[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"protein-metabolism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:protein-metabolism":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,48,75,111,130,149,168,195,223,244,267,290,319,342,376],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644846","effects-of-protein-type-and-mineral-form-on-amino-acid-availability-100644846",false,"NCT07677098","Effects of Protein Type and Mineral Form on Amino Acid Availability","Effects of Protein Type and Mineral Form on Postprandial Amino Acid Availability in Healthy Young Adults: a Randomized Cross-over Study","ProMin","To be eligible to participate in this study, a participant must meet all of the following criteria:\n\n* Male or female sex\n* Aged between 18 - 35 years inclusive\n* BMI between 18 - 30 kg\u002Fm2\n* Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)\n* No physical limitations (i.e., able to perform all activities associated with daily living independently)\n\nA potential participant who meets any of the following criteria will be excluded from participation in this study:\n\n* Intolerant to milk protein and\u002For dairy-based products\n* Smoking regularly\n* Diagnosed with gastro-intestinal disorders\n* Diagnosed with metabolic disorders (e.g. diabetes)\n* Diagnosed with musculoskeletal disorders\n* Blood donation in the past 2 months\n* Females: pregnancy\n* Use of any medication known to affect protein metabolism (e.g. corticosteroids, non-steroidal anti-inflammatories or prescribed acne medications)\n* Chronic use of gastric acid suppressing drugs (e.g. proton pump inhibitors, H2-antagonists)",true,"ALL","18 Years","35 Years",{"count":22,"type":23},16,"ESTIMATED","INTERVENTIONAL",[26],"NA","To compare postprandial plasma amino acid availability, expressed as incremental area under the curve (iAUC), over a 6 hour period following ingestion of 25 g of different protein isolates in healthy, young adults. The primary objective is divided into the following 2 sub-studies, each with 3 comparisons:\n\n* Sub-study 1: whey protein, calcium caseinate, sodium caseinate.\n* Sub-study 2: calcium caseinate, magnesium caseinate, potassium caseinate.",[29],"Protein Metabolism",[31,32,33,34],"Amino acid","Satiety hormone","Minerals","Protein kinetics","NOT_YET_RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-30","ACTUAL",{"date":41,"type":23},"2026-09-15",{"date":43,"type":23},"2027-07-15",{"name":45,"class":46},"Maastricht University Medical Center","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":17,"sex":18,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":47},"100594537","stable-isotopes--adults-with-obesity-100594537","NCT07020741","Stable Isotopes- Adults With Obesity","Assessing Metabolic Health With Stable Isotope Tracer Techniques in Adults With Obesity","Si-OBA","Inclusion Criteria:\n\n* ages 19-59\n* Obese \\>\u002F= 30 kg\u002Fm\\^2 and \\>\u002F= 102 cm for males and \\>\u002F= 88 cm for females\n* Godin Leisure-time or exercise questionnaire \\\u003C14 units\n\nExclusion Criteria:\n\n1. Pregnant or become pregnant\n2. Any known food allergies\n3. Smoker\n4. Are physically active\n5. Have any known metabolic diseases\n6. Have been weight unstable within the last 6 months (lost or gained \\>10% of body mass)\n7. Non eumenorrheic or on a hormonal birth control","19 Years","59 Years",{"count":59,"type":23},8,[26],"In a crossover design, 8 participants will receive caloric drinks containing stable isotopes. In one arm of the study, participants will consume 6 hourly drinks containing two stable isotopes. Repeated blood, breath, urine, and muscle biopsies will be taken. In the second arm, participants will consume 1 drink containing 75g glucose, labeled with two stable isotopes of glucose. Periodic blood and breath will be taken over three hours.",[63,64,29],"Obese Patients (BMI ≥ 30 kg\u002Fm²)","Glucose Metabolism","RECRUITING","2026-04-28",{"date":68,"type":39},"2026-04-29",{"date":70,"type":39},"2025-09-12",{"date":72,"type":23},"2026-12-31",{"name":74,"class":46},"University of Illinois at Urbana-Champaign",{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":17,"sex":18,"minAge":56,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":85,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},"100621225","diet-synergy-in-muscle-protein-synthesis-100621225","NCT07367854","Diet Synergy in Muscle Protein Synthesis","Impact of Food Combinations on the Stimulation of Post-exercise Muscle Protein Synthesis