[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prolonged-mechanical-ventilation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prolonged-mechanical-ventilation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,51,81,109,133,153,179,202],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100627161","effects-of-mobilization-using-a-powered-lower-limb-exoskeleton-with-prolonged-mechanical-ventilation-100627161",false,"NCT07445035","Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation","Physiological and Functional Adaptations Associated With Robot-assisted Lower-limb Activity in Ventilator-dependent Hospitalized Patients","Inclusion Criteria:\n\n* Able to maintain a seated position for at least 1 minute.\n* The participant or their legal representative is able to sign the informed consent form.\n\nExclusion Criteria:\n\n* Inability to follow instructions.\n* Intubation\u002Ftracheostomy prior to current admission.\n* Diagnosis of severe left heart failure.\n* Diagnosis of neuromuscular disorders.\n* Unable to stand.\n* Complete paralysis of the lower extremities.\n* Presence of unhealed ulcers in the lower extremities.\n* Deep vein thrombosis of the lower extremities.\n* Lower-limb amputation.\n* Severe hypertension\n* Severe cardiac conditions\n* Severe bilateral joint disorders\n* Severe pain while standing\n* Severe osteoporosis\n* Lower-limb fracture\n* Ongoing epileptic seizure","ALL","45 Years","65 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged mechanical ventilation admitted to a Respiratory Care Center. The goal is to provide clinical evidence for integrating rehabilitation and respiratory care in this patient population.",[27,28,29,30,31],"Prolonged Mechanical Ventilation","Ventilator Weaning","Ventilator Dependent","Exoskeleton Device","Exercise Training",[33,34,35,36,37],"prolonged mechanical ventilation","ventilator weaning","lower limb muscle strengthening","exoskeleton robot","exercise training","RECRUITING","2026-06-29",{"date":41,"type":42},"2026-07-01","ACTUAL",{"date":44,"type":42},"2026-06-26",{"date":46,"type":21},"2026-12-31",{"name":48,"class":49},"Fu Jen Catholic University","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":50},"100643112","mechanical-power-and-pulmonary-complications-in-cabg-surgery-100643112","NCT07639489","Mechanical Power and Pulmonary Complications in CABG Surgery","Association of Intraoperative Mechanical Power With Postoperative Pulmonary Complications and Prolonged Mechanical Ventilation in Coronary Artery Bypass Graft Surgery","MP-CABG","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for elective, first-time isolated CABG surgery\n* Use of cardiopulmonary bypass (CPB)\n* Intraoperative mechanical ventilation applied under general anesthesia with recordable ventilator data\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Emergency cardiac surgery\n* Off-pump CABG (without CPB)\n* Preoperative requirement for invasive mechanical ventilation\n* Advanced chronic lung disease\n* Incomplete or unreliable intraoperative ventilatory data\n* Intraoperative use of advanced non-standard support (ECMO)","18 Years",{"count":61,"type":21},110,"OBSERVATIONAL","This prospective observational study evaluates the association between intraoperative mechanical power (MP) - a composite measure of the total energy delivered to the lungs during mechanical ventilation - and postoperative pulmonary complications (PPCs) and prolonged mechanical ventilation in adult patients undergoing elective coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB). Intraoperative ventilatory parameters including tidal volume, respiratory rate, airway pressures, and PEEP will be recorded and used to calculate MP and driving pressure (DP). No additional interventions will be applied beyond standard clinical care.",[65,66,27],"Postoperative Pulmonary Complications","Coronary Artery Bypass Graft Surgery (CABG)",[68,69],"intraoperative ventilation","lung-protective ventilation","NOT_YET_RECRUITING","2026-06-06",{"date":73,"type":42},"2026-06-10",{"date":75,"type":21},"2026-06",{"date":77,"type":21},"2026-09",{"name":79,"class":80},"Fusun Gozen","OTHER_GOV",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":50},"100621605","eit-guided-respiratory-physiotherapy-for-prolonged-mechanical-ventilation-pmv-100621605","NCT07372794","EIT-Guided Respiratory Physiotherapy for Prolonged Mechanical Ventilation (PMV)","Electrical Impedance Tomography-Guided Respiratory Physiotherapy for Liberation From Prolonged Mechanical Ventilation: A Multicenter Randomized Controlled Trial","PMV","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Invasive mechanical ventilation for ≥ 21 consecutive days.