[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"psychological\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:psychological":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,46,81,114,140,163,189,218,256,286,314,342,363],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100475367","smartphone-app-based-mindfulness-intervention-for-french-and-english-speaker-cancer-survivors-100475367",false,"NCT05470010","Smartphone App-Based Mindfulness Intervention for French and English Speaker Cancer Survivors","The SEAMLESS Study: A Pragmatic Multi-Site Randomized Waitlist-Controlled Trial of a Smartphone App-Based Mindfulness Intervention for French and English Speaker Cancer Survivors","SEAMLESS","Inclusion Criteria:\n\n* Adult ≥ 18 years\n* Diagnosed with any type of cancer (stages I-IV)\n* Completed primary treatment (i.e. surgery, chemotherapy, radiation therapy) at least 2 weeks (14days) prior. Note: ongoing maintenance therapy, hormone-blocking therapies, intermittent bone-modifying agents, herceptin and targeted therapy with trastuzumab are not exclusionary.\n* Have access to a smartphone with data or wifi connection.\n* Willing to devote 20-30 mins of time to mindfulness practices daily during the 4-week intervention period.\n* Participant consent must be appropriately obtained in accordance with applicable local and regulatory requirements. Each participant must sign a consent form (e-consent) prior to enrollment in the study to document their willingness to participate.\n* Participant is able (i.e. sufficiently fluent) and willing to complete the MBCS Journey and outcome measures in either English or French. The baseline assessment must be completed within required timelines, prior to randomization.\n* In accordance with CCTG policy, protocol intervention is intended to begin within 7 calendar days of patient randomization.\n* Participants must be willing to complete the MBCS Journey and complete the follow-up questionnaires\n\nExclusion Criteria:\n\n* Major communication difficulties at the time of recruitment, as assessed by the research team (e.g. severe hearing impairment or cognitive impairment (score of ≤ 6; as assessed by the centre CRA using the three questions from the Brief Screen for Cognitive Impairment (BSCI)) listed in the screening CRF, which could interfere with completing the intervention and\u002For the questionnaires (i.e. inability to read or write)\n* Suffering from untreated Major Depressive Disorder or other psychiatric disorders that would interfere with participation. (Note: Participants will be referred for treatment and invited to call back once in remission).\n* Previous experience practicing in-person or app-based mindfulness once a week or more within the last year.","ALL","18 Years",{"count":20,"type":21},345,"ESTIMATED","INTERVENTIONAL",[24],"NA","There is a need to develop, evaluate, and disseminate self-directed, easily accessible, safe, affordable, and effective psychosocial interventions to people living with cancer (PLWC) post-treatment. Smartphone app-based health interventions are an innovative way to deliver psychosocial cancer-care. The Mindfulness-Based Cancer Survivorship (MBCS) Journey app is a mobile app format of the Mindfulness-based Cancer Recovery program. In the SEAMLESS Study, the investigators aim to evaluate the MBCS Journey app (a 4 week mind-body intervention) in cancer survivors post-treatment. This is a randomized wait-list controlled trial. Participants will either be assigned into the immediate group (will receive intervention immediately after enrollment) or the waitlist group (wait for 3 months before receiving the intervention).",[27,28],"Cancer","Psychological",[30,31,32],"Cancer survivors","Smartphone app","Mindfulness","RECRUITING","2026-06-29",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":37},"2025-03-07",{"date":41,"type":21},"2026-12-31",{"name":43,"class":44},"Canadian Cancer Trials Group","NETWORK",7,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":64,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100512176","smartphone-based-cognitive-emotion-regulation-training-for-unpaid-primary-caregivers-of-persons-with-alzheimers-disease-100512176","NCT05949047","Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease","Biobehavioral Mechanisms of Smartphone-based Cognitive Emotion Regulation Training for Unpaid Primary Caregivers of Persons With Alzheimer's Disease","Inclusion Criteria:\n\nHealthy Adult Caregivers\n\n* Unpaid primary caregiver of patient with Alzheimer's Disease\u002FAlzheimer's Disease and Related Dementias (AD\u002FADRD)\n* At least 18 years of age, with no maximum age, provided that all other inclusion\u002Fexclusion criteria are met\n* Must be able to speak, read, and write in English\n* Must be free of any current or past DSM diagnosis (i.e. healthy adults), with the exception of current or past mood or anxiety disorders or past substance-related disorders (i.e., current or past mood or anxiety disorders and\u002For past substance-related disorders would not represent an exclusion factor)\n* Must have a smartphone. This represents any major iOS or Android-based smartphone. The smartphone will also be used for collection of ecological momentary assessment (EMA) data via SurveySignal.