[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"psychological-stress\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:psychological-stress":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,49,84,119,173,224,272,299,326,352,386,411,434,464,498,527,556,582,602,633,654],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641340","effect-of-mandala-coloring-on-menopausal-attitude-perceived-stress-and-mindfulness-100641340",false,"NCT07657429","Effect of Mandala Coloring on Menopausal Attitude, Perceived Stress and Mindfulness","The Effect of Mandala Coloring on Menopausal Attitudes, Perceived Stress, and Mindfulness in Women During Menopause: A Randomized Controlled Trial","MANDALA-MENO","* Inclusion Criteria:\n\n  * Women aged 45-55 years\n  * Being in the menopausal period (absence of menstruation for at least 12 months)\n  * Ability to read and understand Turkish\n  * Voluntary agreement to participate in the study\n* Exclusion Criteria:\n\n  * Diagnosed psychiatric or cognitive disorders\n  * Communication problems preventing participation\n  * Visual impairment or fine motor limitations preventing mandala coloring\n  * Use of hormone replacement therapy\n  * Regular participation in mandala coloring, mindfulness, or similar mind-body practices","FEMALE","45 Years","55 Years",{"count":21,"type":22},140,"ESTIMATED","INTERVENTIONAL",[25],"NA","Menopause is a natural life stage associated with hormonal changes that may affect women physically and psychologically. During this period, women may experience increased stress levels, negative attitudes toward menopause, and decreased mindfulness. Mandala coloring is a structured art-based intervention that may promote relaxation and improve psychological well-being. This randomized controlled trial aims to evaluate the effect of mandala coloring on attitudes toward menopause, perceived stress, and mindfulness levels among menopausal women.",[28,29,30],"Menopause","Psychological Stress","Mindfulness",[32,28,33,30,34,35],"Mandala Coloring","Perceived Stress","Women Health","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-06-24",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":22},"2026-05-30",{"date":44,"type":22},"2026-09-30",{"name":46,"class":47},"Ondokuz Mayıs University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":67,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":48},"100392576","covid-19-pandemic-impact-on-alcohol-pia---a-natural-history-study-100392576","NCT04391816","COVID-19 Pandemic Impact on Alcohol (PIA) - A Natural History Study","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Participants who have enrolled in the NIAAA Natural History Protocol (14-AA-0181) and completed screening and phenotyping assessments.\n2. Willing and able to complete frequent (weekly to monthly) surveys either online or by phone.\n\nEXCLUSION CRITERIA:\n\nAs this is a natural history protocol, there are no formal exclusionary criteria for this study. Participants who are determined by the interviewer to be uncooperative or unable to provide consent via telephone will not be enrolled into the study.",true,"ALL","18 Years","100 Years",{"count":60,"type":22},1500,"OBSERVATIONAL","Background:\n\nThe SARS-CoV-2 virus has caused a pandemic infection called COVID-19. It is a global threat to people, communities, and health systems. Researchers are concerned about the mental health effects of the pandemic. They want to learn more about how it is affecting people s alcohol use and problems, and how it may continue to affect them over time.\n\nObjective:\n\nTo study the impact of the COVID-19 pandemic on alcohol use and consequences in individuals across the spectrum of alcohol use and those with alcohol use disorder.\n\nEligibility:\n\nParticipants who have been screened under the NIAAA Screening, Assessment and Management Protocol (14-AA-0181)\n\nDesign:\n\nParticipants will complete a baseline survey by phone. It will ask about alcohol use, alcohol dependence, and stress. It covers 2 time periods: the 12 months before the pandemic started and the time since it started.\n\nParticipants will get an ID code and a link to an online survey. They will complete the online survey within a week of the phone survey.\n\nParticipants will complete a series of online surveys over 24 months. For the first year, surveys will be completed weekly for the first 4 weeks, then biweekly for the next 8 weeks, and then every 1-2 months for the rest of the year. For the second year, surveys will be completed every 6 months. Surveys will cover the following topics:\n\n* Alcohol use and its consequences\n* Other substance use\n* Stress\n* Impact of the COVID-19 pandemic\n* Pain\n* Physical health\n* Sleep\n* Quality of life.\n\nBecause the course of the pandemic may change, the frequency of the surveys may change.\n\nParticipation lasts 2 years.",[64,65,66,29],"Alcohol Drinking","Alcohol-Related Disorders","Pandemic",[68,69,70,71,72,73],"Coronavirus","Alcohol Use Disorder","SARS-CoV2","Stress","Social Isolation","Natural History","RECRUITING","2026-06-23",{"date":37,"type":40},{"date":78,"type":40},"2020-06-03",{"date":80,"type":22},"2026-12-31",{"name":82,"class":83},"National Institute on Alcohol Abuse and Alcoholism (NIAAA)","NIH",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":18,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":98,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":48},"100638756","theta-healing-based-intervention-in-women-with-polycystic-ovary-syndrome-100638756","NCT07630441","Theta Healing-Based Intervention in Women With Polycystic Ovary Syndrome","The Effect of a Theta Healing-Based Intervention on Fertility Anxiety, Body Self-Compassion, and Body Image in Women Diagnosed With Polycystic Ovary Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Women aged 18-45 years\n* Diagnosed with Polycystic Ovary Syndrome (PCOS)\n* Able to read and understand Turkish\n* Voluntary participation in the study\n* Access to a smartphone and internet connection\n\nExclusion Criteria:\n\n* Diagnosed psychiatric disorder\n* Participation in another psychological intervention program\n* Any health condition preventing participation in the intervention sessions\n* Incomplete questionnaire responses",{"count":92,"type":22},142,[25],"This randomized controlled study aims to evaluate the effect of a Theta Healing-based intervention on fertility concerns, self-compassion, and body image in women diagnosed with Polycystic Ovary Syndrome (PCOS). Participants will be randomly assigned to intervention and control groups. The intervention group will receive a structured 5-day Theta Healing-based online intervention program, while the control group will continue routine care. Outcome measures will be assessed at baseline and 6 weeks after the intervention.",[96,97,29],"Polycystic Ovarian Syndrome (PCOS)","Infertility",[99,100,101,102,103,104,105,106,107,108,109],"PCOS","POLYCYSTIC OVARY SYNDROME","THETA HEALING","SELF-COMPASSION","BODY IMAGE","COMPLEMENTARY THERAPY","MEDITATION","REPRODUCTIVE HEALTH","Women's Health","Mind-Body Intervention","fertility anxiety","2026-06-03",{"date":112,"type":40},"2026-06-05",{"date":114,"type":22},"2026-06-08",{"date":116,"type":22},"2026-09-15",{"name":118,"class":47},"Ankara Medipol University",{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":127,"targetDuration":129,"studyType":61,"phases":4,"briefSummary":130,"conditions":131,"keywords":144,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":48},"100640521","neurofinance-human-stress-trial-during-financial-and-informational-volatility-100640521","NCT07622589","NeuroFinance Human Stress Trial During Financial and Informational Volatility","NeuroFinance Human Stress Trial During Financial and Informational Volatility (NFHST)","NFHST","Inclusion Criteria:\n\n* Adults age 18 years and older.