in Healthy Adults","POTATO","Inclusion Criteria:\n\n* Age 19-40 yrs\n* Pre-menopausal\n* Recreationally-active\n* Weight stable for prior 6 months\n\nExclusion Criteria:\n\n* Age outside of range (20 - 35 yrs)\n* Pregnancy\n* Irregular menstrual cycles (i.e., \\~21 day or \\~35 day cycle)\n* Participation in previous research using L-\\[1-13C\\] leucine and L-\\[ring-2H5\\] phenylalanine\n* Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.)","40 Years",{"count":5,"type":23},[26],"In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise, participants will ingest either 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 5 g fat, 37 g carbohydrates, and 4 g fiber), 2 slices of white bread and beef combination (262 kcals, 19.8 g protein, 6.8 g fat, 28 g carbohydrates, and 1.8 g fiber) or 2 ounce-equivalent beef (93% lean meat\u002F7% fat; 110 kcals, 14.8 g protein, and 5 g fat). Repeated blood and muscle biopsies will be collected to determine whole body leucine kinetics, amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.",[88,89,90,29,91,92],"Muscle Protein Synthetic Response to Protein","Muscle Protein Synthesis","Muscle Health","Recreational Activities","Isotope Labeling",[94,95,96,97,98,99,100,101],"protein","leucine kinetics","food matrix","protein synthesis","potato","stable isotope tracers","constant infusions","food combinations","2026-04-27",{"date":104,"type":39},"2026-05-01",{"date":106,"type":39},"2026-03-01",{"date":108,"type":23},"2028-11-01",{"name":74,"class":46},2,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":118,"targetDuration":4,"studyType":24,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":47},"100635442","digestion-and-absorption-kinetics-of-beef-consumed-alone-or-as-part-of-a-mixed-meal-a-crossover-trial-in-young-adults-100635442","NCT07552740","Digestion and Absorption Kinetics of Beef Consumed Alone or as Part of a Mixed-Meal: a Crossover Trial in Young Adults","Meat vs Meal","Inclusion Criteria:\n\n* Aged between 18-35 years\n* BMI between 18.5-30 kg\u002Fm2\n* Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)\n* No physical limitations (i.e., able to perform all activities associated with daily living independently)\n\nExclusion Criteria:\n\n* Smoking\n* Vegan, vegetarian, or does not consume beef protein\n* Diagnosed musculoskeletal disorders\n* Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)\n* Chronic use of gastric acid-suppressing medication or anti-coagulants\n* Unstable weight over the last three months\n* Diagnosed GI tract disorders or diseases\n* Blood donation in the past 2 months\n* Females: pregnancy",{"count":119,"type":23},10,[26],"The purpose of this study is to assess the digestion and absorption kinetics of beef consumed alone or as part in healthy adults. In a randomized, crossover design, 10 young, healthy adult males and females aged 18-35 years, will consume a meal consisting of 25 g protein from minced beef alone or as part of a mixed-meal during two separate experimental trials. The main study endpoint is the exogenous rate of amino acid appearance in response to the ingested beef over a 10-h period.",[29],"2026-04-22",{"date":102,"type":39},{"date":126,"type":23},"2026-09-01",{"date":128,"type":23},"2028-01-01",{"name":45,"class":46},{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":137,"targetDuration":4,"studyType":24,"phases":139,"briefSummary":140,"conditions":141,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":47},"100635695","optimal-protein-intake-to-maximize-whole-body-protein-balance-in-healthy-adults-100635695","NCT07556029","Optimal Protein Intake to Maximize Whole-Body Protein Balance in Healthy Adults","PAAKO","Inclusion Criteria:\n\n* Aged between 18-35 years\n* BMI between 18.5-30 kg\u002Fm2\n* Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)\n* No physical limitations (i.e., able to perform all activities associated with daily living independently)\n\nExclusion Criteria:\n\n* Smoking\n* Diagnosed musculoskeletal disorders\n* Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications)\n* Chronic use of gastric acid-suppressing medication or anti-coagulants\n* Unstable weight over the last three months\n* Diagnosed GI tract disorders or diseases\n* Blood donation in the past 2 months\n* Females: pregnancy",{"count":138,"type":23},12,[26],"The purpose of this study is to assess the optimal protein intake to maximize whole-body protein net balance in healthy adults. In a randomized, double-blinded, crossover design, 12 