[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prone-position\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prone-position":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,53,81,113,137,168,193,219,251,280,303,330,356,376],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100643703","bedside-assessment-of-right-ventricular-output-lying-in-prone-or-supine-position-100643703",false,"NCT07632027","Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position","The BAROLO Study Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position. Hemodynamic Changes Due to Prone Position in Patients After Cardiac Surgery - a Prospective Randomized Controlled Trial Evaluating the Effect of Prone Position on Right Heart Function","BAROLO","Inclusion Criteria:\n\n* Scheduled for cardiac surgery using cardiopulmonary bypass\n\nExclusion Criteria:\n\n* BMI \\>40\n* Emergency surgery\n* In need of secondary surgery\n* Advanced grown up congenital heart disease\n* Pulmonary disease\n* Hemodynamic instability with Norepinephrine \\>0.4mcg\u002Fkg\u002Fmin\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient","ALL","18 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.\n\nRecruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.\n\nProne position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.\n\nThe investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.",[27,28,29,30,31,32,33,34,35,36,37,38,39],"Right Ventricular Function","Prone Position","Atelectasis","Atelectases, Postoperative Pulmonary","Cardiac Output","Vasoconstriction","Heart Failure","Recruitment Maneuver","Respiratory Mechanics","Pulmonary Arterial Pressure","Cardiac Surgery","Cardiac Surgery Recovery","Cardiopulmonary Bypass","NOT_YET_RECRUITING","2026-06-03",{"date":43,"type":44},"2026-06-08","ACTUAL",{"date":46,"type":21},"2026-09",{"date":48,"type":21},"2028-10",{"name":50,"class":51},"Sahlgrenska University Hospital","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":52},"100454486","efficacy-of-hofa-versus-hydrocolloid-dressings-in-the-prevention-of-pus-in-critically-ill-prone-patients-100454486","NCT05198167","Efficacy of HOFA Versus Hydrocolloid Dressings in the Prevention of PUs in Critically Ill Prone Patients","Efficacy of Hyperoxygenated Fatty Acids Versus Hydrocolloid Dressings in the Prevention of Pressure Ulcers in Critically Ill Prone Patients","Inclusion Criteria:\n\nAll patients in prone position admitted to participating ICU who agree to be included in the study or, if they are unable to communicate, the consent is authorized by their referring family member.\n\nExclusion Criteria:\n\nPatients with previous pressure ulcers in the following prone-related locations: shoulders, thorax, genitals, iliac crest, knees, ankles, facial.",{"count":61,"type":21},262,[24],"Introduction: Prone position (PP) treatment as a rescue strategy for patients with acute respiratory distress syndrome (ARDS) is a technique increasingly used in our daily practice and, as a result of the current health situation due to SARS COV-2, has become the treatment of choice for many patients. Many of the associated complications can be considerably reduced with the implementation of standardized procedures and a team trained and specialized in this technique and its subsequent care.\n\nAim: To evaluate the efficacy of the use of Hyperoxygenated Fatty Acids (HOFA) compared to the use of hydrocolloid dressings (HCD) in the prevention of Pressure ulcers (PUs) occurrence in critically ill patients in prone position.\n\nMethods: A randomized clinical trial will be conducted to compare the occurrence of PUs and other complications in patients undergoing PP in the ICU of the HUPHM. Two care groups will be formed in which HOFA and hydrocolloid dressings will be used, respectively, following a strict care protocol previously established in the unit. In addition, other variables related to medical and nursing treatment that may influence the appearance of PUs and other complications associated with PP will also be analyzed.\n\nScientific relevance: PUs have a major socioeconomic and quality of life impact on patients. Dressings and topical agents for prevention are widely used, however, it is unclear which treatment is most effective in preventing PUs in the prone patient.