[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"prospective-study\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:prospective-study":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,74,106,140],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100611667","phase-1-prospective-clinical-study-on-human-umbilical-cord-mesenchymal-stem-cell-derived-exosomes-for-the-treatment-of-childhood-autism-100611667",false,"NCT07243561","Prospective Clinical Study on Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Childhood Autism","EXO-ASD","Inclusion Criteria:\n\n* Diagnosis meets the ICD-11 ASD criteria or DSM-5 ASD clinical diagnostic standards.\n* No significant improvement in core symptoms was observed after ≥3 months of standardized behavioral intervention.\n* Score ≥30 on the CARS2, indicating mild-to-moderate or more severe autism.\n* Aged 3 (inclusive) to 7 (inclusive) years, regardless of gender\n* Voluntary participation in this clinical study, with written informed consent provided by the patient's legal guardian, and willingness to undergo examinations, treatment, and cooperate with follow-up visits.\n* In the investigator's judgment, the patient is capable of understanding and complying with study requirements.\n\nExclusion Criteria:\n\n* History of severe allergic reactions.\n* Any severe mental disorder or other types of autism spectrum disorders.\n* History of epileptic seizures within the past six months.\n* Autism secondary to epilepsy, cerebrovascular disease, or traumatic brain injury.\n* Disease severity rated as normal, borderline mental disorder, or mild mental disorder on the Clinical Global Impression scale.\n* Moderate or severe extrapyramidal symptoms or tardive dyskinesia.\n* Severe self-injurious behavior.\n* Active systemic or severe localized infections, including human immunodeficiency virus, syphilis, and hepatitis.\n* Autoimmune diseases.\n* Major organ impairment.\n* Severe pulmonary or hematological diseases, malignancies, or immunodeficiency.\n* Concurrent treatments that may interfere with the safety and efficacy evaluation of stem cell therapy.\n* Participation in other clinical trials within the past three months.\n* Other clinical conditions deemed by investigators as unsuitable for study inclusion.","ALL","3 Years","7 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24,25],"PHASE1","PHASE2","This clinical study aims to evaluate whether a nasal spray containing exosomes derived from human umbilical cord mesenchymal stem cells (hUC-MSC-EXOs) can safely and effectively improve core symptoms in children aged 3-7 years with autism spectrum disorder (ASD). It is a 24-week, randomized, controlled, open-label trial. Forty pediatric patients with ASD will be randomly assigned at a 1:1 ratio to two groups: an active exosome nasal spray treatment group and a no-intervention control group. The treatment group will receive the nasal spray every other day, totaling 10 administrations throughout the study. The no-intervention control group will receive no experimental treatment but will undergo the same assessments and safety checks concurrently with the treatment group. This design aims to monitor the safety and efficacy of the hUC-MSC-EXOs nasal spray.",[28,29],"Autism Spectrum Disorder (ASD","Prospective Study",[31,32,33],"Autism Spectrum Disorder","umbilical cord mesenchymal stem cells","exosome","RECRUITING","2026-04-12",{"date":37,"type":38},"2026-04-14","ACTUAL",{"date":40,"type":38},"2025-09-01",{"date":42,"type":21},"2026-07-30",{"name":44,"class":45},"Dongfang People's Hospital","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":59,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":46},"100622519","environmental-and-behavioral-factors-in-infertility-and-art-outcomes-100622519","NCT07384676","Environmental and Behavioral Factors in Infertility and ART Outcomes","A Large-Scale Prospective Cohort Study on the Association of Environmental Exposures and Behavioral Factors With Infertility and Assisted Reproductive Technology (ART) Success Rates","Inclusion Criteria:\n\n* A. Women aged 18 to 46 who use their own eggs; Men aged 18 to 55 who use their own sperm; B. Patients meeting the diagnostic criteria for infertility; C. Medical history clearly indicating the duration of persistent infertility; D. Voluntarily participating in the project and signing the informed