[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prolonged-labor\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prolonged-labor":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100564974","maternal-maneuvers-during-prolonged-labor-100564974",false,"NCT06636149","Maternal Maneuvers During Prolonged Labor","CIRCUIT: Maternal Maneuvers During Prolonged Labor, A Pilot Randomized Control Trial","CIRCUIT","Inclusion Criteria:\n\n* English-speaking patients\n* Singleton, vertex pregnancies\n* 34 weeks' gestation or later\n* Admitted to Labor and Delivery in spontaneous labor or for an induction of labor\n* Prolonged labor course as defined by: cervical dilation less than 6 cm after 8 hours or more of ruptured membranes (spontaneous or artificial) and oxytocin infusion, or cervical dilation 6 cm or more and less than 1-cm cervical dilation change over 2 hours or more with ruptured membranes and oxytocin infusion\n\nExclusion Criteria:\n\n* Intraamniotic infection prior to randomization\n* Magnesium sulfate treatment\n* Major fetal anomalies\n* BMI ≥50\n* Non-reassuring fetal status prior to randomization\n* Any maternal diagnosis that precludes safety or feasibility of intrapartum circuit of maternal position changes","FEMALE","12 Years",{"count":20,"type":21},82,"ESTIMATED","INTERVENTIONAL",[24],"NA","This pilot, randomized control trial will test whether or not a specific circuit of position changes improves maternal outcomes in cases of prolonged labor.\n\nPatient who have prolonged labor will be approached for consent and randomization to one of two study groups: circuit intervention against routine standard of care position changes. 82 patients will be enrolled in the study. Exclusion criteria will include: any uterine infection prior to randomization, magnesium sulfate treatment, major fetal anomalies, BMI ≥50, non-reassuring fetal status prior to randomization, or any maternal diagnosis that precludes safety or feasibility of the circuit of maternal position changes.\n\nThe 3 aims of the study will include: the outcome that the circuit of position changes has on the duration of the first stage of labor, maternal and neonatal morbidity, and maternal satisfaction.",[27,28],"Labor Stage, First","Prolonged Labor",[30,31,32,33,34],"Circuit","Position changes","Labor","Prolonged labor","Labor dystocia","RECRUITING","2026-03-11",{"date":38,"type":39},"2026-03-13","ACTUAL",{"date":41,"type":39},"2024-12-10",{"date":43,"type":21},"2028-05-31",{"name":45,"class":46},"Washington University School of Medicine","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":5},"100617650","efficacy-of-bicarbonate-on-the-risk-of-assisted-delivery-in-nulliparous-women-with-prolonged-labour-100617650","NCT07321379","Efficacy of Bicarbonate on the Risk of Assisted Delivery in Nulliparous Women With Prolonged Labour","Efficacy of Bicarbonate on the Risk of Assisted Delivery in Danish Nulliparous Women With Prolonged Labour: a Double-blinded Parallel Randomized Controlled Trial (The ProLabour Trial)","ProLabour","Inclusion Criteria:\n\n* Age ≥18 years.\n* Danish or English speaking.\n* Cephalic presentation.\n* Gestational age ≥34+0 - \\\u003C42+0 (days +weeks) at onset of labour.\n* Normal foetal heart rate pattern in the 20 minutes prior to inclusion.\n* Spontaneous onset of labour or non-medical induced labour (balloon catheter and\u002For artificial rupture of membranes).\n* Active first stage of labour confirmed, according to Danish national guidelines: Cervical dilatation at ≥4 - \\\u003C10 cm with regular painful contractions.\n* Prolonged labour diagnosed, according to Danish national guidelines: Cervical dilatation progresses at less than 2 cm over a 4-hour period.\n\nExclusion Criteria:\n\n* Clinical suspicion of infection (2 confirmed temperatures ≥38.5°C with epidural, ≥38 °C without epidural, or broad-spectrum antibiotics initiated)\n* Significant medical comorbidity in the form of renal or heart condition, assessed case-by-case basis.\n* Serious obstetric complication\n* Known allergy or intolerance to sodium bicarbonate.\n* Ingestion of sodium bicarbonate in active labour prior to inclusion.\n* Current treatment with following medicines: Gabpabpentin, Tetracycline, Ketoconazole (NB! These medications are already generally advised contradicted against induring pregnancy)","18 Years","50 Years",{"count":59,"type":21},1520,[24],"The goal of this clinical trial is to learn if oral bicarbonate can treat prolonged labour in nulliparous women with prolonged labour.\n\nThe main question it aims to answer is: Do oral bicarbonate and restrictive oxytocin use reduce assisted delivery rate (emergency cesarean and vacuum\u002Fforceps delivery) in nulliparous women with prolonged labour.\n\nResearchers will compare bicarbonate and placebo (a look-alike substance that contains no drug) to see if bicarbonate works to treat prolonged labour.\n\nParticipants will:\n\n* drink bicarbonate or placebo\n* have cervical dilatation reassessed after 2 hours. If still slow progression, they will follow standard protocol for oxytocin augmentation\n* will receive a questionnaire 1 month post partum to assess birth experience\n\n1\u002F3 of participants will have amniotic fluid lactate measured at inclusion and after 2 hours",[28,63],"Labor Dystocia",[32,65,66,67,68,69,70],"Bicarbonate","Caesarean section","Assisted birth","Oxytocin","Labor augmentation","Intrapartum","NOT_YET_RECRUITING","2026-01-08",{"date":74,"type":39},"2026-01-12",{"date":76,"type":21},"2026-02-01",{"date":78,"type":21},"2028-01-31",{"name":80,"class":46},"Copenhagen University Hospital, Hvidovre",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":47},"100536715","oxytocin-rest-to-reduce-cesarean-delivery-100536715","NCT06268431","Oxytocin Rest to Reduce Cesarean Delivery","Oxytocin Rest to Reduce Cesarean Delivery in Prolonged Labor: An Open-Label, Randomized Controlled Trial","ORCA","Inclusion Criteria:\n\n* ≥18 years of age\n* Singleton gestation in vertex presentation\n* ≥36 weeks gestation\n* Prolonged latent labor, defined as cervical dilation \\\u003C6cm after ≥8 hours since rupture of membranes and on continuous oxytocin\n\nExclusion Criteria:\n\n* Not meeting the above criteria\n* Any contraindication to continuous oxytocin at time of randomization\n* Cesarean section anticipated by the clinical team at time of randomization (for any reason excepting labor dystocia)\n* \\>18 hours between rupture of membranes and randomization\n* Known intraamniotic infection at randomization\n* Fetal demise\n* Any contraindication to vaginal delivery\n* Maternal eclampsia","55 Years",{"count":91,"type":21},350,[24],"Prolonged labor is usually managed with continuous oxytocin infusion. \"Oxytocin rest\" has been proposed as a strategy to resolve protracted labor in patients who have received continuous oxytocin without progress. This strategy involves discontinuing oxytocin then restarting infusion after a period of time, under the theory that washout of the oxytocin receptor will strengthen uterine contractions to improve labor progress. \"Oxytocin rest\" is performed on labor and delivery units across the United States. Yet, there is no randomized or prospective data to support the practice.\n\nThe purpose of this study is to assess whether oxytocin rest of 60 minutes in patients with prolonged labor reduces risk for cesarean delivery.",[28,95,63],"Failed Induction","2024-10-15",{"date":98,"type":39},"2024-10-17",{"date":100,"type":39},"2024-03-19",{"date":102,"type":21},"2026-03-15",{"name":104,"class":46},"Christiana Care Health Services"]