[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"psychotherapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:psychotherapy":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,66,94,124],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100604260","evaluation-of-meaning-centered-group-psychotherapy-in-integrative-medicine-100604260",false,"NCT07147205","Evaluation of Meaning-centered Group Psychotherapy in Integrative Medicine","Eligibility Criteria\n\n1. Age 18 or older.\n2. Male or female.\n3. Diagnosis or history of malignant cancer (excluding non-melanoma skin cancer) or tumor disease.\n4. Able to read, write, and speak in English.\n5. Has access to iOS or Android smartphone, computer, or tablet or device capable of logging onto Zoom.\n6. Referred to the Integrative Medicine Clinic, completed consult with IMC physician, referred to health psychology and completed health psychology assessment.\n7. Participates in at least one MCGP group session.\n8. Willing to review informed consent statement and agree to complete questionnaires.\n\nExclusion Criteria\n\n1. Children will not be enrolled in this study.\n2. Pregnant women will not be enrolled in this study.\n3. Cognitively impaired subjects will not be enrolled in this study.","ALL","18 Years",{"count":18,"type":19},72,"ESTIMATED","INTERVENTIONAL",[22],"NA","To learn more about your experience participating in a virtual Meaning-Centered Psychotherapy group.",[25,26],"Psychotherapy","Integrative Medicine","RECRUITING","2026-03-13",{"date":30,"type":31},"2026-03-16","ACTUAL",{"date":33,"type":31},"2025-10-03",{"date":35,"type":19},"2029-02-01",{"name":37,"class":38},"M.D. Anderson Cancer Center","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":46,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":20,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":65},"100484398","phase-2-a-clinical-trial-of-interventions-to-support-family-surrogates-of-critically-ill-patients-100484398","NCT05587517","A Clinical Trial of Interventions to Support Family Surrogates of Critically Ill Patients","Inclusion Criteria:\n\n* Patients who, during their hospital stay, have been admitted to the ICU and are near EoL, as indicated by a modified \"surprise question\" whereby physicians are asked to identify patients whom they do not expect to survive the next 12 months.\n* Surrogate decision-makers of patients who were admitted to the ICU or step-down unit during their current admission\u002Fstay, or within 1 month of discharge from their last admission\u002Fstay.\n* Surrogate decision-makers are 18 years or older.\n* Surrogate decision-makers whom physicians or advance practice providers (i.e. physician assistants, nurse practitioners) indicate as the designated health care proxy or decision-making patient surrogates, or who are listed as such in the patient's medical charts or by self-report of the surrogate.\n* Surrogate decision-makers must speak English.\n* Surrogate decision-makers must report \"syndromal\" levels of pre-loss grief (PG-12 score ≥ 25) or peritraumatic distress (PDI ≥ 23).\n* Surrogate decision makers will need to reside in a state in which an interventionist is licensed or otherwise be able to comply with current telehealth regulations.\n* Surrogate decision-makers will need to be willing to utilize a device (computer, tablet, phone) with internet.\n* Surrogate decision-makers who are able and willing to provide an emergency contact.\n\nExclusion Criteria:\n\n* Patients and surrogate decision-makers who do not meet the eligibility criteria.\n* Surrogate decision-makers who indicate the presence of cognitive impairment based on responses to the Ultra-Brief Confusion Assessment Method and\u002For significant psychiatric or cognitive disturbance sufficient, in the investigator\u002Fstudy staff's judgment, to preclude completion of the assessment measures, interview or informed consent.\n* Surrogate-decision makers who endorse suicidal ideation in the past month based on responses to the Columbia Suicide Severity Rating Scale.\n* Surrogate-decision makers who are unable to access a functional device for videoconferencing and decline the offer to use a study loner device.",true,{"count":48,"type":19},172,[50],"PHASE2","Hypotheses 1a and 1b: Compared to Supportive Conversation arm, the EMPOWER intervention will significantly decrease surrogate decision makers' symptoms of grief and Post Traumatic Stress Disorder (PTSD) (primary outcomes); and H1b. experiential avoidance, depression, regrets, and increases in patients' value-concordant care (secondary outcomes) at T1-T4.\n\nHypothesis 2. Qualitative data will provide insights not captured by quantitative data.