consent form;\n\nExclusion Criteria:\n\n* A. The groups of artificial insemination patients with any of the following ARTs contraindications: a. The female has a sperm-egg combination disorder caused by tubal factors. b. The female has acute infections of the reproductive and urinary systems or sexually transmitted diseases. c. The female has genetic diseases, severe physical illnesses, or mental and psychological disorders. d. There is a history of giving birth to infants with congenital defects and it has been confirmed that the defect was caused by the female. e. The female has been exposed to teratogenic doses of radiation, toxins, or drugs and is in the active period. f. The female has bad habits such as alcoholism or drug abuse. B. The groups of first-generation and second-generation IVF patients with any of the following ARTs contraindications: a. Either of the parties providing gametes has acute infections of the reproductive and urinary systems and sexually transmitted diseases or has bad habits such as alcoholism or drug abuse. b. Either of the parties providing gametes has been exposed to teratogenic doses of radiation, toxins, or drugs and is in the active period. c. The female partner of the recipient who provides eggs or embryos has acute infections of the reproductive and urinary systems and sexually transmitted diseases, or has bad habits such as alcoholism or drug abuse. d. The female has an unviable uterus or severe physical illnesses that cannot withstand pregnancy. C. No embryo transfer was performed after egg retrieval; D. More than 180 days have passed since egg retrieval and frozen embryo transfer was performed.",true,"18 Years","46 Years",{"count":58,"type":21},5000,"18 Months","OBSERVATIONAL","This large-scale study aims to understand how everyday environment and lifestyle may affect the success of fertility treatments like IVF. The main idea is that exposure to certain environmental chemicals (e.g., from plastics or air pollution) and personal habits (e.g., diet, stress) could be linked to whether these treatments result in a successful pregnancy and live birth.\n\nThe study will follow approximately 5,000 couples undergoing fertility treatment in Hunan, China. Participants will answer questionnaires about their health, lifestyle, and environment and provide small biological samples (like blood and urine) during their standard treatment process. Their treatment outcomes will be tracked anonymously.The goal is to identify factors that might lower the chances of treatment success. This knowledge could help future patients and doctors make informed decisions and could guide public health advice on reducing potential risks. The study has received ethical approval, and all participant information will be kept strictly confidential.",[63,64,29],"Environmental Exposure","Assisted Reproductive Technology","2026-01-26",{"date":67,"type":38},"2026-02-03",{"date":69,"type":38},"2024-12-01",{"date":71,"type":21},"2034-12-31",{"name":73,"class":45},"The Third Xiangya Hospital of Central South University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":80,"minAge":55,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":83,"conditions":84,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100613914","maternal-informing-on-labor-induction-impact-on-childbirth-experience-100613914","NCT07272785","Maternal Informing on Labor Induction: Impact on Childbirth Experience","Inclusion Criteria:\n\n* Planned induction of labor at the antenatal ward or at the outpatient clinic\n* Adequate language skills (Finnish, Swedish, English)\n\nExclusion Criteria:\n\n* Induction at the delivery ward or at the obstetric emergency care clinic\n* Spontaneous onset of labor or a planned cesarean delivery\n* Age below 18 years at the time of recruitment","FEMALE",{"count":82,"type":21},50,"The aim of this study is to explore the information provided to mothers about labor induction and its connection to their childbirth experience. In addition, the study examines how the use of social media may influence the birth experience among patients undergoing labor induction.",[85,86,87,88,29,89,90],"Labor, Induced","Labor, Obstetric","Pregnancy","Humans","Prospective Study , Questionaires","Childbirth Experience",[92,93,87,94,95],"Childbirth experience","Induction of