\n* Must provide significant level of caregiving to their care recipient\n* Must be at least minimally-stressed\n\nCognitively Impaired Adults\n\n* Must have diagnosed with Alzheimer's Disease\u002FAlzheimer's Disease and Related Dementias (AD\u002FADRD)\n* Must be the care recipient of the primary caregiver who is completing the study\n* Must be able to understand and willing to complete a questionnaire and the consent form\n* Must have minimum level of dementia symptoms\n\nExclusion Criteria:\n\nHealthy Adult Caregivers\n\n* Current or past psychiatric disorders (e.g., psychotic and personality disorders) with the exception of current or past mood or anxiety disorders or past substance-related disorders (i.e., current or past mood or anxiety disorders and\u002For past substance-related disorders would not represent an exclusion factor)\n* Currently receiving psychotherapy that specifically addresses caregiver burden\u002Fdistress or employs cognitive reappraisal as a major component\n* Significant visual, auditory, or cognitive impairment that compromises their ability to understand and complete the task\n* Caregiver participants who cease meeting inclusion criteria during the study will be dismissed from the study and compensated pro-rata.\n* Has formerly participated in a study from our lab involving the same or essentially same design (e.g., former participants who provided pilot\u002Fpreliminary data for this study)\n\nCognitively Impaired Adults\n\n* The care recipient does not wish to participate, and\u002For their caregiver does not want them to participate\n* Significant visual, auditory, or cognitive impairment that compromises their ability to understand and complete questionnaires, even with their caregiver's help will exclude them from the study\n* Has formerly participated in a study from our lab involving the same or essentially same design (e.g., former participants who provided pilot\u002Fpreliminary data for this study)",true,{"count":55,"type":21},270,[24],"Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementias (ADRD) not only exact a heavy toll on patients, they also impose an enormous emotional, physical, and financial burden on unpaid, often family, caregivers. The strain of providing care for a loved one diagnosed with AD, often across several years, is associated with elevated depression risk and poorer overall health. Emotion regulation skills represent an ideal target for psychological intervention to promote healthy coping in ADRD caregivers. The project seeks to use an experimental medicine approach to test the efficacy and biobehavioral mechanisms of a novel, relatively brief, targeted, scalable, smartphone-based cognitive emotion regulation intervention aimed at improving psychological outcomes (i.e., reducing perceived stress, caregiver burden, and depressive symptoms) in ADRD unpaid primary caregivers as well as examine potential benefits of the caregiver intervention on quality of life in care recipients. Cognitive reappraisal is the ability to modify the trajectory of an emotional response by thinking about and appraising emotional information in an alternative, more adaptive way. Reappraisal can be operationalized via two primary tactics: psychological distancing (i.e. appraising an emotional stimulus as an objective, impartial observer) and reinterpretation (i.e., imagining a better outcome than what initially seemed apparent). The project will investigate the efficacy and underlying biobehavioral mechanisms of a novel, one-week cognitive reappraisal intervention in this population, with follow-up assessments at 2 weeks, 4 weeks, and 3 months. ADRD unpaid primary caregivers will be randomly assigned to receive training in either distancing, reinterpretation, or a no regulation natural history control condition, with ecological momentary assessments of self-reported positive and negative affect, remotely- collected psychophysiological health-related biomarkers (i.e., heart rate variability data) using pre-mailed Polar H10 chest bands, and health-related questionnaire reports. Distancing training is expected to result in longitudinal reductions in self-reported negative affect, longitudinal increases in positive affect, and longitudinal increases in HRV that are larger than those attributable to reinterpretation training and no-regulation control training.",[59,60,61,62,28,63],"Caregivers","Emotions","Emotion Regulation","Stress","Psychophysiology",[65,66,67,68,69],"emotion regulation","caregiving","affective science","psychophysiology","psychoneuroimmunology","2026-05-27",{"date":72,"type":37},"2026-05-29",{"date":74,"type":37},"2023-09-14",{"date":76,"type":21},"2027-05-31",{"name":78,"class":79},"Bryan Denny","OTHER",1,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":53,"sex":17,"minAge":89,"maxAge":18,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":92,"briefSummary":93,"conditions":94,"keywords":98,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":4},"100635847","many-trauma-affected-youth-face-long-waits-for-therapy-worsening-stress-and-avoidance-ciss-a-90-minute-session-based-on-stanfords-cue-centered-therapy-offers-coping-tools-and-psychoeducation-during-this-gap-this-pilot-tests-cisss-feasibility-acceptability-and-impact-on-30-40-adolescents-100635847","NCT07558005","Many Trauma-affected Youth Face Long Waits for Therapy, Worsening Stress, and Avoidance. CISS, a 90-minute Session Based on Stanford's Cue-Centered Therapy, Offers Coping Tools and Psychoeducation During This Gap. This Pilot Tests CISS's Feasibility, Acceptability, and Impact on 30-40 Adolescents.","CISS: CCT-Informed Single Session Intervention","CISS","Inclusion Criteria:\n\n* Age: 13 to 18 years old (adolescents).