[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"propofol\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:propofol":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,47,77,102,130,161,187,212,233,258,281,300,328],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100644754","remimazolam-on-the-incidence-of-postoperative-acute-kidney-injury-100644754",false,"NCT07674719","Remimazolam on the Incidence of Postoperative Acute Kidney Injury","The Effect of Intraoperative Remimazolam Administration on the Incidence of Postoperative Acute Kidney Injury After Hepatobiliary and Pancreatic Surgery : a Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Ages 19 or older and under 85\n* Patients scheduled to undergo elective hepatopancreatic surgery under general anesthesia\n* American Society of Anesthesiologists (ASA) physical grade 1-3\n* Those who voluntarily consented to a written informed consent form prior to participation in the study\n\nExclusion Criteria:\n\n* Patients with hypersensitivity to other benzodiazepine drugs, including remimazolam, and to the components of this drug (e.g., patients with severe hypersensitivity to dextran 40)\n* Patients with hypersensitivity to propofol\n* Patients with underlying conditions: liver, neurological disorders, or acute narrow-angle glaucoma\n* Patients with severe or acute respiratory failure\n* Patients in shock or a coma\n* Patients taking TCA antidepressants\n* Patients with preoperative chronic kidney disease","ALL","19 Years","85 Years",{"count":20,"type":21},78,"ESTIMATED","INTERVENTIONAL",[24],"NA","We hypothesized that in patients undergoing elective hepatobiliary-pancreatic surgery, the group in which anesthesia is induced and maintained with remimazolam during surgery would maintain hemodynamic stability and reduce the incidence of postoperative acute kidney injury compared to propofol. The purpose is to provide practical evidence for perioperative management differentiated from other surgeries for hepatobiliary-pancreatic surgery patients for whom intraoperative fluid therapy is restricted.",[27,28,29,30,31,32,33],"Remimazolam","Propofol","Acute Kidney Injury","Hemodynamic Stability","Hepatobiliary Surgery","Fluid Therapy","Fluid Therapy DURING SURGERY","NOT_YET_RECRUITING","2026-06-24",{"date":37,"type":38},"2026-06-29","ACTUAL",{"date":40,"type":21},"2026-06-26",{"date":42,"type":21},"2028-06-26",{"name":44,"class":45},"Seoul National University Bundang Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":46},"100612877","minto-and-eleveld-remifentanil-target-controlled-infusion-tci-models-a-clinical-comparison-100612877","NCT07259291","Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison","Minto and Eleveld Remifentanil Target Controlled Infusion (TCI) Models: a Clinical Comparison Through qNOX and ANIi Reactions to Post-tetanic Count","TCI","Inclusion Criteria:\n\n* Undergo general anaesthesia with Targeted Controlled Infusion of Propofol (Eleveld model) and Remifentanil (Minto or Eleveld model)\n\nExclusion Criteria:\n\n* Neurological disease\n* Psychiatric disease","FEMALE","18 Years","80 Years",{"count":59,"type":21},100,"OBSERVATIONAL","Remifentanil is commonly used as an opioid during general anesthesia. In recent years, several pharmacokinetic\u002Fpharmacodynamic (PK\u002FPD) models for target-controlled infusion (TCI) have been developed, with the Eleveld model being one of the most recent and designed for broad applicability.\n\nThe aim of this study is to compare the Eleveld TCI model with the routinely used Minto model, in order to evaluate potential differences in the predicted effect-site concentrations (CeR) required to achieve equivalent analgesia levels, as measured by qNOX (CONOX monitor) and the Analgesia Nociception Index (ANI). Post-Tetanic Count (PTC) was also assessed during the maintenance phase to investigate possible differences in nociceptive index responses between the two TCI models.",[28,63,64],"Anesthesia Brain Monitoring","Remifentanil",[66],"Analgesia monitoring","RECRUITING","2026-06-05",{"date":70,"type":38},"2026-06-08",{"date":72,"type":38},"2025-11-25",{"date":74,"type":21},"2026-12-30",{"name":76,"class":45},"University of Padova",{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100462718","phase-4-evaluation-of-propofol-dosing-based-on-total-body-weight-using-closes-loop-anaesthesia-delivery-system-100462718","NCT05305313","Evaluation of