labor","Childbirth","Obstetrics","2025-12-16",{"date":98,"type":38},"2025-12-23",{"date":100,"type":38},"2025-12-08",{"date":102,"type":21},"2026-06",{"name":104,"class":105},"Turku University Hospital","OTHER_GOV",{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":119,"conditions":120,"keywords":124,"overallStatus":130,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":46},"100607949","clinical-evaluation-of-additive-and-subtractive-onlay-restorations-100607949","NCT07195201","Clinical Evaluation of Additive and Subtractive Onlay Restorations","Prospective Evaluation of Onlay Restorations Produced by Additive and Subtractive Manufacturing in Vital Posterior Teeth: A Split-Mouth","CIP-ONLAY","Inclusion Criteria:\n\nParticipant-Level Criteria\n\n* Adults aged 18-84 years\n* No active periodontal disease (probing depth ≤ 3 mm, no clinical attachment loss)\n* No parafunctional habits such as bruxism, clenching, or foreign object chewing\n* Willingness to attend regular follow-up visits during the study period\n* Adequate oral hygiene status\n* No history of systemic disease or medically stable condition if present\n* No history of similar restorative procedures involving the target teeth Tooth-Level Criteria\n* Vital posterior teeth (premolars or molars) confirmed by thermal or electric pulp testing; teeth requiring endodontic treatment or with necrosis will be excluded\n* Permanent posterior teeth located in functional occlusion (premolar or molar region)\n* Teeth with moderate structural loss suitable for onlay restorations, including mesio-occlusal (MO), disto-occlusal (DO), or mesio-occluso-distal (MOD) cavities with partial crown loss but sufficient remaining tooth structure not requiring full coverage\n* Periodontally healthy teeth with no mobility, no clinical attachment loss, and probing depth ≤ 3 mm\n* Teeth that can be matched in contralateral quadrants to allow split-mouth design (structurally and clinically comparable teeth)\n* Teeth free from cracks, fractures, or internal resorption; supporting tissues without structural defects that may compromise restoration success\n* Teeth with clearly defined preparation margins located in enamel or sound dentin; subgingival margins extending deep into the sulcus will not be included\n* Teeth without previous extensive prosthetic restorations (crowns, inlays\u002Fonlays, or implant-supported restorations)\n* Opposing natural teeth in stable occlusal contact with the restored tooth\n\nExclusion Criteria:\n\n* Teeth with pulp necrosis or a history of endodontic treatment (previous root canal therapy or non-vital teeth)\n* Teeth with excessive tissue loss requiring full crown coverage and unsuitable for onlay restoration\n* Teeth presenting with cracks, fractures, internal or external resorption, or structural defects compromising prognosis\n* Advanced periodontal disease, including clinical attachment loss, furcation involvement, mobility, or probing depth \\> 3 mm\n* Teeth with subgingival cavity margins extending deep into the gingival sulcus, increasing periodontal risk\n* Teeth with a history of fixed prosthetic restorations (previous crowns, inlays\u002Fonlays, or bridge restorations)\n* Teeth lacking proximal contacts due to adjacent tooth absence, leading to compromised contact stability and occlusal load distribution\n* Teeth in regions with orthodontic appliances or fixed retainers that may interfere with restorative procedures or evaluation\n* Opposing teeth absent or lacking stable occlusal contact with the restoration site\n* Patients with systemic diseases contraindicate elective dental treatment (e.g., uncontrolled diabetes, immunocompromised status)\n* Pregnant or breastfeeding women\n* Patients unable or unwilling to attend scheduled follow-up visits \\[baseline (1 week), 6 months, 12 months, and 18 months\\]","84 Years",{"count":116,"type":21},29,[118],"NA","The goal of this clinical trial is to learn whether onlay restorations produced by additive manufacturing \\[three-dimensional (3D) printing\\] and subtractive manufacturing \\[Computer-Aided Design\u002FComputer-Aided Manufacturing (CAD\u002FCAM) milling\\] perform equally well in vital posterior teeth. The main questions it aims to answer are:\n\n* Do 3D printed onlay restorations show similar marginal adaptation and clinical performance compared to CAD\u002FCAM milled onlays?