\n\nTrauma Exposure: History of chronic or single-event trauma (e.g., interpersonal violence, serious accidents, natural disaster) as documented in Child and Adolescent Mental Health Services (CAMHS) intake records.\n\nService Status: Currently on a CAMHS waitlist for trauma-focused therapy, or self-referred but hesitant to begin multi-session treatment.\n\nCapacity and Consent: Ability to provide informed assent (ages 13-15 with parental permission) or informed consent (ages 16-18).\n\nExclusion Criteria:\n\nCurrent Trauma Treatment: Actively engaged in any form of trauma-focused psychotherapy (e.g., TF-CBT, EMDR, CCT) at the time of enrollment.\n\nSevere Cognitive Impairment: Intellectual disability or cognitive impairment (e.g., IQ \\\u003C 70) that precludes comprehension of psychoeducational material or completion of self-report questionnaires.\n\nAcute Suicidality: Endorsement of imminent self-harm or suicide risk (e.g., PHQ-9 item 9 ≥ 2) during screening that necessitates immediate crisis management rather than study participation.","13 Years",{"count":91,"type":21},40,[24],"Many young people who have experienced traumatic events such as sexual assault, domestic violence, serious accidents, or natural disasters face long waits before they can begin full trauma-focused therapy. During this waiting period, symptoms such as avoidance, anxiety, and distress may worsen, and many youth lose motivation or confidence to start treatment. The Cue-Centered Therapy (CCT)-Informed Single Session Intervention (CISS) was designed to bridge this gap by offering a one-time, 90-minute session that teaches coping and self-understanding skills while youth are still on the waiting list.\n\nThis study is a pilot feasibility trial conducted in partnership between Stanford University and the University of Auckland. The purpose of the study is to evaluate whether CISS is a practical, acceptable, and safe intervention for young people aged 13-18 who have been exposed to trauma and are currently waiting for or hesitant to begin full-length therapy within New Zealand Hapai Ora Clinics.\n\nYouth participants will meet once with a trained Hapai Ora clinician who will deliver the 90-minute CISS session. The session combines psychoeducation about trauma cues with skill-building strategies to improve coping, confidence, and readiness to engage in future treatment. Participants will complete short questionnaires before and after the session, and again at 3- and 6-month follow-ups. Measures will assess coping self-efficacy, treatment readiness, posttraumatic stress symptoms, and whether participants eventually begin full-length therapy.\n\nThe study will recruit approximately 30-40 adolescents across Hapai Ora clinical sites in Auckland, New Zealand. All clinicians providing the intervention are qualified mental-health professionals trained in both CISS and child-safety protocols. Participation involves minimal risk-similar to discussing difficult topics in a supportive therapy session.\n\nFindings from this pilot study will help researchers understand whether CISS can be feasibly and safely delivered within public mental-health services, and whether it shows promise in helping young people build coping skills, reduce avoidance, and increase readiness to start therapy. The results will guide future larger-scale trials and inform the development of single-session, early-intervention approaches for trauma-exposed youth worldwide.",[95,96,28,62,97],"Wellbeing","Mental Health","Trauma Exposure",[99,87,100,101,102,103],"Trauma Intervention","Cue Centered Therapy (CCT)","Single-Session Intervention","Chronic Trauma","Trauma","NOT_YET_RECRUITING","2026-04-22",{"date":107,"type":37},"2026-04-30",{"date":109,"type":21},"2026-06-01",{"date":111,"type":21},"2028-11-30",{"name":113,"class":79},"Stanford University",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":53,"sex":17,"minAge":122,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":125,"briefSummary":126,"conditions":127,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":4},"100630983","a-feasibility-randomised-control-trial-to-evaluate-early-perinatal-bereavement-counselling-for-parents-who-have-experienced-a-perinatal-death-100630983","NCT07494760","A Feasibility Randomised Control Trial to Evaluate Early Perinatal Bereavement Counselling for Parents Who Have Experienced a Perinatal Death","Perinatal Loss - Early Referral for Counselling (PEARL-C): A Feasibility Randomised Controlled Trial","PEARL-C","Inclusion Criteria:\n\n* Women and partners of women who have had a late fetal loss (from 16 weeks), stillbirth or neonatal death within the maternity unit at Wythenshawe Hospital.\n* For the qualitative interviews, healthcare professionals who have been involved with referrals to the intervention and\u002For the delivery of the intervention\n\nExclusion Criteria:\n\n* Less than 16 years of age\n* Anyone who lacks the capacity to consent\n* Inability to read English (interpreters will be provided for counselling sessions and interviews if needed).","16 Years",{"count":124,"type":21},26,[24],"The goal of this feasibility randomised control trial is to determine if a trial to evaluate perinatal bereavement counselling for parents who have experienced a perinatal death is feasible. The main question it aims to answer is:\n\n• Is a trial to evaluate access to perinatal bereavement counselling feasible?