[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"proximal-humeral-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:proximal-humeral-fracture":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,48,72,98,123,147,173],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100637906","optimized-costoclavicular-block-for-elderly-proximal-humeral-fracture-surgery-100637906",false,"NCT07612514","Optimized Costoclavicular Block for Elderly Proximal Humeral Fracture Surgery","Effect of an Optimized Ultrasound-Guided Costoclavicular Brachial Plexus Block Strategy on Anesthetic Efficacy and Diaphragmatic Function in Elderly Patients Undergoing Internal Fixation of Proximal Humeral Fractures: A Multicenter, Prospective, Randomized Controlled Clinical Trial","OptCCB","Inclusion Criteria:\n\n* Signed informed consent\n* Age ≥65 years\n* BMI \\\u003C30\n* American Society of Anesthesiologists (ASA) physical status I to III\n* Unilateral proximal humeral fracture scheduled for open reduction and internal fixation via an anterior surgical approach (including deltopectoral approach and anteromedial deltoid approach)\n\nExclusion Criteria:\n\n* Inability to perform T2 thoracic paravertebral block for any reason\n* Coagulation dysfunction or current use of anticoagulant therapy\n* History of upper extremity nerve injury or phrenic nerve injury\n* Severe polytrauma\n* Preoperative uncontrolled severe respiratory dysfunction (resting SpO2 \\\u003C90% or home oxygen therapy, or FEV1 \\\u003C30% of predicted value)\n* Preoperative uncontrolled asthma, pulmonary infection, pneumothorax, or history of prior lung surgery\n* Preoperative uncontrolled hypertension with admission systolic blood pressure \\>180 mmHg or diastolic blood pressure \\>110 mmHg\n* Preoperative uncontrolled coronary artery disease, valvular heart disease, or arrhythmia\n* Any condition that precludes nerve block performance (e.g., local infection or swelling at the puncture site, inability to change position)\n* Inability to communicate or cooperate with anesthesia administration (e.g., language barrier, intellectual disability, Alzheimer's disease, Parkinson's disease)\n* Allergy to ropivacaine or any other contraindication to nerve block","ALL","65 Years",{"count":20,"type":21},356,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Proximal humeral fractures are common in elderly patients and often require surgical fixation (open reduction and internal fixation). Traditional regional anesthesia techniques, such as the interscalene brachial plexus block, may provide incomplete pain relief in the medial upper arm area and carry a high risk of hemidiaphragmatic paralysis, which can lead to breathing difficulties.\n\nObjective: This study aims to evaluate whether an optimized nerve block strategy-ultrasound-guided costoclavicular brachial plexus block combined with superficial cervical plexus block and T2 thoracic paravertebral block-improves anesthetic success and reduces diaphragm dysfunction compared to the traditional interscalene approach in elderly patients undergoing proximal humeral fracture surgery.\n\nStudy Design: This is a multicenter, prospective, randomized, controlled, double-blind (participants and outcome assessors), superiority clinical trial.\n\nPopulation: A total of 356 elderly patients (aged ≥65 years) with unilateral proximal humeral fractures scheduled for open reduction and internal fixation via an anterior surgical approach will be enrolled from three centers in Shanghai, China.\n\nIntervention: Participants will be randomly assigned in a 1:1 ratio to one of two groups:\n\n* Experimental Group (Optimized Strategy): Receives ultrasound-guided costoclavicular brachial plexus block + superficial cervical plexus block + T2 thoracic paravertebral block (0.375% ropivacaine 20 mL for brachial plexus, 0.25% ropivacaine 10 mL for each of the other blocks).\n* Control Group (Traditional Strategy): Receives ultrasound-guided interscalene brachial plexus block + superficial cervical plexus block + T2 thoracic paravertebral block (same drug regimen).\n\nAll nerve blocks will be performed under ultrasound guidance by a single anesthesiologist. Patients and outcome assessors will be blinded to group assignment; the performing anesthesiologist cannot be blinded due to the distinct anatomical approaches.\n\nMain Outcomes:\n\n* Primary Outcome: Nerve block success rate, defined as no pain or only mild pain requiring no rescue analgesics (e.g., intravenous opioids, conversion to general anesthesia, or local infiltration) during surgery.\n* Key Secondary Outcomes: Rate of hemidiaphragmatic paralysis (assessed by ultrasound M-mode); rate of conversion to general anesthesia; postoperative pain (NRS, 0-10) at 24 hours; perioperative stress biomarkers (cortisol, ACTH, IL-6, HMGB-1, CRP, galectin-3); and postoperative shoulder function recovery.