[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pruritis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pruritis":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,54,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":38,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100607351","incidence-of-pruritus-using-intrathecal-fentanyl-versus-epidural-fentanyl-to-initiate-labour-analgesia-100607351",false,"NCT07187427","Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.","Randomized Trial Comparing the Injection of Intrathecal Fentanyl Versus Epidural Fentanyl for the Initiation of Labour Analgesia on the Incidence of Pruritis.","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Vaginal delivery\n* Gestational age ≥ 37 weeks\n* Requesting neuraxial analgesia\n* French or English language\n\nExclusion Criteria:\n\n* ASA score \\> 3\n* Allergy or contraindication to receiving opioids\u002Flocal anesthesia (morphine or fentanyl)\n* BMI \\> 40 kg\u002Fm²\n* Hepatic or renal failure,\n* Severe preeclampsia and signs of severity according to the criteria of the American College of Obstetricians and Gynecologists\n* Maternal hemorrhage (placental abruption, hepatic subcapsular hematoma,...)\n* Severe scoliosis\n* Biliary cholestasis or polymorphic eruption of pregnancy\n* Inability to provide informed consent, either secondary to mental or physical disability or a significant language barrier (inability to understand English or French)\n* Prior administration of an opioid or opioid misuse","FEMALE","18 Years",{"count":19,"type":20},80,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women. Specifically, this study aim to compare intrathecal fentanyl with epidural fentanyl in order to determine whether the epidural route is associated with a lower occurrence and severity of pruritus. By clarifying these differences, the research seek to optimize analgesic strategies during labor while minimizing opioid-related side effects",[26,27,28,29,30,31,32,33,34,35,36,37],"Pruritis","Hypotension Drug-Induced","Urinary Retention","Fetal Bradycardia During Labor","Nausea and Vomitting","Satisfaction, Patient","Labor Analgesia","Neuraxial Opioid","Opioid Analgesic Adverse Reaction","Term Labour","Fentanyl Analgesia","Fentanyl Adverse Reaction",[39,40],"neuraxial opioid induced pruritus during labor","Intrathecal fentanyl versus Epidural fentanyl","NOT_YET_RECRUITING","2025-11-20",{"date":44,"type":45},"2025-11-26","ACTUAL",{"date":47,"type":20},"2026-01",{"date":49,"type":20},"2027-05",{"name":51,"class":52},"St. Justine's Hospital","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":17,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":21,"phases":65,"briefSummary":67,"conditions":68,"keywords":69,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":53},"100533499","phase-2-dupixent-in-adults-with-refractory-post-burn-pruritus-in-an-ambulatory-clinic-100533499","NCT06226610","Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic","A Phase 2 Double-Blind, Randomized, Placebo-Controlled Study to Assess the Efficacy of Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic","Inclusion Criteria:\n\n• Persons 18-60 year old with post-burn hypertrophic scars of any size which required grafting or epidermal autografting for an acute burn injury, with continued complaint of pruritus due to inadequate relief from standard of care (medical management by antihistamine and neuroleptic medications) after at least four weeks and are a minimum of four weeks after their last grafting surgery, and who speak English sufficient to participate in the study.\n\nExclusion Criteria:\n\n* Currently taking Dupixent for any other diagnosis\n* known allergy to Dupixent\n* pregnant and or lactating mothers\n* anyone treated for pruritus using laser therapy\n* currently receiving adequate relief for pruritis under standard of care medical management by antihistamine or neuroleptic medications\n* Currently taking steroids\n* persons with developmental delays or otherwise unable to complete measures\n* prisoners or anyone otherwise unable to give their own consent or who is not their own guardian\n* one or more of the following existing disorders: conjunctivitis; any co-existing dermatological condition except burns; any type of cancer; requiring dialysis; chronic Stage 3 or higher kidney disease; biliary disorder; gall bladder disorder; or another renal or hepatic disorder which, in the opinion of study physician, deems this study inappropriate for an eligible individual.\n* Persons unable to provide their own consent, including prisoners when their incarcerated status is not itself the focus of study, are routinely excluded from clinical trials at this site\n* We further exclude persons with other dermatological conditions (other than burn) , which may have pruritis or pain associated with them and who may be treated with medications other than Dupixent, and whose perceived benefit could confound our results.\n* We similarly exclude anyone treated for pruritis by laser therapy as their perceived benefit could confound our results.","ALL","60 Years",{"count":64,"type":20},46,[66],"PHASE2","The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.",[26],[70],"Itching, itch","RECRUITING","2025-09-16",{"date":74,"type":45},"2025-09-19",{"date":76,"type":45},"2024-11-21",{"date":78,"type":20},"2026-12-31",{"name":80,"class":52},"Akron Children's Hospital",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":61,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":21,"phases":89,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":53},"100567695","effect-of-kidney-replacement-therapy-with-polymethylmethacrylate-membranes-on-pruritus-related-quality-of-life-in-patients-receiving-maintenance-haemodialysis-100567695","NCT06671535","Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis","Inclusion Criteria:\n\n* Diagnosis of CKD stage 5D, maintenance hemodialysis not less than 3 months prior screening;\n* Moderate-to-severe pruritis (WI-NRS score ≥ 4);\n* Adequate dialysis dose (spKt\u002FV≥1,4 and\u002For eKt\u002FV≥1,2);\n* Dialysis treatment regimen: three sessions per week of at least 4 hours duration;\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Presence of active skin disease, cholestasis, severe secondary hyperparathyroidism and other conditions that, in the investigator's opinion, may be responsible for pruritus.\n* Noncompliance of the patient with the protocol (in the investigator's opinion).\n* Use of haemodiafiltration.",{"count":88,"type":20},62,[23],"This randomized controlled trial aims to evaluate the effect of polymethylmethacrylate dialysis membranes use on the intensity of pruritus in patients with CKD stage 5D receiving maintenance hemodialysis.\n\nThe main question it aims to answer is: Does the use of polymethylmethacrylate (PMMA) membranes reduce the intensity of pruritus in dialysis patients?\n\nResearchers will compare PMMA membranes to standard polysulfone-based membranes to see if PMMA works to reduce moderate-to-severe pruritis and pruritis-related quality of life.\n\nParticipants will:\n\n* receive maintenance hemodialysis with PMMA or polysulfone membranes for 2 months;\n* fill in questionnaires about intensity of pruritis and its impact on daily life.",[92,93,26],"CKD (Chronic Kidney Disease) Stage 5D","Hemodialysis",[95,96,97],"polymethylmethacrylate membranes","CKD-associated pruritis","PMMA membranes","2025-03-02",{"date":100,"type":45},"2025-03-04",{"date":102,"type":45},"2025-01-27",{"date":104,"type":20},"2025-10",{"name":106,"class":52},"Saint Petersburg State University, Russia"]