\n\nResearchers will compare the intervention group (parents who have received counselling) to the control group (parents who have not received counselling) to see if there are differences in measurements of parents' grief and psychological symptoms.\n\n* Participants allocated to the intervention and control group will receive usual bereavement care from the perinatal bereavement team at the hospital\n* Parents allocated to the intervention group will receive counselling\n* Parents will complete validated psychometric questionnaires about their levels of perinatal grief, psychological distress, depression, and quality of life\n* Parents in the intervention group will be asked a series of open-ended written questions about their experience of participating in the trial\n* Healthcare professionals who have been involved with delivery of the intervention\u002Freferrals will be interviewed about their experience of the trial.",[128,129,28,130],"Stillbirth","Perinatal Death","Grief","2026-03-20",{"date":133,"type":37},"2026-03-27",{"date":135,"type":21},"2026-03-01",{"date":137,"type":21},"2027-09-01",{"name":139,"class":79},"University of Manchester",{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":152,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":80},"100583305","psychobiological-responses-following-exercise-and-brain-stimulation-100583305","NCT06874595","Psychobiological Responses Following Exercise and Brain Stimulation","Inclusion Criteria:\n\n* Healthy adults\n* aged 18 to 50\n* consent and complete a Physical Activity Readiness Questionnaire (PAR-Q)\n* be free from any neurological or psychiatric disorder\n* not be taking any medication that could affect the central nervous system\n* not have any contraindication for HD-tDCS (i.e. not having metal implanted in the head, pacemaker, medical bumps, seizures, lesions on the scalp or head ) or for bioelectrical impedance (i.e., electronic medical implant, such as a pacemaker or implantable cardioverter defibrillator, and limb amputation)\n* not be regular users of tobacco products (cigarettes, cigars, chewing tobacco)\n* not consume an average of more than ten alcoholic beverages per week\n\nExclusion Criteria:\n\n* Individuals who do not meet the PAR-Q screening criteria for participation in moderate physical activity will be excluded from participating in this study\n* women who are pregnant will be exclude from this study","50 Years",{"count":148,"type":21},29,[24],"Anxiety disorders are the most common mental health diagnosis in the US; 19.1% of U.S. adults (23.4% for females and 14.3% for males). In addition, the Global Burden of Disease study (2010) found that anxiety disorders were the sixth leading cause of disability (years of life lived with disability). These debilitating disorders are characterized by excessive worry and fear about everyday situations, and physical symptoms including restlessness, being easily fatigued, difficulty concentrating, irritability, muscle tension, or sleep disturbance. Furthermore, anxiety is linked to other mental disorders including depression and substance abuse; is associated with cardiovascular disease risk factors and a higher rate of cardiovascular disease; and is related to premature mortality. These data have led to the investigation of a breadth of plausible treatments for anxiety, including medications and psychotherapy. However, likely due to the breadth of complex mechanisms involved in the pathophysiology of anxiety disorders and the unfavorable side effects of various medications, a considerable number of individuals do not have a satisfactory response to these treatments. This has led investigators to examine plausible novel interventions to alleviate anxiety and its symptoms.",[28],[153],"Exercise and Brain Stimulation","2026-03-12",{"date":156,"type":37},"2026-03-16",{"date":158,"type":37},"2025-03-19",{"date":160,"type":21},"2027-02",{"name":162,"class":79},"Virginia Commonwealth University",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":4,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":17,"minAge":89,"maxAge":18,"enrollmentInfo":170,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":187,"locationsCount":80},"100469846","skills-group-for-youth-at-clinical-high-risk-for-psychosis-100469846","NCT05398120","Skills Group for Youth at Clinical High-Risk for Psychosis","Testing the Feasibility of a Skills Group for Adolescents and Young Adults at Clinical High-risk for Psychosis","Participant Inclusion Criteria:\n\n* 13-18 years of age\n* Meet criteria for clinical high-risk syndrome (i.e., at clinical high risk for developing a psychotic disorder). CHR status is determined based off of scoring a 3 (moderate) - 5 (severe) on the Structured Interview for Psychosis-Risk Syndromes and\u002For having a first degree relative with psychotic disorder and\u002For the individual meets criteria for schizotypal personality disorder. Additionally individuals with a brief intermittent psychotic symptoms can be included as well (e.g., frankly psychotic symptoms that are very brief)\n* Individuals must be enrolled in the HOPE team at the University of Pittsburgh since this group is embedded within that service\n\nParticipation Exclusion Criteria:\n\n* Group member meeting criteria for a current\u002Fpast psychotic disorder\n\nInclusion Criteria for Parents or Legal Guardians:\n\n* Must be the parent, legal guardian of a 13-18 year-old\n* For parents of CHR adolescents, their adolescent must meet criteria for a psychosis-risk