young, healthy adult males and females aged 18-35 years, will consume a test diet consisting of free amino acid mixtures based on milk protein that vary in protein content 7 separate acute metabolic trials. The main study endpoint is optimal protein intake based on the lowest protein intake that maximizes whole-body protein net balance.",[29],"2026-04-21",{"date":68,"type":39},{"date":145,"type":23},"2026-08-01",{"date":147,"type":23},"2027-04-01",{"name":45,"class":46},{"id":150,"slug":151,"hasResults":11,"nctId":152,"briefTitle":153,"officialTitle":153,"acronym":154,"eligibilityCriteria":117,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":155,"targetDuration":4,"studyType":24,"phases":157,"briefSummary":158,"conditions":159,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":47},"100635014","amino-acid-oxidation-of-whole-food-protein-a-dose-response-crossover-trial-in-young-adults-100635014","NCT07547176","Amino Acid Oxidation of Whole-Food Protein: a Dose-Response Crossover Trial in Young Adults","BURGER",{"count":156,"type":23},20,[26],"The purpose of this study is to assess the amino acid oxidation dose-response relationship of ingested whole-food protein in healthy adults. In a randomized, crossover design, 20 young, healthy adult males and females aged 18-35 years, will consume a dinner consisting of 0.32, 0.74, and 1.32 g protein･kg BM-1 (corresponding to 1, 2, and 4 minced beef patties, respectively) during 3 separate experimental trials.The main study endpoint is the amino acid oxidation of ingested protein over a 24-h period.",[29],"2026-04-20",{"date":162,"type":39},"2026-04-23",{"date":164,"type":39},"2025-11-01",{"date":166,"type":23},"2027-03-01",{"name":45,"class":46},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":176,"targetDuration":4,"studyType":24,"phases":177,"briefSummary":178,"conditions":179,"keywords":180,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":47},"100617384","validating-iaao-for-muscle-outcomes-100617384","NCT07317921","Validating IAAO for Muscle Outcomes","Validating the Indicator Amino Acid Oxidation Technique for Muscle Outcomes","VIM","Inclusion Criteria:\n\n* Participants will be aged 18-35 years old\n* Participants will have a BMI within the normal range (i.e., 18.5-24.9) and waist-to-hip circumference ratio of \\\u003C0.95 for males and \\\u003C0.8 for circumference for females to ensure homogeneity of the sample population\n* Participants are willing to abide by the compliance rules of this study (e.g., abstain from extraneous physical activity 48h prior to session 4\n* Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants)\n* Physical activity score of ≥24 units as measured by the Godin leisure time exercise questionnaire\n\nExclusion Criteria:\n\n* Inability to adhere to any of the compliance rules judged by principal investigator\n* Self-reported regular tobacco or illicit drug use (e.g., growth hormone or testosterone)\n* Current use of hormonal contraceptives\n* Individuals with a history of allergy to local anesthetics (e.g., lidocaine)",{"count":59,"type":23},[26],"Consuming dietary protein stimulates whole-body and muscle protein synthesis, the latter of which is typically measured using invasive primed constant infusions of stable isotopes with concurrent muscle biopsies. Alternative non-invasive methodologies have been developed (namely the indicator amino acid oxidation (IAAO) technique) to estimate the impact of protein ingestion on whole-body protein synthesis as a proxy for determining dietary protein requirements. Given that the IAAO technique is based on principles of protein metabolism which occur in the liver, it is unclear how representative the IAAO outcomes of whole-body protein synthesis is to skeletal muscle protein synthesis. Validation of the IAAO technique against gold-standard, biopsy-derived measures of muscle metabolism (i.e., muscle protein synthesis) would assist in mitigating the invasiveness of muscle physiology and nutrition research.",[29],[181,29,182,183,184,185],"Muscle biopsy","Stable isotopes","Protein oxidation","Indicator amino acid oxidation","Protein synthesis","2025-12-18",{"date":188,"type":39},"2026-01-05",{"date":190,"type":39},"2025-12-01",{"date":192,"type":23},"2026-05-20",{"name":194,"class":46},"University of Toronto",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":17,"sex":203,"minAge":19,"maxAge":83,"enrollmentInfo":204,"targetDuration":4,"studyType":24,"phases":205,"briefSummary":206,"conditions":207,"keywords":211,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":222,"locationsCount":47},"100612822","menstrual-cycle-vs-oral-contraceptives-effects-on-muscle-protein-metabolism-after-resistance-exercise-100612822","NCT07258576","Menstrual