[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"proton-pump-inhibitor-adverse-reaction\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:proton-pump-inhibitor-adverse-reaction":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100476453","lactobacillus-reuteri-strain-combination-in-children-treated-with-ppi-100476453",false,"NCT05484128","Lactobacillus Reuteri Strain Combination in Children Treated With PPI","Lactobacillus Reuteri Strain Combination (Strains DSM 17938 and ATCC PTA 6475) in Children Treated With Proton Pump Inhibitors","Inclusion Criteria:\n\n* Age: children between 1 month and 14 years of age;\n\n  o We start with children older than 4 years of age.\n* Necessity of therapy with Proton Pump Inhibitors for Gastroesophageal reflux disease and\u002For Functional Dyspepsia;\n* Informed consent obtained.\n\nExclusion Criteria:\n\n* Neurological pathologies (PCI and Spastic tetra-paresis);\n* Nasogastric feeding;\n* Known immunodeficiency;\n* Previous therapy with gastric acid inhibitors;\n* HP infection;\n* Assumption of prebiotics, other probiotics or symbiotics in the previous month;\n* Malnutrition or severe dystrophy;\n* Cystic Fibrosis.","ALL","12 Months","14 Years",{"count":20,"type":21},172,"ESTIMATED","INTERVENTIONAL",[24],"NA","Probiotics might be of help in preventing dysbiosis and emergence of SIBO. Gastrus consisted of a mixture of two human strains of L. Reuteri DSM 17938 and ATCC PTA 6475; the first have extensive data supporting its use in gastric infections (18) however, it lacks the anti-inflammatory properties that have been provided by L. Reuteri DSM ATCC PTA 6475 that has excellent acid resistance and has strong anti-inflammatory properties (19); for these reasons, Gastrus is the best candidate for this indication.",[27,28,29],"Gastric Lesion","Proton Pump Inhibitor Adverse Reaction","Probiotic",[31,32,33,34],"Reuteri","Proton Pump Inhibitor","gastrus","infections","RECRUITING","2024-12-03",{"date":38,"type":39},"2024-12-05","ACTUAL",{"date":41,"type":39},"2020-03-04",{"date":43,"type":21},"2025-12-31",{"name":45,"class":46},"University of Bari","OTHER"]