[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ptsd-childbirth-related\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ptsd-childbirth-related":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,76,101,133],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100606397","the-new-empowerment-after-exposure-to-trauma-next-study-100606397",false,"NCT07175025","The New Empowerment After eXposure to Trauma (NEXT) Study","NEXT","Inclusion Criteria:\n\n* 18 years of age or older\n* able to read and speak English\n* diagnosis of probable PTSD as determined by the PTSD Checklist for DSM-5 (PCL-5)\n* pregnant or postpartum (delivered within 12 weeks) at the time of the eligibility screen Exclusion criteria\n* current severe suicide risk as determined by the Columbia Suicide Severity Rating Scale Screener (C-SSRS)\n* current psychotic or manic symptoms as determined by the DIAMOND screener and the Mood Disorder Questionnaire for Bipolar Disorder\n* cognitive impairment\n* concurrent trauma-focused psychotherapy\n* medical advice limiting participation in exposure therapy\n* current legal actions related to trauma\n* does not meet criteria for PTSD\n* not pregnant or delivered more than 12 weeks after timing of eligibility screening","FEMALE","18 Years","50 Years",{"count":20,"type":21},106,"ESTIMATED","INTERVENTIONAL",[24],"NA","The NEXT Study is a randomized controlled pilot examining the feasibility and acceptability of a revised perinatal PTSD protocol. This study will randomize perinatal participants with PTSD to receive NET (n=45); treatment group) and will be compared to perinatal women randomized to usual care (n=45; comparator group). The overall objective of this project is to determine the most feasible and acceptable protocol for a brief virtual perinatal PTSD intervention.",[27,28],"PTSD - Post Traumatic Stress Disorder","PTSD (Childbirth-Related)",[30,31,32,33,34],"Pregnancy","Postpartum Period","Narrative Exposure Therapy","Post-Traumatic Stress Disorder","Brief interventions","RECRUITING","2026-06-16",{"date":38,"type":39},"2026-06-18","ACTUAL",{"date":41,"type":39},"2025-09-24",{"date":43,"type":21},"2028-07-31",{"name":45,"class":46},"Indiana University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100490153","preventing-childbirth-related-ptsd-with-expressive-writing-100490153","NCT05662423","Preventing Childbirth-Related PTSD With Expressive Writing","The Effects of Expressive Writing Following Traumatic Childbirth","CARES","Inclusion Criteria:\n\n* Women who recently delivered at Massachusetts General Hospital (MGH).\n* Women who are at risk for developing CB-PTSD based on their scoring of \\>16 on the Peritraumatic Distress Inventory (PDI).\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>50.\n* Stillbirth.\n* Down's Syndrome, other serious genetic disorder in the newborn, or serious birth defect (e.g., microcephaly, spina bifida).\n* Admission to the neonatal intensive care unit (NICU) for more than 1 week or infant that is not medically healthy.\n* Current diagnosable DSM-5 psychotic or bipolar disorder, or current substance abuse disorder.\n* Active suicidality (assessed case by case).\n* Present substance abuse as indicated in medical records.\n* Severe maternal morbidity (assessed case by case).\n* General anesthesia.\n* Inability to understand the study procedures, risks, and side effects, or to otherwise give informed consent for participation due to neurological or other reasons.\n* Inability to understand English.",true,{"count":58,"type":21},136,[24],"The goal of this clinical trial is to test a brief psychological intervention given to individuals in the first days following childbirth who have experienced a potentially stressful childbirth. The treatment is aimed at preventing post-traumatic stress disorder following childbirth and promoting maternal-infant bonding.