syndrome",{"count":171,"type":21},30,[24],"This study is intended to test the feasibility of an integrated cognitive behavioral therapy (CBT) and dialectical behavioral therapy (DBT) skills group for adolescents and young adults at clinical high-risk (CHR) for psychosis. The current study applies a skills group drawing from evidence-based practices (e.g., cognitive behavioral therapy (CBT), dialectical behavioral therapy (DBT)) to those at CHR for psychosis. Up to 30 CHR individuals (starting with a minimum of 3 participants, N accounts for attrition as well), aged 13-18, already receiving clinical services within the HOPE team at University of Pittsburgh will be offered a weekly skills group. Data collected on feasibility and outcome measures will occur pre (within 1 month) -post (up to 4-5 months) and half-way (up to 2-3 months) through the intervention. Taken together, the aim of the proposed intervention is to provide novel insights regarding the utility of a newly developed intervention that integrates both CBT and DBT skills for those at CHR for psychosis.",[175,28],"Clinical High-Risk",[177,178,179,180],"Group intervention","Dialectical behavioral therapy skills","Cognitive behavioral therapy skills","Psychosis-risk","2026-02-06",{"date":183,"type":37},"2026-02-10",{"date":185,"type":37},"2022-04-26",{"date":41,"type":21},{"name":188,"class":79},"University of Pittsburgh",{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":4,"eligibilityCriteria":195,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":196,"targetDuration":4,"studyType":22,"phases":198,"briefSummary":199,"conditions":200,"keywords":204,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":80},"100590506","effect-of-exobdnf-lactic-acid-bacteria-supplement-on-cognitive-functions-sleep-and-psychological-100590506","NCT06968299","Effect of ExoBDNF Lactic Acid Bacteria Supplement on Cognitive Functions, Sleep and Psychological","Effect of ExoBDNF Lactic Acid Bacteria Supplement on Cognitive Functions, Sleep and Psychological Outcomes: An Open-label Trial","Inclusion Criteria:\n\n1. Subjects must be volunteers who are 18 years of age or older, mentally clear and able to communicate.\n2. Subjects who agree to participate in this trial and voluntarily sign the trial consent form.\n\nExclusion Criteria:\n\n1. Subjects who are expected to be or have been confirmed to be pregnant (medical history).\n2. Subjects with gallbladder disease, gastrointestinal disease, gout, porphyria, or a history of gastric weight control surgery.\n3. Subjects with high blood pressure (≥160\u002F100 mmHg after resting for 10 minutes) or taking diuretics.\n4. Subjects with heart disease, hepatorenal insufficiency, hyperthyroidism or hypothyroidism, Cushing's syndrome, malignant tumors, or any other disease that may affect the results of the study.\n5. Subjects with severe hearing or visual impairment that makes it impossible to perform examinations and assessments.\n6. Subjects with any history of brain surgery, penetrating, neurovascular, infectious or other severe brain injury, epilepsy or other major neurological abnormalities, such as traumatic brain injury with loss of consciousness for more than 24 hours, or memory loss after head trauma for more than 7 days were excluded.\n7. Subjects with intellectual disabilities.\n8. Subjects who had consumed probiotics or were expected to consume probiotics within 2 weeks before the screening visit.\n9. Subjects who had participated in or were expected to participate in clinical trials within 4 weeks before the screening visit.",{"count":197,"type":21},50,[24],"This open-label, single-group, pre\u002Fpost-test clinical study was conducted to investigate whether ExoBDNF probiotic supplementation could improve cognitive ability. It is expected that 40 subjects aged 18 years and above will be recruited, with a target of 30 cases, to take ExoBDNF probiotics for a total of 8 weeks.",[201,202,203,28],"Cognitive Functions Perceptual Disturbances","Cognitive Function Abnormal","Sleep",[205,206,207],"Probiotics","ExoBDNF","Cognitive functions","2025-11-18",{"date":210,"type":37},"2025-11-24",{"date":212,"type":37},"2025-05-20",{"date":214,"type":21},"2025-12-30",{"name":216,"class":217},"SunWay Biotech Co., LTD.","INDUSTRY",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":53,"sex":17,"minAge":225,"maxAge":226,"enrollmentInfo":227,"targetDuration":4,"studyType":229,"phases":4,"briefSummary":230,"conditions":231,"keywords":240,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":80},"100561829","community-park-based-programs-for-health-promotion-fit2play-prospective-cohort-study-100561829","NCT06595251","Community Park-Based Programs for Health Promotion: Fit2Play Prospective Cohort Study","F2P","Inclusion Criteria:\n\n* All participants enrolled in the Miami-Dade Fit2Play study will be included in this secondary analysis\n\nExclusion Criteria:\n\n* Anyone not enrolled in the Miami-Dade Fit2Play study will be excluded from this secondary analysis","6 Years","14 Years",{"count":228,"type":21},5000,"OBSERVATIONAL","The Fit2Play prospective cohort study examines the effects of a park-based youth physical activity afterschool program on youth participant fitness and mental health outcomes. Duke will perform a secondary analysis of the data collected as part of the Fit2Play prospective cohort study run by Miami-Dade County Parks and Recreation.",[232,233,234,235,236,237,238,239,28],"Overweight","Obesity","Hypertension","Prehypertension","Anxiety","Well-being","Depression","Low