Propofol Dosing Based on Total Body Weight Using Closes-loop Anaesthesia Delivery System","Evaluation of Propofol Dosing Based on Total Body Weight Versus Adjusted Body Weight in Obese Patients Receiving Total Intravenous Anaesthesia With Automated Closed-Loop Anaesthesia Delivery System: A Randomized Controlled Study","Inclusion Criteria:\n\n1. ASA physical status II\u002FIII\n2. laparoscopic and non-laparoscopic surgery of more than 60-minutes duration\n3. Body mass index \\> 35kg\u002Fm2\n\nExclusion Criteria:\n\n1. Cardiovascular disorders (uncontrolled hypertension, Atrio-ventricular block, sinus bradycardia, congenital heart disease, reduced LV compliance \\& diastolic dysfunction)\n2. Neurological disorders (previous neurosurgery, psychiatric disorders, autonomic nervous system disorders- orthostatic hypotension, transient ischemic attacks)\n3. Hepato-renal insufficiency\n4. Uncontrolled diabetes mellitus\n5. Known allergy\u002Fhypersensitivity to study drug\n6. Pulmonary dysfunction (restrictive \u002Fobstructive lung disease)\n7. Acute\u002Fchronic drug dependence\u002Fsubstance abuse","65 Years",{"count":86,"type":21},46,[88],"PHASE4","The pharmacokinetic profile of various drugs is altered in obese patients especially those administered by the intravenous route. Propofol is the commonly used intravenous anesthetic agent for induction and maintenance of anaesthesia as part of total intravenous anaesthesia (TIVA) regimen. A major concern with propofol dosing based on total body weight (TBW) in obese patients is disproportionate drug administration leading to undue drug accumulation in body with a potential to overdosing, delayed recovery from anaesthesia, and adverse hemodynamic outcome. Studies on propofol dosing based on various weight scalars have recommended that lean body weight (LBW) should be used for calculating bolus dose during anaesthesia induction and TBW or adjusted body weight (ABW) for arriving at an infusion dose required for maintenance of anesthesia. Although propofol delivery based on dose calculated by TBW has been well researched the evidence for propofol delivery based on dose calculated by ABW is lacking.\n\nRecent advance in the delivery of propofol has been the development of computer controlled anaesthesia delivery systems. These devices deliver propofol based on patient's frontal cortex electrical activity as determined by bispectral index (BIS). Evaluation of anaesthesia delivery by these systems has shown that they deliver propofol and maintain depth of anaesthesia with far more precision as compared to manual administration. One such indigenously developed computer controlled anaesthesia delivery system is the closed loop anesthesia delivery system (CLADS). CLADS functions on control of processed EEG response parameter captured from anesthetized patients with the help of a BIS- monitor, which is continuously fed into an automated drug infusion pump. The infusion pump then accordingly delivers the anesthetic drug to the patients based on pharmacodynamic requirements. The investigators plan to evaluate the propofol maintenance dose requirement based on TBW versus ABW using CLADS for propofol delivery.",[91,92,28],"Obesity, Morbid","Anesthesia","2026-04-22",{"date":95,"type":38},"2026-04-27",{"date":97,"type":38},"2022-04-19",{"date":99,"type":21},"2027-11-10",{"name":101,"class":45},"Sir Ganga Ram Hospital",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":111,"conditions":112,"keywords":118,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":46},"100610009","induction-agent-choice-with-early-mortality-and-prognostic-outcomes-in-critically-ill-patients-100610009","NCT07222007","Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients","Association of Induction Agent Choice With Early Mortality and Prognostic Outcomes in Critically Ill Patients: A Large-Scale Retrospective Cohort Analysis","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Admission to the surgical ICU for critical care\n* Administration of one of the studied induction agents\n* Availability of complete clinical data\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Absence of documented induction agent administration\n* Incomplete or missing medical records",{"count":110,"type":21},4,"The aim of this retrospective cohort study is to compare the safety and efficacy of induction agents for tracheal intubation in critically ill adult