Cycle vs. Oral Contraceptives: Effects on Muscle Protein Metabolism After Resistance Exercise","The Effect of Menstrual Cycle Phase and Oral Contraceptive Use on Muscle Protein Metabolism Post-Resistance Training","MCOC","Inclusion Criteria:\n\n* Age: 18-40 years\n* BMI between 18.5-29.9 kg\u002Fm2 (non-obese)\n* Recreationally active (resistance train minimum twice a week)\n* Using monophasic or triphasic oral contraceptives for \\>1 year (for oral contraceptive users)\n* Have regular menstrual cycles (21-35 days) for the past 3 months and discontinued any hormonal contraceptive use for at least 6 months (non-oral contraceptive users)\n* Must meet a progesterone sufficiency test (non-oral contraceptive users)\n\nExclusion Criteria:\n\n* Mid-luteal progesterone levels \\\u003C16umol\n* Chronic disease diagnosis (cardiovascular, thyroid, diabetes)\n* Current or recent remission of cancer\n* Regular use of non-steroidal anti-inflammatory drugs (NSAIDs; except low-dose aspirin), anticoagulants\n* Use of prescription drugs that would impact muscle protein synthesis, e.g. Statins, Lithium, ADHD medication.\n* Insertion of intrauterine device (IUD) - exception: copper\n* Use of emergency contraception in the last 3 months (e.g. Plan B)\n* Severe food allergies (e.g. soy, nuts)\n* Smoking, use of performance enhancing drugs (growth hormones, testosterone)","FEMALE",{"count":156,"type":23},[26],"The muscles of the body are constantly breaking down old proteins and building new ones. These two processes, protein breakdown and protein synthesis, together are known as protein turnover. Protein turnover is essential for maintaining healthy muscle.\n\nDespite its importance, females have historically been underrepresented in protein metabolism research. A long-standing assumption has been that fluctuations in female sex hormones such as estrogen and progesterone, whether across the natural menstrual cycle or in individuals using oral contraceptives (OCs), make metabolism and training responses too variable to study. Because of this, many researchers have excluded female participants for logistical reasons.\n\nResistance exercise, such as weightlifting, is the most effective way to increase muscle size and strength. Each resistance-training session triggers muscle protein synthesis (MPS), the process by which new muscle proteins are built. Consuming dietary protein or individual amino acids further increases the rate at which new proteins are formed. Over time, higher rates of protein synthesis support muscle growth and the maintenance of other lean tissues in the body.\n\nThe purpose of this study is to examine how menstrual cycle phases and OC use influence the synthesis of proteins in both muscle tissue and the rest of the body. Improving scientific understanding in this area will support more effective, evidence-based training and nutrition recommendations for females.",[208,209,210,29],"Female Sex Hormones","Menstrual Cycle","Oral Contraceptives",[29,208,209,210,212,213,214,215],"Resistance Exercise","Weightlifting","Indicator Amino Acid Oxidation","Stable Isotope Tracer","2025-11-28",{"date":218,"type":39},"2025-12-02",{"date":220,"type":39},"2025-07-20",{"date":126,"type":23},{"name":194,"class":46},{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":17,"sex":18,"minAge":229,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":24,"phases":233,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":47},"100612501","anabolic-response-to-beef-vs-plant-protein-in-prefrail-older-adults-using-a-novel-stable-isotope-pulse-method-100612501","NCT07254403","Anabolic Response to Beef vs Plant Protein in (Pre)Frail Older Adults Using a Novel Stable Isotope Pulse Method","Inclusion criteria:\n\n* Age 65-95 years old\n* Ability to walk, sit down, and stand up (independently or with walking assistance device)\n* No recent use (\\\u003C 4 weeks prior to start of the study) of dietary supplements and medication influencing protein and amino acid metabolism (e.g., antibiotics, oral corticosteroids)\n* Willingness to lay supine in bed for up to 6 hours\n* Willingness and ability to comply with the protocol\n\nExclusion criteria\n\n* Presence of malnutrition (BMI \\\u003C 17 kg\u002Fm2), 2). BMI \\>35 kg\u002Fm2 to avoid weight-related metabolic disturbances,\n* Established diagnosis and active treatment of chronic disease: Insulin-dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV\u002FAIDS, Asthma (moderate to severe), Hep (A, B, or C)\n* History of untreated metabolic disease including hepatic or renal disorder\n* Presence of fever within the last 3 days\n* Cirrhosis of liver\n* Diagnosis of dementia, neurodegenerative disease (e.g., Alzheimer's disease, Parkinson's disease, Huntington's chorea, frontotemporal dementia).