\n* Clinically stable and eligible for respiratory physiotherapy as determined by the treating team.\n* Expected to remain on invasive mechanical ventilation for at least 48 hours after enrollment.\n* Written informed consent obtained from the patient or legally authorized representative.\n\nExclusion Criteria:\n\n* Contraindications to electrical impedance tomography .\n* Hemodynamic instability requiring high-dose vasoactive support.\n* Severe hypoxemia refractory to optimization.\n* Unstable fractures or other contraindications to mobilization or positioning.\n* Pregnancy.\n* Expected death within 48 hours.",{"count":90,"type":21},200,[24],"Patients with prolonged mechanical ventilation (PMV) frequently experience impaired ventilation distribution, respiratory muscle dysfunction, secretion retention, and delayed liberation from mechanical ventilation. Electrical impedance tomography (EIT) provides real-time bedside visualization of regional ventilation and enables individualized respiratory physiotherapy strategies.\n\nThis multicenter randomized controlled trial aims to evaluate whether EIT-guided respiratory physiotherapy improves ventilator-free days at day 28 compared with conventional respiratory physiotherapy in adult patients with PMV.\n\nRespiratory physiotherapy consists of airway clearance, chest physiotherapy techniques, breathing pattern optimization, and therapeutic positioning. In the EIT-guided group, real-time EIT imaging is used to individualize physiotherapy strategies based on predefined ventilation distribution indicators, while the control group receives standardized physiotherapy according to institutional protocols without EIT guidance.\n\nSecondary outcomes include successful liberation from mechanical ventilation, diaphragm ultrasound parameters, EIT-derived ventilation distribution indices (exploratory mechanistic outcomes), ICU Mobility Scale, healthcare resource utilization, and safety outcomes.",[27,94,95],"Respiratory Failure","Critical Illness",[97,27,98,28,99],"Electrical Impedance Tomography","Respiratory Physiotherapy","Ventilator-Free Days","2026-04-28",{"date":102,"type":42},"2026-05-04",{"date":104,"type":42},"2026-02-16",{"date":106,"type":21},"2026-12-15",{"name":108,"class":49},"Capital Medical University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":115,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":50},"100636030","effects-of-music-therapy-on-anxiety-symptoms-in-patients-with-prolonged-mechanical-ventilation-a-randomized-controlled-trial-100636030","NCT07560384","Effects of Music Therapy on Anxiety Symptoms in Patients With Prolonged Mechanical Ventilation: A Randomized Controlled Trial","Inclusion Criteria:\n\n\\- 1、Age \\> 50 years 2、Diagnosed with Prolonged Mechanical Ventilation (PMV), meeting the following criteria: Continuous mechanical ventilation for ≥ 21 days Daily mechanical ventilation duration ≥ 6 hours Ventilation via endotracheal tube, tracheostomy, or non-invasive interface (face\u002Fnasal mask).\n\n3、Voluntarily signed the informed consent form (either by the patient or their legal representative).\n\nExclusion Criteria:\n\n* 1、Cognitive or psychiatric disorders: history of severe mental illness (e.g., schizophrenia, severe depression, bipolar disorder) or diagnosed moderate-to-severe dementia\u002Fcognitive impairment.\n\n  2、Presence of delirium: assessed as positive by the Confusion Assessment Method for the ICU (CAM-ICU) prior to enrollment.\n\n  3、Extreme hemodynamic instability: unstable vital signs requiring frequent resuscitation, or in the acute phase of a severe cardio-cerebrovascular accident.\n\n  4、Untreated hearing impairment. 5、Physical conditions preventing safe earphone use (e.g., skin damage, burns, facial or cranial fractures).\n\n  6、Poor prognosis: end-stage disease or assessed by the investigator as having a life expectancy insufficient to complete the intervention and follow-up period.","50 Years",{"count":90,"type":21},[24],"The purpose of this study is to evaluate the effects of music therapy on anxiety symptoms in patients requiring prolonged mechanical ventilation (PMV). PMV patients, defined as those ventilated for more than 21 days, often experience intense psychological stress and anxiety due to long-term intubation and the ICU environment. High anxiety can lead to \"patient-ventilator asynchrony,\" which delays the weaning process.