patients.",[113,114,115,116,28,117],"Critically Ill","Intubation Complication","Oxygenation","Airway Management","Ketamine",[119],"intubation, critically ill patients, airway management","2026-04-11",{"date":122,"type":38},"2026-04-14",{"date":124,"type":21},"2026-04-18",{"date":126,"type":21},"2026-07-01",{"name":128,"class":129},"Zeliha Alicikus","OTHER_GOV",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":22,"phases":140,"briefSummary":141,"conditions":142,"keywords":147,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":46},"100593428","robotic-assisted-bronchoscopy-under-moderate-sedation-with-propofol-100593428","NCT07006311","Robotic-assisted Bronchoscopy Under Moderate Sedation With Propofol","Robotic-assisted Bronchoscopy Under Moderate Sedation With Propofol: A Single-center Pilot Study.","Robofol","Inclusion Criteria:\n\n* informed consent signed by the subject\n* aged at least 18 years\n* scheduled for bronchoscopy with moderate sedation and tracheal intubation in order to obtain at least 1 specimens of the lung via transbronchial biopsy\n* necessary periinterventional laboratory examinations needed for the bronchoscopy\n* judgement of the subject\n\nExclusion Criteria:\n\n* endobronchial lesion causing lobar atelectasis\n* inability or contraindications to undergo bronchoscopy (e.g. severe cardiopulmonary diseases, coagulation disorders, intolerance to anesthesia or endoscopic operation, psychiatric disorders or severe neurosis)\n* pregnant or lactating women",{"count":139,"type":21},30,[24],"In this study, the investigators want to find out whether robot-assisted bronchoscopy also works with moderate sedation (Propofol), as is already used in standard bronchoscopies. The study is being conducted as a pilot study. This means that it is an initial test run for a scientific investigation. The investigators are testing on a small scale whether the intervention works as predicted before a larger study is conducted.",[143,144,28,145,146],"Lung Lesions","Robotic Assisted Bronchoscopy","Bronchoscopy","Bronchoscopy Biopsy",[148,149,150,151],"Robotic-assisted bronchoscopy","robotic assisted bronchoscopy","diagnosis of lung lesions","moderate sedation","2025-09-16",{"date":154,"type":38},"2025-09-22",{"date":156,"type":38},"2025-08-14",{"date":158,"type":21},"2026-06-01",{"name":160,"class":45},"University of Zurich",{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":84,"enrollmentInfo":168,"targetDuration":4,"studyType":22,"phases":170,"briefSummary":171,"conditions":172,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":46},"100597736","sevoflurane-with-or-without-intravenous-lidocaine-infusion-versus-propofol-anesthesia-on-intracranial-pressure-and-cerebral-oxygenation-during-laparoscopic-hysterectomy-100597736","NCT07062367","Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy","Effect of Sevoflurane With or Without Intravenous Lidocaine Infusion Versus Propofol Anesthesia on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Hysterectomy: A Randomized Controlled Study","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I and Ⅱ.\n* Body mass index (BMI) ≤35.\n* Females scheduled for laparoscopic hysterectomy.\n\nExclusion Criteria:\n\n* Patients' refusal to participate in the study.\n* Hypersensitivity and allergy to drugs of the study.\n* Contraindication for optic nerve sheath diameter assessment. E.g., patient with pre-existing ophthalmic diseases, a history of ophthalmic surgery\n* Any central nervous system or cardiovascular disease, severe hepatic or renal impairment\n* Intraoperative circumstances, such as inability to perform optic nerve sheath diameter or conversion to open surgery\n* If peak inspiratory pressure (PIP) exceeds 35.",{"count":169,"type":21},90,[24],"This study will be conducted to evaluate the effects of different anesthetic modalities \\[sevoflurane with or without intraoperative lidocaine infusion and Propofol total intravenous anesthesia (TIVA)\\] on intracranial pressure (ICP) and cerebral oxygenation assessed by non-invasive methods during laparoscopic hysterectomy (LH).",[173,174,28,175,176,177],"Sevoflurane","Lidocaine","Intracranial Pressure","Cerebral Oxygenation","Laparoscopic Hysterectomy","2025-07-02",{"date":180,"type":38},"2025-07-14",{"date":182,"type":38},"2025-02-01",{"date":184,"type":21},"2027-02-01",{"name":186,"class":45},"Tanta University",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":191,"acronym":4,"eligibilityCriteria":192,"healthyVolunteers":193,"sex":16,"minAge":194,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":22,"phases":198,"briefSummary":199,"conditions":200,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":46},"100583949","comparison-of-ciprofol-and-propofol-under-ioc1-and-ioc2-monitoring-for-adenotonsillectomy-100583949","NCT06882980","Comparison of Ciprofol and Propofol Under IoC1 and IoC2 Monitoring for Adenotonsillectomy","Inclusion Criteria:\n\n* ASA I\u002FII, age 3-11 years, weight 13-50 kg.