\n* Ability to provide informed consent.\n* Willingness and ability to comply with study procedures and remote monitoring requirements.\n* Access to a compatible smartphone, tablet, or internet-connected device for decentralized study participation.\n* Willingness to utilize wearable physiologic monitoring technologies during the study period.\n* Participants with varying degrees of financial market exposure, occupational stress exposure, or digital media exposure are eligible.\n* Healthy volunteers and participants with self-reported stress-related symptoms may be enrolled.\n* Ability to read and understand English-language consent and study materials.\n\nExclusion Criteria:\n\n* Individuals unable or unwilling to provide informed consent.\n* Individuals unable to comply with remote monitoring procedures or wearable device usage requirements.\n* Active medical or psychiatric instability that, in the opinion of study investigators, may interfere with study participation or data integrity.\n* Current incarceration or institutionalization limiting voluntary participation.\n* Participation in another interventional clinical trial that may substantially interfere with physiologic monitoring outcomes.\n* Any condition that would significantly impair safe study participation as determined by the study investigators.",{"count":128,"type":22},2500,"24 Months","The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven stress environments affect human physiologic and behavioral health. Participants will undergo remote monitoring using wearable biosensors, cardiovascular telemetry devices, sleep tracking systems, heart rate variability monitoring, and behavioral analytics platforms. The study will use artificial intelligence and machine learning systems to analyze relationships between external financial and informational events and biologic stress responses, including autonomic nervous system activity, sleep disruption, cardiovascular strain, emotional resilience, and inflammatory signaling. The goal of the study is to develop predictive digital biomarkers and AI-assisted forecasting systems capable of identifying stress-related physiologic deterioration before clinical manifestation.",[29,132,133,134,135,136,137,138,139,140,141,142,143],"Anxiety","Emotional Stress","Autonomic Nervous System Dysfunction","Sleep Disturbance","Insomnia","Behavioral Health","Cognitive Fatigue","Occupational Stress","Financial Stress","Burnout Syndrome","Heart Rate Variability","Neurobehavioral Manifestations",[145,146,147,148,149,150,142,151,152,153,154,155,156,157,158,159,160,161,162,163],"NeuroFinance","Financial Stress Medicine","Wearable Biosensors","Artificial Intelligence","Machine Learning","Digital Biomarkers","Sleep Monitoring","Behavioral Analytics","Cardiovascular Telemetry","Decentralized Clinical Trial","Emotional Resilience","Physiologic Stress","Market Volatility","Economic Uncertainty","Social Media Exposure","Cognitive Performance","Stress Forecasting","Precision Wellness","Remote Patient Monitoring","2026-05-27",{"date":110,"type":40},{"date":167,"type":22},"2026-07-15",{"date":169,"type":22},"2029-06-30",{"name":171,"class":172},"Truway Health, Inc.","INDUSTRY",{"id":174,"slug":175,"hasResults":11,"nctId":176,"briefTitle":177,"officialTitle":178,"acronym":179,"eligibilityCriteria":180,"healthyVolunteers":55,"sex":56,"minAge":181,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":184,"conditions":185,"keywords":201,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":48},"100346729","psychosocial-environmental-and-chronic-disease-trends-in-puerto-rico-100346729","NCT03794531","Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico","Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends","PROSPECT","Inclusion Criteria:\n\n1. Age 30-75 years old at the time of enrollment\n2. Non-institutionalized\n3. Living in PR at the time of the first interview and the year before and not planning to move from the island within 3 years\n4. Able to answer questions without assistance\n5. Living in a stable dwelling\n\nExclusion Criteria:","30 Years","75 Years",{"count":128,"type":22},"The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing cardiovascular-related disparities in Puerto Rico. To this end, investigators will establish 'PROSPECT: Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic disease Trends', an island-wide, longitudinal population cohort of 2,500 adults (30-75 years) in PR recruited with a community-wide sampling strategy, and assessed in a network of several partner clinics across the island. The study will collect comprehensive data on multiple psychosocial, dietary, and food-related factors, CVD biological markers, and medical record data, with follow-up at 2-years, and will assess variations by urban-rural area and by timing before-after Maria.",[186,187,188,189,190,191,192,193,194,29,195,196,197,198,199,200],"Heart Diseases","Type2 Diabetes","Hypertension","Obesity","Dyslipidemias","Metabolic Syndrome","Cardiovascular Diseases","Chronic Disease","Inflammation","Physiological Stress","Depressive Symptoms","Coping Behavior","Diet Habit","Lifestyle","Food Insecurity",[202,203,204,205,206,207,208,209,210,211,212,213,214],"Hispanics\u002FLatinos","Minority health","Puerto Rico","Cardiovascular disease","Cardiometabolic health","Chronic disease risk factors","Disaster research","Caribbean and Latin America","Population health","Prospective study","Allostatic load","Food insecurity","Longitudinal study","2026-04-30",{"date":217,"type":40},"2026-05-05",{"date":219,"type":40},"2019-03-01",{"date":221,"type":22},"2029-04-30",{"name":223,"class":47},"Harvard School of Public Health (HSPH)",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":232,"targetDuration":4,"studyType":61,"phases":4,"briefSummary":234,"conditions":235,"keywords":248,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":269,"locationsCount":271},"100585203","health-surveillance-at-constructor-university-bremen-cub-and-among-haw-hamburg-employees-100585203","NCT06899308","Health Surveillance at Constructor University Bremen (CUB) and Among HAW-Hamburg Employees","Health Surveillance at Constructor University Bremen (CUB) to Assess Students' and HAW-Hamburg Employees' Health and Wellbeing - Explanatory Sequential Mixed-Methods Approach","CUB-HS2025","Inclusion Criteria:\n\n* English language skills\n* Reading and writing skills\n* Internet access\n* Student status\n* Consent to participate in the study\n\nExclusion Criteria:\n\n* Illiteracy\n* Massively limited cognitive abilities ( i.e. linguistic components of the digital offerings must be able to be used, and questionnaires completed, or interviews participated in) and severe psychiatric disorders (e.g., severe depression)",{"count":233,"type":22},363,"The aim of Health Surveillance is to analyze and describe the state of health of students at Constructor University, key influencing factors and individual resources by using mixed-method design.",[236,132,237,238,239,240,133,241,29,242,243,244,245,246,247],"Social Isolation or Loneliness","Anxiety Depression (Mild or Not Persistent)","Health Behavior","Observational Study","Stress, Psychological","Life Stress","Stress, Emotional","Stress (Psychology)","Substance Abuse","Substance Addiction","Substance Dependence","Substance Use",[249,250,251,252,253,254,255,256,257,258,259,260,261,262],"Healthy students","Health literacy","Disability","Age","Gender","Study characteristics","PHQ-4","Self-efficacy","Satisfaction with Life Scale (SWLS)","Subjective health status","Student satisfaction","UCLA-LS","HEI-Stress","Mixed Method","2026-04-25",{"date":265,"type":40},"2026-05-01",{"date":267,"type":40},"2025-03-17",{"date":80,"type":22},{"name":270,"class":47},"Jacobs University Bremen gGmbH",2,{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":4,"eligibilityCriteria":278,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":18,"enrollmentInfo":279,"targetDuration":4,"studyType":23,"phases":281,"briefSummary":282,"conditions":283,"keywords":285,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":48},"100626856","effect-of-ashwagandha-root-extract-on-stress-anxiety-and-sleep-quality-in-adults-experiencing-minority-stress-100626856","NCT07441070","Effect of Ashwagandha Root Extract on Stress, Anxiety, and Sleep Quality in Adults Experiencing Minority Stress","Efficacy and Safety of Ashwagandha (Withania Somnifera) Root Extract on Stress, Anxiety, and Sleep Quality in Adults Experiencing Minority Stress: A Randomized, Double-Blind, Placebo-Controlled Study","Inclusion Criteria:\n\n1. Self-identified as a sexual or gender minority (e.g., lesbian, gay, bisexual, transgender, queer, non-binary).\n2. Aged 18-45 years.\n3. Moderate to high perceived stress levels (PSS-10 total score \\>14).\n4. Willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Current psychiatric diagnosis (e.g., major depressive disorder, bipolar disorder, psychosis).\n2. Use of anti-anxiety or sleep medication (including sleep aids, cannabis or melatonin) in the last 3 months.\n3. Known allergy or intolerance to Ashwagandha.\n4. Any chronic illness that may confound the results (e.g., known liver illness, severe insomnia, or neurological disorders).",{"count":280,"type":22},80,[25],"Sexual and gender minority adults often experience elevated levels of chronic stress due to stigma, discrimination, and social adversity, commonly referred to as minority stress. This persistent stress is associated with increased anxiety, mood disturbances, impaired sleep quality, and reduced quality of life. There is a need for safe, non-pharmacological interventions that can support mental well-being in this population.\n\nThis randomized, double-blind, placebo-controlled study is designed to evaluate the efficacy and safety of Ashwagandha (Withania somnifera) root extract in reducing stress and improving anxiety and sleep quality in adults experiencing minority stress. A total of 80 adults aged 18 to 45 years who self-identify as sexual or gender minorities and report moderate to high perceived stress will be enrolled.\n\nParticipants will be randomly assigned to receive either Ashwagandha root extract (300 mg capsules taken twice daily) or an identical placebo for 8 weeks. Efficacy will be assessed using validated psychological and quality-of-life questionnaires, including the Perceived Stress Scale, Depression Anxiety Stress Scale, Pittsburgh Sleep Quality Index, and other mood and minority stress measures. Salivary cortisol will be measured as a biological marker of stress. Safety will be evaluated through monitoring of adverse events throughout the study.",[284,29,132],"Minority Stress",[286,287,288],"Ashwagandha","LGBTQ health","Withania somnifera","2026-04-22",{"date":291,"type":40},"2026-04-27",{"date":293,"type":22},"2026-04-29",{"date":295,"type":22},"2026-08-15",{"name":297,"class":298},"SF Research Institute, Inc.","NETWORK",{"id":300,"slug":301,"hasResults":11,"nctId":302,"briefTitle":303,"officialTitle":304,"acronym":4,"eligibilityCriteria":305,"healthyVolunteers":55,"sex":17,"minAge":57,"maxAge":306,"enrollmentInfo":307,"targetDuration":4,"studyType":23,"phases":309,"briefSummary":310,"conditions":311,"keywords":315,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":322,"leadSponsor":324,"locationsCount":4},"100632957","short-term-mindfulness-intervention-for-anxiety-and-maternal-attachment-in-nicu-mothers-100632957","NCT07520435","Short-Term Mindfulness Intervention for Anxiety and Maternal Attachment in NICU Mothers","Effect of a Short-Term Mindfulness-Based Stress Reduction Program on Anxiety and Maternal Attachment in Mothers With Infants Admitted to the Neonatal Intensive Care Unit: A Randomized Controlled Trial","Inclusion Criteria:\n\nMothers aged 18 to 50 years Mothers whose newborns are admitted to the Neonatal Intensive Care Unit (NICU) Mothers of infants without congenital anomalies Mothers who have not previously participated in any mindfulness-based or psychological support program Mothers without cognitive impairment Mothers who are willing to participate voluntarily and comply with all study procedures Mothers who are able to communicate in Turkish\n\nExclusion Criteria:\n\nMothers who wish to withdraw from the study voluntarily Mothers whose infants are discharged from the NICU during the intervention period Mothers receiving MBSR or any other psychological therapy Mothers using psychopharmacological medication","50 Years",{"count":308,"type":22},66,[25],"This randomized controlled study aims to evaluate the effects of a short-term mindfulness-based stress reduction (MBSR) program on anxiety levels and maternal attachment in mothers whose infants are admitted to the Neonatal Intensive Care Unit (NICU). A total of 33 mothers will be recruited and assigned to intervention and control groups. The intervention group will receive a structured four-session mindfulness program, while the control group will receive standard care. Data will be collected using the Maternal Attachment Scale and the State-Trait Anxiety Inventory. The findings are expected to provide evidence on the effectiveness of mindfulness-based interventions in reducing anxiety and improving maternal-infant bonding during the postpartum period.",[312,313,314,29],"Postpartum Anxiety","Postpartum Period","Maternal Behavior",[30,316,317,35],"Mindfulness-Based Stress Reduction","Anxiety Disorders","2026-04-03",{"date":320,"type":40},"2026-04-09",{"date":291,"type":22},{"date":323,"type":22},"2026-07-01",{"name":325,"class":47},"Saglik Bilimleri Universitesi",{"id":327,"slug":328,"hasResults":11,"nctId":329,"briefTitle":330,"officialTitle":330,"acronym":331,"eligibilityCriteria":332,"healthyVolunteers":55,"sex":56,"minAge":333,"maxAge":306,"enrollmentInfo":334,"targetDuration":4,"studyType":23,"phases":336,"briefSummary":337,"conditions":338,"keywords":340,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":4},"100622935","exploring-the-decision-to-drink-more-alcohol-following-manipulations-of-stress-and-social-context-100622935","NCT07390084","Exploring