\n\nIn this study, 200 participants will be randomly assigned to either a control group receiving standard care or an experimental group receiving patient-directed music therapy. The music therapy intervention involves listening to selected music through noise-canceling headphones for 30 minutes, twice daily, over a 14-day period. The study will measure improvements in anxiety levels, pain, and sleep quality to determine if music therapy can help break the cycle of anxiety and facilitate recovery.",[120,27],"Anxiety",[122,27,120,123,124],"Music Therapy","Intensive Care Unit","Patient-Directed Music Intervention","2026-04-24",{"date":127,"type":42},"2026-05-01",{"date":129,"type":21},"2026-05",{"date":131,"type":21},"2027-05",{"name":108,"class":49},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":139,"maxAge":59,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":151,"locationsCount":50},"100525705","application-of-early-bundle-management-of-mechanical-ventilation-to-prevent-ventilator-dependence-in-children-100525705","NCT06125210","Application of Early Bundle Management of Mechanical Ventilation to Prevent Ventilator Dependence in Children","Inclusion Criteria:\n\n（1）All stable children receiving mechanical ventilation\n\n（1）Stable condition: respiratory rate does not exceed 20% of the basic respiratory rate, PEEP\\\u003C 8. 60%, VIS score\\\u003C 20, there is no hypotension (70mmHg+ age ×2, 70mmHg under one year old), no higher than the P95 of the same sex and age\n\nExclusion Criteria:\n\n1. Status epilepticus\n2. Active intracranial hemorrhage\n3. Intracranial hypertension\n4. Unstable fracture of the spine\n5. Spinal cord injury\n6. There are injuries that affect the implementation of rehabilitation\n7. Acute surgery was performed on the same day.\n8. Body temperature over 40℃\n9. Brain function failure","28 Days",{"count":141,"type":21},150,[24],"This study is based on the risk factors of previous studies to formulate a bundle treatment plan to prevent ventilator dependence in children, in order to reduce the proportion of ventilator dependence in children and provide a theoretical basis for reasonable intervention of children with mechanical ventilation.\n\nParticipants will receive intensive rehabilitation, nutrition, and tracheotomy at different time periods.\n\nResearchers will compare the control group to see whether it can reduce the incidence of ventilator dependence",[27],"2026-02-12",{"date":147,"type":42},"2026-02-17",{"date":149,"type":42},"2024-09-01",{"date":46,"type":21},{"name":152,"class":49},"Children's Hospital of Fudan University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":165,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":174,"leadSponsor":176,"locationsCount":178},"100606563","low-serum-creatinine-as-a-predictor-of-prolonged-mechanical-ventilation-and-weaning-failure-100606563","NCT07177183","Low Serum Creatinine as a Predictor of Prolonged Mechanical Ventilation and Weaning Failure","SECRET-VENT","Inclusion Criteria:\n\n* Patients \\\u003C18 years of age\n* Patients admitted to post-ICU care units at Chronicare Group a.s. in the Czech Republic within 12 months\n\nExclusion Criteria:\n\n* Patients who are unlikely to be weaned from ventilatory support.\n* Patients in palliative care or with a survival probability of \\\u003C3 months\n* Patients with advanced malignancy\n* Patients with a history of chronic kidney disease\n* Patients with a history of chronic liver disease\n* Patients with supranormal serum creatinine on admission to the post-ICU care unit\n* Patients who refused to sign the Informed Consent with participation in the study.",{"count":161,"type":21},492,[24],"The main objective of the study is to determine whether a subnormal serum creatinine value upon admission to the Post-ICU Care Unit predicts the need for prolonged ventilatory support. A parallel objective of the study is to determine whether exogenous in-take of the dietary supplement creatine in patients with subnormal serum creatinine value is associated with a shortened duration of ventilatory support and improved patients outcome.",[27,95],[166,167,168,169],"Prolonged mechanical ventilation","Critical illness","Creatinine","Creatine supplementation","2026-02-02",{"date":172,"type":42},"2026-02-05",{"date":170,"type":21},{"date":175,"type":21},"2028-02-02",{"name":177,"class":49},"University Hospital Ostrava",2,{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":22,"phases":188,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":4},"100608321","effects-of-imt-on-weaning-and-diaphragmatic-function-in-pmv-patients-100608321","NCT07200037","Effects of IMT on Weaning and Diaphragmatic Function in PMV Patients","Effects of Inspiratory Muscle Training on Weaning and Diaphragmatic Function in Prolonged Mechanical Ventilation Patients: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients who received therapy in the HDU of the Respiratory Rehabilitation Center of Beijing Rehabilitation Hospital Affiliated to Capital Medical University and met the PMV criteria clearly recommended by the NAMDRC consensus in 2005, which is \"mechanical ventilation for at least 6 hours a day for 21 consecutive days\".