[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pseudotumor-cerebri\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pseudotumor-cerebri":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100443167","stenting-versus-neurosurgical-treatment-of-idiopathic-intracranial-hypertension-100443167",false,"NCT05050864","Stenting Versus Neurosurgical Treatment of Idiopathic Intracranial Hypertension.","Randomized Controlled Trial Evaluating the Efficacy of Venous Sinus Stenting Versus Neurosurgical Internal Ventricular Shunt on Papillary Edema in the Management of Idiopathic Intracranial Hypertension","HYDROPTIC","Inclusion Criteria:\n\n* Patient aged 18 or over\n* HTICi proven greater than 25cm of water\n* Presence of papillary edema (grade\\> 0 on the Frisen scale)\n* Stenosis of at least one transverse sinus on MRI\n* Failure of medical treatment and surgical \u002F interventional indication defined by the medical team taking care of the patient\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* Fulminant HTICi\n* Contraindication to antiplatelet aggregation\n* Contraindication to one or the other of the interventions under study\n* Pregnant or breastfeeding woman","ALL","18 Years",{"count":20,"type":21},276,"ESTIMATED","INTERVENTIONAL",[24],"NA","Idiopathic intracranial hypertension (HTICi) is a pathology, affecting young adults with a predominance of women, due to an increase in intracranial pressure, which may be associated with stenosis of the cerebral venous sinuses and whose origin remains unknown.\n\nThis hypertension can lead to papillary edema (OP) which can lead to a narrowing of the visual field and progress to blindness. Along with weight reduction, acetazolamide, which reduces the production of cerebrospinal fluid (CSF), is prescribed as a first-line treatment. Its efficacy is inconsistent in resolving papillary edema and there are many side effects.\n\nIn the event of ineffectiveness or dependence on acetazolamide associated with hygiene and dietetic rules, a second line of therapy is then considered: neurosurgical (internal shunt of the LCS) or endovascular (venous stenting) treatment.\n\nThese invasive techniques have each proven their effectiveness in the rapid and permanent resorption of OP, allowing improvement or preservation of visual function. In terms of induced morbidity, the superiority of one technique over the other, if it exists, has not been established.\n\nOur objective is to compare the efficacy, safety, and safety of LCS bypass surgery versus venous sinus stenting in HTICi with moderate to severe visual impairment after failure of medical treatment defined by the absence of resorption of the OP after several months",[27,28,29],"Pseudotumor Cerebri","Cerebrospinal Fluid","Transverse Sinuses",[31,32,33,34],"Endovacascular","ventricular shunt","papillary edema","visual field","RECRUITING","2025-12-30",{"date":38,"type":39},"2026-01-05","ACTUAL",{"date":41,"type":39},"2022-03-02",{"date":43,"type":21},"2026-12-07",{"name":45,"class":46},"Fondation Ophtalmologique Adolphe de Rothschild","NETWORK",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":47},"100309129","multifocal-chromatic-pupilloperimetry-in-patients-with-pseudotumor-cerebri-and-healthy-subjects-100309129","NCT03304314","Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.","Assessment of Pupillary Response and Visual Field Defects by Objective Multifocal Chromatic Pupillometer in Patients With Pseudotumor Cerebri and Healthy Subjects","Inclusion Criteria:\n\nHealthy subjects\n\n1. Male or female patients, age between 18 and 80 years, inclusive\n2. Informed written consent will be obtained from all participants.\n3. Normal eye examination\n4. Best-corrected visual acuity (BCVA) of 20\u002F20\n5. Normal color vision test (Ishihara\u002FHRR)\n6. Normal Spectral-Domain Optical Coherence Tomography (SD-OCT)\n7. Normal 24-2 Humphrey visual field (SITA Standard) and:\n\n   * Short duration (≤10 minutes)\n   * Minimal fixation losses, False POS errors and False NEG errors (less than 33% for each one of reliability indices)\n\nPTC patients\n\n1. Male or female patients, age between 18 and 80 years, inclusive\n2. Best-corrected visual acuity (BCVA) of at least 20\u002F100 in worse eye\n3. Optic disc edema\n4. PTC diagnosis based on Modified Dandy Criteria ( lumbar puncture with opening pressure higher than or equal to 25 cm H2O, normal cerebrospinal fluid constituents, and unremarkable brain imaging results except typical for PTC\n\nExclusion Criteria:\n\nHealthy subjects\n\n1. History of past (last 3 months) or present ocular disease or ocular surgery\n2. Use of any topical or systemic medications that could adversely influence pupillary reflex\n3. Intolerance to gonioscopy, slit lamp examination, Goldmann applanation tonometry or other schedule study procedure.\n4. Mental impairment or instability such as that informed consent may not be obtained or compliance with tester instructions is unlikely.\n5. Visual media opacity including cloudy corneas.\n6. Any condition preventing accurate measurement or examination of the pupil.\n\nPTC patients\n\n1. Any other neurologic or ophthalmic disease other than PTC\n2. Use of any topical or systemic medications that could adversely influence pupillary reflex\n3. Intolerance to gonioscopy, slit lamp examination, Goldmann applanation tonometry or other schedule study procedure.\n4. Mental impairment or instability such as that informed consent may not be obtained or compliance with tester instructions is unlikely.\n5. Visual media opacity including cloudy corneas.\n6. Any condition preventing accurate measurement or examination of the pupil.",true,"80 Years",{"count":58,"type":21},100,[24],"PTC(Pseudotumor cerebri) patients may develop increased Intracranial pressure (ICP) that can produces increased pressure around the distal optic nerve,which is likely followed by venule compression, ischemia, and loss of visual function.Vision loss in PTC is most commonly characterized by standard automated perimetry to measure peripheral visual field sensitivity.\n\nPupillometry is a promising approach for functional assessment in PTC because it is noninvasive, objective, performed quickly with minimal patient cooperation needed.\n\nThe feasibility of using chromatic multifocal pupillometry for assesment of PTC will be examined.",[27],[63,64,65,66,67],"PTC","EYES","Pseudotumor cerebri","increased Intracranial pressure","ICP","2025-09-30",{"date":70,"type":39},"2025-10-06",{"date":72,"type":39},"2017-11-03",{"date":74,"type":21},"2027-12-31",{"name":76,"class":77},"Sheba Medical Center","OTHER_GOV"]