\n* (Possible) pregnancy\n* Presence of acute illness or metabolically unstable chronic illness\n* Active dependence on alcohol or drugs\n* Newly prescribed long-term oral corticosteroids\n* Planned elective surgery requiring 2 or more days of hospitalization during the entire study\n* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject\n* Already enrolled in another clinical trial\n* Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient\n* Known allergy to any of the components of the feeding (soy, beef)\n* Established daily diet of vegetarian\u002Fvegan composition","65 Years","95 Years",{"count":232,"type":23},60,[26],"Frailty is a common clinical syndrome in older adults that increases the risk for poor health outcomes including falls, disability, hospitalization, and mortality. Previous research showed increased protein needs and reduced anabolic response to meals in older adults, indicating the need for proteins with a high anabolic capacity to prevent and attenuate physical and cognitive health decline throughout the frailty cycle. Recently, more people have chosen to eliminate animal (i.e., beef) products from their diets which is concerning because of beef's anabolic properties due to high essential amino acid (EAA) levels and many other positive health effects. The Researchers' recently developed stable isotope amino acid pulse method enables measurement of the true intracellular anabolic response to a meal and bioavailability of food-derived amino acids. The research objective is to examine differences in the anabolic response and bioavailability of individual EAA and non-essential amino acids (NEAA) in beef as compared to plant protein in older adults with and without (pre-)frailty.",[29],"2025-11-19",{"date":216,"type":39},{"date":239,"type":39},"2025-10-31",{"date":241,"type":23},"2026-12",{"name":243,"class":46},"Texas A&M University",{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":248,"acronym":4,"eligibilityCriteria":249,"healthyVolunteers":17,"sex":18,"minAge":250,"maxAge":230,"enrollmentInfo":251,"targetDuration":4,"studyType":24,"phases":253,"briefSummary":254,"conditions":255,"keywords":256,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":266,"locationsCount":47},"100564374","prandial-metabolic-phenotyping-in-sarcopenic-older-adults-comparing-plant-based-and-whey-based-protein-100564374","NCT06628349","Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein","Inclusion Criteria:\n\n* Age 50-95 years old\n* Diagnosis of Chronic Obstructive Pulmonary Disease (COPD); COPD group only\n* Stable body-weight (±5%) for the past 3 months\n* Ability to walk, sit down, and stand up (independently or with walking assistance device)\n* Willingness to lay supine in bed for up to 6 hours\n* Willingness and ability to comply with the protocol\n\nExclusion Criteria:\n\n* Established diagnosis and active treatment of chronic disease: Insulin dependent diabetes mellitus, active malignancy, heart disease, kidney disease, liver disease, HIV\u002FAIDS, Asthma (moderate to severe), Hep (A,B, or C)\n* History of untreated metabolic disease including hepatic or renal disorder\n* Presence of acute illness or metabolically unstable chronic illness\n* Hysterectomy\n* Active dependence of alcohol or drugs\n* Use of short course of oral corticosteroids within 4 weeks preceding study day\n* Current use of long-term oral corticosteroids\n* Use of protein or amino acids containing nutritional supplements within 5 days of the first study day\n* Presence of fever within the last 3 days\n* Planned elective surgery requiring 2 or more days of hospitalization during the entire study\n* (Possible) pregnancy\n* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject\n* Already enrolled in another clinical trial\n* Any condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient\n* Known allergy to any of the components of the feeding (soy, pea, or whey - dairy)\n* Established daily diet of vegetarian \u002F vegan composition\n* \\\u003C23 MoCa score","50 