the Decision to Drink (More) Alcohol Following Manipulations of Stress and Social Context","DoraR00","Inclusion Criteria:\n\n* Drinking alcohol at least once a week\n* Consuming 4 (female) or 5 (male) drinks in one occasion at least once a month\n\nExclusion Criteria:\n\n* Currently pregnant or trying to become pregnant\n* Past or current treatment for alcohol use\n* Past or current medical condition that contraindicates alcohol use\n* Past or current reaction to alcohol that contraindicates alcohol use\n* Past or current medication that contraindicates alcohol use","21 Years",{"count":335,"type":22},160,[25],"This preregistration documents an experiment examining the effects of acute stress and social context on alcohol-related decision-making. The study uses a 2x2 factorial design (stress vs. control × social vs. alone) with dyadic recruitment.",[29,339],"Social Interaction",[341,342],"stress induction","value-based decision-making","2026-02-04",{"date":345,"type":40},"2026-02-06",{"date":347,"type":22},"2026-02-01",{"date":349,"type":22},"2027-06-30",{"name":351,"class":47},"University of Washington",{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":359,"targetDuration":4,"studyType":23,"phases":361,"briefSummary":362,"conditions":363,"keywords":368,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":382,"leadSponsor":384,"locationsCount":48},"100623010","effectiveness-of-a-waitlist-app-stappvoorstap-during-mental-healthcare-waiting-times-100623010","NCT07391072","Effectiveness of a Waitlist App \"Stappvoorstap\" During Mental Healthcare Waiting Times","Bridging the Gap: A Multiple Baseline Design Study on the Effectiveness of a Mobile-based Stress Management Intervention in Adults on Waiting Lists for Mental Healthcare","Inclusion Criteria:\n\n* Currently on a waiting list at a mental health organization in the Netherlands.\n* Aged 18 years or older\n* Owns a smartphone and has the ability to operate it\n* Sufficient proficiency in Dutch or English language (at least B1 level)\n\nExclusion Criteria:\n\n* Currently enrolled in another medical-scientific research study",{"count":360,"type":22},54,[25],"This study evaluates the effectiveness of Stappvoorstap, a mobile self-management application designed for adults on mental health waiting lists in the Netherlands. The app helps users monitor daily stress levels, recognize personal stress patterns, and provides coping strategies, relaxation exercises, and supportive resources. Using a multiple baseline single-case experimental design, participants use the app for 4 weeks while completing weekly questionnaires measuring perceived stress, coping self-efficacy, and quality of life. The study aims to determine whether the app can reduce stress and improve wellbeing during the waiting period before mental healthcare treatment begins.",[29,364,365,366,367],"Coping Ability","Mental Health","Quality of Life","Coping Skills",[369,370,371,372,373,374,375,376,377],"waiting list","mental health","stress management","mobile health","self-management","mHealth","ecological momentary intervention","single-case experimental design","perceived stress","2026-01-29",{"date":380,"type":40},"2026-02-05",{"date":267,"type":40},{"date":383,"type":22},"2027-12",{"name":385,"class":47},"GGZ Centraal",{"id":387,"slug":388,"hasResults":11,"nctId":389,"briefTitle":390,"officialTitle":391,"acronym":4,"eligibilityCriteria":392,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":393,"enrollmentInfo":394,"targetDuration":4,"studyType":23,"phases":396,"briefSummary":397,"conditions":398,"keywords":399,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":402,"lastUpdatePostDateStruct":403,"startDateStruct":405,"completionDateStruct":407,"leadSponsor":409,"locationsCount":48},"100493285","horse-assisted-intervention-heart-rate-variability--stress-100493285","NCT05703165","Horse-assisted Intervention, Heart Rate Variability & Stress","Horse-assisted Intervention and Heart Rate Variability in Participants Under Stressful Conditions","Inclusion Criteria:\n\n* Male, female and diverse\n* Age between 18-75 years\n\nExclusion criteria:\n\n* Animal hair allergies (especially horse hair allergies, fear of horses)\n* Acute severe psychiatric conditions (e.g. psychosis)\n* Persons, unable to give signed informed consent,\n* All persons, who have not signed the informed consent form.","80 Years",{"count":395,"type":22},123,[25],"In this study, the effects of an animal-assisted intervention on people with increased stress levels are investigated. The data collected will be compared with those of participants with high stress levels but without animal-assisted intervention (participants only observe nature) and with a control group consisting of people without stress exposure.\n\nThe study will be performed in the following setting: Questionnaire examination on chronic stress, questionnaire on current well-being and heart rate variability (HRV) measurement before the horse-assisted intervention, one HRV measurement and one questionnaire examination (POMS) on current well-being after the horse-assisted intervention, one questionnaire (POMS) on current well-being 5 days after the horse-assisted intervention.",[29],[400,401],"psychological stress","animal-assisted intervention","2025-09-23",{"date":404,"type":40},"2025-09-29",{"date":406,"type":22},"2026-05",{"date":408,"type":22},"2028-01-01",{"name":410,"class":47},"Medical University of Graz",{"id":412,"slug":413,"hasResults":11,"nctId":414,"briefTitle":415,"officialTitle":415,"acronym":416,"eligibilityCriteria":417,"healthyVolunteers":55,"sex":56,"minAge":418,"maxAge":419,"enrollmentInfo":420,"targetDuration":4,"studyType":23,"phases":422,"briefSummary":423,"conditions":424,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":429,"completionDateStruct":431,"leadSponsor":432,"locationsCount":48},"100518346","cerebrovascular-health-and-resilience-in-midlife-100518346","NCT06029348","Cerebrovascular Health and Resilience in Midlife","CHARM","Inclusion Criteria:\n\n* Able to attend 2 study visits at the University of Pittsburgh campus in Oakland (Pennsylvania)\n* Able to read and speak English\n\nExclusion Criteria:\n\n* Uncontrolled hypertension (systolic blood pressure \\>160 or diastolic blood pressure \\>100 mmHg)\n* Current use of anticonvulsant, anti-Parkinson, neuroleptic, or antipsychotic medications\n* Current use of glucocorticoids (e.g., oral prednisone) or ephedrine\n* Current chronic conditions of the lungs, liver and kidney, as well as cancer (chemotherapy and radiation) treatment in the past 12 months (allowances are made for non-melanoma skin cancer treatment, controlled asthma, and allergy inhalers)\n* Self-reported major neurological disorders or brain injuries (e.g., multiple sclerosis, cerebral palsy, major head injury)\n* Self-reported psychotic illnesses (mania, bipolar disorder, schizophrenia)\n* Current pregnancy or childbirth within the past 6 months\n* Suspected mild cognitive impairment or dementia\n* Self reported sleep apnea\n* Self-reported history of myocardial infarction, stroke, or revascularization procedures, as well as treatment for cardiac arrhythmias\n* Self-reported lack of comfort to undergo MRI testing\n* Presence of