\n\nEndoscopic T\\&A or adenoidectomy.\n\nExclusion Criteria:\n\n* Recent upper respiratory infection.\n\nDifficult airway, organ dysfunction, developmental\u002Fpsychiatric disorders.\n\nDrug allergies.",true,"3 Years","11 Years",{"count":197,"type":21},236,[24],"The goal of this clinical trial is to compare the Ciprofol and Propofol Under IoC1 and IoC2 Monitoring for Adenotonsillectomy Participants will be randomly allocated to two groups: Ciprofol group (Group C) and Propofol group (Group P). For those in Group C: they will be given ciprofol during anesthesia induction and maintenance .For those in Group P: they will be pgiven ciprofol during anesthesia induction and maintenanc This study evaluates ciprofol versus propofol under IoC1\u002FIoC2 guidance in pediatric T\\&A, providing evidence for ciprofol's efficacy and safety in pediatric anesthesia.",[201,28,202],"Adenotonsillectomy","Ciprofol","2025-06-11",{"date":205,"type":38},"2025-06-12",{"date":207,"type":38},"2025-02-22",{"date":209,"type":21},"2025-11-22",{"name":211,"class":45},"Maternal and Child Health Hospital of Hubei Province",{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":22,"phases":220,"briefSummary":221,"conditions":222,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":4},"100585857","comparison-of-sevoflurane-and-propofol-on-ani-100585857","NCT06907823","Comparison of Sevoflurane and Propofol on ANI","Comparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study","Inclusion Criteria:\n\n* American society of anesthesiologists physical status class I or II\n\nExclusion Criteria:\n\n* history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc.\n* history of allergic reaction to sevoflurane and\u002For propofol\n* history of and\u002For family history of malignant hyperthermia\n* neurodegenerative disorder\n* psychiatric disorder\n* arrhythmia\n* diabetes mellitus\n* drug abuse history",{"count":139,"type":21},[24],"The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.",[28,173,223],"Analgesia Nociception Index","2025-06-08",{"date":226,"type":38},"2025-06-10",{"date":228,"type":21},"2025-06-30",{"date":230,"type":21},"2025-12-31",{"name":232,"class":45},"Pusan National University Yangsan Hospital",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":240,"targetDuration":4,"studyType":22,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":46},"100571176","remimazolam-besylate-in-sedation-of-postcardioperative-patients-100571176","NCT06716840","Remimazolam Besylate in Sedation of Postcardioperative Patients","Remimazolam Besylate Versus Propofolfor Sedation of Postcardioperative Patients in Intensive Care Unit: a Prospective,Single-center,Randomized Non-inferior Trial","Inclusion Criteria:\n\n1. age ≥ 18 years ;\n2. admitted to the intensive care unit after cardiac surgery with techanical ventilation；\n3. expected to extubation within 48hours ；\n4. participant has given informed consent\n\nExclusion Criteria:\n\n1. pregnant or lactating women\n2. known or suspected hypersensitivity to the study drug\n3. history of impaired consciousness or psychiatric illness\n4. severe bradycardia with a heart rate of \\\u003C 50 beats per minute\n5. systolic blood pressure \\\u003C 90 mmHg with fluid resuscitation and vasopressor maintenance\n6. atrioventricular block（II or III degree）, Left ventricular ejection fraction(LVEF) \\\u003C30%\n7. participated in other clinical studies within 3 months",{"count":241,"type":21},120,[24],"Intensive care medicine is vital in managing patients after cardiac surgery with endotracheal intubation，in order to provide extensive monitoring to assure clinical stabilization. During this time of recovery, sedation is frequently employed. However, prolonged sedation risks negative sequelae.At present,propofol, benzodiazepines, and dexmedetomidine are typical drugs used for sedation of patients in intensive