Physical Fitness",[241,242,243,96,244,245,246],"Youth","Afterschool","Parks and Recreation","Physical Health","Physical Activity","Exercise","2025-09-03",{"date":249,"type":37},"2025-09-04",{"date":251,"type":37},"2020-05-07",{"date":253,"type":21},"2027-05-17",{"name":255,"class":79},"Duke University",{"id":257,"slug":258,"hasResults":11,"nctId":259,"briefTitle":260,"officialTitle":261,"acronym":4,"eligibilityCriteria":262,"healthyVolunteers":11,"sex":17,"minAge":263,"maxAge":264,"enrollmentInfo":265,"targetDuration":4,"studyType":22,"phases":267,"briefSummary":268,"conditions":269,"keywords":273,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":80},"100389902","psychological-treatment-to-support-the-consequences-of-cognitive-impairment-100389902","NCT04356924","Psychological Treatment to Support the Consequences of Cognitive Impairment","Evaluation of a Novel Psychological Intervention Tailored for Patients With Early Cognitive Impairment (PIPCI)","* Criteria's for inclusion\n* \\\u003C 75 years.\n* SCD or MCI diagnosis. All cognitive MCI-subtypes are eligible.\n* Mild to moderate psychological symptoms that are indicated to be related to the patient's CI. The psychological symptoms should affect the patients daily living and behavior, exemplified by avoidance behavior, social anxiety and perceived stigmatization.\n* Fluency in the Swedish language.\n* The patients should have access to a mobile telephone to be able to receive reminders via Short Message Service (SMS).\n* Signed informed consent.\n* Criteria's for exclusion\n* Dementia diagnosis and\u002For occurrence of serious illness and\u002For injury that requires immediate investigation or treatment of another type, or which is expected to worsen in the coming year (i.e., not including dementia)\n* Severe psychiatric comorbidity (e.g., high suicide risk), and\u002For severe psychiatric disorder. This will be assessed in the MINI evaluation and during the clinical cognitive examination).\n* Anti-depressant medication introduced or alterations in dosage \\\u003C 6 months ago (i.e., un-stable dose).\n* Mini Mental State Examination (MMSE) score \\\u003C 26 and\u002For a Montreal Cognitive Assessment (MoCA) score \\\u003C 24.\n* Stroke or head trauma \\\u003C 6 months ago.\n* Substance abuse","45 Years","75 Years",{"count":266,"type":21},138,[24],"The burden of cognitive impairment is severe, and often hinders affected people to act independently in daily life. Individuals in different stages of cognitive decline are frequently affected by existential distress and associated health issues (such as stress symptoms, anxiety, and depression), as well as social avoidance due to the unclear prognosis. Although the need for psychological support is large, there is a lack of efficient individualized psychological treatments- and methods to maintain psychological health that sufficiently impact daily life and promote behavioral- and biological change. In keeping with that notion, the investigators have developed a novel psychological treatment manual focused on supporting individuals with early phase cognitive impairment. The treatment manual is centered on facilitating behavioral change in accordance with personal values and long-term goals even in the presence of negative experiences, as well as to promote meaningful life-style changes. Conceptually, the treatment manual has its basis in the cognitive behavioral therapy (CBT) tradition, but the investigators have strived to adapt the manual to suit a cognitively affected population. The investigators will evaluate the psychological treatment in a RCT were the investigators will include approximately 138 individuals in their early phases of cognitive decline and randomize them into either an experimental group (psychological treatment), an active control group (cognitive training), or a treatment as usual control group. Evaluations will be conducted with, psychological health measures, cognitive assessments, and with biological markers.\n\nThe investigators hypothesize that in comparison with the control conditions, the response to psychological treatment will be associated with improved psychological health and improved cellular protection.",[270,28,271,272],"Cognitive Impairment","Psychotherapy","Health Behavior",[274,275,276],"Cognitive impairment","Psychological treatment","Dementia prevention","2025-06-26",{"date":279,"type":37},"2025-07-01",{"date":281,"type":37},"2023-09-07",{"date":283,"type":21},"2028-06-30",{"name":285,"class":79},"Karolinska Institutet",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":290,"acronym":291,"eligibilityCriteria":292,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":293,"targetDuration":4,"studyType":22,"phases":295,"briefSummary":296,"conditions":297,"keywords":300,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":80},"100575123","whatsapp-based-psycho-socio-educational-intervention-welove-for-prevention-of-psychological-and-sleep-problems-in-pregnant-women-and-their-partners-a-three-arm-double-blinded-pilot-randomised-controlled-trial-100575123","NCT06768190","WhatsApp-based Psycho-socio-educational Intervention (WeLove) for Prevention of Psychological and Sleep Problems in Pregnant Women and Their Partners: A Three-arm Double-blinded Pilot Randomised Controlled Trial","WhatsApp-based","Inclusion Criteria:\n\n* pregnant with a gestation of \\>12 to 28 weeks and their partners over 18 years\n* able to read and understand Chinese\n* have electronic devices with WhatsApp that can contact the Internet\n* can provide written consent and voluntary participation in this study\n\nExclusion Criteria:\n\n* current severe medical illnesses\n* psychological and sleep disorders",{"count":294,"type":21},120,[24],"Objectives: (1) evaluate the feasibility and acceptability of the WhatsApp-based psycho-socio-educational intervention (WeLove); (2) preliminarily examine the effects of the intervention on psychological symptoms (depression, anxiety, stress symptoms), sleep quality, and life satisfaction; and (3) preliminarily examine the interdependence between psychological symptoms and sleep quality in pregnant women and their partners.