[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ptosis-eyelid\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ptosis-eyelid":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100612173","comparative-study-of-ziplyft-treatment-vs-traditional-blepharoplasty-for-upper-eyelid-rejuvenation-100612173",false,"NCT07250139","Comparative Study of Ziplyft Treatment vs. Traditional Blepharoplasty for Upper Eyelid Rejuvenation","Inclusion Criteria:\n\n1. Provide signed written consent prior to participation in any study-related procedures.\n2. Ability, comprehension, and willingness to follow study instructions, and likely to complete all study visits.\n3. Male or female adults, ≥ 35 years old at the Preoperative Visit willing to return for required follow-up visits.\n4. Subjects with excess eyelid skin are eligible to undergo the procedure in the opinion of the investigator.\n5. Female subjects must be 1-year postmenopausal, surgically sterilized, or, if of childbearing potential, have a negative urine pregnancy test at the Preoperative Visit. Women of childbearing potential must use an acceptable form of contraception throughout the study. Acceptable methods include at least one of the following: intrauterine (intrauterine device), hormonal (oral, injection, patch, implant, ring), barrier with spermicide (condom, diaphragm), or abstinence.\n\nExclusion Criteria:\n\n1. Subjects with a current Ptosis diagnosis\n2. Subjects with a history of Graves' Disease\n3. Subjects with Myasthenia Gravis\n4. Subjects that in the opinion of the investigator are anatomically not conducive to using devices (e.g., heavy brow, severe hollowing of the upper eyelid, history of ocular or orbital trauma).\n5. Subjects that have had any previous surgery eyelid or eyebrow region.\n6. Use of anticoagulation therapy, including, but not limited to Aspirin, NSAIDS, Ibuprofen within 7 days and Xarelto, Warfarin, Enoxaparin, Plavix within 3 days prior to planned study procedure.\n7. Active or recent (within 3 months) tobacco user\n8. Allergy to adhesive glue\n9. Participation in any study of an investigational, interventional product within 30 days prior to the Preoperative Visit or at any time during the study period.\n10. Pregnant or nursing females.","ALL","35 Years",{"count":18,"type":19},50,"ESTIMATED","INTERVENTIONAL",[22],"NA","This study will compare two surgery techniques used for upper eyelid (eyelift) surgery: traditional surgery and a newer method called Ziplyft (a non-powered, hand-held clamp). This study will use a \"split-face\" design, meaning one eyelid will be treated with the traditional surgery method and the other with Ziplyft, allowing a direct side-by-side comparison.\n\nThe objectives of the study are to compare Ziplyft treatment vs. traditional surgery by evaluating bruising, wound closure and incision, surgery case time, and subject\u002Fsurgeon surveys.",[25,26,27],"Dermatochalasis of Upper Eyelid","Ptosis, Eyelid","Blepharoplasty",[29,30,31],"Dermatochalasis of upper eyelid, Ptosis of upper eyelid, blepharoplasty,","Ziplyft","upper eyelid surgery","RECRUITING","2025-11-18",{"date":35,"type":36},"2025-11-26","ACTUAL",{"date":38,"type":19},"2025-12-08",{"date":40,"type":19},"2026-09-30",{"name":42,"class":43},"Osheru Inc.","INDUSTRY",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":15,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":20,"phases":55,"briefSummary":56,"conditions":57,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100593197","anterior-versus-posterior-white-line-advancement-technique-in-the-correction-of-aponeurotic-ptosis-100593197","NCT07003308","Anterior Versus Posterior White Line Advancement Technique in the Correction of Aponeurotic Ptosis","Comparative Study of the Efficacy of Anterior Versus Posterior White Line Advancement Technique in the Correction of Primary Aponeurotic Ptosis","Inclusion Criteria:\n\n* Age over 18 years.\n* Diagnosis of primary aponeurotic upper eyelid ptosis.\n* Levator muscle function of 12 mm or greater.\n* Provision of written informed consent after receiving adequate information about the study.\n\nExclusion Criteria:\n\n* Diagnosis of non-aponeurotic eyelid ptosis.\n* Poor levator muscle function.\n* History of recurrent eyelid ptosis or previous eyelid ptosis surgery.\n* Medical or surgical history that, in the investigator's judgment, may interfere with participation.\n* Individuals with childbearing potential who are not using highly effective contraception methods.\n* Refusal to participate in the study or to sign the informed consent form.","18 Years",{"count":54,"type":19},54,[22],"The goal of this clinical trial is to compare the efficacy of two surgical techniques-anterior and posterior white line advancement-for the correction of primary aponeurotic ptosis in adult patients. The main questions it aims to answer are:\n\nDoes the anterior approach lead to a greater improvement in Marginal Reflex Distance 1 (MRD1) at 6 months compared to the posterior approach?\n\nAre there differences in eyelid symmetry, contour, visual function, and patient satisfaction between the two techniques?\n\nResearchers will compare the anterior approach group to the posterior approach group to see if one offers better functional and aesthetic outcomes, fewer complications, or higher patient satisfaction.\n\nParticipants will:\n\nBe randomly assigned to receive either anterior or posterior white line advancement surgery.\n\nUndergo preoperative and postoperative evaluations at 7 days, 2 months, and 6 months, including:\n\nMeasurements of eyelid position (MRD1), contour, and symmetry\n\nVision and tear film tests (e.g., refraction, TBUT, Schirmer's test)\n\nSurveys on dry eye symptoms (OSDI), scar quality (POSAS 2.0), satisfaction, and psychosocial function\n\nMonitoring of surgical time and complications",[26],[59,60,61,62,63],"eyelid","levator palpebrae","oculoplastic surgery","ophthalmology","blepharoptosis","2025-10-02",{"date":66,"type":36},"2025-10-07",{"date":68,"type":36},"2025-06-01",{"date":70,"type":19},"2027-01-30",{"name":72,"class":73},"Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz","OTHER"]