care unit.Each has its own advantages and disadvantages.The investigators try to find near-ideal agents for sedation,characterized by good sedative effect,minimal adverse effects and rapid awakening facilitating earlier extubation.Remimazolam appeared to be an effective and safe sedative for short term sedation. Study participants were predicated on age (\\> 18 years), admission following cardiac surgery, still mechanical ventilation within 48 hours,and prior informed consent.Participants were randomized to receive remimazolam besylate or propofol in a 1:1 ratio for sedation with a target sedation depth before extubation.Finally，the investigators will compare the sedation effect and safety between the 2 groups ，to prove if remimazolam is appropriate for sedation in patients after cardiac surgery in intensive care unit.",[27,28,245,246,247,248],"Sedation","Mechanical Ventilation","Intensive Care","Cardiac Surgery","2025-02-16",{"date":251,"type":38},"2025-02-18",{"date":253,"type":38},"2025-02-10",{"date":255,"type":21},"2025-05-31",{"name":257,"class":45},"First Affiliated Hospital of Zhejiang University",{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":4,"eligibilityCriteria":264,"healthyVolunteers":193,"sex":16,"minAge":56,"maxAge":84,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":267,"briefSummary":268,"conditions":269,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":46},"100575675","the-effect-of-general-anesthesia-with-remimazolam-and-propofol-on-rhythmic-state-and-cognitive-function-100575675","NCT06775366","The Effect of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function","Effects of General Anesthesia with Remimazolam and Propofol on Rhythmic State and Cognitive Function","Inclusion Criteria:\n\nAge 18-65 years old, ASAI-III class, BMI18.5-25kg\u002Fm2 Inpatients undergoing laparoscopic cholecystectomy The estimated time of operation is 1.5\\~2.5 hours Preoperative brief mental status examination (MMSE) score ≥24 Voluntary participation and signed informed consent\n\nExclusion Criteria:\n\nPregnant or lactating women Patients who are allergic to remimazolam or contraindicated Patients who are dependent on or tolerant to opioids or have long-term alcoholism Serious cardiovascular system, respiratory system, liver and kidney diseases History of obstructive sleep apnea mental disorders or neurological diseases Patients who participated in clinical trials of other drugs within the last 3 months The attending physician or researcher considers that there are other circumstances that are not suitable for participation in this study Refuse to participate in the study",{"count":266,"type":21},174,[24],"This study want to observe the effects of remimazolam and propofol for general anesthesia on postoperative rhythm and cognitive function. The observation group was given remimazolam for general anesthesia, and the control group was given propofol for general anesthesia. Both drugs are commonly used as intravenous anesthetics for general anesthesia and have been shown to be safe for use in general anesthesia. The investigators hope can understand the effects of remimazolam and propofol for general anesthesia on rhythm status and cognitive function through this study, further reduce the occurrence of postoperative cognitive function impairment, and enable subjects to better recover.",[270,28,27,271],"Cognitive Functioning","Circadian Rhythm","2025-02-12",{"date":274,"type":38},"2025-02-14",{"date":276,"type":21},"2025-02-24",{"date":278,"type":21},"2026-05-30",{"name":280,"class":45},"The Second Affiliated Hospital of Chongqing Medical University",{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":289,"conditions":290,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":294,"startDateStruct":295,"completionDateStruct":297,"leadSponsor":298,"locationsCount":46},"100526714","the-effects-of-anesthetics-on-brain-network-connectivity-in-patients-with-supratentorial-glioma-100526714","NCT06138340","The Effects of Anesthetics on Brain Network Connectivity in Patients With Supratentorial Glioma","The Alterations of Brain Network Connectivity Under Sedation and Anesthesia in Patients With Supratentorial Glioma","Inclusion Criteria:\n\n* Diagnosed as unilateral supratentorial glioma by MRI\n* Selective operation\n* Age over 18 years old\n* ASA I-II\n* Right handedness\n\nExclusion Criteria:\n\n* History of cerebrovascular disease, brain