[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ptsd-and-trauma-related-symptoms\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ptsd-and-trauma-related-symptoms":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,76,97,161],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100625272","tf-cbt-for-autistic-youth-pilot-implementation---open-pilot-100625272",false,"NCT07420478","TF-CBT for Autistic Youth Pilot Implementation - Open Pilot","Implementation Science-Guided Pilot Study of Trauma-Focused Cognitive Behavioral Therapy for Autistic Youth in Community Mental Health Settings","Inclusion Criteria for Therapists\n\n1. Employed as a clinician at a participating Community Mental Health Center (CMHC; publicly-funded mental health program) for at least 6 months.\n2. Trained in TF-CBT.\n3. Has an eligible autistic youth on current caseload (see below).\n\nInclusion Criteria for Child Participants\n\n1. Between 6 and 18 years old (up to 17 years, 11 months).\n2. Current medical diagnosis of autism.\n3. Has a non-offending caregiver who is able to participate in treatment (i.e., caregiver who is not the perpetrator of the abuse\u002Fother trauma).\n4. Initiated outpatient psychotherapy services from participating therapist within enrolled CMHC.\n5. A moderate level of trauma-related distress as measured by the Child and Adolescent Trauma Screen-2 (CATS-2).\n\nExclusion Criteria for Child Participants\n\n1\\. Does not present with trauma-related distress (score falls within the \"Normal\" range as measured by the Child and Adolescent Trauma Screen-2 Self- and Parent-Report).","ALL","6 Years",{"count":19,"type":20},24,"ESTIMATED","INTERVENTIONAL",[23],"NA","Compared to the general population, autistic youth are at increased risk for both exposure to potentially traumatic events and trauma-related symptoms following trauma exposure. Autistic people identify approaches to effectively addressing trauma as a top mental health research priority, yet providers in community settings often report inadequate training in trauma treatment. The purpose of this study is to conduct an open pilot to evaluate the feasibility and acceptability of an evidence-based intervention for youth affected by trauma, Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), that has been modified for autistic youth served in Community Mental Health Centers.",[26,27,28,29,30],"Autism Spectrum Disorder","PTSD and Trauma-related Symptoms","Autism","Trauma and Stressor Related Disorders","Mental Health Services",[28,32,33,34,35,36,37],"Trauma","PTSD","Mental health symptoms","TF-CBT","Implementation science","Trauma-Focused Cognitive Behavioral Therapy","RECRUITING","2026-05-11",{"date":41,"type":42},"2026-05-13","ACTUAL",{"date":44,"type":42},"2026-05-05",{"date":46,"type":20},"2027-02-28",{"name":48,"class":49},"Dartmouth-Hitchcock Medical Center","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":50},"100636254","phase-2-kalm-b-ketamine-assisted-psychotherapy-kap-to-lessen-morbidity-after-burn-injury-100636254","NCT07563296","KALM-B: Ketamine-assisted Psychotherapy (KAP) to Lessen Morbidity After Burn Injury","KALM-B","Inclusion Criteria:\n\n* Subjects 18 - 65 yrs with \\> 15 % Total Body Surface Area Burns.\n* National Stressful Events Survey Acute Stress Disorder Short Scale (NSESSS) average total score\\>= 2 (severity scale of none (0), mild (1), moderate (2), severe (3), or extreme (4) ) prior to discharge from UUH.\n\nExclusion Criteria:\n\n* Allergy or previous adverse reactions to ketamine\n* Pending surgical interventions\n* Active systemic infection, sepsis, or hemodynamic instability\n* Physical limitations from burn injury that preclude safe travel to outpatient visits or positioning for therapy.\n* Lack of reliable transportation, caregiver support, or housing stability.\n* Language barrier\n* Personal history or first- or second-degree relatives with schizophrenia, bipolar affective disorder, delusional disorder, schizoaffective disorder, psychosis, or other psychotic spectrum illness.\n* Currently meeting DSM-5 criteria for Dissociative Disorder, or other psychiatric conditions judged to be incompatible with the establishment of rapport or safe exposure to ketamine.\n* Currently meeting DSM-5 criteria for Cluster B Personality Disorder.\n* Severe depression requiring immediate standard-of-care treatment (e.g., hospitalization).\n* Suicidal ideation over the past month as assessed as a yes to question 3, 4, or 5 on the Columbia-Suicide Severity Rating Scale, Suicidal Ideation section\n* Current or prior history of PTSD diagnosis\n* Current or history within the last two years of meeting DSM-V criteria of substance use disorder (excluding caffeine and nicotine).