\n\nKeywords: Prone Position; Nursing care; Pressure ulcer; Fatty acids; Prevention; Complications.",[28,65],"Pressure Ulcer",[67,68,69,70],"Nursing Care","Fatty acids","Prevention","Complications","RECRUITING","2026-05-12",{"date":74,"type":44},"2026-05-15",{"date":76,"type":44},"2021-06-12",{"date":78,"type":21},"2027-07",{"name":80,"class":51},"Puerta de Hierro University Hospital",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100634903","comparison-of-5-vs-8-cmho-peep-on-respiratory-mechanics-in-prone-lumbar-surgery-100634903","NCT07545733","Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar Surgery","The Effect of Different PEEP Levels Accompanied by PCV-VG Mode on Respiratory Mechanics and Gas Exchange in Lumbar Surgeries Performed in the Prone Position Under TIVA","PROPEEP","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Scheduled for elective lumbar spine surgery in the prone position\n* Planned general anesthesia with total intravenous anesthesia (TIVA)\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* History of significant pulmonary disease (e.g., COPD, asthma)\n* Severe cardiovascular disease\n* Pregnancy\n* Known difficult airway\n* Requirement for intraoperative vasopressor infusion due to hemodynamic instability\n* Conversion to different surgical position or change in surgical plan\n* Incomplete data or protocol deviation","65 Years",{"count":91,"type":21},60,[24],"This randomized controlled clinical trial aims to compare the effects of two different positive end-expiratory pressure (PEEP) levels (5 cmH₂O and 8 cmH₂O) on respiratory mechanics in patients undergoing lumbar spine surgery in the prone position under total intravenous anesthesia (TIVA). Prone positioning may adversely affect lung compliance and gas exchange, making optimal ventilatory strategies essential. Driving pressure and mechanical power are considered key determinants of ventilator-induced lung stress. This study will evaluate the impact of different PEEP levels on respiratory parameters and intraoperative physiological changes.",[95,96,28,97],"Lumbar Disc Herniation","Spinal Surgery","General Anesthesia",[99,100,101,102,28,103],"PEEP","Driving Pressure","Mechanical Power","PCV-VG Ventilation","Lung Protective Ventilation","2026-04-28",{"date":106,"type":44},"2026-04-29",{"date":108,"type":21},"2026-05-01",{"date":110,"type":21},"2026-09-03",{"name":112,"class":51},"Harran University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":52},"100617991","effects-of-periodic-recruitment-maneuvers-on-atelectasis-and-respiratory-mechanics-during-elective-spine-surgery-assessed-by-lung-ultrasonography-100617991","NCT07325812","Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography","Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective lumbar spine surgery under general anesthesia\n* Surgery planned to be performed in the prone position\n* Expected surgical duration of at least 2 hours\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* History of thoracic surgery\n* Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease)\n* Clinically significant cardiac disease\n* Pregnancy or breastfeeding\n* Known airway anomalies\n\nIntraoperative surgical duration shorter than 2 hours\n\nRefusal or inability to provide informed consent",{"count":91,"type":21},[24],"During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis (partial lung collapse). Atelectasis can impair intraoperative oxygenation and may increase the risk of postoperative pulmonary complications. Alveolar recruitment maneuvers (ARM) are routinely used in anesthesia practice to reopen collapsed lung regions; however, it remains unclear whether periodic application of ARM throughout surgery provides additional benefit compared with standard single-time application.\n\nThis prospective, randomized controlled clinical study aims to evaluate whether periodic alveolar recruitment maneuvers applied during elective spine surgery in the prone position reduce intraoperative atelectasis and improve respiratory mechanics compared with the standard approach of performing ARM only after positioning and before extubation. Adult patients undergoing elective spine surgery under general anesthesia will be randomly assigned to either a periodic ARM group or a standard ARM group.\n\nLung aeration will be assessed using lung ultrasound, a non-invasive and radiation-free bedside imaging method. The primary outcome is the incidence of intraoperative atelectasis assessed before extubation. Secondary outcomes include lung ultrasound aeration scores, respiratory mechanics parameters (such as airway pressures and compliance), oxygenation indices, and the occurrence of transient intraoperative respiratory or hemodynamic events.\n\nThe findings of this study may help optimize intraoperative ventilation strategies in prone spine surgery and contribute to improved perioperative respiratory safety.",[29,124,97,28],"Mechanical Ventilation",[29,126,127,28,35],"Alveolar Recruitment Maneuver","Lung Ultrasound","2026-04-02",{"date":130,"type":44},"2026-04-08",{"date":132,"type":21},"2026-04",{"date":134,"type":21},"2026-07",{"name":136,"class":51},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":52},"100606520","the-pre-vail-study-100606520","NCT07176624","The PRE-VAIL Study","The Effect of Reducing Enteral Nutrition Before Prone Positioning on Clinical Outcomes in Mechanically Ventilated ARDS Patients: A Multicenter Randomized Controlled Trial (The PRE-VAIL Study)","Inclusion Criteria:\n\n* Age ≥18 years