[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"psychiatric-comorbidities\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:psychiatric-comorbidities":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100604206","esketamine-nasal-spray-in-real-world-settings-in-treatment-resistant-depression-100604206",false,"NCT07146503","Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression","ESKPSY: Esketamine in Real-World Settings: Clinical Outcomes, Predictors of Response, Life Functioning and Biological Pathways","ESKPSY","Inclusion criteria were: (a) age 18-74, (b) DSM-5 diagnosis of a major depressive episode (MDE), (c) failure to respond to at least 2 prior antidepressant treatments (ADTs), and (d) current treatment with an SSRI or SNRI for which esketamine nasal spray was deemed appropriate.","ALL","18 Years","74 Years",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","This observational study investigates the use of Esketamine Intranasal Spray in patients with Treatment-Resistant Depression in Real-World Settings. The study aims to evaluate the clinical outcomes, including efficacy and safety, of esketamine treatment. It also explores predictors of treatment response, focusing on biological pathways such as genetics, neuroimaging, and psychophysical measures. Additionally, the study examines how esketamine impacts patients' life functioning, including social and occupational aspects. The goal is to better understand who benefits most from esketamine and how it affects daily life, to improve personalized care for patients with difficult-to-treat depression.",[26,27,28,29,30,31,32,33],"Depression and Quality of Life","Treatment Resistant Depression (TRD)","Anhedonia","Apathy","Anxiety","Cognition","Temperament","Psychiatric Comorbidities","RECRUITING","2026-03-25",{"date":37,"type":38},"2026-03-31","ACTUAL",{"date":40,"type":38},"2022-11-01",{"date":42,"type":22},"2030-08",{"name":44,"class":45},"Riccardo Guglielmo","OTHER",5,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":58,"studyType":23,"phases":4,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100603079","structural-brain-volumetry-changes-in-eating-disorders-100603079","NCT07131852","Structural Brain Volumetry Changes in Eating Disorders.","Inclusion Criteria:\n\n* Age above 13 years.\n* DSM-5 diagnosis of an eating disorder (AN, BN, BED) confirmed by structured interview.\n\nExclusion Criteria:\n\n* Neurological or any previous psychiatric diagnosis.\n* IQ less than 70.\n* MRI contraindication (metal implants, pacemaker, severe claustrophobia).",true,"13 Years","60 Years",{"count":57,"type":22},80,"1 Day","The goal of this observational study is to investigate the relationship between structural brain changes and psychiatric comorbidities in individuals diagnosed with eating disorders (EDs). The main question it aims to answer is:\n\nHow are structural brain volumetric changes associated with psychiatric comorbidities in patients with eating disorders?\n\nParticipants with a clinical diagnosis of an eating disorder will undergo brain MRI scans for volumetric analysis and structured psychiatric assessments to identify comorbid conditions. Data will be collected cross-sectionally from patients receiving routine clinical care, with the aim of identifying neurobiological and psychiatric patterns that could inform targeted treatment and prevention strategies.",[61,33],"Eating Disorders",[61,63,64,65],"Anorexia Nervosa","Binge eating disorders","bulimia disorders","NOT_YET_RECRUITING","2025-08-13",{"date":69,"type":38},"2025-08-20",{"date":71,"type":22},"2025-12-10",{"date":73,"type":22},"2027-05-20",{"name":75,"class":45},"Assiut University",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":84,"minAge":18,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":107,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":131},"100597441","therapeutic-writing-for-adults-suffering-from-chronic-pain-and-comorbid-mental-health-disorders-100597441","NCT07058532","Therapeutic Writing for Adults Suffering From Chronic Pain and Comorbid Mental Health Disorders","Therapeutic Writing Intervention in Pain Rehabilitation","TWfCP&MH","Inclusion Criteria:\n\n* Adult women (18 years or older), assigned female at birth and self-identify as women\n* Diagnosed with or experience of chronic, widespread (non-cancer) pain lasting at least two years\n* Diagnosed with or living with one or more mild mental health disorders (e.g., anxiety, mild depression), without current or past severe psychiatric conditions\n* Diagnosed with or experience of nociplastic pain (e.g., fibromyalgia)\n* Not currently using medications that may impair cognitive functioning (e.g., benzodiazepines, anticholinergics, opioids, antipsychotics)\n* Able to attend approximately 11 in-person visits over a 3-month period\n* Willing and able to participate in a structured therapeutic writing intervention\n* Purposefully selected to reflect a range of lived experiences relevant to the study's aims\n\nExclusion Criteria:\n\n* Presence of severe mental health disorders (e.g., schizophrenia, bipolar disorder, severe depression, or other psychotic conditions)\n* Use of medications known to impair memory, attention, or decision-making (e.g., benzodiazepines, anticholinergics, opioids, antipsychotics)\n* Participation in other concurrent treatments that may influence study outcomes\n* Cognitive limitations that would hinder meaningful engagement in the writing intervention\n* Individuals not assigned female at birth or who do not identify as women","FEMALE",{"count":46,"type":22},"INTERVENTIONAL",[88],"NA","The goal of this observational study is to understand the effects and experiences of therapeutic writing interventions in adult women with chronic pain and co-occurring mental health conditions. The main questions it aims to answer are:\n\nCan therapeutic writing help relieve chronic pain and emotional distress?\n\nHow does writing support emotional processing, regulation, and meaning-making during rehabilitation?\n\nParticipants will take part in a two-part writing intervention involving:\n\nGuided writing exercises that focus on emotional processing, emotion regulation, and creating meaning.\n\nIndividual interviews after the writing sessions to explore their experiences.\n\nThe study uses qualitative analysis methods-phenomenology and logotherapy-to better understand how these writing interventions may support recovery, improve well-being, and offer non-pharmacological tools for managing chronic pain and mental health challenges.",[91,92,93,33,94,95,96,97,98,99,100,101,102,103,104,105,106],"Chronic Pain","Mental Health Disorder","Psychiatric &Amp;Amp;or Mood Disorder","Psychiatric Diagnosis","Emotional Pain","Emotional Distress","Emotion Regulation","Emotional Processing","Meaning of Life","Meaning Made","Meaning of Life and Life Satisfaction","Depressive Disorder","Anxiety Disorders","Sleep Disorder","Comorbid Depression","Process, Acceptance",[108,109,110,111,112,113,114,115,116,117,118,119,120,121],"Therapeutic writing","Chronic pain","Mental health disorders","Psychiatric disorders","Emotion regulation","Emotional processing","Meaning-making","Non-pharmacological intervention","Logotherapy","Phenomenological analysis","Psychosocial rehabilitation","Pain management","Pain coping","Creative writing","2025-06-30",{"date":124,"type":38},"2025-07-10",{"date":126,"type":22},"2025-08",{"date":128,"type":22},"2026-04",{"name":130,"class":45},"Toni Salikka",1]