implants or objects that are unsafe for MRI (e.g., tattooed eyeliner), as well as any other contraindications that would prevent MRI testing\n* Self-reported lack of comfort to undergo the laboratory math task","40 Years","59 Years",{"count":421,"type":22},450,[25],"This study examines cardiovascular responses to a brief psychological challenge under laboratory conditions among adult volunteers. The study volunteers are asked to complete two study sessions. In one session, the volunteers are asked to provide demographic and health-related information via questionnaires and an interview. In that session, volunteers would then be asked to undergo evaluations of their body composition, blood pressure, heart rate, and other signs of cardiovascular function and health. Lastly, volunteers would be asked to take part in a brief and challenging psychological task after a period of rest while cardiovascular activity is measured. In the other session, volunteers are asked to undergo magnetic resonance imaging and to complete neuropsychological tests of memory, attention, and processing speed. In addition to these two sessions, volunteers are asked to complete online questionnaires. The study is designed to examine associations between transient changes in cardiovascular activity induced by the psychological task, measures of overall cardiovascular health, and measures of cerebrovascular health measured by magnetic resonance imaging. Study results are expected to provide new information about the relationships between cardiovascular activity changes to psychological challenges and cardiovascular and cerebrovascular health in adults.",[29,192,425],"Cerebrovascular Disorders","2025-09-22",{"date":428,"type":40},"2025-09-26",{"date":430,"type":40},"2023-10-17",{"date":169,"type":22},{"name":433,"class":47},"University of Pittsburgh",{"id":435,"slug":436,"hasResults":11,"nctId":437,"briefTitle":438,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":23,"phases":443,"briefSummary":445,"conditions":446,"keywords":448,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":462,"locationsCount":48},"100585192","phase-2-psilocybin-assisted-therapy-for-intergenerational-trauma-100585192","NCT06899165","Psilocybin-Assisted Therapy for Intergenerational Trauma","Processing Intergenerational Trauma With Psilocybin-Assisted Therapy","Inclusion criteria:\n\n* Age at least 18 years old at time of signing the informed consent\n* Biological child of at least one parent who directly survived\u002Fescaped a genocide\n* Meets diagnostic criteria for a depressive or anxiety disorder\n* Capable of providing informed consent and complying with study procedures\n* Currently using or agreeing to use adequate contraceptive methods.\n* Fluent in speaking and reading English\n* Able to swallow pills\n* Agrees to have study visits recorded with audio and video\n* Able to provide a contact person who can be reached by investigators in the event of the participant becoming unwell or unreachable\n* Agrees to inform the investigators within 48 hours of any medical conditions and procedures\n* Agrees to release of outside medical and psychiatric records\n* Must not participate in any other interventional clinical trials for the duration of the study.\n* Must commit to medication dosing, therapy, and all study procedures.\n\nExclusion Criteria:\n\n* Not able to give adequate informed consent.\n* Was directly exposed to or survived a genocide.\n* Has a history of any medical condition, or any significant clinical finding on screening tests, that could make receiving psilocybin harmful.\n* Has acute, severe or unstable medical illness.\n* Has a history of stroke or Transient Ischemic Attack (TIA).\n* Has a history of psychiatric hospitalization within the last 6 months.\n* Current serious suicide risk.\n* Unable or unwilling to safely taper off prohibited psychiatric medications.\n* Abusing alcohol or other substances.\n* Has used psychedelics within 3 months of enrollment.\n* Are pregnant or nursing or able to become pregnant and are not practicing an effective means of contraception.",{"count":442,"type":22},100,[444],"PHASE2","This is an open-label psilocybin-assisted therapy study that will examine the safety and tolerability of psilocybin-assisted therapy in the offspring of genocide survivors with mood and anxiety disorders.\n\nThe study will also investigate the efficacy of psilocybin-assisted therapy in reducing symptoms such as depression, anxiety and stress, as well as changes to the psychological effects of parental exposure to genocide, and changes to psychological resilience.",[29,447,132],"Depression",[449,450,451,452,453,454],"psilocybin","psilocybin-assisted therapy","intergenerational trauma","psychedelic","stress","genocide","2025-09-02",{"date":457,"type":40},"2025-09-08",{"date":459,"type":40},"2025-08-28",{"date":461,"type":22},"2030-01-02",{"name":463,"class":47},"Rachel Yehuda",{"id":465,"slug":466,"hasResults":11,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":470,"eligibilityCriteria":471,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":419,"enrollmentInfo":472,"targetDuration":4,"studyType":23,"phases":474,"briefSummary":475,"conditions":476,"keywords":480,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":489,"lastUpdatePostDateStruct":490,"startDateStruct":492,"completionDateStruct":494,"leadSponsor":496,"locationsCount":48},"100603640","effect-of-adding-progressive-muscle-relaxation-to-physical-therapy-program-on-fatigue-mobility-and-stress-among-individuals-with-traumatic-lower-limb-amputation-in-the-gaza-strip-100603640","NCT07139145","Effect of Adding Progressive Muscle Relaxation to Physical Therapy Program on Fatigue, Mobility and Stress Among Individuals With Traumatic Lower Limb Amputation in the Gaza Strip","Effect of Adding Progressive Muscle Relaxation to Physical Therapy Program on Fatigue, Mobility and Stress Among Traumatic Lower Limb Amputees in Gaza Strip","PMR-AMP","Inclusion Criteria:\n\n* Adults aged 18 to 59 years.\n* Unilateral traumatic trans-femoral\u002Ftranstibial amputation.\n* Post prosthetic fitting.\n\nExclusion Criteria:\n\n* Severe comorbidities (e.g., uncontrolled cardiovascular disease).\n* Severe cognitive impairment or mental illness.\n* Recent orthopaedic surgery (\\\u003C3 months)",{"count":473,"type":22},60,[25],"Lower limb amputation is a life-altering condition with profound physical and psychological consequences, including fatigue, impaired mobility, stress, and asymmetrical weight-bearing. These challenges are particularly severe in conflict-affected settings like the Gaza Strip, where access to rehabilitation services is limited.\n\nThis study aims to evaluates the effect of adding Progressive Muscle Relaxation (PMR), a simple and cost-effective relaxation technique, to standard physical therapy on Fatigue, mobility, weightbearing distribution and stress outcomes among adults with unilateral traumatic lower limb amputation in Gaza.\n\nStudy design:\n\nRCT with 60 participants will be randomly assigned to either (1) a control group receiving standard physiotherapy or (2) an intervention group receiving standard physiotherapy plus PMR.