old\n* Within 24 hours of admission to the ICU, one or more organ systems have failed (the Sequential Organ Failure Assessment (SOFA) score of any single organ system is ≥2)\n* Meet the diagnostic criteria for moderate\u002Fsevere ARDS (even after optimizing the ventilation Settings, the oxygenation index is still \\\u003C 150mmHg and PEEP is still ≥5 cm H2O)\n* It is expected to stay in the ICU for more than 48 hours\n\nExclusion Criteria:\n\n* There are contraindications for the prone position\n* There are contraindications for EN, preventing the initiation of early EN (≤48 hours)\n* Expected to die within 48 hours\n* Pregnancy",{"count":145,"type":21},259,[24],"During the prone position, there may be an increase in intragastric pressure. The investigators focus on a scientific question: Whether reducing enteral nutrition before the prone position will benefit patients with severe mechanically ventilated acute respiratory distress syndrome (ARDS).\n\nThe experimental group had the enteral nutrition dose reduced before the prone position, while the control group did not have the enteral nutrition dose reduced",[149,28,150,151],"ARDS (Moderate or Severe)","Enteral Nutrition Feeding","Intensive Care Unit (ICU) Admission",[153,154,155,156,157,158],"ARDS","Mechanical ventilation","Prone position","Enteral nutrition","Gastric retention","Clinical outcome","2026-02-05",{"date":161,"type":44},"2026-02-09",{"date":163,"type":44},"2025-09-14",{"date":165,"type":21},"2028-02-20",{"name":167,"class":51},"The First Hospital of Jilin University",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":4},"100621788","ori-guided-fio-titration-in-prone-spine-surgery-impact-on-postoperative-atelectasis-assessed-by-lung-ultrasound-100621788","NCT07375173","ORI-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Oxygen Reserve Index-Guided FiO₂ Titration in Prone Spine Surgery: Impact on Postoperative Atelectasis Assessed by Lung Ultrasound","Inclusion Criteria:\n\n1. Adults aged 18 to 80 years\n2. Patients with an ASA physical status of I, II, or III\n3. Individuals with a body mass index (BMI) between 18 and 35 kg\u002Fm²\n\nExclusion Criteria:\n\n1. History of or active upper or lower respiratory tract infection within the past month\n2. Pulmonary emphysematous\u002Fbullous disease or COPD\n3. Pre-existing significant atelectasis or consolidation (Preoperative LUS showing a score of 3 consolidation or ≥2 regions with a score ≥2)\n4. Severe obstructive sleep apnea requiring CPAP therapy\n5. NYHA class III-IV heart failure, EF \\\u003C35%, or severe valvular disease\n6. Severe arrhythmia or hemodynamic instability requiring high-dose vasopressors\n7. Body mass index (BMI) \\>35 kg\u002Fm²\n8. Severe anemia (Hb \\\u003C9 g\u002FdL) or polycythemia (Hb \\>18 g\u002FdL)\n9. Non-diagnostic or unclear preoperative lung ultrasound images\n10. Preoperative SpO₂ ≤ 94%\n11. Inability to apply the sensor due to finger deformity, or inadequate signal caused by digital hypoperfusion","80 Years",{"count":177,"type":21},74,[24],"Atelectasis is a frequent pulmonary complication after general anesthesia, often triggered by preoxygenation and intraoperative hyperoxia. High inspiratory oxygen fractions (FiO₂) can promote absorption atelectasis, ventilation-perfusion mismatch, hemodynamic alterations, and oxidative injury.\n\nThis study evaluates the effect of two intraoperative oxygen management strategies-oxygen reserve index (ORI)-guided FiO₂ titration versus fixed 50% FiO₂-on postoperative atelectasis in patients undergoing thoracolumbar spine surgery under general anesthesia. Atelectasis severity will be assessed using lung ultrasonography (LUS), scored across 12 thoracic regions (0-3 per region, total 0-36), while respiratory function changes will be examined via preoperative and 24-hour postoperative spirometry (FVC, FEV₁, FEV₁\u002FFVC).\n\nBecause postoperative spirometry may be influenced by pain, Numeric Rating Scale (NRS) scores will be recorded to help distinguish true restrictive patterns from pain-limited respiratory effort.\n\nThe study aims to determine whether ORI-guided FiO₂ titration can reduce postoperative atelectasis and improve respiratory outcomes compared with a fixed FiO₂ approach.",[30,28,181,127,182],"Spine Surgery","Oxygen Reserve Index","2026-01-24",{"date":185,"type":44},"2026-01-29",{"date":187,"type":21},"2026-03-15",{"date":189,"type":21},"2026-11-30",{"name":191,"class":192},"Ankara Etlik City Hospital","OTHER_GOV",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":197,"acronym":198,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":206,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":52},"100398754","early-verticalization-of-the-patient-with-acute-respiratory-distress-syndrome-assessment-of-feasibility-and-safety-100398754","NCT04472260","Early Verticalization of the Patient With Acute Respiratory Distress Syndrome: Assessment of Feasibility and Safety.","STAND_ARDS1","Inclusion Criteria:\n\n* Major patient \\> 18 years of age\n* ARDS patients with PaO2\u002FFiO2 ratio \\\u003C 150 at any time within 24 hours prior to the screening visit\n* Hemodynamically stable patient with mean arterial pressure (MAP) \\> 65 mmHg maintained without vasopressor or with norepinephrine at a dosage of less than 0.5 µg\u002Fkg\u002Fmin.