[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pseudohypoparathyroidism\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pseudohypoparathyroidism":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100436950","natural-history-study-of-parathyroid-disorders-100436950",false,"NCT04969926","Natural History Study of Parathyroid Disorders","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n* Subjects known to have, suspected of having, or at risk of developing a parathyroid or related disorder.\n* Age \\>= 6 months.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n* Children \\\u003C= 6 months\n* Patients with conditions that in the opinion of the investigators can interfere with the study objectives.","ALL","6 Months","100 Years",{"count":19,"type":20},3000,"ESTIMATED","OBSERVATIONAL","Background:\n\nParathyroid disorders are very common in the general population and include disorders of parathyroid excess, deficiency, or defects in parathyroid hormone (PTH) signaling. PTH, the main secretory product of parathyroid glands is responsible for regulation of calcium-phosphate homeostasis.\n\nObjective:\n\ni) To investigate the cause of parathyroid disorders\n\nii) To describe evolution, natural history, and longitudinal trends of parathyroid and related disorders seen in syndromic presentations like multiple endocrine neoplasia, hyperparathyroidism-jaw tumor syndrome\n\nEligibility:\n\nPeople ages 6 months older who have, are at risk of having, or are related to a person with a parathyroid or related disorder.\n\nDesign:\n\nParticipants will be screened with a review of their medical records.\n\nParticipants will be seen, tested, and treated by doctors based on their condition. Their visits may be in person or via telehealth.\n\nParticipants will complete questionnaires. They will answer questions about their physical, mental, and social health.\n\nParticipants may give samples such as saliva, blood, urine, or stool.\n\nParticipants may give cheek cell samples. They will do this using a cheek swab or by spitting into a cup.\n\nAdult participants may give a skin biopsy. For this, a small bit of skin is removed with a punch tool.\n\nParticipants may have medical photos taken.\n\nIf participants have surgery during the course of their regular care either at the NIH\n\nor at a different hospital or doctor s office, researchers will ask for some of the leftover\n\ntissue.\n\nParticipants will be in the study as long as they are being seen by their doctor.",[24,25,26,27,28],"Parathyroid Cancer","Primary Hyperparathyroidism","Pseudohypoparathyroidism","Inheritable Bone Diseases","Multiple Endocrine Neoplasia, Type 1",[30,31,24,32,33,34],"Hyperparathyroidism","calcium disorders","Inheritable","PSEUDOHYPOPARATHYROIDISM","Natural History","RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-23","ACTUAL",{"date":41,"type":39},"2021-11-30",{"date":43,"type":20},"2031-01-22",{"name":45,"class":46},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":78},"100511909","idmet-radico-cohort-radico-idmet-100511909","NCT05945576","IDMet (RaDiCo Cohort) (RaDiCo-IDMet)","National Cohort on Imprinting Disorders and Their Metabolic Consequences","IDMet","Inclusion Criteria:\n\n* Patients (adults and children) affected with an ID regardless of the severity of the disease\n* A confirmed diagnosis of ID (based on molecular diagnosis)\n* A signed informed consent for adults or signed informed consent of parents\u002Fguardians of minors\u002F protected adult.\n\nNon-Inclusion Criteria:\n\nThere are no non-inclusion criteria.",{"count":57,"type":20},2000,"The goal of this observational study is to describe the natural history of imprinting disorders (IDs) according to their metabolic profile in all patients (adults and children) affected with an ID regardless of the severity of the disease, with a molecular characterization, with a signed informed consent for all subjects, followed in one partner's center.\n\nThe main questions it aims to answer are:\n\n* Can we identify common metabolic profiles for all imprinted diseases?\n* Which imprinting disorders have an impact on the metabolic profiles of IDs?\n* Which are the metabolic risks associated to IDs?\n* Can we use the metabolic profiles for the clinical classification and prognosis of IDs?\n* Are there common therapeutic approaches for all IDs?",[60,61,62,63,64,65,66,26,67],"Silver Russell Syndrome","Beckwith-Wiedemann Syndrome","Transient Neonatal Diabetes Mellitus","Angelman Syndrome","Prader-Willi Syndrome","Temple Syndrome","Kagami-Ogata Syndrome","Familial Precocious Puberty","2026-02-10",{"date":70,"type":39},"2026-02-12",{"date":72,"type":39},"2017-03-10",{"date":74,"type":20},"2028-03",{"name":76,"class":77},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",20]