\n\nOutcomes will be measured using validated instruments: Fatigue Severity Scale (FSS), 2-Minute Walk Test (2MWT), Perceived Stress Scale (PSS-10), and dual bathroom scale method for weight-bearing distribution. Assessments will be conducted at baseline, post-intervention (6 weeks), and follow-up (8 weeks).\n\nThe study aims to determine whether integrating PMR into rehabilitation improves fatigue reduction, functional mobility, stress management, and weight-bearing symmetry compared to physiotherapy alone. Findings will contribute to evidence-based rehabilitation strategies for amputees in low-resource, high-stress environments.",[477,478,479,29],"Traumatic Lower Limb Amputation","Fatigue","Mobility Impairment",[481,482,483,478,484,71,485,486,487,488],"Progressive Muscle Relaxation (PMR)","Physiotherapy","Rehabilitation","Mobility","Weight-Bearing Symmetry","Gaza Strip","Amputees","Randomized Controlled Trial (RCT)","2025-08-17",{"date":491,"type":40},"2025-08-24",{"date":493,"type":22},"2025-09-15",{"date":495,"type":22},"2026-02-26",{"name":497,"class":47},"Marah Radi",{"id":499,"slug":500,"hasResults":11,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":18,"enrollmentInfo":505,"targetDuration":4,"studyType":23,"phases":506,"briefSummary":508,"conditions":509,"keywords":512,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":517,"lastUpdatePostDateStruct":518,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":48},"100522244","early-phase-1-relief-of-psychoemotional-stress-using-xenon-sedation-100522244","NCT06080100","RELIEF OF PSYCHOEMOTIONAL STRESS USING XENON SEDATION","RELIEF OF PSYCHOEMOTIONAL STRESS BEFORE REFRACTIVE LASER VISION CORRECTION SURGERY USING XENON SEDATION","Inclusion Criteria:\n\n* upcoming operation ReLEx® SMILE;\n* high anxiety and stress instability (Spielberger-Khanin test of 46 points or more);\n* signed informed consent to participate in the study.\n\nExclusion Criteria:\n\n\\- concomitant somatic diseases in the decompensation stage.",{"count":21,"type":22},[507],"EARLY_PHASE1","The goal of this clinical trial is to propose for implementation and evaluate the effectiveness of xenon sedation for the relief of psychoemotional stress disorder before the operation of refractive laser vision correction patients with high anxiety and stress instability who underwent xenon analgosedation before refractive laser vision correction. The main question\\[s\\] it aims to answer are:\n\n1. To develop a method of xenon sedation in patients with a high level of psychoemotional stress before surgery - refractive laser vision correction.\n2. To evaluate the effect of inhaled xenon anesthesia in a sub-narcotic dose on the duration of surgery, satisfaction of surgeons and patients with anesthesia, the level of postoperative pain in patients in comparison with anxiolytics.\n\nThe following will be studied: the level of preoperative anxiety, the dynamics of glycemia and blood cortisol levels, heart rate variability, electrical microamplitudes of the ECG signal, the anti-stress and analgesic effect of xenon.\n\nIf there is a comparison group: the researchers will compare \\[the group with xenon sedation and the control group\\] to see if there is \\[an anti-stress effect of xenon in patients before laser vision correction\\].",[29,510,132,511],"Anesthesia","Xenon",[513,514,515,516],"sedation","laser refractive interventions","anxiety","xenon","2025-06-24",{"date":519,"type":40},"2025-06-27",{"date":521,"type":40},"2023-11-01",{"date":523,"type":22},"2026-04-01",{"name":525,"class":526},"The S.N. Fyodorov Eye Microsurgery State Institution","OTHER_GOV",{"id":528,"slug":529,"hasResults":11,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":4,"eligibilityCriteria":533,"healthyVolunteers":55,"sex":56,"minAge":4,"maxAge":4,"enrollmentInfo":534,"targetDuration":4,"studyType":23,"phases":536,"briefSummary":537,"conditions":538,"keywords":541,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":547,"lastUpdatePostDateStruct":548,"startDateStruct":550,"completionDateStruct":552,"leadSponsor":554,"locationsCount":48},"100576654","effect-of-aerobic-exercise-with-synchronous-music-on-functions-among-medical-students-100576654","NCT06788106","Effect of Aerobic Exercise With Synchronous Music on Functions Among Medical Students","Effect of Different Aerobic Exercise Intensities With Synchronous Music on Psychophysiological, Attentional, Executive Functions and Brain Functional Connectivity Among Medical Students in Jiangsu Province, China","Inclusion Criteria:\n\n* Medical students willing to participate in aerobic training\n* Population of low questionnaire evaluation results\n* Subjects achieved a result of 7met or more on the Treadmill Test using the Bruce protocol\n* The medical students with low to moderate physical activity level. They are able to exercise, once or twice per week, but are not in the habit of doing so daily\n\nExclusion Criteria:\n\n* History of major depressive disorder in the past 6 months\n* Have a history of alcohol, drug abuse or use of psychiatric drugs\n* Have a history of head trauma, neurological disease or other serious illness",{"count":535,"type":22},134,[25],"Researchers invite participants to volunteer to participate in this cross-sectional, interventional study. This research examines the effects of 8-week aerobic exercise of different intensities combining synchronized music on psychology, attention, and executive function among Chinese college students, and also validates the reliability and validity of the Chinese version of Brief College Student Hassles Scale, the Perceived Stress Scale for Medical Students, Brief Multidimensional Students'Life Satisfaction Scale, Positive Thinking Skills Scale, Attentional Function Index, Procrastination Assessment Scale-Student and Behavioral Assessment of the Dysexecutive Syndrome-College version, providing a research basis for aerobic exercise to improve the cognitive function and mental health level of Chinese college students. Participants will be invited to participate in the intervention study, in which participants will be assigned to the intervention group and control group. Participation in this study will last approximately 8 weeks for a total of 24 sessions, 40 minutes each session, and participants will not be forced to participate in this study if they do not wish to. This study will include up to 134 participants who will be assigned to the intervention and control groups in a randomized manner.",[29,539,540],"Aerobic Exercise","Medical Students",[542,370,543,544,545,546],"medical students","psychophysiological function","attentional function","executive funcion","brain functional connectivity","2025-03-24",{"date":549,"type":40},"2025-03-26",{"date":551,"type":40},"2025-02-26",{"date":553,"type":22},"2025-12-21",{"name":555,"class":47},"Universiti Sains Malaysia",{"id":557,"slug":558,"hasResults":11,"nctId":559,"briefTitle":560,"officialTitle":561,"acronym":562,"eligibilityCriteria":563,"healthyVolunteers":55,"sex":56,"minAge":564,"maxAge":4,"enrollmentInfo":565,"targetDuration":4,"studyType":23,"phases":567,"briefSummary":568,"conditions":569,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":576,"completionDateStruct":578,"leadSponsor":580,"locationsCount":48},"100416301","a-randomized-controlled-evaluation-of-a-compassion-course-for-healthcare-professionals-100416301","NCT04700878","A Randomized Controlled Evaluation of a Compassion-course for Healthcare Professionals","A Randomized Controlled Evaluation of a Compassion-course With the Aim of Reducing Stress of Conscience and Work-related Stress and Increase Levels of Professional Quality of Life and Self-compassion in Healthcare Professionals","ICOP","Inclusion Criteria:\n\nThe inclusion criteria will be as follows: the participants work directly with patients full-time or part-time, score 45 points or higher on the primary outcome measure Stress of Conscience Questionnaire (SCQ), are proficient in Swedish, have the requisite time to attend a digital course, and accept the course's format.