[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"protein\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:protein":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100626562","leucine-requirements-during-pregnancy-100626562",false,"NCT07437248","Leucine Requirements During Pregnancy","Dietary Leucine Requirements During Early and Late Gestation in Healthy Pregnant Women","Inclusion Criteria:\n\n* Pregnant women aged 20-40 years. (This age range represents typical reproductive age and minimizes potential confounding effects related to adolescent growth or age-associated metabolic changes.)\n* Singleton pregnancy. (Restricting participation to singleton pregnancies reduces variability in nutrient requirements and metabolic demands associated with multiple gestations.)\n* Gestational age of either 11-20 weeks (early gestation) or 31-40 weeks (late gestation).\n\n(These time points represent physiologically distinct stages of pregnancy, allowing comparison of leucine requirements across early and late gestation.)\n\n* Participants who take part in early gestation, can participate in late gestation, if they meet all inclusion criteria.\n* Good general health with no acute or chronic medical conditions. (Including only healthy participants minimizes confounding factors that could alter amino acid metabolism and ensures participant safety.)\n* Fully ambulatory and able to comply with study procedures. (Participants must be able to attend study visits and complete protocol requirements, including dietary intake and sample collection.)\n* Pre-pregnancy body mass index (BMI) between 19 and 28 kg\u002Fm² (This range excludes underweight and obese individuals, whose altered protein and amino acid metabolism could affect study outcomes.)\n* Carrying a viable pregnancy without known complications at enrollment. (Excluding pregnancy complications at baseline reduces risk to participants and supports accurate assessment of physiological amino acid requirements.)\n\nExclusion Criteria:\n\n-Pregnancy-related complications (e.g., hyperemesis gravidarum, GDM, hypertension, pre-eclampsia, anemia).\n\n(These conditions may alter metabolism and increase risk, potentially confounding study outcomes.)\n\n* History of adverse pregnancy outcomes (spontaneous abortion or preterm birth). (May reflect underlying physiological factors affecting amino acid metabolism.)\n* Multiple gestation pregnancies. (Nutritional and metabolic demands differ from singleton pregnancies.)\n* Pregnancy loss within six months of the current pregnancy. (Short intervals may affect maternal nutrient status and metabolic adaptation.)\n* Chronic metabolic, cardiovascular, neurological, genetic, or immune disorders. (These conditions may independently affect protein and amino acid metabolism.)\n* Clinically significant claustrophobia. (May interfere with study procedures requiring ventilated hood measurements.)\n* Use of alcohol, tobacco, or illicit substances during pregnancy. (Substance use affects metabolism and poses maternal and fetal health risks.)\n* Gestational weight loss greater than 1.5 kg. (May indicate inadequate nutritional status.)\n* Pre-pregnancy BMI outside 19-28 kg\u002Fm². (Extremes of BMI are associated with altered protein metabolism.)",true,"FEMALE","20 Years","40 Years",{"count":21,"type":22},40,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to understand how much leucine, an essential amino acid, and protein building block, healthy pregnant women need during early and late pregnancy. Leucine plays an important role in supporting muscle health and fetal growth. Participants will consume carefully prepared meals and provide breath, urine samples, and one blood sample so researchers can measure how the body uses leucine at different stages of pregnancy. The results will help improve nutrition guidelines for pregnant women to better support maternal health and healthy fetal development.",[28,29,30],"Pregnancy","Dietary Analysis","Protein",[32,33,28,34],"Leucine","Amino Acid","Stable Isotope","RECRUITING","2026-04-17",{"date":38,"type":39},"2026-04-22","ACTUAL",{"date":41,"type":39},"2026-04-01",{"date":43,"type":22},"2027-12",{"name":45,"class":46},"University of British Columbia","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100548901","expressions-of-ezrin-and-pip5k1-proteins-in-airway-smooth-muscle-of-asthmatic-patients-100548901","NCT06427018","Expressions of Ezrin and Pip5k1α Proteins in Airway Smooth Muscle of Asthmatic Patients","Assessing the Expressions of Ezrin, Phosphorylated Ezrin, and Pip5k1α in the Airway Smooth Muscle of Asthmatic Patient","Inclusion Criteria:\n\n* Lung tissue samples;\n* The samples come from patients aged 18-70 years old, regardless of gender, who underwent lung tissue sampling for surgical indications during treatment;\n* Paraffin sections of lung tissue from patients diagnosed with bronchial asthma, including tracheal smooth muscle;\n* Paraffin sections of lung tissue from non-asthma patients, including tracheal smooth muscle.\n\nExclusion Criteria:\n\n* Paraffin sections of lung tissue from patients who have been diagnosed with COPD;\n* Other situations where the researcher deems it inappropriate to participate in this study.","ALL","18 Years","70 Years",{"count":59,"type":22},120,"OBSERVATIONAL","Asthma, a prevalent chronic respiratory affliction, significantly impinges upon the quality of life for affected individuals. Timely and appropriate diagnostic measures, coupled with efficacious therapeutic interventions, are paramount in mitigating exacerbations of symptoms and enhancing the life quality of patients.\n\nEzrin plays an important role in maintaining cell morphology, cell migration, cell adhesion and polarisation, but Ezrin expression in airway smooth muscle remains unclear.\n\nPip5k1α is an important kinase involved in intracellular phosphatidylinositol signalling pathways that may be involved in smooth muscle contraction and diastole.\n\nTherefore, further studies are necessary to elucidate the changes of Ezrin and Pip5k1α in patients with asthma to provide a basis for investigating alternative treatments for asthma.",[63,30],"Asthma",[63,65,66,67],"Ezrin","Pip5k1α","Airway smooth muscle","2026-01-12",{"date":70,"type":39},"2026-01-14",{"date":72,"type":39},"2024-05-28",{"date":74,"type":22},"2026-12-31",{"name":76,"class":46},"Lei-Miao Yin"]