\n\nSafety Monitoring: Adverse events, including unplanned conversion to general anesthesia, respiratory depression, pneumothorax, and severe hemidiaphragmatic paralysis, will be recorded and managed according to predefined protocols. An independent Data Monitoring Committee will review safety data and conduct interim analyses for futility.\n\nStudy Duration: The study is expected to take approximately 24 months from first patient enrollment to final follow-up completion.\n\nEthical Approval: This study has been approved by the Ethics Committee of Shanghai Tongren Hospital. Approvals from the ethics committees of the other participating centers (Shanghai Sixth People's Hospital and Shanghai Xuhui Central Hospital) will be obtained before study initiation at those sites.",[27,28,29],"Proximal Humeral Fracture","Anesthesia, Regional","Diaphragmatic Paralysis",[27,31,32,33,29,34],"Elderly","Costoclavicular Block","Interscalene Block","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-05-21",{"date":38,"type":39},"2026-05-28","ACTUAL",{"date":41,"type":21},"2026-10-01",{"date":43,"type":21},"2029-09-30",{"name":45,"class":46},"Shanghai Tong Ren Hospital","OTHER",3,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100310997","clinical-outcomes-of-the-alps-proximal-humerus-plating-system-100310997","NCT03328650","Clinical Outcomes of the ALPS Proximal Humerus Plating System","ALPS PHP","Inclusion Criteria:\n\n* Patients who present with a proximal humerus fracture requiring primary or revision ORIF using A.L.P.S Proximal Humerus Plating System\n* Patients who present with a proximal humerus fracture that involves the metaphysis\n* 18 years or older\n\nExclusion Criteria:\n\n* Patients under the age of 18\n* Patients who have an infection, sepsis, or osteomyelitis\n* Patients who are unwilling to take part in study, have documented psychiatric disorder that limits ability to consent and maintain follow-up, or who may have severe problems maintaining follow-up (e.g. patients who are prisoners, homeless, intellectually changed without adequate family support)\n* Patients who do not speak English (do to unavailability of non-English surveys)\n* Patients who have known risk factors of pathologic fractures (e.g. bone metastasis)\n* Patients who have received treatment for osteoporosis (e.g. bisphosphonate) within the last 5 years or whose treatment lasted longer than 5 years\n* Patients who have Type 1 diabetes\n* Patients who have other bone disease (e.g. osteogenesis imperfecta, Paget's disease, thyroid disease, Vitamin D deficiency, hyperparathyroidism)\n* Patients that have a history of cancer, abnormal serum calcium, or chronic steroid use","18 Years",{"count":57,"type":21},150,"OBSERVATIONAL","The purpose of this study is to document the performance and clinical outcomes of the A.L.P.S® Proximal Humerus Plating System.\n\nSpecific Aims:\n\n* Conduct physical assessments measuring shoulder strength and range of motion, physician assessment of radiographs\n* Obtain patient-reported outcomes regarding pain level, function capabilities, and work\u002Fleisure restrictions\n* Document revisions, complications, and adverse events",[27],"RECRUITING","2026-05-05",{"date":64,"type":39},"2026-05-11",{"date":66,"type":39},"2017-08-07",{"date":68,"type":21},"2031-12-01",{"name":70,"class":46},"Vanderbilt University Medical Center",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":17,"minAge":80,"maxAge":4,"enrollmentInfo":81,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":71},"100402680","researches-about-proximal-humerus-fractures-100402680","NCT04523415","Researches About Proximal Humerus Fractures","The Reliability and Reproducibility of Edelson Classification About Proxima Humeral Fractures","Inclusion Criteria:\n\n* Whole imaging data ;\n* Clear record of demographic data;\n* Three dimensional construction with mimics (with CT of B30);\n* Patients older than 17 years with displaced PHF occurring less than 3 weeks before allocation and treatment.\n\nExclusion Criteria:\n\n* Patients with the presence of neurological disease (syringomyelia and);\n* Open fractures;\n* Pathological fracture (other than osteoporotic);\n* Not a resident in the hospital catchment area",true,"17 Years",{"count":82,"type":21},800,"Majority of previous classifications based on two-dimensional images to analyze these complicated 3-D fractures. Small or delicate changes in rotation and positioning can result to considerable disagreement in the interpretation of standard radiographs. Therefore, a classification system which had a better reliability and reproducibility for the fractures is warranted and helpful for orthopedic surgeons. Furthermore, CT and 3-D CT construction images with high resolution give a much clearer view of the pattern of proximal humeral fractures. Edelson proposed a new three-dimensional classification for fractures of the proximal humerus. The results concluded that it was a useful in classifying these injuries with reasonable interobserver reliability.