Years",{"count":252,"type":23},100,[26],"The researchers overall objective is to determine whether plant and animal protein based proteins affect the anabolic responses across aging populations differently due to specific changes in the essential amino acids (EAA) and non-essential amino acids (NEAA) kinetic responses. The researchers central hypothesis is that a high EAA to NEAA ratio in a protein meal is related to higher anabolic response to the meal. The researchers also hypothesize that the type of NEAA in a protein meal also affects the anabolic capacity of the meal. The researchers rationale is that finding the amino acid composition of a meal that will maximally induce protein anabolism will guide novel nutritional approaches to prevent and treat sarcopenia, thereby reducing both overall economic burden and improving individual patient outcomes.",[29],[257,258,259,260],"Prandial","Sarcopenia","Plant protein","Animal protein",{"date":262,"type":39},"2025-11-25",{"date":264,"type":39},"2024-02-01",{"date":241,"type":23},{"name":243,"class":46},{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":17,"sex":18,"minAge":273,"maxAge":274,"enrollmentInfo":275,"targetDuration":4,"studyType":24,"phases":277,"briefSummary":278,"conditions":279,"keywords":280,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":47},"100470046","prandial-metabolic-phenotype-in-adults-100470046","NCT05400733","Prandial Metabolic Phenotype in Adults","Inclusion Criteria:\n\n* Age: 60-80, inclusive\n* Stable body-weight (± 5%) for the past 3 months\n* Subject is judged to be in satisfactory health based on medical history, physical examination, and laboratory screening evaluations.\n* Ability to walk, sit down and stand up independently or with walking mobility aids\n* Ability to lie in supine or elevated position for up to 7 hours\n* Willingness and ability to comply with the protocol\n\nExclusion Criteria:\n\n* Established diagnosis of current malignancy\n* History of untreated metabolic diseases including hepatic or renal disorder\n* Presence of acute illness or metabolically unstable chronic illness\n* Presence of fever within the last 3 days\n* Use of short course of oral corticosteroids within 4 weeks preceding study day\n* (Possible) pregnancy\n* Failure to give informed consent or Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements\n* Already enrolled in another clinical trial and that clinical trial interferes with participating in this study\n* Any other condition according to the PI or nurse that was found during the screening visit, that would interfere with the study or safety of the patient","60 Years","80 Years",{"count":276,"type":23},50,[26],"Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents. The investigating lab developed a pulse method combining multiple stable isotopes to study multiple metabolic pathways in the same individual simultaneously. By measuring whole-body metabolism in a large group of older adults, the investigators may be able to unravel age-related deterioration in protein turnover (synthesis and breakdown) that contributes to impaired functional capacity. Metabolic profiles could explain differences in pathways in the aging process with special interest in metabolism of amino acids as they have been associated with aging-related disorders.",[29],[281],"prandial","2025-09-26",{"date":284,"type":39},"2025-10-01",{"date":286,"type":39},"2022-06-24",{"date":288,"type":23},"2026-09",{"name":243,"class":46},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":295,"acronym":296,"eligibilityCriteria":297,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":298,"enrollmentInfo":299,"targetDuration":4,"studyType":24,"phases":301,"briefSummary":302,"conditions":303,"keywords":304,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":47},"100604391","animal-and-microbial-based-dietary-protein-efficiency-in-adults-100604391","NCT07148908","Animal and Microbial-based Dietary Protein Efficiency in Adults","The Effects of Animal- and Microbial-based Protein Sources on Whole-body Protein Metabolism in Healthy Adults","YPQ","Inclusion Criteria:\n\n* Healthy, male and female, recreationally-active participants.\n* Healthy will be defined as screened by the PAR-Q+ (Appendix B) and The Physical Activity Readiness Questionnaire (Appendix C).\n* Participants will be aged 18-45 years old.\n* Participants are willing to abide by the compliance rules of this study.\n* Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).