\n\nMethods: The investigators will use WhatsApp to provide the six sessions of the intervention, which include psychological, social, and educational components. A three-arm double-blinded pilot randomised controlled trial (RCT) is used in 60 couples, followed by individual face-to-face interviews for process evaluation in 10 to 20 couples based on data saturation. Participants will be assigned to one of three groups and 20 couples per group: intervention 1 (couples for WeLove), intervention 2 (pregnant women for WeLove), or the control group (use WhatsApp as normal). Participants will be assessed pre- and post-intervention. Generalised estimating equation analysis and thematic analysis will be performed to examine the research objectives.",[298,28,299],"Sleep Problems","Well-Being, Psychological",[301,302,303,304],"Couple-based intervention","Psycho-socio-educational intervention (WeLove)","Psychological well-being","Sleep outcome","2025-01-21",{"date":307,"type":37},"2025-01-23",{"date":309,"type":37},"2025-01-06",{"date":311,"type":21},"2027-01-31",{"name":313,"class":79},"Chinese University of Hong Kong",{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":321,"minAge":18,"maxAge":4,"enrollmentInfo":322,"targetDuration":4,"studyType":22,"phases":324,"briefSummary":325,"conditions":326,"keywords":327,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":80},"100486662","metabolomic-evaluation-of-psycho-surgical-synergy-on-body-image-restoration-after-breast-cancer-100486662","NCT05616988","Metabolomic Evaluation of Psycho-surgical Synergy on Body Image Restoration After Breast Cancer","BrEva","Inclusion Criteria:\n\n* Presence of diagnosis of breast cancer\n* indication to undergo surgical mastectomy treatment\n* Italian nationality\n* level of education not lower than a secondary school diploma, ensuring sufficient writing skills.\n\nExclusion Criteria:\n\n* the occurrence of metastases and\u002For relapse during the study phase,\n* the refusal of patients to undergo reconstruction treatment\n* the presence of existing psychopathological diagnosis","FEMALE",{"count":323,"type":21},80,[24],"The aim of the present study is to verify the effects of a psychological-clinical intervention supported by the technique of expressive writing, on the post-operative course in terms of mental and physical health in patients undergoing surgical mastectomy treatment with post-oncological breast reconstruction. In particular, it is hypothesised that patients undergoing psychological, emotional and social well-being in the phase following surgical treatment, together with an improvement in the inflammatory profile and a possible change in the tryptophan\u002Fkynurenine ratio and cortisol.\n\nFor this purpose, the recruited patients will be randomly divided into two groups. The first experimental group will consist of 10 patients with an indication for reconstruction using autologous tissues (DIEP, FALD) and 10 patients with an indication for reconstruction using the immediate prosthesis technique who will carry out the psychological-clinical intervention focusing on expressive writing about their experience of the surgical treatment.\n\nThe psychological-clinical intervention includes five interviews interspersed with three days of expressive writing by Pennebaker (1986).\n\nThe writing task consists of writing about a traumatic experience or an event significant to the person, for a controlled period of time (usually 15 to 30 minutes) and on consecutive days (2 to 3 days).\n\nThe second control group will consist of 10 patients with an indication for reconstruction using autologous tissues (DIEP, FALD) and 10 patients with an indication for reconstruction using the immediate prosthesis technique who will not undergo any kind of psychological-clinical intervention and will be able to apply for the latter at the end of the research.\n\nIn order to verify the effectiveness of the psychological-clinical intervention, the patients will undergo a psychological evaluation (anxiety, depression, alexithymia, distress, resilience, hope for the future, quality of life, body image, psychological and affective experiences related to breast reconstruction) and a survey of physiological variables (inflammatory response, ratio tryptophan\u002Fkynurenine ratio and salivary cortisol) at the various times envisaged in the study: T0 (1 month pre-surgery mastectomy with breast reconstruction), T1(the day after the end of the psychological-clinical intervention), T2 (3 months post psychological-clinical intervention) and T3 (6 months post psychological-clinical intervention).",[28],[328,329,330,331,332],"Mind-Body Intervention","Metabolomics","Breast Reconstruction","Body Image","Breast