\n* Patient having already undergone at least 1 but less than 5 PP sessions\n* Patient under continuous intravenous sedation (IVSE) or not responding to simple order.\n* Written consent of support person or family.\n\nExclusion Criteria:\n\n* Pregnant women (positive pregnancy test during screening)\n* Breastfeeding women\n* Protected Majors\n* Body weight greater than 198 kg (bed load limit)\n* Patient with one or two lower limbs amputated at the trans tibial or upper level\n* Contraindication to standing (orthopedic fracture, neurological instability with the presence of an intracranial pressure sensor or an external ventricular shunt....)\n* Deep venous thrombosis of the lower limbs with curative anticoagulation for less than 48 hours\n* Hemodynamic instability (MAP \\\u003C 65 mm Hg) despite the use of norepinephrine at a dosage equal or greater than 0.5 µg\u002Fkg\u002Fmin.\n* Person under guardianship or trusteeship\n* Non-beneficiary patient of a health insurance plan\n* Moribund patient",{"count":201,"type":21},32,[24],"Acute Respiratory Distress Syndrome (ARDS) is defined according to the Berlin definition (1) as diffuse lung damage occurring in patients with a predisposing risk factor.\n\nPositioning in the prone position (PP) has been shown to decrease mortality in patients with moderate to severe ARDS.\n\nHowever, this technique is not without deleterious effects such as ventilator-associated pneumonia, endotracheal tube obstruction, development of pressure ulcers, and increased workload for the caregivers.\n\nThere are other positioning techniques such as the \"upright\" position, which simulates a relative verticality, which allows to increase the effects of the prone position and even in some patients to improve oxygenation without the PP in the acute phase of ARDS.\n\nHowever, given the revolution caused by the use of PP in ARDS patients, verticalization have not been studied in more details.\n\nToday, there is a bed on the market that allows patients to be truly upright without having to transfer them to a tilt table.\n\nThe investigators believe that raising ARDS patients in the acute phase is safe and feasible in routine practice. In this research protocol comparing PP and verticalization in a crossover trial design in acute ARDS patients, the investigators want to show that this technique can be safe and feasible, with the same effects on oxygenation as PP.",[205,28],"Acute Respiratory Distress Syndrome",[207,208,209,155],"Acute respiratory distress syndrome","Verticalization","Intensive Care Unit","2025-12-22",{"date":212,"type":44},"2025-12-30",{"date":214,"type":44},"2021-10-15",{"date":216,"type":21},"2026-07-14",{"name":218,"class":51},"Centre Hospitalier Régional d'Orléans",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":11,"sex":17,"minAge":227,"maxAge":4,"enrollmentInfo":228,"targetDuration":230,"studyType":231,"phases":4,"briefSummary":232,"conditions":233,"keywords":236,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":242,"lastUpdatePostDateStruct":243,"startDateStruct":245,"completionDateStruct":247,"leadSponsor":249,"locationsCount":4},"100607132","electrical-impendance-tomography-usage-in-icu-100607132","NCT07184580","Electrical Impendance Tomography Usage in ICU","Electrical Impendance Tomography Usage in ICU : Registry Creation","EITICU","Inclusion Criteria for ICU Patients:\n\n* Patient aged more than 12 years old (no pediatric EIT belt)\n* Patient monitored by an EIT belt\n\nExclusion criteria Patient who expressed opposition to participate.","12 Years",{"count":229,"type":21},1000,"2 Months","OBSERVATIONAL","Electrical Impedance Tomography (EIT) is a non-invasive, radiation-free, bedside imaging technique that has been in clinical use for over three decades (1).\n\nIt is primarily utilized to monitor regional lung ventilation in mechanically ventilated patients. In recent years, EIT has become a routine tool in critical care settings due to its capacity to provide real-time, bedside insights into pulmonary function. Its applications are diverse, ranging from support during non-invasive ventilation and endotracheal intubation (2) to the management of complex cases of mechanical ventilation. One of its key advantages lies in guiding the optimization of Positive End-Expiratory Pressure (PEEP) titration, which may help tailor ventilatory support to individual patients and potentially reduce the mechanical power delivered to the lungs(3,4).