\n* Current substance use disorders may be identified through the drug urine screening test or undergoing treatment (methadone\u002FSuboxone) .\n* Congestive heart failure, including all New York Heart Association Classes.\n* Angina pectoris, cardiac hypertrophy, cardiac ischemia, myocardial infarction\n* Uncontrolled hypertension at the time of enrollment (BP\\>140 systolic or 90 diastolic), coronary artery disease, artificial heart valve\n* Prolonged or congenital long QT syndrome (\\>450 ms), serious cardiac arrhythmias, tachycardia, a clinically significant screening ECG abnormality\n* History of hypersensitivity to ketamine\n* Receiving ketamine treatments for psychiatric condition within the past 6 months\n* Seizure disorder\n* Moderate to severe dementia\n* History of significant traumatic brain injury\n* Requires the use of supplemental oxygen.\n* Require Propranolol for Burn Hypermetabolism\n* Any other condition that would, in the Investigator's judgment, contraindicate the subject's participation in the clinical study due to safety concerns or compliance with clinical study procedures (e.g., infection\u002Finflammation, intestinal obstruction, unable to swallow medication, \\[patients may not receive the drug through a feeding tube\\], social\u002F psychological issues, etc.)\n* Subjects taking prohibited medications. A washout period of prohibited medications for a period of at least five half-lives should occur prior to study registration. These medications include antipsychotic medications, doses of benzodiazepines in excess of 20mg diazepam equivalents per day.","18 Years","65 Years",{"count":61,"type":20},12,[63],"PHASE2","A study looking at the safety and tolerability of KAP (Ketamine-Assisted Psychotherapy) in the burn population.",[27],"NOT_YET_RECRUITING","2026-04-28",{"date":69,"type":42},"2026-05-04",{"date":71,"type":20},"2026-04-01",{"date":73,"type":20},"2028-04-01",{"name":75,"class":49},"Irma Fleming",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":50},"100605560","lifu-mechanisms-for-ptsd-in-healthcare-workers-100605560","NCT07164105","LIFU Mechanisms for PTSD in Healthcare Workers","Mechanisms of Low Intensity Focused Ultrasound of the Ventral Anterior Cingulate Cortex for Post-Traumatic Stress Disorder in Frontline Healthcare Workers","Inclusion Criteria:\n\n1. Adults in a frontline healthcare position (e.g. emergency medical services)\n2. Ages 18-65 years\n3. PTSD Checklist for DSM-5 (PCL-5) score ≥ 33 and \\\u003C 65, OR at least partial PTSD as measured by the MINI\n4. English proficiency as evaluated by language ability during screening\n\nExclusion Criteria:\n\n1. Neurological disorders\n2. DSM-5 diagnosis of psychotic disorders, eating disorder, obsessive-compulsive disorder, moderate to severe alcohol or substance use disorder within the past year, bipolar disorder, or major depressive disorder with psychosis\n3. Suicidal intent or plan (as measured by Suicide-Risk-Assessment-C-SSRS \"Yes\" answers to items 3, 4 or 5 of Suicidal Ideation-Past 1 month section, or any \"Yes\" answer to any of the items of Suicidal Behavior-Past 3 months section), or any suicide attempt in the last 3 months.\n4. History of severe traumatic brain injury (as indicated by score ≥ 3 on the Tulsa Head Injury Screen) or of skull fractures\n5. Contraindications to MRI as determined by the MR Environment Screening\n6. Pregnancy, determined by urine pregnancy test administered prior to every MRI scanning procedure\n7. Evidence of inability to comply with study procedures based on experimenter judgement.\n8. Change in the dose or prescription of a medication within the 6 weeks before enrolling in the study that could affect brain functioning, e.g., anxiolytics, antipsychotics, antidepressants, benzodiazepines, or mood stabilizers.\n9. Non-correctable vision or hearing problems\n10. Unstable medical diagnoses\n11. Any structural abnormalities in the LIFU target region on screening brain MRI.",{"count":84,"type":20},66,[23],"The goal of this clinical trial is to evaluate whether low-intensity focused ultrasound (LIFU) of the ventral anterior cingulate cortex (vACC) can normalize dysfunctional brain activation patterns and behaviors in frontline healthcare workers with post-traumatic stress disorder. The main questions it aims to answer are:\n\n* Does LIFU of the vACC effect activity and connectivity of the vACC and amygdala?\n* Does LIFU of the vACC reduce post-traumatic stress symptoms? Researchers will compare LIFU to sham modulation to see if LIFU modulates activity of vACC-amygdala circuitry and affects threat sensitivity and emotion regulation.