\n* Use of monophasic combined oral contraceptives (COC) containing 21 active pills (e.g., Yaz, Marvelon, Cyclen, etc.; the brand of COC will be recorded) (female participants).\n\nExclusion Criteria:\n\n* Inability to adhere to any of the compliance rules judged by principal investigator (e.g. dairy protein or yeast allergy).\n* Self-reported regular tobacco use.\n* Self-reported illicit drug use (e.g., growth hormone, testosterone, etc.).\n* Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.\n* Use of multiphasic COCs due to the difficulty of controlling for hormonal fluctuations in such formulations (female participants).\n* Use of COCs containing \\>21 active pills per cycle due to potential differences in their effect on metabolism (female participants).\n* Use of other forms of hormonal contraception (e.g., progestin-only pill, hormonal IUD, intravaginal ring) (female participants).\n* Not currently or previously (in the past 6 months) on a vegan diet","45 Years",{"count":300,"type":23},13,[26],"Given the relatively high carbon footprint and sustainability of animal-based proteins, there is a growing interest in determining the nutritional quality non-animal-based protein sources. The overall objective of this investigation is to examine the impact of different animal and microbial-based protein sources to support whole body protein synthesis in adults. To do this, investigators will employ a 'breath test' method developed in our laboratory as well as urine sampling. The results of this study will allow us to better understand the impact of dietary protein quality for maintaining health and body protein mass in adults.",[29],[305,306,307,308,309,97],"Protein quality","protein metabolism","stable isotopes","protein oxidation","indicator amino acid oxidation","2025-08-22",{"date":312,"type":39},"2025-08-29",{"date":314,"type":39},"2025-07-01",{"date":316,"type":23},"2025-12-31",{"name":318,"class":46},"Daniel Moore",{"id":320,"slug":321,"hasResults":11,"nctId":322,"briefTitle":323,"officialTitle":323,"acronym":324,"eligibilityCriteria":325,"healthyVolunteers":17,"sex":18,"minAge":229,"maxAge":326,"enrollmentInfo":327,"targetDuration":4,"studyType":24,"phases":329,"briefSummary":330,"conditions":331,"keywords":332,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":47},"100576267","milk-vs-wheat-protein-intake-to-maximize-whole-body-protein-synthesis-rates-in-healthy-older-adults-100576267","NCT06783075","Milk Vs Wheat Protein Intake to Maximize Whole-body Protein Synthesis Rates in Healthy Older Adults","Plant-IAAO","Inclusion Criteria:\n\n* Aged between 65-85 years\n* BMI between 18.5-30 kg\\*m\\^-2\n* Healthy, recreationally active (maximal one intensive exercise training per week)\n* No physical limitations (i.e., able to perform all activities associated with daily living independently)\n\nExclusion Criteria:\n\n* Smoking\n* Diagnosed musculoskeletal disorders\n* Use of any medications known to affect protein metabolism (i.e., corticosteriods, non-steroidal anti-inflammatories)\n* Chronic use of gastic acid-suppressing medication or anti-coagulants\n* Unstable weight over the last 3 months\n* Diagnosed GI tract disorders or diseases\n* Blood donation in the past 2 months","85 Years",{"count":328,"type":23},24,[26],"Dietary protein intake is essential for tissue renewal and growth. Current recommendations for protein intake are based on studies using egg protein as reference protein. Egg protein is an animal-based protein with a high quality. Protein quality is determined by the composition of (essential) amino acids and digestibility. Therefore, different proteins have a different quality. Due to the environmental crisis, an increasing number of people consumes more plant-based proteins. These plant-based proteins often have a lower protein quality compared to animal-based proteins. Therefore, the aim of this study is to investigate whether optimal protein intake depend on protein quality. The optimal protein intake of an animal-based protein with a high quality (milk) will be compared to the optimal protein intake of a plant-based protein with a low quality (wheat).",[29],[333],"whole-body protein