\n\nDespite these benefits, current evidence does not conclusively demonstrate a reduction in mortality associated with the use of EIT in critical care (5,6). Nevertheless, EIT shows promise in several emerging areas, such as monitoring ventilation distribution during prone positioning - even in awake, non-intubated patients (7) - and in the early detection of atelectasis under various clinical conditions (8).\n\nRecently, advancements in EIT technology have led to the development of new models capable of assessing pulmonary \"pulsatility,\" thereby expanding the potential clinical applications of EIT beyond traditional ventilation monitoring. This feature may facilitate the bedside detection of conditions such as atelectasis, pneumonia, pleural effusion, and even pulmonary embolism (9,10).\n\nIn this context, the Intensive Care Unit at Erasme Hospital is acquiring two EIT devices to enhance diagnostic capabilities and improve the care of patients requiring either non-invasive or invasive ventilation during their ICU stay. To support the systematic implementation of these devices and enable future research, it is necessary to establish a registry documenting their clinical use within the ICU. This registry will serve as a foundation for tracking usage patterns, evaluating outcomes, and potentially contributing to future scientific studies.\n\nStandard ICU data such as SOFA scores and SAPS II will be recorded, as is already routinely done in some registries like Epimed.\n\nThis registry will be specific to the Erasme ICU and will collect detailed data on ventilation parameters, EIT measurements, and recruitment maneuvers in patients undergoing mechanical ventilation-whether invasive or non-invasive-when the clinical team determines that a recruitment maneuver is indicated and chooses to use an EIT device for monitoring.\n\nData will be entered into RedCap by the attending physicians or physiotherapists responsible for the patient.\n\nData collection will be prospective, as it is not technically possible to automatically synchronize the recording of ventilation parameters and EIT measurements using the existing software systems.\n\nThere are no expected risks for the patients, as the procedures involved are considered standard practice in intensive care settings.\n\nPatients may benefit from the collection of these data, as it allows for closer monitoring of ventilation parameters during their ICU stay.\n\nAs this is a registry-based study, there will be no predefined duration or fixed number of patients. However, we estimate data will be recorded over a five-year period, with an inclusion of at least 300 patients per year.\n\nInclusion Criteria for ICU Patients:\n\n* Patient aged more than 12 years old (no pediatric EIT belt)\n* Patient monitored by an EIT belt OR Patient undergoing a recruitment maneuver OR Patient undergoing prone position.",[153,234,28,235],"Alveolar Recruitment Manoeuvres","Electrical Impedance Tomography (EIT)",[153,237,238,239,240,241],"Recruitment manoeuvres","Prone positioning","PEEP optimization","EIT","Electrical impedance tomography","2025-09-17",{"date":244,"type":44},"2025-09-22",{"date":246,"type":21},"2025-10-15",{"date":248,"type":21},"2031-04",{"name":250,"class":51},"Erasme University Hospital",{"id":252,"slug":253,"hasResults":11,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":4,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":175,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":260,"briefSummary":261,"conditions":262,"keywords":268,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":278,"locationsCount":52},"100603619","hemodynamic-effects-of-surgical-position-in-prone-vs-supine-percutaneous-nephrolithotomy-100603619","NCT07138872","Hemodynamic Effects of Surgical Position in Prone vs. Supine Percutaneous Nephrolithotomy","The Effect of Surgical Position on Hemodynamics in Percutaneous Nephrolithotomy Performed in Prone and Supine Positions","Inclusion Criteria:\n\n* ASA physical status I-III\n* Presence of renal calculi indicated for PNL\n\nExclusion Criteria:\n\n* Pregnancy\n* Uncontrolled coagulopathy\n* Previous renal surgery\n* Severe cardiac, pulmonary, or neurological disease\n* Preoperative urinary tract infection (non-sterile urine culture)\n* Surgery duration \\\u003C60 minutes or \\>120 minutes\n* Preoperative blood transfusion\n* Multiple access tracts",{"count":259,"type":21},84,[24],"This prospective, randomized controlled study evaluates the hemodynamic effects of prone and supine positions during percutaneous nephrolithotomy (PNL) for large kidney stones. Surgical position may influence intraoperative and postoperative hemodynamic stability. Prone positioning can increase intrathoracic pressure and reduce venous return, whereas supine positioning may provide greater hemodynamic stability. A total of 84 patients will be randomized to undergo PNL in prone or supine positions. Primary outcomes include changes in hemodynamic parameters during surgery. Results