[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"proximal-cavities-of-posterior-teeth\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:proximal-cavities-of-posterior-teeth":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100628139","early-phase-1-clinical-performance-of-a-novel-self-cured-resin-composite-compared-to-a-light-cured-bioactive-resin-composite-restoration-in-proximal-cavities-of-posterior-teeth-100628139",false,"NCT07457749","Clinical Performance of a Novel Self-cured Resin Composite Compared to a Light-cured Bioactive Resin Composite Restoration in Proximal Cavities of Posterior Teeth","Clinical Performance of a Novel Self-cured Resin Composite Compared to a Light-cured Bioactive Resin Composite Restoration in Proximal Cavities of Posterior Teeth: A 2-year Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n1. Subjects between the ages of 18-47 years old\n2. Primary caries removal\n3. Good or moderate oral hygiene\n4. Free of periodontal diseases (probing depth and attachment levels within normal limits\u002F no furcation involvement\u002F no mobility)\n5. Cooperative patients who agree to keep the scheduled recall appointments for data collection and maintenance\n\nExclusion Criteria:\n\n1. Composite or amalgam removal\n2. Caries extended to the cemento-enamel junction in Class II caries\n3. Grade II or III mobility\n4. Considerable periodontal disease without treatment\n5. Endodontically treated teeth with extensive loss of tooth tissues\n6. Severe wear facets and\u002For parafunctional activities as clenching or nocturnal bruxism.\n7. Subjects who are pregnant during the duration of the study\n8. Subjects with high caries activity","ALL","18 Years","47 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"EARLY_PHASE1","The development of dental caries is multi-factorial mainly due to the presence of 4 elements which are: dental biofilm, fermentable carbohydrates , dental hard tissue and time. Other additional social and environmental factors can have a substantial impact on the onset and course of the disease. Dietary habits, oral hygiene, salivary flow and fluoride exposure are key factors that influence the susceptibility to dental caries. If dental caries is properly managed, it is a preventable and reversible disease. The proximal teeth surfaces are the most susceptible sites for demineralization from the acidic byproducts. In modern restorative dentistry, clinicians always seek solutions that streamline procedures, improve outcomes and reduce chair time for patients. Traditional light-cured composite systems often involve a complex seven step process which includes etching, priming, bonding and curing which consumes from 90 to 120 seconds to be completed. With each additional step, the risk of technique errors increases, potentially compromising the longevity of the restoration. Self-cure composites, with their simplified application process, are emerging as a preferred choice over the traditional seven-step composite materials. Recently, a novel self-cured high-performance bulk-fill restorative material has been introduced into the market (Stela, SDI, Victoria, Australia). It's particularly known for its \"unlimited\" depth of cure and self-adhesive properties.",[27],"Proximal Cavities of Posterior Teeth",[29,30,31,32],"clinical performance","self-cured resin composite","bioactive","proximal cavities","RECRUITING","2026-03-17",{"date":36,"type":37},"2026-03-19","ACTUAL",{"date":39,"type":37},"2026-02-18",{"date":41,"type":21},"2028-03-18",{"name":43,"class":44},"British University In Egypt","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100625985","performance-of-reinforced-3d-printed-versus-direct-bulk-filled-resin-composites-for-restoring-extensive-class-ii-cavities-in-vital-molars-100625985","NCT07429747","Performance of Reinforced 3D-Printed Versus Direct Bulk-Filled Resin Composites for Restoring Extensive Class II Cavities in Vital Molars","Performance of Reinforced 3D-Printed Versus Direct Bulk-Filled Resin Composites for Restoring Extensive Class II Cavities in Vital Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\nPatient-related:\n\n* Adults aged 22 to 45 years.\n* Low to moderate caries risk.\n* Normal occlusion.\n* No signs or symptoms of temporomandibular joint disorders.\n* Satisfactory oral hygiene.\n* Medically fit to receive routine restorative dental treatment.\n\nLesion-related:\n\n* Permanent molar requiring a compound Class II restoration.\n* Primary carious lesion classified as ICDAS score 5.\n* Presence of an adjacent tooth and a sound opposing tooth in occlusion.\n* No clinical signs or symptoms of irreversible pulpitis in the involved, adjacent, or opposing teeth.\n* No radiographic evidence of periapical pathology.