\n\nHypothesis 3. Reductions in experiential avoidance will mediate reductions in grief and Post Traumatic Stress Disorder (PTSD) symptoms, highlighting it as important to target in future implementation.",[53,54,25,55],"Grief","Trauma","Critical Care","2025-10-27",{"date":58,"type":31},"2025-10-29",{"date":60,"type":31},"2022-10-11",{"date":62,"type":19},"2027-12-11",{"name":64,"class":38},"Weill Medical College of Cornell University",3,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":20,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":93},"100593771","smart-therapist-training-a-hybrid-factorial-smart-design-100593771","NCT07010770","SMART Therapist Training: A Hybrid Factorial-SMART Design","SMART","Inclusion Criteria:\n\nWe have designed the sample to be representative of therapists who are eligible for CPT rollout training.\n\n* Participants must be licensed mental health clinicians or a mental health trainee in VA service (e.g., practicum students, psychology interns, postdoctoral fellows) whose formal job responsibilities include the provision of psychotherapy services to Veterans on a regular basis\n* Participants must be able to participate for 9 months.\n* Participants must work in a setting where CPT may be implemented (12 weekly 60-minute individual sessions or 90-minute group sessions).\n* Participants must have local\u002Fsupervisor support to implement CPT and fully participate in all training and consultation activities.\n* Participating trainees (e.g. psychology interns) on a 6-month training rotation must have permission from their supervisors to continue the study into their next rotation.\n\nExclusion Criteria:\n\n* Participant is not a licensed mental health clinician\n* Participant is already certified in CPT",{"count":74,"type":19},240,[22],"Cognitive Processing Therapy (CPT) is highly effective in randomized controlled trials, but its effectiveness drops substantially in standard clinical practice, largely due to therapist \"drift\" from fidelity to the protocol. What remains unknown is which components of CPT training yield high therapist fidelity. Thus, there is a critical need to use empirical approaches to identify the most effective components of CPT training and to develop an adaptive training model for CPT by testing sequences of empirically-supported training strategies. The long-term goal of this research is to develop a sustainable model of therapy training that is personalized to the needs of the therapist trainee.\n\nThe overall objective of this application is to empirically optimize an adaptive model for CPT training. The rationale is that developing an adaptive training model will improve efficiency and personalization, yield higher fidelity, and ultimately improve Veteran outcomes. We expect that completion of this project will produce an adaptive CPT training program that yields high therapist fidelity. Improving CPT fidelity in VHA will have a positive impact on the health and wellbeing of Veterans with PTSD.",[78,25],"Stress Disorders, Post-Traumatic",[80,25,78,81,82],"Therapeutics","Referral and Consultation","Veterans","2025-08-29",{"date":85,"type":31},"2025-09-02",{"date":87,"type":31},"2025-08-15",{"date":89,"type":19},"2030-08-30",{"name":91,"class":92},"VA Office of Research and Development","FED",4,{"id":95,"slug":96,"hasResults":11,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":101,"maxAge":102,"enrollmentInfo":103,"targetDuration":4,"studyType":20,"phases":105,"briefSummary":106,"conditions":107,"keywords":111,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":39},"100389902","psychological-treatment-to-support-the-consequences-of-cognitive-impairment-100389902","NCT04356924","Psychological Treatment to Support the Consequences of Cognitive Impairment","Evaluation of a Novel Psychological Intervention Tailored for Patients With Early Cognitive Impairment (PIPCI)","* Criteria's for inclusion\n* \\\u003C 75 years.\n* SCD or MCI diagnosis. All cognitive MCI-subtypes are eligible.\n* Mild to moderate psychological symptoms that are indicated to be related to the patient's CI. The psychological symptoms should affect the patients daily living and behavior, exemplified by avoidance behavior, social anxiety and perceived stigmatization.\n* Fluency in the Swedish language.\n* The patients should have access to a mobile telephone to be able to receive reminders via Short Message Service (SMS).\n* Signed informed consent.\n* Criteria's for exclusion\n* Dementia diagnosis and\u002For occurrence of serious illness and\u002For injury that requires immediate investigation or treatment of another type, or which is expected to worsen in the coming year (i.e., not including dementia)\n* Severe psychiatric comorbidity (e.g., high suicide risk), and\u002For severe psychiatric disorder. This will be assessed in the MINI evaluation and during the clinical cognitive examination).\n* Anti-depressant medication introduced or alterations in dosage \\\u003C 6 months ago (i.e., un-stable dose).\n* Mini Mental State Examination (MMSE) score \\\u003C 26 and\u002For a Montreal Cognitive Assessment (MoCA) score \\\u003C 24.\n* Stroke or head trauma \\\u003C 6 months ago.