trauma, chemotherapy and radiotherapy, or psychotropic drugs\n* History of intracranial surgery\n* Drug and\u002For alcohol abuse\n* History of dementia or mental illness\n* Pregnant or lactating women\n* Contraindications for MRI\n* Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block\n* Severe hepatic or renal dysfunction",{"count":241,"type":21},"Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.",[291,292,293,28],"Brain Network Connectivity","Postoperative Delirium","Dexmedetomidine",{"date":274,"type":38},{"date":296,"type":38},"2023-08-31",{"date":230,"type":21},{"name":299,"class":45},"Beijing Tiantan Hospital",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":306,"eligibilityCriteria":307,"healthyVolunteers":11,"sex":55,"minAge":56,"maxAge":4,"enrollmentInfo":308,"targetDuration":4,"studyType":22,"phases":309,"briefSummary":310,"conditions":311,"keywords":313,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":46},"100556254","virtual-reality-for-anxiolysis-and-pharmacological-sparing-100556254","NCT06522711","Virtual Reality for Anxiolysis and Pharmacological Sparing","Virtual Reality as a Strategy for Intra-operatory Anxiolysis and Pharmacological Sparing in Patients Undergoing Breast Surgeries : the V-RAPS Randomized Controlled Trial","V-RAPS","Inclusion Criteria:\n\n* Fully consented female patients above the age of 18 years;\n* Undergoing elective, awake, breast surgery performed under paravertebral block.\n\nExclusion Criteria:\n\n* Hearing or visual impairment;\n* History of epilepsy, seizure or severe dizziness;\n* Severe mental impairment;\n* Recent eye or facial surgery or wounds;\n* Inability to use the VR hand controller.",{"count":59,"type":21},[24],"The goal of this clinical trial is to learn if virtual reality can reduce propofol requirements in adult, female patients undergoing elective breast surgery under regional anesthesia. The main question it aims to answer is:\n\nCan virtual reality immersion reduce intra-operative propofol requirements in adult female patients undergoing elective breast surgery under regional anesthesia?\n\nResearchers will compare time and weight-adjusted average propofol requirements in both the intervention group and the control group to see if there is a reduction in sedative usage in the group using the virtual reality device.\n\nParticipants will be randomly assigned to either a virtual reality (intervention) group or a control group.\n\n* The patients in the virtual reality group will have a virtual reality headset on during the surgery with a preselected scenario of their choice.\n* Both groups will have access to patient-controlled sedation under the supervision of an anesthesiologist and will be permitted to self-administer propofol boluses as needed.",[312,28],"Virtual Reality",[314,315,316,317,28,318],"Virtual reality","Anxiety","Patient-controlled sedation","Pain","Breast surgery","2024-07-25",{"date":321,"type":38},"2024-07-26",{"date":323,"type":21},"2024-09-01",{"date":325,"type":21},"2026-09-01",{"name":327,"class":45},"Ciusss de L'Est de l'Île de Montréal",{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":332,"acronym":4,"eligibilityCriteria":333,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":84,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":341,"lastUpdatePostDateStruct":342,"startDateStruct":344,"completionDateStruct":345,"leadSponsor":346,"locationsCount":46},"100555078","additive-effects-of-clonidine-used-in-propofol-sedation-in-colonoscopy-100555078","NCT06507410","Additive Effects of Clonidine Used in Propofol Sedation in Colonoscopy","Inclusion Criteria:\n\n* Age 18-65 years.\n* Both sexes.\n* American Society of Anesthesiology (ASA) physical status I-II.\n* Patients undergoing colonoscopy.\n\nExclusion Criteria:\n\n* Patients had recent history of colonoscopy.\n* Previous colonic resection.\n* Severe heart failure (ejection fraction \\\u003C 30%).\n* Known history of hypersensitivity to propofol or clonidine and any need for anesthetic drug administration other than the study protocol.",{"count":335,"type":21},62,[24],"The objective of this study was to compare safety, satisfaction, and efficiency outcomes of propofol versus propofol with clonidine in patients undergoing colonoscopy.",[339,28,245,340],"Clonidine","Colonoscopy","2024-07-20",{"date":343,"type":38},"2024-07-23",{"date":341,"type":38},{"date":323,"type":21},{"name":186,"class":45}]