\n* Are there any differences in biological compatibility, surface properties, or postoperative sensitivity between the two techniques over time? Researchers will compare onlay restorations fabricated with 3D printing and CAD\u002FCAM milling using a split-mouth study design.\n\nParticipants will:\n\n* Receive one onlay restoration produced by 3D printing and another produced by CAD\u002FCAM milling, placed on opposite sides of the mouth\n* Have checkups at baseline (1st week), 6 months, 12 months, and 18 months after treatment\n* Be evaluated using the Fédération Dentaire Internationale (FDI) criteria for marginal adaptation, surface quality, anatomical form, and biological compatibility",[121,29,122,123],"CAD-CAM","3D Printing","Clinical Assessment",[125,126,127,128,129],"onlay restorations","cad-cam","additive manufacturing","3D printing","FDI criteria","NOT_YET_RECRUITING","2025-09-23",{"date":133,"type":38},"2025-09-26",{"date":135,"type":21},"2025-11-15",{"date":137,"type":21},"2027-08-31",{"name":139,"class":45},"Ayse Tugba Erturk Avunduk",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":54,"sex":16,"minAge":147,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":150,"conditions":151,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":46},"100596676","health-related-physical-fitness-and-executive-function-in-older-adults-a-prospective-study-100596676","NCT07048561","Health-related Physical Fitness and Executive Function in Older Adults: A Prospective Study","Changes in Health-related Physical Fitness on the Behavioural and Electrophysiological Aspects of Cool and Hot Executive Function in Older Adults: A Prospective Study","Inclusion Criteria:\n\n* Age 65 or above.\n* Able to engage in fitness testing.\n* Normal vision or corrected-to-normal vision.\n\nExclusion Criteria:\n\n* Suffering from cardiopulmonary-related diseases.\n* Suffering from cognitive, neurological or psychiatric disorders (e.g., dementia, Parkinson's disease, epilepsy, depression, schizophrenia, etc.).\n* Suffering from infectious diseases (e.g., hepatitis, human immunodeficiency virus or Creutzfeldt-Jakob disease).\n* Having a history of drug or alcohol abuse.\n* Having colour vision deficiency (e.g., colour blindness).\n* Having a family history of aneurysm.\n* Taking medications that affect brain function.","65 Years",{"count":149,"type":21},200,"This study aims to explore the relationship between health-related physical fitness and behavioural and electrophysiological aspects of cool and hot executive function in older adults through a year prospective study design. The main questions it aims to answer whether changes in health-related physical fitness will positively predict changes in behavioural and electrophysiological aspects of cool and hot executive functions in older adults. The participants will be asked to complete pre-test, a one-year observation period, and post-test. Both pre- and post-tests will measure health-related physical fitness, executive function, and various demographic variables and covariates. Health-related physical fitness assessments include cardiorespiratory endurance (YMCA submaximal cycle test), muscular strength (grip strength, chest press, and leg press), muscular endurance (30-second chair stand, 30-second bicep curl), flexibility (range of motion), and balance (Balance Error Scoring System). Executive function will be measured using the Stroop test and emotional Stroop test, with concurrent EEG recording of brain activity. Demographic variables and covariates include sex, age, years of education, annual income, Pittsburgh Sleep Quality Index (PSQI), International Physical Activity Questionnaire (IPAQ) Taiwan short form, World Health Organisation Quality of Life Brief Assessment (WHOQOL-BREF) Taiwan version, Geriatric Depression Scale, Mini-Mental State Examination (MMSE), digit span tests, and step count recorded by mobile phones or watches over the previous month, resting heart rate, and resting blood pressure. No interventions will be conducted during the one-year observation period, maintaining participants' normal daily living conditions.",[152,153,154,29,155],"Older Adults (65 Years and Older)","Fitness Testing","Executive Function (Cognition)","Event-Related Potentials","2025-06-29",{"date":158,"type":38},"2025-07-02",{"date":160,"type":38},"2025-06-01",{"date":162,"type":21},"2027-03-31",{"name":164,"class":45},"National Taiwan Normal University"]