\n* Substance abuse","45 Years","75 Years",{"count":104,"type":19},138,[22],"The burden of cognitive impairment is severe, and often hinders affected people to act independently in daily life. Individuals in different stages of cognitive decline are frequently affected by existential distress and associated health issues (such as stress symptoms, anxiety, and depression), as well as social avoidance due to the unclear prognosis. Although the need for psychological support is large, there is a lack of efficient individualized psychological treatments- and methods to maintain psychological health that sufficiently impact daily life and promote behavioral- and biological change. In keeping with that notion, the investigators have developed a novel psychological treatment manual focused on supporting individuals with early phase cognitive impairment. The treatment manual is centered on facilitating behavioral change in accordance with personal values and long-term goals even in the presence of negative experiences, as well as to promote meaningful life-style changes. Conceptually, the treatment manual has its basis in the cognitive behavioral therapy (CBT) tradition, but the investigators have strived to adapt the manual to suit a cognitively affected population. The investigators will evaluate the psychological treatment in a RCT were the investigators will include approximately 138 individuals in their early phases of cognitive decline and randomize them into either an experimental group (psychological treatment), an active control group (cognitive training), or a treatment as usual control group. Evaluations will be conducted with, psychological health measures, cognitive assessments, and with biological markers.\n\nThe investigators hypothesize that in comparison with the control conditions, the response to psychological treatment will be associated with improved psychological health and improved cellular protection.",[108,109,25,110],"Cognitive Impairment","Psychological","Health Behavior",[112,113,114],"Cognitive impairment","Psychological treatment","Dementia prevention","2025-06-26",{"date":117,"type":31},"2025-07-01",{"date":119,"type":31},"2023-09-07",{"date":121,"type":19},"2028-06-30",{"name":123,"class":38},"Karolinska Institutet",{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":15,"minAge":131,"maxAge":4,"enrollmentInfo":132,"targetDuration":4,"studyType":20,"phases":134,"briefSummary":135,"conditions":136,"keywords":140,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":39},"100466659","engage-for-late-life-depression-and-comorbid-executive-dysfunction-100466659","NCT05356611","Engage for Late-Life Depression and Comorbid Executive Dysfunction","Engage: A Treatment for Late-Life Depression and Comorbid Executive\u002FCognitive Dysfunction","Inclusion Criteria:\n\n* Age 60 or older\n* Ability to read, write, and speak English\n* Located in Las Vegas or surrounding area\n* Ability to travel to UNLV campus by self or possible caregiver for regular study visits\n* Clinically significant symptoms of depression as evidenced by: 1) Scores \\> 5 on the Geriatric Depression Scale-Short Form (GDS-SF)\n* Mild cognitive impairment as evidenced by: 1) Scores \\> 18 and \\\u003C 25 on the Montreal Cognitive Assessment (MoCA)\n\nExclusion Criteria:\n\n* Active suicidal ideation\n* History of suicide attempt(s)\n* Current symptoms of: 1) Psychosis; 2) Active substance use disorder\n* Reported history of: 1) Bipolar disorder (\"manic depression\"); 2) Intellectual disability\n* Currently in or scheduled to initiate individual psychotherapy to avoid treatment interference\n* Psychotropic medication permitted if dose was stable over the past 2 weeks\n* Currently living in an institutional setting (e.g., assisted living, inpatient, skilled nursing)\n* Presence of notable memory-specific cognitive deficits as evidenced by: scores \\\u003C 9 on the MoCA memory subscale (rendering it difficult to participate in and track\u002Frecall events for weekly psychotherapy)","60 Years",{"count":133,"type":19},20,[22],"Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations. Cognitive decline is one such factor that places significant burden on older adults and can interfere with traditional mental health therapies. Engage is a behavioral treatment approach that has shown to be effective in treating late life depression. The investigators are testing the feasibility of Engage as a treatment method for late life depression in older adults with cognitive decline. The objective is to corroborate Engage as an alternative late life depression treatment method for a sub-population of older adults with cognitive decline. Cognitive decline poses a unique mental health treatment barrier that is often over looked in younger populations. With a relatively higher prevalence of cognitive decline in older adulthood, it is imperative that a feasible mental health treatment program that can be effective in the presence of cognitive decline.",[137,25,138,139],"Depression in Old Age","Mild Cognitive Impairment","Executive Dysfunction",[141,142],"Older Adults","Late-Life Depression","2024-08-04",{"date":145,"type":31},"2024-08-06",{"date":147,"type":31},"2023-09-24",{"date":149,"type":19},"2025-05",{"name":151,"class":38},"University of Nevada, Las Vegas"]