\n\nParticipants will:\n\n* Complete two fMRI sessions (before and after LIFU)\n* Receive a single session of LIFU or sham modulation of the vACC\n* Wear a wearable device that tracks sleep and heart rate metrics",[27],"2026-04-15",{"date":90,"type":42},"2026-04-20",{"date":92,"type":42},"2025-12-29",{"date":94,"type":20},"2028-08",{"name":96,"class":49},"Laureate Institute for Brain Research, Inc.",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":21,"phases":106,"briefSummary":107,"conditions":108,"keywords":118,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":160},"100587056","effectiveness-implementation-and-cost-of-cognitive-processing-therapy-in-prisons-100587056","NCT06923423","Effectiveness, Implementation, and Cost of Cognitive Processing Therapy in Prisons","STRIDES2","Inclusion Criteria:\n\n* 18 years of age or older\n* Able to understand and speak English\n* Able to give informed consent\n* All items listed in \"Inclusion criteria for all participants\"\n* Be currently incarcerated in one of the prisons that have partnered as study sites\n* Have met criteria for a drug use disorder in the year prior to their current incarceration (≥ 2 symptoms on a DSM-5 drug use disorder checklist)\n* Have used drugs in the 30 days prior to their current incarceration\n* Have a history of traumatic event exposure\n* Endorse clinically significant posttraumatic stress symptoms (score ≥ 4 on the Primary Care PTSD Screen for DSM-5; PC-PTSD-5)\n* Expect to be incarcerated for at least long enough to complete CPT-CJ as it is being implemented at the particular site (i.e., anticipated to be \\~3 months, but will depend on dates associated with next available intervention group)\n* Expect to be released from prison within 12 months following the end of treatment (i.e., within \\~15 months of the pre-treatment assessment)\n* Willing to consent to randomization to treatment condition\n\nExclusion criteria for prisoners (additional requirements assessed during pre-treatment assessments or indicated by prison staff; will result in being withdrawn from the study prior to randomization by the PI):\n\n* Unable to provide any locator information for post-release assessments\n* Determined to be releasing sooner than would allow the individual to complete CPT-CJ\n* Determined to have an unavoidable scheduling conflict or facility restriction (e.g., disciplinary, medical) that would prevent participation in CPT-CJ. Of note, if the scheduling conflict or facility restriction is expected to resolve following the next round of randomization at the study site, the participant may be put on \"hold for next round\" status rather than withdrawn unless other exclusionary criteria would be met by that time (e.g., release).",{"count":105,"type":20},640,[23],"Addiction and trauma exposure are common among the 5.5 million people (1 in 47 adults) in the U.S. who are in prison or under supervision. About 85% of people in prison have a substance use disorder or are there for a drug-related crime, and many have experienced serious trauma before being incarcerated. Posttraumatic stress symptoms (PTSS) are often a result of trauma and are linked to more severe drug use, higher rates of relapse, and increased crime. PTSS and substance use disorder (SUD) each raise the chances of new arrests for people who are justice-involved, showing that addressing trauma and addiction could help reduce repeat offenses and the costs of incarceration. However, treatments for PTSS are rarely available in prisons, and there is little research on whether providing therapy for PTSS in prison can lower drug use, PTSS, or crime after release.\n\nThe goal of this clinical trial is to see if trauma-focused group therapy (CPT) provided while in prison, can help people after release from prison. The therapy has been adapted for use in prisons (CPT-CJ) and will be compared to trauma focused therapy delivered via a self-help workbook\n\nThis study will:\n\n* test whether a trauma-focused group therapy (CPT-CJ) can reduce post-incarceration drug and alcohol use, mental health issues, and drug-related crime, compared to trauma-focused self-help,\n* evaluate a strategy called implementation facilitation, which helps support the use of this therapy in prisons, and\n* measure the cost of the therapies and support strategies to help plan for future expansion.