\n\nIt could be hypothesized that patients with proximal humeral fractures would benefit from this 3D classification, but there is a scarcity of application of the classification in large samples. T",[27],[86,87,88],"Proximal Humeral","Fracture","Classifications","2026-01-21",{"date":91,"type":39},"2026-01-23",{"date":93,"type":39},"2019-01-01",{"date":95,"type":21},"2026-03-31",{"name":97,"class":46},"Hebei Medical University Third Hospital",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":106,"maxAge":18,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":110,"conditions":111,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":122},"100548101","surgical-versus-non-surgical-treatment-of-displaced-proximal-humerus-fracture-in-adults-aged-50-to-65-years-100548101","NCT06416618","Surgical Versus Non-surgical Treatment of Displaced Proximal Humerus Fracture in Adults Aged 50 to 65 Years","Surgical Versus Non-surgical Treatment of Displaced Proximal Humerus Fracture in Adults Aged 50 to 65 Years: a Pragmatic Randomized Controlled Trial","PHF50-65","Inclusion Criteria:\n\n* Patients aged between 50 and 65 years with a displaced PHF assessed to be constructible by the treating surgeon after a low-energy trauma will be considered for eligibility.\n* Patients should be cognitively capable of answering the follow-up questionnaires.\n\nExclusion Criteria:\n\n* The patient does not understand written and spoken native language (Danish or Finnish\u002FSwedish)\n* Inability to give informed consent\n* Fractures assessed to be unreconstructedly by the treating surgeon\n* Isolated tuberosity fracture, fracture dislocations, open fractures, and fractures with involvement of the articular surface\n* Less than 25% contact between head fragment and metaphysis\u002Fdiaphysis measured at two perpendicular radiographs at two weeks.\n* Pathological fractures or previous fractures in the same proximal humerus\n* Concomitant fractures, which could influence the outcome\n* Paralysis in upper extremity","50 Years",{"count":108,"type":21},60,[24],"The goal of this clinical trial is to study whether surgery results in better functional outcomes than non-surgical treatment among patients aged 50-65 with a displaced proximal humerus fracture.\n\nThe main questions it aims to answer are:\n\n• Does osteosynthesis result in better patient-reported functional outcomes compared to non-surgical treatment at 12 months follow-up?\n\nAim is also to characterize the patient group aged 50-65 regarding fracture morphology, osteoporosis, and clinical frailty scale.\n\nThe study compare operation with either plate or nail fixation to non-surgical treatment.\n\nParticipants will:\n\n* Receive either surgical treatment or non-surgical treatment.\n* At 6 months, 1 year, and 2 years, the patient will answer two short questionnaires (Oxford Shoulder Score and Eq-5D-3L).\n\nThe primary outcome will be Oxford Shoulder Score at 12 months. The secondary outcome will be OSS at 6 and 24 months and EQ-5D-3L score measured at the same time-points. Adverse events and conversion to surgery will be registered. OSS and EQ-5D-3L will be completed just before the 6 months visit.",[27,112],"Shoulder Fractures","2025-09-11",{"date":115,"type":39},"2025-09-18",{"date":117,"type":39},"2024-05-15",{"date":119,"type":21},"2028-12-31",{"name":121,"class":46},"Zealand University Hospital",2,{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":130,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":71},"100493346","exactech-proximal-humerus-fracture-plate-system-post-market-clinical-follow-up-100493346","NCT05703958","Exactech Proximal Humerus Fracture Plate System Post Market Clinical Follow-up","An Open Label, Multi-Center, Retrospective and Prospective Evaluation of Equinoxe Proximal Humerus Fracture Plates Clinical and Radiographic Outcomes","Inclusion Criteria:\n\n* Patient is indicated to receive Equinoxe Proximal Humerus Fracture Plate or has previously underwent primary surgery with Equioxe Proximal Humerus Fracture Plate\n* Patient is willing to participate by complying with pre- and postoperative visit requirements\n* Patient is willing to agree to be followed for up to 10 years following their index surgery\n* Patient is willing and able to review and sign a study informed consent form\n\nExclusion Criteria:\n\n* Osteomyelitis of the proximal humerus or scapula\n* Inadequate or malformed bone that precludes adequate support or fixation of the prosthesis\n* Patient's age, weight, or activity level would cause the surgeon to expect early failure of the system\n* The patient is unwilling or unable to comply with the post-operative care instructions\n* Alcohol, drug, or other subtance abuse\n* Any disease state that could adversaly affect the function or longevity of the implant\n* Patient is pregnant\n* Patient is a prisoner\n* Patient has a physical or mental condition that would invalidate the results","21 Years",{"count":132,"type":21},151,"The objective of