Cancer","2024-12-09",{"date":335,"type":37},"2024-12-13",{"date":337,"type":37},"2022-10-26",{"date":339,"type":21},"2026-11",{"name":341,"class":79},"University of Roma La Sapienza",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":22,"phases":351,"briefSummary":352,"conditions":353,"keywords":4,"overallStatus":104,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":80},"100523388","mindful-yoga-for-older-adults-and-caregivers-100523388","NCT06095037","Mindful Yoga for Older Adults and Caregivers","Examining the Effectiveness of Mindful Yoga in Enhancing Psychological Well-being Among Older Adults Discharged From Hospital and Their Caregivers: A Cluster Randomized Controlled Trial","Inclusion Criteria:\n\nOlder adults discharged from hospital\n\n* older adults aged 65 years or above;\n* individuals who have been discharged from a local hospital within the previous 3 months who qualify for the Pilot Scheme on Support for Elderly Persons Discharged from Public Hospitals after Treatment and are receiving services from community support services;\n* individuals with no mobility issues or who have limited mobility but can access the intervention sites using a wheelchair and are capable of practicing mindful yoga, even if in a wheelchair; and\n* individuals who can understand Cantonese.\n\nCaregivers:\n\n• living with older adults during the transition period from hospital to home.\n\nExclusion Criteria:\n\nOlder adults discharged from hospital\n\n* older adults diagnosed with depression, anxiety, or stress disorders by certified doctors;\n* older adults diagnosed with severe dementia;\n* homebound older adults who face difficulty attending the intervention sites; and\n* older adults having a tech-enabled Hospital Admission Risk Reduction Program for the Elderly (HARRPE) score \\\u003C0.17 or \\>0.29.\n\nCaregivers:\n\n• Family caregivers who have been diagnosed with severe mental health issues will be excluded from the proposed study.",{"count":350,"type":21},668,[24],"This study will adopt the intervention of mindful yoga to improve the psychological well-being of older adults who discharged from hospital and their caregivers in Hong Kong.",[28],"2024-12-03",{"date":356,"type":37},"2024-12-05",{"date":358,"type":21},"2025-03-01",{"date":360,"type":21},"2028-09-01",{"name":362,"class":79},"The University of Hong Kong",{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":53,"sex":17,"minAge":370,"maxAge":4,"enrollmentInfo":371,"targetDuration":4,"studyType":22,"phases":373,"briefSummary":374,"conditions":375,"keywords":378,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":80},"100498932","the-effects-of-multi-psycho-oncology-care-courses-100498932","NCT05776680","The Effects of Multi-Psycho-Oncology Care Courses","The Effects of Multi-Psycho-Oncology Care Courses Through Remote Psychological Support, Emotional Awareness Situation Videos and Empathic Concern Intervention on Physical and Psychological Status, Self-Efficacy and Empathy in Oncology Nurses","Intervention group\n\n* Inclusion Criteria:\n* Over 20 years old (inclusive)\n* Oncology nurses currently working in clinical practice\n* Exclusion Criteria:\n* Those who are unwilling or unable to participate in this course training for a full one- year period.\n* Those who have registered for the advanced oncology nursing course organized by the Society in the current year.\n\nControl group\n\n* Inclusion Criteria:\n* Over 20 years old (inclusive)\n* Oncology nurses currently working in clinical practice\n* Those who have registered for the advanced oncology nursing course organized by the Society in the current year\n* Exclusion Criteria:\n* Those who have participated in multiple oncology psychological care courses, those who are unwilling or unable to participate in the training of distance psychological support courses for a full one-year period.\n* Those who participate in the advanced course of oncology nursing are unwilling or unable to participate in the data evaluation of the complete bi-annual time point.\n* Those who have participated in this research project.","20 Years",{"count":372,"type":21},280,[24],"When the patient's mood has not yet reached a moderate to high severity level, psychological support is usually provided by the clinical nurses. However, the result of past research showed that the needs of patients and their caregivers were not satisfied with the psychological level. Scholars pointed out that it may be related to factors such as excessive clinical workload or insufficient psychological support and care capacity. In addition, under the influence of COVID-19 in the past two years, medical staff are facing more physical and mental pressure. Oncology nurses have a heavy workload and are affected by the COVID 19 epidemic, which reflects that nurses need psychological support. Therefore, this study intends to reduce stress through remote physical and mental support activities, and use the Internet to intervene in guided relaxation and meditation. Considering the scheduling of clinical nurses, a remote and unstructured course content that does not require continuity will be selected, and then advanced to provide the empathetic care skills of oncology nurses.",[27,28,376,377],"Oncology","Empathy",[379,380,381,377,382],"cancer","Oncology nurse","Psychological support","Training course","2024-11-04",{"date":385,"type":37},"2024-11-06",{"date":387,"type":37},"2022-08-22",{"date":389,"type":21},"2024-12-31",{"name":391,"class":79},"National Taiwan University Hospital"]