\n\nExclusion Criteria:\n\nPatient-related:\n\n* Bruxism.\n* Poor cooperation.\n* Inability or unwillingness to attend follow-up visits.\n* Anticipated travel during the study period.\n* Poor oral hygiene.\n* Chronic or advanced periodontitis.\n* Known allergy to any study materials.\n* Pregnant or breastfeeding women.\n\nLesion-related:\n\n* Teeth with visible fractures or cracks.\n* Rampant caries.\n* Defective restorations on adjacent or opposing teeth.\n* Atypical extrinsic staining that may interfere with evaluation.\n* Radiographic signs of apical pathology.","22 Years","45 Years",{"count":20,"type":21},[57],"NA","Most published research on 3D-printed restorative materials is laboratory-based, focusing primarily on mechanical performance and material properties under controlled conditions. While such studies provide important foundational data, they do not fully replicate the complexity of the oral environment. Only a limited number of clinical investigations have directly compared 3D-printed restorations with conventional direct composite restorations in Class II cavities Furthermore, the integration of a digital workflow introduces additional costs and time requirements related to equipment, software, and training. These factors must be justified by demonstrable improvements in clinical outcomes or cost-effectiveness. By evaluating both clinical performance and economic impact, this trial aims to generate practical, real-world evidence that can guide clinicians in selecting appropriate restorative materials and techniques for routine dental practice.",[60,61,62,27,63],"Class II Lesions","3D Printing","Bulk Fill","Composite Restorations","NOT_YET_RECRUITING","2026-03-02",{"date":67,"type":37},"2026-03-04",{"date":69,"type":21},"2026-02-20",{"date":71,"type":21},"2027-10-01",{"name":73,"class":44},"Ahmed Reda Abd EL Rahman",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":45},"100582113","clinical-evaluation-of-self--cure-bulk-fill-resin-composite-versus-conventional-bulk-fill-resin-composite-versus-conventional-bulk-fill-resin-composite-clinical-evaluation-of-self--cure-bulk-fill-resin-composite-versus-conventional-bulk-fill-resin-composite-100582113","NCT06859086","Clinical Evaluation of Self- Cure Bulk-Fill Resin Composite Versus Conventional Bulk-Fill Resin Composite Versus Conventional Bulk-Fill Resin Composite Clinical Evaluation of Self- Cure Bulk-Fill Resin Composite Versus Conventional Bulk-Fill Resin Composite","Clinical Evaluation of Self- Cure Bulk-Fill Resin Composite Versus Conventional Bulk-Fill Resin Composite in Restoration of Proximal Lesions Over a Period Of 24 Months Follow-Up: A Randomized Clinical Trial","Patient-related criteria:\n\nInclusion criteria:\n\n* Patients consulting in one of the outpatient clinics listed above.\n* Able to tolerate necessary restorative procedures.\n* Provide informed consent.\n* Accepts the 18 months follow-up period.\n\nExclusion criteria:\n\n* Medically compromised patients, as they will not be able to attend multiple appointments or may require special management.\n* Pregnant women; as radiographs cannot be taken for them.\n* Allergy to any of the restorative materials, including anesthetics.\n* Uncooperative patients, will not abide by the instructions or attend the appointments.\n\nTooth related criteria:\n\nInclusion criteria:\n\n* Teeth with primary proximal carious lesions.\n* Teeth are vital according to pulp-sensitivity tests.\n* Well-formed and fully-erupted in normal functional occlusion with natural antagonist and adjacent teeth.\n\nExclusion criteria:\n\n* Deciduous teeth; as the study is targeting only permanent teeth.\n* Teeth with previous restorations, which may add another variable to the study (type of old restorative material, extent of recurrent caries).\n* Spontaneous pain or prolonged pain after sensitivity tests (cold and electrical tests), which would indicate irreversible pulpal damage.\n* Negative sensitivity tests, periapical radiolucencies and sensitivity to axial or lateral percussion, which would indicate pulp necrosis.\n* Teeth presenting external or internal resorption, with adverse pulpal reactions which may affect the outcome of the study.\n* Teeth with cervical caries; which can't be evaluated on periapical radiographs.","100 Years",{"count":83,"type":21},56,[57],"the aim of this study is To evaluate and compare the clinical performance of Self- Cure Bulk fill Composite Resin Versus Conventional Bulk fill resin composite in Restoration of Proximal Lesions over a Period of 24 months Follow-up.",[27],"2025-03-02",{"date":89,"type":37},"2025-03-05",{"date":91,"type":21},"2025-04",{"date":93,"type":21},"2027-05",{"name":95,"class":44},"Cairo University"]