may guide surgical position selection, especially in patients with potential hemodynamic risk.",[263,264,28,265,266,267],"Percutaneous Nephrolithotomy (PCNL)","Surgical Positioning","Supine Position","Hemodynamic Stability","Nephrolithiasis",[269,28,270,265,271,267],"PCNL","Percutaneous Nephrolithotomy","Hemodynamic stability","2025-08-16",{"date":274,"type":44},"2025-08-24",{"date":276,"type":44},"2025-06-01",{"date":212,"type":21},{"name":279,"class":192},"Gaziosmanpasa Research and Education Hospital",{"id":281,"slug":282,"hasResults":11,"nctId":283,"briefTitle":284,"officialTitle":285,"acronym":4,"eligibilityCriteria":286,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":89,"enrollmentInfo":287,"targetDuration":288,"studyType":231,"phases":4,"briefSummary":289,"conditions":290,"keywords":293,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":301,"locationsCount":4},"100598093","measurement-of-intraocular-pressure-in-patients-undergoing-laminectomy-in-the-prone-position-100598093","NCT07067008","Measurement of Intraocular Pressure in Patients Undergoing Laminectomy in the Prone Position","Measurement of Intraocular Pressure (With Non-contact Tonometer) in Patients Undergoing Laminectomy in the Prone Position: A Clinical Study","Inclusion Criteria:\n\n* Patients scheduled for laminectomy surgery under general anesthesia\n\nPatients with ASA physical status I-II-III\n\nPatients who can cooperate postoperatively\n\nPatients without eye diseases or conditions affecting eye physiology (such as glaucoma)\n\nPatients who have not undergone eye surgery\n\nPatients who consent to participate in the study\n\nExclusion Criteria:\n\n* Patients scheduled for laminectomy surgery but not receiving general anesthesia\n\nPatients with ASA physical status IV-V\n\nPatients who do not consent to participate in the study\n\nPatients who cannot cooperate postoperatively\n\nPatients with eye diseases or conditions affecting eye physiology (such as glaucoma)\n\nPatients who have undergone eye surgery\n\nPatients from whom consent cannot be obtained",{"count":91,"type":21},"1 Day","Laminectomy surgeries, typically performed for lumbar disc herniation and spinal disorders, are often lengthy surgical procedures requiring patients to be in the prone position. While this position provides better visibility of the surgical field, it can lead to physiological changes in intraocular pressure (IOP) in anesthetized patients. An increase in IOP, though rare, has the potential to cause severe ocular complications such as postoperative vision loss (POVL), which is one of the most feared complications after spinal surgery.\n\nOne of the main mechanisms of IOP elevation in the prone position is the impediment of venous return in the head and neck region due to gravity, leading to an increase in episcleral venous pressure. Additionally, direct mechanical pressure on the face and globe can also increase IOP. Anesthesia management can also play a role in IOP dynamics by affecting intrathoracic pressure and venous return. This complex interaction necessitates careful monitoring of eye health in anesthetized patients in the prone position. Non-contact tonometers offer a non-invasive, rapid, and reliable method for IOP measurement. They are particularly advantageous for repeated measurements in anesthetized patients. This clinical study aims to evaluate changes in IOP using a non-contact tonometer in patients undergoing laminectomy in the prone position and to identify anesthesia- and patient-related factors influencing these changes. The data obtained will contribute to the development of anesthesia and positioning strategies aimed at reducing the risk of ocular complications.",[291,292,28],"Laminectomy","Intraocular Pressure",[28,292,291],"2025-07-15",{"date":296,"type":44},"2025-07-18",{"date":298,"type":21},"2025-08-15",{"date":300,"type":21},"2025-10-30",{"name":302,"class":51},"Elazıg Fethi Sekin Sehir Hastanesi",{"id":304,"slug":305,"hasResults":11,"nctId":306,"briefTitle":307,"officialTitle":307,"acronym":308,"eligibilityCriteria":309,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":310,"targetDuration":4,"studyType":22,"phases":312,"briefSummary":314,"conditions":315,"keywords":317,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":321,"lastUpdatePostDateStruct":322,"startDateStruct":324,"completionDateStruct":326,"leadSponsor":328,"locationsCount":52},"100478861","phase-2-improvement-of-lung-and-thoracic-compliance-in-ards-patients-in-prone-position-by-using-inflatable-air-bag-100478861","NCT05515484","Improvement of Lung and Thoracic Compliance in ARDS Patients in Prone Position by Using Inflatable Air Bag","MAPIC","Inclusion Criteria:\n\n* patients with ARDS under mechanical ventilation with P\u002FF ratio\\\u003C150\n* Age \\>18 y\u002Fo\n* Admitted in the medical ICU of Amiens under mechanical ventilation sedated,\n* With signed informed consent (patient