\n\n  * The patients' conditions were relatively stable, they were conscious, had no intellectual disability, no mental illness, no cognitive impairment, and gave informed consent.\n\n    * They had spontaneous breathing and could tolerate short periods of being off the ventilator to complete the training.\n\n      * The ventilator parameters met the following requirements: PEEP ≤ 10 cmH2O, FiO2 \\\u003C 0.60, RR \\\u003C 25.\n\nExclusion Criteria:\n\n1\\) brain injuries, pulmonary contusions and lacerations, rib fractures, unhealed wounds in the chest and abdomen, etc. The condition is severe, and inspiratory muscle training and diaphragm ultrasound assessment cannot be performed. 2) No spontaneous breathing, completely dependent on mechanical ventilation; 3) Pre-existing pulmonary infection or severe heart, lung or kidney diseases before clinical trials, with unstable hemodynamics; 4) Poor cognitive function, poor compliance, and non-cooperation with treatment.-",{"count":187,"type":21},120,[24],"Prolonged mechanical ventilation (PMV) and weaning failure can lead to extended hospital stays, as well as increased morbidity and mortality during hospitalization. Therefore, PMV not only increases the economic burden on patients and their families, but also adds to the societal economic burden and consumes critical care medical resources. Inspiratory muscle training (IMT) is widely used by physical therapists in critically ill patients to improve respiratory function and enhance quality of life. IMT helps improve diaphragmatic function, and the improvement of diaphragmatic function in turn promotes better respiratory function, which is clinically significant for accelerating weaning. However, most studies on the effects of IMT on weaning success rates and the duration of mechanical ventilation have limitations such as small sample sizes, homogeneous patient populations, and short intervention periods. As a result, there is still no unified, high-quality evidence-based consensus. The purpose of this study is to further clarify the role of IMT in improving diaphragmatic function and increasing weaning success rates in patients with prolonged weaning, through clinical treatment and the collection and analysis of relevant data.",[27],[192,166,193],"Inspiratory muscle training","weaning","2025-09-28",{"date":196,"type":42},"2025-09-30",{"date":198,"type":21},"2025-10-01",{"date":200,"type":21},"2026-09-01",{"name":108,"class":49},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":209,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":212,"conditions":213,"keywords":214,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":50},"100487978","lung-ventilation-and-perfusion-in-different-phenotypes-of-chronic-critical-illness-with-prolonged-mechanical-ventilation-100487978","NCT05634135","Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation","The Difference and Prognostic Significance of Lung Ventilation and Perfusion in Different Phenotypes of Chronic Critical Illness With Prolonged Mechanical Ventilation","Inclusion Criteria:\n\n* Patients with at least 10 days of mechanical ventilation at the intensive care unit of National Taiwan University Hospital and transferred to the Respiratory Care Center of National Taiwan University Hospital for weaning training\n* Patients who have undergone tracheostomy and still have a tracheotomy tube\n* Are at least 20 years old\n* Stable respiratory condition with inspired oxygen fraction not exceeding 50%\n\nExclusion Criteria:\n\n* Hemodynamic instability or continuous use of vasopressors\n* Pregnancy","20 Years",{"count":211,"type":21},103,"This project will conduct a series of analysis of physiological and clinical data on tracheostomy patients who receive prolonged mechanical ventilation, hoping to find out the different manifestations of patients through the investigation by a variety of physiologic measurements, so as to understand whether different types of patients phenotype to derive different clinical strategies for liberation of the mechanical ventilator.",[27],[215,216,193,217],"Ventilation","mechanical ventilation","oxygen uptake","2024-12-26",{"date":220,"type":42},"2024-12-30",{"date":222,"type":42},"2022-07-31",{"date":224,"type":21},"2025-02-17",{"name":226,"class":49},"National Taiwan University Hospital"]