surgery. Polysomnography, total sleep time, cerebral oxygen saturation, cerebral hemodynamic parameters, CRS-R scores, GCS scores, WHIM scores and NCS scores will be investigated.",[26,27,28],"Stellate Ganglion Block","Prolonged Disorders of Consciousness","Sleep","NOT_YET_RECRUITING","2025-11-27",{"date":32,"type":33},"2025-12-10","ACTUAL",{"date":35,"type":21},"2026-01-01",{"date":37,"type":21},"2027-01-01",{"name":39,"class":40},"Beijing Tiantan Hospital","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":55,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":41},"100552453","effects-of-esketamine-on-consciousness-related-brain-network-characteristics-in-patients-with-prolonged-disorders-of-consciousness-100552453","NCT06473285","Effects of Esketamine on Consciousness-related Brain Network Characteristics in Patients With Prolonged Disorders of Consciousness","Patients with prolonged disorders of consciousness:\n\nInclusion Criteria:\n\n* Age 18 - 65 years old, native Chinese speaker, dextromanual;\n* Chronic disorder of consciousness;\n* Spinal cord electrical stimulator implantation under general anesthesia;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Continuous sedation was administered within 72 hours prior to the study;\n* Open head injury, parenchymal resection and other damage of brain structural integrity;\n* The intracranial compliance decreased due to hydrocephalus and swelling;\n* Known hearing impairment;\n* Airway stenosis and various causes of severe ventilation or ventilation dysfunction;\n* Known or suspected severe cardiac, pulmonary, hepatic, and renal dysfunction;\n* History of drug allergy to esketamine;\n* Associated with other mental or neurological diseases;\n* Other reasons are not suitable to participate in this study.\n\nHealthy brain volunteers:\n\nInclusion Criteria:\n\n* Age 18 - 65 years old;\n* Patients undergoing surgical treatment under elective general anaesthesia;\n* American Society of Anesthesiologists (ASA) I-II;\n* Native Chinese speaker;\n* Dextromanual;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Previous history of craniocerebral disease, imaging suggests organic brain lesions;\n* People with uncontrolled hypertension, hyperthyroidism, elevated intracranial pressure, epileptic seizures;\n* History of drug allergy to esketamine;\n* Hearing abnormality;\n* History of drug and alcohol abuse;\n* People with mental and behavioral disorders.",{"count":49,"type":21},80,"INTERVENTIONAL",[52],"NA","Prolonged disorders of consciousness (pDoC) are pathologies in which there is a loss of consciousness for more than 28 days. The number of patients with pDoC is increasing as the level of critical care treatment and monitoring improves. However, clinical trials for patients with pDoC are limited by small sample sizes, lack of placebo groups, and use of heterogeneous outcome measures. As a result, few therapies have strong evidence to support their use. In recent years, ketamine has been used with remarkable success in the treatment of neuropsychiatric disorders by inducing neuroplasticity, increasing neurophysiologic complexity, and expanding functional brain connectivity states. Considering increased brain plasticity as well as brain complexity, it may be beneficial for consciousness recovery. In this study, the investigators aimed to explore the effects of esketamine on brain networks and level of consciousness in patients with pDoC, and to discuss its possible use as a wakefulness-promoting treatment for patients with pDoC.",[27],[56,57,58,59],"Esketamine","Multichannel electroencephalogram","Event-related potential","Brain network characteristics","RECRUITING","2024-06-23",{"date":63,"type":33},"2024-06-25",{"date":65,"type":33},"2024-06-01",{"date":67,"type":21},"2025-05-30",{"name":39,"class":40}]