[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pseudobulbar-affect\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pseudobulbar-affect":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100546539","structural-and-functional-networks-in-als-an-insight-into-pseudobulbar-affect-100546539",false,"NCT06396260","Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect","Inclusion Criteria:\n\n* Diagnosed with ALS in the last 6 months according to Gold Coast Criteria\n\nExclusion Criteria:\n\n* \\- Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and\u002For tablet, or through telephone interview.\n* Lack of ability to cooperate.\n* Pregnancy\n* Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.\n* Alcohol addiction defined as over 21 units weekly.\n* Lesional neurological diseases, such as stroke, tumor or multiple sclerosis\n* Epilepsy\n* Neurodegenerative diseases other than ALS\n* Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia\n* Contraindication for MRI and MEG scan according to hospital guidelines\n* Severe liver or kidney disease\n* Dysregulated heart disease\n* Ongoing treatment with any antidepressants or any antipsychotics at recruitment.\n* Diagnosed with frontotemporal dementia.",true,"ALL","18 Years","90 Years",{"count":20,"type":21},50,"ESTIMATED","INTERVENTIONAL",[24],"NA","The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).",[27,28],"Amyotrophic Lateral Sclerosis","Pseudobulbar Affect",[30,31,32],"Diffusion Kurtosis Imaging","Magnetoencephalography","Connectivity","RECRUITING","2025-01-28",{"date":36,"type":37},"2025-01-29","ACTUAL",{"date":39,"type":37},"2024-05-26",{"date":41,"type":21},"2026-12-31",{"name":43,"class":44},"Aalborg University Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":5},"100551210","piloting-the-attention-training-technique-for-post-stroke-emotionalism-100551210","NCT06457126","Piloting the Attention Training Technique for Post-Stroke Emotionalism","Applying the Metacognitive Model to Post-Stroke Emotionalism: A Multiphasic Case Series Piloting the Attention Training Technique","Inclusion Criteria:\n\n* Confirmed primary clinical diagnosis of an ischemic or haemorrhagic stroke.\n* At least six months or more post-stroke\n* Reported\u002Fobserved difficulties with symptoms of PSE (episodes of uncontrollable and unpredictable crying that is not mood congruent and happens in situations that the person would not have otherwise cried)\n* Scores between 6-16 on the Testing Emotionalism after Stroke Questionnaire (TEARS-Q; Broomfield et al., 2021)\n* Scores \\> 25 on the Frenchay Aphasia Screening Test (FAST; Enderby, Wood, and Wade 1987).\n* Aged 18 or over.\n* Has the Mental Capacity (Mental Capacity Act, 2005) to provide informed consent.\n* Has carer support and consents to their carer being involved.\n* Proficient in English Language\n* No anticipated changes to antidepressant medication (if applicable).\n\nExclusion Criteria:\n\n* Less than six months post-stroke\n* Presenting with PSE without a primary diagnosis of an ischemic or haemorrhagic stroke and\u002For as a result of another neurological condition.\n* Hyper acutely or acutely unwell with concurrent medical conditions.\n* Receiving palliative or end of life care.\n* Severe or distressing behaviours that may impede on engagement or cause further distress.\n* Visual or hearing impairment unable to be corrected.",{"count":54,"type":21},14,[24],"The aim of this mutli-phasic systematic case series is to explore if the Attention Training Technique (ATT) can improve symptoms of Post Stroke Emotionalism. It will teach the ATT to at least three people who have had a stroke at least six months ago, have PSE and are currently receiving support from a Community Neurorehabilitation service in the North West of England. Stroke survivors will also require the support of a carer\u002Floved to record their symptoms on a daily basis. Stroke survivors will attend weekly appointments either at the community service site or via video-call for up to 15 weeks. There is also the option to complete an interview to discuss their experiences of learning the ATT. This study hopes to be the first step in establishing evidence in support of a novel psychological intervention to help improve PSE symptoms.\n\nPhase 1 of the study aims to explore the effects associated with the ATT on PSE symptoms. The primary research questions are:\n\n1a. Is the ATT associated with an improvement of PSE symptoms?\n\n1b. Does this replicate across individual cases?\n\nIf these are not initially supported, the ATT delivery will be extended, addressing:\n\n1. c. Is the ATT associated with an improvement of PSE symptoms when some parameters (e.g., frequency and dose) are modified?\n\n   Only if a clear association between ATT and symptom change is demonstrated, will Phase 2 begin.\n\n   Phase 2 aims to understand the relative mechanisms underlying any treatment effect. The primary research question for Phase 2 is:\n2. a. Is the ATT associated with a greater change in PSE symptoms than a comparator passive listening intervention (controlling for non-specific factors, (e.g., provision of a credible intervention, task practice and therapist involvement))?\n\nThe comparator intervention will be a passive version of the ATT whereby participants are instructed to not follow the instructions on the audio-recording.\n\nSecondary research questions throughout Phase 1 and 2 will address:\n\n1\\. Is the active ATT (and passive ATT) associated with an improvement in executive functioning, attention, mood and quality of life and is there any difference between the two interventions?",[58,59,28,60,61],"Stroke","Emotionality","Lability Emotional","Crying",[58,63,64,65],"Post Stroke Emotionalism","Attention Training Technique","Crying Symptoms","NOT_YET_RECRUITING","2024-06-12",{"date":69,"type":37},"2024-06-13",{"date":71,"type":21},"2024-06-24",{"date":73,"type":21},"2025-08-30",{"name":75,"class":44},"University of Manchester"]