[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"protein-malnutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:protein-malnutrition":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100590306","the-effect-of-a-plant-based-protein-dense-sauce-on-essential-amino-acid-concentrations-and-gut-fullness-in-older-adults-100590306",false,"NCT06965699","The Effect of a Plant-based, Protein-dense Sauce on Essential Amino Acid Concentrations and Gut Fullness in Older Adults","Testing the Effect of a Plant-based, Protein-dense Sauce (ProSauce) on Metabolic Availability of Essential Amino Acids and Gut Fullness and Satiety in Older Adults","ProSauce","Inclusion Criteria:\n\n* Aged 60 and over\n* Living independently in the community\n* Capacity to provide informed consent\n* Non-smoking (vaping is considered smoking)\n* No known medical conditions that might influence the study outcomes, e.g., heart disease, diabetes mellitus, obesity, disthyroidism and other endocrinopathies and renal failure\n* Not taking any medications that might influence the study outcomes e.g., taking anabolic steroids or corticosteroids long term\n* No clinically diagnosed eating disorders\n* No severe dislike or allergy to any of the study food\n* No hospitalisations in the last 6 months\n* Not dieting and weight stable for 3 months before the study (\\\u003C 3 kg change in weight)\n\nExclusion Criteria:\n\n* Age \\\u003C 60y\n* Smoking\n* Food allergies\n* Cognitive and mobility issues\n* Hospitalisation in the last 6 months\n* Known medical conditions that might influence the study outcomes\n* Taking medications that influence the study outcomes",true,"ALL","60 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to determine whether meals fortified with plant-based high protein sauce (ProSauce) provide better metabolic availability of essential amino acids compared to meals with standard lower-protein sauce without resulting in excessive gut fullness and satiety. The main questions it aims to answer are:\n\nDoes meals with high-protein sauce deliver better metabolic availability of amino acid profile? Does this high-protein sauce also not lead to excessive appetite suppression due to its liquid form? Researchers will compare high protein sauce to a commercially available standard low protein sauce.\n\nParticipants will consume two meals, either protein-fortified or standard low-protein sauce, in a randomised order with at least a one-week washout period between each meal. The investigators will collect venous blood samples over a 6-hour postprandial period to measure plasma essential (and non-essential) amino acid and insulin concentrations. The investigators will also measure appetite-related hormones from venous plasma and assess subjective appetite using a visual analogue scale, taken in parallel with the blood sample time points.",[28,29],"Malnutrition Elderly","Protein Malnutrition",[31,32,33,34],"plant-based protein sauce","older adults","amino acid metabolic availability","appetite regulation","RECRUITING","2025-09-17",{"date":38,"type":39},"2025-09-23","ACTUAL",{"date":41,"type":39},"2025-07-10",{"date":43,"type":22},"2026-04-30",{"name":45,"class":46},"University of Exeter","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":59,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":69,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":47},"100488978","impact-of-very-high-protein-content-enteral-nutrition-formulas-on-critically-ill-multiple-trauma-patients-100488978","NCT05647135","ImpACt of Very High Protein Content Enteral nUtrition Formulas on Critically Ill MUltipLe trAuma paTiEnts","ImpACt of Very High Protein Content Enteral nUtrition Formulas on Protein Metabolism and Residual Gastric Volume in Critically Ill MUltipLe trAuma paTiEnts","ACCUMULATE","Inclusion Criteria:\n\n* Adult patients (\\>18 yrs) admitted to the ICU\n* Multiple trauma (Injury severity score \\> 18)\n* Intubation and mechanical ventilation upon admission in ICU or during the first 24 hours of admission, for at least 48 h\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnant women\n* Patients not intubated or not mechanically ventilated or receiving only non-invasive ventilation\n* Patients with enteral feeding contraindication 48 h after admission\n* Patients with recent gastrointestinal surgical intervention\n* Patients on chronic therapy with corticosteroids","18 Years",{"count":58,"type":22},70,"8 Weeks","OBSERVATIONAL","This prospective observational randomized study aims to determine energy, protein intake and gastrointestinal tolerance while using enteral nutrition formulas with very high protein content and enteral nutrition formulas with normal protein content.\n\n* Differences regarding achieving protein and calorie daily targets when using enteral nutrition formulas with different protein content\n* Differences regarding residual gastric volume when using enteral nutrition formulas with different protein content\n* Differences regarding body composition when using enteral nutrition formulas with different protein content",[63,64,65,29,66,67,68],"Metabolism","Trauma","Nutritional Deficiency","Gastroparesis","Muscle Loss","Calorie Malnutrition Protein",[70,71,72,73,74,75,76],"enteral nutrition","multiple trauma","energy target","protein target","body composition","gastric residual volume","enteral nutrition intolerance","2024-07-17",{"date":79,"type":39},"2024-07-22",{"date":81,"type":39},"2023-03-01",{"date":83,"type":22},"2024-12-01",{"name":85,"class":46},"Romanian Society for Enteral and Parenteral Nutrition",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":47},"100551307","comparison-of-clinical-outcomes-according-to-high-protein-provision-in-critically-ill-patients-after-abdominal-surgery-100551307","NCT06458387","Comparison of Clinical Outcomes According to High-protein Provision in Critically Ill Patients After Abdominal Surgery","Comparison of Clinical Outcomes According to High-protein Provision Through Parenteral Nutrition in Critically Ill Patients Immediately After Abdominal Surgery: a Prospective, Single-blinded, Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients admitted after abdominal surgery to our institution's surgical ICU\n* They were enrolled regardless of the surgical method, either open, laparoscopy, or robotic.\n\nExclusion Criteria:\n\n* aged under 18 years\n* underwent surgery under local or regional anesthesia\n* pregnant\n* readmitted to the ICU due to any cause\n* diagnosed with renal failure and receiving renal replacement therapy\n* patients diagnosed with multiorgan failure, represented by a high Sequential Organ Failure Assessment (SOFA) score (≥9) upon ICU admission\n* failed to provide informed consent, or with 'do-not-resuscitate' status.",{"count":94,"type":22},152,[25],"Protein malnutrition in critically ill patients is a global concern due to its association with prolonged hospital stays, and higher morbidity rates. Patients who undergo abdominal surgery are particularly vulnerable due to alterations in gastrointestinal function and prolonged fasting. Despite the significance of proper nutrition, the optimal target of protein supplementation remains controversial.\n\nThe investigators aimed to evaluate the effects of high protein provision, targeting a protein intake of at least 1.5 g\u002Fkg\u002Fday for the first 3 days after abdominal surgery, on 6-month mortality.",[29],"NOT_YET_RECRUITING","2024-06-11",{"date":101,"type":39},"2024-06-13",{"date":103,"type":22},"2024-07",{"date":105,"type":22},"2027-06",{"name":107,"class":46},"Seoul St. Mary's Hospital"]