or relative if patient is not conscious)\n\nExclusion Criteria:\n\n* patients not eligible for a prone position\n* Patients with tracheostomy",{"count":311,"type":21},30,[313],"PHASE2","ARDS is frequent in ICU and may lead to many complications and to death. Prone position is widely used in ADRS patients and demonstrated to decrease mortality. Regarding the chest wall compliance data are missing but the theorical response is that this compliance is decreased in a prone position mainly due to anterior chest and abdomen compression in this position which are more compliant that dorsal part of the body. As well prone position could be associated with complications as pressure ulcers. Because prone position is associated with complications, air bag were developped to decrease pressure on the chest and abdomen and to decrease pressure ulcers. Then, trying to improve chest compliance in prone position and reducing the risk of pressures ulcers could be a challenge with this system in comparison with standard care.",[153,28,124,316],"Airbag",[153,318,319,320],"prone position","mechanical ventilation","airbag","2025-05-22",{"date":323,"type":44},"2025-05-28",{"date":325,"type":44},"2022-08-23",{"date":327,"type":21},"2025-08",{"name":329,"class":51},"Centre Hospitalier Universitaire, Amiens",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":4,"eligibilityCriteria":336,"healthyVolunteers":11,"sex":17,"minAge":288,"maxAge":337,"enrollmentInfo":338,"targetDuration":4,"studyType":22,"phases":340,"briefSummary":341,"conditions":342,"keywords":344,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":52},"100506737","supporting-infant-development-through-tummy-time-positioning-and-limiting-baby-gear-100506737","NCT05878275","Supporting Infant Development Through Tummy Time, Positioning, and Limiting Baby Gear","Supporting Infant Development: The Impact of a Tummy Time Intervention on Infant Development","Inclusion Criteria:\n\n1. Parent of the infant speaks and reads English\n2. Individual is the parent or legal guardian of the infant.\n3. Infant is 1 month of age or younger\n4. Infant was carried to at least 37-weeks' gestation\n5. Parent must own a cell phone will internet access and Zoom or Face Time capability\n6. Parent must have a working email address.\n7. Parent is over the age of 18 years\n8. Family resides within a 30-min driving distance from the University of Tennessee Health Science Center,\n9. Infant birthweight of at least 2500 g\u002F 5.5 pounds\n10. Parental report of no know medical condition, health complication or problem since birth\n11. that could have an impact on infant movement behaviors or development.\n12. Parent reports that infant does not have a diagnosis of Gastroesophageal reflux disease (GERD).\n13. Family does not expect to move from the area within 3 years of enrollment\n\nExclusion Criteria:\n\n1\\. Infant is regularly cared for by an adult other than their parent for 20 hours or more per week.","4 Years",{"count":339,"type":21},50,[24],"The goal of this clinical trial is to examine the impact of an educational intervention on infant motor skill development. The main question it aims to answer is: Question 1) Does exposure to an educational intervention on infant development positively impact infant motor skill development? Researchers will compare the intervention group to the treatment as usual group see if there are differences in infant motor skill development.\n\nThe purpose of the proposed study is to determine if tummy time, play positions, screen time, and use of baby gear impacts early motor skill development in children. This is a Pilot study. A Pilot study is a small study that is carried out to collect information that will help in the planning of a larger study with the same topic.",[28,343],"Child Development",[28,345,346],"Tummy Time","Infant Development","2025-03-24",{"date":349,"type":44},"2025-03-28",{"date":351,"type":44},"2023-11-17",{"date":353,"type":21},"2028-12-31",{"name":355,"class":51},"University of Tennessee",{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":360,"acronym":4,"eligibilityCriteria":361,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":362,"targetDuration":4,"studyType":231,"phases":4,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":52},"100579660","by-assessing-the-continuous-respiratory-physiological-changes-through-prone-position-determine-the-optimal-duration-for-prone-position-100579660","NCT06827184","By Assessing the Continuous Respiratory Physiological Changes Through Prone Position, Determine the Optimal Duration for Prone Position","Inclusion Criteria:\n\n1. Acute respiratory distress syndrome\n2. Age \\> 18\n3. Serial arterial blood gas data：PaO2\u002FFiO2 \\\u003C150. The mechanical ventilator setting：FiO2\\>0.6, PEEP\\>5 cmH2O\n\nExclusion Criteria:\n\n1. Implantable electronic devices (e.g., pacemakers)\n2. Body mass index \\> 30\n3. Major thoracic