\n\nIncarcerated participants (N = 640; 50% female) will be enrolled from \\~10 prisons in \\~5 states, ensuring variability in population and setting characteristics. They will:\n\n* take surveys and answer questions up to 5 times (before starting treatment, right after getting treatment, right before leaving prison, 3 months after leaving prison and 6 months after leaving prison)\n* complete CPT group therapy or self-help therapy\n* provide urine samples 3 months and 6 months after leaving prison\n\nPrison stakeholders (e.g., prison staff, prison leadership, governmental officials; N = \\~15 per site) who will be purposively sampled based on their role in CPT-CJ implementation will also participate in some surveys.",[109,110,27,111,112,113,32,114,115,116,117],"PTSD - Post Traumatic Stress Disorder","PTSD and Alcohol Use Disorder","Substance Use Disorder (SUD)","Depression","Mental Health","Trauma Exposure","Traumatic Stress Disorder","Traumatic Stress","Post Traumatic Stress Symptoms",[119,120,121,122,123,124,125,126,127,128,129,130,131,32,112,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150],"Post traumatic Stress Disorder","Post traumatic Stress Symptoms","Substance Use","Substance Use Disorder","Cognitive Processing Therapy","Cognitive Processing Therapy for Criminal Justice Setting","Trauma focused self help","Facilitation","Implementation Facilitation","Implementation","Cost Estimation and Offsets","Drug Use Disorder","Alcohol Use Disorder","Adult","Incarcerated","Prison","Imprisonment","Intervention","Treatment Comparison","Acceptability","Feasibility","Budget Impact","Cost Estimate","Implementation Evaluation","Recidivism","Self Help","Workbook","Criminal Justice","Effectiveness","Evidence Based Intervention","CPT","CPT-CJ","2026-01-20",{"date":153,"type":42},"2026-01-21",{"date":155,"type":42},"2025-07-07",{"date":157,"type":20},"2028-12",{"name":159,"class":49},"University of Arkansas",6,{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":4,"eligibilityCriteria":167,"healthyVolunteers":11,"sex":16,"minAge":168,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":21,"phases":172,"briefSummary":173,"conditions":174,"keywords":183,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":194,"lastUpdatePostDateStruct":195,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":50},"100591636","bridging-affect-consciousness-mentalization-and-trauma--exploring-an-integrative-treatment-approach-for-personality-disorder-pd-100591636","NCT06983002","Bridging Affect Consciousness, Mentalization and Trauma- Exploring an Integrative Treatment Approach for Personality Disorder (PD).","Affect Consciousness (AC) as an Integrated add-on Component in Mentalization-based Group Treatment for Patients With Personality Disorder (PD)- a Mixed Method Explorative Study.","Inclusion Criteria: Participation in a MBT programme for severe AvPD and\u002For BPD 2025-2035. Half the participants join an AC group as add on to standard MBT based on randomisation on a cluster level, 25 % of the rest of the 50% representing the control group patientsample join an Body Awareness Group as add on to proper MBT and the last 25%, representering the control group participates in an Art psychotherapy group as add on to MBT, Norwegian language proficiency, age 20- 40 years.\n\nExclusion Criteria: Diagnosed with schizotypal or antisocial PD, psychotic- or bipolar I disorder, pervasive developmental disorder, ongoing drug\u002F alcohol dependence, organically contingent symptoms and\u002For attention deficit hyperactivity disorder if not effectively treated with medication.","20 Years","40 Years",{"count":171,"type":20},300,[23],"Study background: Specialized Group Outpatient Clinic within specialist mental health services, tailoring two year group treatment programmes for severe Avoidant PD (AvPD) and Borderline PD (BPD) with Affect Consciousness (AC) targeting specific areas of emotional dysfunction. Aims: Our main hypothesis, adding AC to Mentalization- based treatment (MBT) to expand the breadth and depth of therapeutically productive work on affect, will aim to examine health indicators, processes and mechanisms of change in depth. The study will extracts preliminary data after 5 years and 10 years to investigate clinical change, variation and outcome during MBT for PD employing AC as add on to MBT. The study has a randomized controlled trail design, with MBT with or without AC as add-on. The RCT is grounded on original literature on Affect Theory, as a framework for understanding patient functioning, and MBT, framing the therapy.Implications: AC methodology as add on can lead to more tailored treatment programmes, service planning, allocation of resources, guidelines, ACI certification and method development for PDs.",[175,176,177,178,179,180,181,182,33,109,27],"Personality Disorder, Borderline","Personality Trait","Personality Disorder","Personality Type","Personality Disorder, Avoidant","Affect Consciousness","Mentalization","Reflective Functioning",[184,185,180,186,187,188,32,189,190,191,192,193],"Affect Integration","RCT","MBT","AvPD","BPD","Personality Disorder (PD)","Personality functioning","Emotional dysfunction","Bodily Awareness","Art Therapy","2025-05-13",{"date":196,"type":42},"2025-05-21",{"date":198,"type":20},"2025-05-19",{"date":200,"type":20},"2035-04-19",{"name":202,"class":203},"Helse Stavanger HF","OTHER_GOV"]