\n\nThe exclusion criteria include being partially or fully on sick leave due to stress.\n\nAll criteria are assessed on the basis of self-assessment forms of the participants, but in case of uncertainty, follow-up questions can be done by phone.","20 Years",{"count":566,"type":22},548,[25],"The aim is to investigate whether an internet-based compassion course of five modules contributes to reducing stress of conscience and work-related stress, increase the experience of professional quality of life and self-compassion in healthcare professionals.",[29,570,571,572],"Compassion","Occupational Health","Cognitive Behavioral Therapy","2025-03-14",{"date":575,"type":40},"2025-03-19",{"date":577,"type":40},"2021-02-01",{"date":579,"type":22},"2027-12-31",{"name":581,"class":47},"Linnaeus University",{"id":583,"slug":584,"hasResults":11,"nctId":585,"briefTitle":586,"officialTitle":586,"acronym":587,"eligibilityCriteria":588,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":418,"enrollmentInfo":589,"targetDuration":4,"studyType":23,"phases":591,"briefSummary":592,"conditions":593,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":595,"lastUpdatePostDateStruct":596,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":600,"locationsCount":48},"100583635","trauma-and-cardiometabolic-health-in-an-american-indian-community-100583635","NCT06878885","Trauma and Cardiometabolic Health in an American Indian Community","IHPIPO'TO'TSP","Inclusion Criteria:\n\n* 18-40 years\n* Identifying as American Indian\n* Living on or near Blackfeet reservation\n\nExclusion Criteria:\n\n* Uncontrolled hypertension",{"count":590,"type":22},400,[25],"Volunteers for the study are asked to participate in two laboratory sessions. In the first laboratory session, volunteers are asked to provide a blood sample which will be used to measure factors related to health. Participants also complete questionnaires related to demographic and health-related information and undergo evaluations of their body composition. In the second laboratory visit, participants are asked to have cardiovascular, neuroendocrine, and inflammatory activity measured during a brief period of rest and during a short challenging psychological task. Participants will also complete questionnaires. The study is designed to examine the associations between experiences such as trauma and resiliency with changes in bodily systems during a challenge and current health.",[29,594,365],"Cardiometabolic Conditions","2025-03-10",{"date":267,"type":40},{"date":598,"type":40},"2024-05-10",{"date":349,"type":22},{"name":601,"class":47},"Montana State University",{"id":603,"slug":604,"hasResults":11,"nctId":605,"briefTitle":606,"officialTitle":607,"acronym":4,"eligibilityCriteria":608,"healthyVolunteers":11,"sex":56,"minAge":57,"maxAge":4,"enrollmentInfo":609,"targetDuration":611,"studyType":61,"phases":4,"briefSummary":612,"conditions":613,"keywords":617,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":624,"lastUpdatePostDateStruct":625,"startDateStruct":627,"completionDateStruct":629,"leadSponsor":631,"locationsCount":48},"100475980","the-associations-of-psychological-stress-with-therapy-efficacy-and-prognosis-of-lung-cancer-stress-lung-100475980","NCT05477979","The Associations of Psychological Stress With Therapy Efficacy and Prognosis of Lung Cancer (STRESS-LUNG)","Cohort Studies of Associations of Psychological Stress With Therapy Efficacy and Prognosis of Lung Cancer, Including Non-small-cell Lung Cancer and Small-cell Lung Cancer With Early and Advanced Staging (STRESS-LUNG)","Cohort 1 (STRESS-LUNG-1):\n\nInclusion Criteria:\n\n1. Age ≥ 18 years;\n2. Histologically confirmed diagnosis of NSCLC;\n3. Unresectable locally advanced, metastatic, or recurrent stage ⅢB-Ⅳ based on AJCC TNM staging 8th edition;\n4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1;\n5. Systematic treatments naive ( e. g., chemotherapy, anti-angiogenic drugs, targeted drugs, and immunotherapy );\n6. Presence of at least one measurable lesion according to the Response Evaluation Criteria in Advanced Solid Tumors version 1.1 (RECIST v1.1) ;\n7. Receiving PD-1\u002FPD-L1 inhibitors monotherapy or combination with chemotherapy;\n8. Informed and agreed to participate in the study;\n\nExclusion Criteria:\n\n1. Epidermal growth factor receptor (EGFR)-sensitizing mutation and\u002For anaplastic lymphoma kinase (ALK) gene and\u002For ROS proto-oncogene 1 (ROS1) fusion-positive;\n2. Combined with other malignant tumors in the past 3 years;\n3. Concurrent acute or chronic psychiatric disorders;\n4. Current receiving anti-depressive or anti-anxiety therapy;\n5. Previous treatment with other clinical drug trials;\n6. Patients with symptomatic brain metastasis;\n7. Can't cooperate with psychological scale assessment;\n\nCohort 2 (STRESS-LUNG-2):\n\n1. Age ≥ 18 years；\n2. Pathologically diagnosed as small cell lung cancer；\n3. Unresectable locally advanced, metastatic, or recurrent stage Ⅲ-Ⅳ based on AJCC TNM staging 8th edition;\n4. Eastern Cooperative Oncology Group (ECOG) performance status of 0-1;\n5. Systematic treatments naive ( e. g., chemotherapy, anti-angiogenic drugs, targeted drugs, and immunotherapy );\n6. Presence of at least one measurable lesion according to the Response Evaluation Criteria in Advanced Solid Tumors version 1.1 (RECIST v1.1) ;\n7. Receiving PD-1\u002FPD-L1 inhibitors monotherapy or combination with chemotherapy;\n8. Informed and agreed to participate in the study;\n\nExclusion Criteria:\n\n1. Combined with other malignant tumors in the past 3 years;\n2. Concurrent acute or chronic psychiatric disorders;\n3. Current receiving anti-depressive or anti-anxiety therapy;\n4. Previous treatment with other clinical drug trials;\n5. Patients with symptomatic brain metastasis;\n6. Can't cooperate with psychological scale assessment;\n\nCohort 3 (STRESS-LUNG-3):\n\n1. Age ≥18 years ；\n2. Pathologically diagnosed as non-small cell lung cancer;\n3. Resectable clinical stage IB-IIIB based on AJCC TNM staging 8th edition;\n4. At least one measurable lesion can be evaluated according to the RECIST 1.1 standard；\n5. Systematic treatments naive ( e. g., chemotherapy, anti-angiogenic drugs, targeted drugs, and immunotherapy );\n6. Receiving PD-1\u002FPD-L1 inhibitors combined with chemotherapy as neoadjuvant therapy.