this study is to collect and evaluate long-term clinical outcomes data in order to better understand the safety and performance of the Equinoxe Proximal Humerus Fracture Plates over time. This study will follow subjects for a period of up to 10 years post-surgery.",[27,135,136],"Fracture Dislocation","Non-Union Fracture","2024-10-23",{"date":139,"type":39},"2024-10-24",{"date":141,"type":39},"2023-04-19",{"date":143,"type":21},"2034-09-30",{"name":145,"class":146},"Exactech","INDUSTRY",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":17,"minAge":154,"maxAge":4,"enrollmentInfo":155,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":169,"leadSponsor":171,"locationsCount":71},"100526375","duration-of-immobilization-after-reverse-total-arthroplasty-for-proximal-humerus-fractures-100526375","NCT06133920","Duration of Immobilization After Reverse Total Arthroplasty for Proximal Humerus Fractures","Immobilization Versus Early Range of Motion in Reverse Total Arthroplasty in Patients With Proximal Humerus Fractures","Inclusion Criteria:\n\n* Patients 60 years or older who have a displaced proximal humerus fracture\n* Meets surgical criteria for a reverse total shoulder arthroplasty\n* Receive surgical intervention within 6 weeks of initial injury\n\nExclusion Criteria:\n\n* Patients \\\u003C60 years in age\n* Patients who cannot undergo surgery due to medical comorbidities\n* Patients who receive surgical intervention after 6 weeks from initial injury\n* Patients who have preoperative nerve damage from their fractures that would limit the ability to move the arm postoperatively","60 Years",{"count":156,"type":21},40,"The purpose of this study is to evaluate compare postoperative range of motion in patients who are given a sling for comfort only and allowed to start early active range of motion compared to patients who are placed in a sling for 4 weeks with passive range of motion only. Once enrolled, the patients will be randomized through computer randomization then placed in paper packets into either the immobilization group or the early range of motion group.",[27,159],"Reverse Total Shoulder Arthroplasty",[161,162,163],"Proximal Humerus Fracture","Range of Motion","Immobilization","2024-08-19",{"date":166,"type":39},"2024-08-20",{"date":168,"type":39},"2021-02-24",{"date":170,"type":21},"2027-02-01",{"name":172,"class":46},"The Cooper Health System",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":184,"conditions":185,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100551970","ai-prediction-for-proximal-humeral-fractures-100551970","NCT06467006","AI PREDICTION FOR PROXIMAL HUMERAL FRACTURES","ARTIFICIAL INTELLIGENCE-BASED PREDICTION OF CLINICAL OUTCOMES IN PATIENTS SUSTAINING PROXIMAL HUMERAL FRACTURES","Orthopredict","Inclusion Criteria:\n\nPatients sustaining a proximal humerus fracture treated nonoperatively under the criteria of the treating surgeon and patients' preference.\n\nSubjects evaluated within the first 3 weeks after the injury. Patients between 18 and 90 years of age. Patients who have been studied with simple shoulder radiographs in anteroposterior and scapular outlet projections.\n\nParticipants who accept 1-year time follow-up.\n\nExclusion Criteria:\n\nPatients with dementia or difficulty completing the evaluation after one year of follow-up.\n\nPatients who have previously received surgical treatment on the affected limb. Patients who have suffered a previous fracture in the affected limb. Surgically treated patients.","90 Years",{"count":183,"type":21},500,"Our smartphones can recognize the pictures of our family, loved ones and friends. Face recognition software leverages artificial intelligence (AI), image recognition and other advanced technology to map, analyze and confirm the identity of a face.\n\nWe humans do a poor job when classifying the injury related to a patient sustaining a proximal humeral fracture. In consequence, there is great heterogeneity in the treatment of proximal humerus fractures. Moreover, offering relevant information to patients regarding the risk of complications or fracture sequelae is challenging, given that the current series are based on obsolete classifications, and the published series bring together just over hundreds of patients analyzed. With these limitations, patients have few opportunities to participate in decision-making about their injury.\n\nThe present project aim is to integrate new technologies for the prediction of relevant clinical results for the patients presenting a proximal humeral fracture. In brief, AI can help identify similar fracture patterns without human inference, while humans can feed the algorithm with variables of interest such as the functional outcomes and complications related to this particular type of fracture.",[27],"2024-06-14",{"date":188,"type":39},"2024-06-20",{"date":190,"type":21},"2024-09",{"date":192,"type":21},"2027-09",{"name":194,"class":46},"Consorci Sanitari de l'Anoia"]