and abdominal surgery\n4. Patients with unstable spine and pelvis conditions\n5. Pregnant women in the second and third trimesters\n6. Patients with head trauma, elevated intracranial pressure, or elevated intraocular pressure\n7. Hemodynamically unstable patients unsuitable for prone ventilation therapy\n8. Patients with active seizures",{"count":363,"type":21},100,"The prone position leads to a more homogeneous distribution of ventilation by inflation of collapsed alveoli and reduction in alveolar hyperinflation. By employing EIT, the study can obtain a thorough comprehension of the ongoing alterations in regional ventilation before and after adopting the prone position. It is also anticipated that there is an impact on inflammation biomarkers before and after the prone position. This assessment aids in determining the ideal duration for prone position therapy, encompassing the necessary hours and days in the prone position.",[205,28,366],"Electrical Impedance Tomography","2025-02-16",{"date":369,"type":44},"2025-02-19",{"date":371,"type":44},"2024-09-20",{"date":373,"type":21},"2030-12-31",{"name":375,"class":51},"National Taiwan University Hospital",{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":385,"briefSummary":386,"conditions":387,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":393,"completionDateStruct":395,"leadSponsor":397,"locationsCount":52},"100560081","robot-assisted-laparoscopic-partial-nephrectomy-via-the-extraperitoneal-approach-in-the-prone-position-versus-the-lateral-position-100560081","NCT06572501","Robot-assisted Laparoscopic Partial Nephrectomy Via the Extraperitoneal Approach in the Prone Position Versus the Lateral Position","Robot-assisted Laparoscopic Partial Nephrectomy Via the Extraperitoneal Approach in the Prone Position Versus the Lateral position-a Study Protocol for a Single-centre, Prospective, Randomised Controlled Trial","Inclusion Criteria:\n\n1. . Patients with preoperative imaging suggestive of renal occupancy;\n2. . Sex is not limited;\n3. . Age ≥18 years;\n4. . Clinical staging consistent with indications for partial nephrectomy;\n5. . Suitable for robotic-assisted laparoscopic partial nephrectomy via extraperitoneal approach as judged by relevant preoperative clinical data;\n6. . Agree to provide basic clinical information and pathological and imaging data for scientific research and sign an informed consent form;\n7. . Agree to provide monitoring results during the follow-up recurrence monitoring process.\n\nExclusion Criteria:\n\n1. . Patients who did not meet the indications for partial nephrectomy and did not undergo robotic-assisted laparoscopic partial nephrectomy via extraperitoneal approach;\n2. . Patients who refuse to undergo or cannot tolerate surgery in the appropriate position;\n3. . Patients with incomplete documentation of relevant data to provide accurate demographic, perioperative, and prognostic data;\n4. . Any condition which, in the opinion of the investigator, may be detrimental to the subject or result in the inability of the subject to meet or perform the requirements of the study;\n5. . Patients who are unable to provide written informed consent;",{"count":384,"type":21},200,[24],"The goal of this clinical trial is to investigate whether robot-assisted laparoscopic partial nephrectomy by extraperitoneal approach in the prone position had any advantages over the traditional lateral position. The main questions it aims to answer are:\n\nIs prone surgery safe and feasible, and what are the advantages over the traditional lateral position? Does surgery in the prone position have an impact on the patients\\' prognosis? Researchers will compare prone position to lateral position to see if robot-assisted laparoscopic partial nephrectomy by extraperitoneal approach in the prone position has any advantages over the traditional lateral position and whether it has any significant effect on the prognosis of the patients.\n\nParticipants will be randomly allocated 1:1 to two groups: prone position group and lateral position group. The enrolled patients will be underwent robotic-assisted laparoscopic partial nephrectomy via extraperitoneal approach according to the corresponding positions of their groups. Demographic indicators and perioperative-related indicators will be counted and recorded. CT or MRI and related biochemical examinations will be reviewed at 1 month, 3 months, 6 months and 1 year after surgery, and every 1 year thereafter. The similarities and differences of the indicators in different positions will be analysed, and subgroup analyses will be performed according to the corresponding results.",[388,28,389],"Renal Tumor","Robotic Assisted Partial Nephrectomy","2024-08-26",{"date":392,"type":44},"2024-08-27",{"date":394,"type":44},"2023-08-06",{"date":396,"type":21},"2030-01",{"name":398,"class":51},"The First Affiliated Hospital with Nanjing Medical University"]