\n\n6\\. Cardiopulmonary function can withstand surgery; 7. Informed and agreed to participate in the study;\n\nExclusion Criteria:\n\n1. Epidermal growth factor receptor (EGFR)-sensitizing mutation and\u002For anaplastic lymphoma kinase (ALK) gene and\u002For ROS proto-oncogene 1 (ROS1) fusion-positive;\n2. Combined with other malignant tumors in the past 3 years;\n3. Concurrent acute or chronic psychiatric disorders;\n4. Current receiving anti-depressive or anti-anxiety therapy;\n5. Previous treatment with other clinical drug trials;\n6. Can't cooperate with psychological scale assessment;\n\nCohort 4 (STRESS-LUNG-4):\n\n1. Age ≥18 years;\n2. Pathologically diagnosed as non-small-cell lung cancer；\n3. Pathologically stage conformed as early stage of IA-IIIA\n4. Available for tumor tissue samples；\n5. Systematic treatments naive ( e. g., chemotherapy, anti-angiogenic drugs, targeted drugs, and immunotherapy );\n6. Receiving radical surgery;\n7. Informed and agreed to participate in the study;\n\nExclusion Criteria:\n\n1. Combined with other malignant tumors in the past 3 years;\n2. Concurrent acute or chronic psychiatric disorders;\n3. Current receiving anti-depressive or anti-anxiety therapy;\n4. Previous treatment with other clinical drug trials;\n5. Can't cooperate with psychological scale assessment;",{"count":610,"type":22},750,"5 Years","This is the prospective, observational cohort study (STRESS-LUNG) to explore the associations of psychological stress with progression, efficacy of immune checkpoint inhibitors (ICIs) and prognosis of Lung Cancer. The participants including the patients diagnosed with advanced non-small-cell lung cancer (NSCLC) who received the first-line therapy or neoadjuvant therapy of ICIs; patients diagnosed with advanced small-cell lung cancer (SCLC) receiving the first-line therapy ICIs; patients diagnosed with early small-cell lung cancer (SCLC) receiving surgery.",[614,29,615,616],"Lung Cancer","Immune Checkpoint Inhibitors","Cancer, Treatment-Related",[618,619,620,621,622,623],"Lung cancer","Immune checkpoint inhibitors","Psychological stress","Cancer progression","Prognosis","Biomarker","2025-02-21",{"date":626,"type":40},"2025-02-25",{"date":628,"type":40},"2020-06-01",{"date":630,"type":22},"2028-12-31",{"name":632,"class":47},"Second Xiangya Hospital of Central South University",{"id":634,"slug":635,"hasResults":11,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":4,"eligibilityCriteria":639,"healthyVolunteers":55,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":640,"targetDuration":641,"studyType":61,"phases":4,"briefSummary":642,"conditions":643,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":645,"lastUpdatePostDateStruct":646,"startDateStruct":648,"completionDateStruct":650,"leadSponsor":652,"locationsCount":48},"100578612","parental-stress-and-attachment-in-preterm-infants-100578612","NCT06813560","Parental Stress and Attachment in Preterm Infants","Parental Stress and Attachment in Premature Infants in Their First Months of Life in Early Months of Life in Child Development and Early Care Centres.","Inclusion Criteria:\n\n* Children born under 37 weeks of gestation,\n* Parents of legal age and who have sufficient cognitive capacity to understand the informed consent.\n\nExclusion Criteria:\n\n\\-",{"count":473,"type":22},"1 Year","Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term. Furthermore, previous studies have linked prematurity, as an associated risk factor, with possible alterations in the bonding between the child and his or her mother in the first years of life. The possible impact that the stay in the neonatal unit may have on the mental health of the parents is noted. In fact, several studies have shown that the hospital environment of neonatal units may contribute to increased stress and anxiety in mothers. On the other hand, prematurity is one of the causes of referral to Child Development and Early Care Centres, to address their development in the first years of life, as well as for family support. One of the functions of early childhood professionals is to guarantee the development of a secure attachment between the child and his or her caregivers. Little is known about whether maternal stress levels can influence mother-child interactions and thus influence the attachment relationship in the early years of life.\n\nObjective: to analyse the association between mothers' stress level due to preterm birth and attendance at a Child Development and Early Care Centre and child development and patterns of mother-child interactions.",[644,29,195],"Premature Birth","2025-02-03",{"date":647,"type":40},"2025-02-07",{"date":649,"type":22},"2025-02-01",{"date":651,"type":22},"2025-08-01",{"name":653,"class":47},"Cardenal Herrera University",{"id":655,"slug":656,"hasResults":11,"nctId":657,"briefTitle":658,"officialTitle":659,"acronym":660,"eligibilityCriteria":661,"healthyVolunteers":55,"sex":56,"minAge":57,"maxAge":662,"enrollmentInfo":663,"targetDuration":4,"studyType":23,"phases":665,"briefSummary":666,"conditions":667,"keywords":669,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":673,"lastUpdatePostDateStruct":674,"startDateStruct":676,"completionDateStruct":678,"leadSponsor":680,"locationsCount":4},"100549959","effectiveness-of-stress-self-management-health-education-based-on-imb-theory-among-nursing-students-100549959","NCT06440837","Effectiveness of Stress Self-management Health Education Based on IMB Theory Among Nursing Students","Effectiveness of Stress Self-management Health Education Based on IMB Theory Among Nursing Students, Shanxi Province, China","IMB","Inclusion Criteria:\n\n1. cluster\n\n   * dormitories located in Changzhi Medical College\n   * The residents in the dormitory are all nursing students that registered in fist-semester\n2. individual\n\n   * Registered in undergraduate nursing program\n   * Registered in the first-semester study\n   * Have a mobile device that can access internet\n   * Voluntarily participated in this study\n\nExclusion Criteria:\n\n1. cluster\n\n   * The residents in the dormitory are mixed with students from other majors except nursing.\n   * The residents in the dormitory are mixed with nursing students from other grade.\n2. individual\n\n   * Diagnosed with mental problems or severe physical problems, e.g., depression, generalized anxiety disorder, or diabetes\n   * Previous participation in other stress intervention studies","60 Years",{"count":664,"type":22},120,[25],"The aim of this cluster randomized controlled study is to test the effectiveness of IMB stress self-management health education on nursing students registered in first semester. The main question aims to answer are: Does IMB stress self-management health education program improving stress in nursing students? Researcher will compare wait-list group without any intervention to experimental group which received IMB stress self-management health education, to see if IMB stress self-management health education works to improving stress among nursing students.\n\nParticipants will Attend IMB stress self-management health education program once a week for 8 weeks. In addition, complete questionnaires at pre-intervention, post-intervention, 1-month post-intervention, 3-months post-intervention, 6-months post-intervention.",[29,668],"Nursing Students",[670,671,672],"health education","IMB model","cluster-randomized controlled study","2024-06-03",{"date":675,"type":40},"2024-06-04",{"date":677,"type":22},"2024-10-10",{"date":679,"type":22},"2026-08-01",{"name":681,"class":47},"Changzhi Medical College"]