synthesis","2025-01-14",{"date":336,"type":39},"2025-01-20",{"date":338,"type":23},"2025-03-01",{"date":340,"type":23},"2027-01-01",{"name":45,"class":46},{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":348,"eligibilityCriteria":349,"healthyVolunteers":17,"sex":18,"minAge":350,"maxAge":274,"enrollmentInfo":351,"targetDuration":4,"studyType":353,"phases":4,"briefSummary":354,"conditions":355,"keywords":363,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":373,"leadSponsor":375,"locationsCount":47},"100573300","oral-breath-test-to-measure-anabolic-sensitivity-to-a-protein-meal-across-the-age-and-physical-activity-spectrum-100573300","NCT06744491","Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum","Anabolic Sensitivity Across the Lifespan","NFRF","Inclusion Criteria:\n\n* Healthy will be defined as screened by the PAR-Q+ (The Physical Activity Readiness Questionnaire for everyone)\n* Chronological age for Healthy Young (age: 18-35 years) or Older (age: 60-80 years) adults\n* Chronological age between 8 to 16 years, with maturity offset \\\u003C -1 year from age of Peak Height Velocity (aPHV) for children and between -0.5 to +1.5 years from aPHV in adolescent participants\n* BMI between normal to overweight (18.5 - 29.9 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Regular use of nonsteroidal anti-inflammatory dugs (with the exception of daily low-dose aspirin)\n* use of anticoagulants\n* use of a walker, cane, or assistive walking device\n* infectious or gastrointestinal disease\n* inability to comply with study protocol (e.g., unable to track diet)\n* regular tobacco use\n* self-reported illicit drug use (e.g., growth hormone, testosterone, etc.)\n* diagnosed chronic illness (e.g., type 2 diabetes, heart disease, thyroid disease)\n* pregnant\n* hormonal replacement therapy","8 Years",{"count":352,"type":23},80,"OBSERVATIONAL","The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.",[356,357,358,359,360,361,29,362],"Inactivity, Physical","Aging","Healthy Aging","Growth & Development","Sex Differences","Anabolic Sensitivity","Physical Activity",[364,365,366,367,368,307],"anabolic sensitivity","aging","growth and development","physical activity","skeletal muscle","2024-12-16",{"date":371,"type":39},"2024-12-20",{"date":371,"type":23},{"date":374,"type":23},"2025-08-31",{"name":194,"class":46},{"id":377,"slug":378,"hasResults":11,"nctId":379,"briefTitle":380,"officialTitle":380,"acronym":4,"eligibilityCriteria":381,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":229,"enrollmentInfo":382,"targetDuration":4,"studyType":353,"phases":4,"briefSummary":384,"conditions":385,"keywords":390,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":407,"locationsCount":47},"100568382","the-role-of-nutrition-in-muscle-function-of-bariatric-surgery-patients-100568382","NCT06680492","The Role of Nutrition in Muscle Function of Bariatric Surgery Patients","Inclusion Criteria:\n\n* Male and female\n* Aged 18 to 65 years old\n* Undergoing first bariatric surgery (any type)\n* Diabetics and non-diabetics\n* Non-smokers and non-cannabis consumers\n\nExclusion Criteria:\n\n* Pregnant and breastfeeding women\n* Individuals undergoing second bariatric surgery\n* Regular smokers and cannabis consumers\n* Current use of Ozempic (or Ozempic-like medication) and anti-psychotic meds\n* Limited physical mobility (using walking aids such as canes, walkers, or wheelchairs) and issues with hand resistance\n* Kidney disease, non-controlled \u002F unstable hypertension and hypothyroidism, and any metabolic disease other than diabetes",{"count":383,"type":23},75,"Current recommendations for protein intake after bariatric surgery are not based on strong scientific evidence. It remains unclear how much protein should be eaten to minimize muscle loss and preserve the metabolism and function of individuals post-bariatric surgery.\n\nThe objective of this study is to analyze the relationships between changes in body composition, nutrition and protein intake, and muscle function after bariatric surgery to further our understanding of the nutritional needs of patients after bariatric surgery.\n\nWe intend to recruit around 75 participants, men and women, aged between 18 and 65 years. Participants will be recruited from the Bariatric Surgery Clinic, McGill University Health Center.",[386,387,388,29,389],"Obesity, Diabetes, Nutrition, Physical Health","Body Composition Changes","Muscle Function, Handgrip Strength Test","Bariatric Surgery Patients",[391,392,393,394,395,396,397,398,399],"Obesity","Bariatric sugery","Protein function","Muscle function","6-Minute Walk Test","Handgrip Strength Test","Nutritional needs","Nutritional guides","Nutrition","2024-11-06",{"date":402,"type":39},"2024-11-08",{"date":404,"type":39},"2017-06-23",{"date":406,"type":23},"2026-01",{"name":408,"class":46},"Concordia University, Montreal"]