\n\nIn the days following childbirth, participants will be asked to write about their childbirth experience or a neutral event for three consecutive days, for around 15 minutes each day. Additionally, they will complete a short survey before and after the intervention about their birth experience and mental health. Around 2 months postpartum (with the option of up to around Month 3 PP), participants will take part in mental health and physiological assessments, and in a brief play session with their infant.",[28],[63,64,65,66],"Mother-Infant Bonding","Postpartum Depression","Postpartum PTSD","Expressive Writing","2026-05-19",{"date":69,"type":39},"2026-05-22",{"date":71,"type":39},"2023-11-08",{"date":73,"type":21},"2026-07-31",{"name":75,"class":46},"Massachusetts General Hospital",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100619277","early-intervention-for-postpartum-ptsd-comparing-written-exposure-and-capnometry-guided-breathing-therapy-100619277","NCT07342530","Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry-Guided Breathing Therapy","Early Intervention for Postpartum PTSD: Comparing Written Exposure and Capnometry Guided Breathing Therapy","Inclusion Criteria:\n\n* Age ≥18\n* Delivered a live infant within 5 days\n* Severe maternal morbidity or infant admitted to NICU\n* PCL-5 ≥28\n* English-speaking\n* Able to consent and participate\n\nExclusion Criteria:\n\n* Active psychosis or mania\n* Current suicidal crisis\n* Current suicidal intent or plan\n* Cognitive impairment preventing participation",{"count":84,"type":21},70,[24],"The purpose of this study is to examine two early interventions, Written Exposure Therapy and Capnometry Guided Breathing, to reduce post-traumatic stress disorder (PTSD) symptoms in women after childbirth as compared to usual care.",[88,89,28,90],"Written Exposure Therapy","Breathing Techniques","Postpartum Care","2026-04-21",{"date":93,"type":39},"2026-04-24",{"date":95,"type":39},"2026-03-09",{"date":97,"type":21},"2027-12",{"name":99,"class":46},"Stanford University",2,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":107,"targetDuration":4,"studyType":22,"phases":109,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":124,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":47},"100634300","phase-2-perioperative-dexmedetomidine-to-reduce-post-procedure-grief-following-second-trimester-dilation-and-evacuation-100634300","NCT07537894","Perioperative Dexmedetomidine to Reduce Post-procedure Grief Following Second-trimester Dilation and Evacuation","Inclusion Criteria:\n\n* English- or Spanish-fluency\n* 16-26 weeks gestation\n* D\\&E in the operating room\n\nExclusion Criteria:\n\n* Unscheduled or emergent procedure\n* Contraindication to dexmedetomidine per package insert\n* Judgement of clinical anesthesiologist providing care",{"count":108,"type":21},100,[110,111],"PHASE2","PHASE3","People seeking second-trimester dilation and evacuation (D\\&E) procedures are often facing profoundly challenging circumstances, including desired pregnancies complicated by fetal anomalies or demise, serious maternal health conditions, or changes in financial or relationship status. Although abortion regret is uncommon, the emotional burden surrounding these experiences is substantial: many patients experience significant grief and post-traumatic stress symptoms in the weeks to months following care. Perioperative interventions that decrease the body's stress response offer a promising opportunity to reduce downstream psychologic morbidity. Dexmedetomidine has been shown to reduce PTSD symptoms in other high-stress medical and surgical settings. The investigators are undertaking a randomized trial to evaluate whether perioperative administration of dexmedetomidine during second-trimester D\\&E can reduce the frequency and severity of post-procedural grief, directly addressing an unmet need in patient-centered, trauma-informed abortion care.",[114,115,28,116],"Abortion","Stillbirth","Grief (Traumatic Grief and Existential Grief)",[118,119,120,121,122,123],"abortion","dexmedetomidine","fetal demise","stillbirth","grief","PTSD","NOT_YET_RECRUITING","2026-04-10",{"date":127,"type":39},"2026-04-17",{"date":129,"type":21},"2026-07",{"date":131,"type":21},"2028-07",{"name":99,"class":46},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":22,"phases":143,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":47},"100611882","feasibility-and-efficacy-of-gtep-for-birth-trauma-100611882","NCT07246356","Feasibility and Efficacy of GTEP for Birth Trauma","A Study to Explore the Feasibility and Efficacy of Group Traumatic Episode Protocol (GTEP) for Reducing Trauma Symptoms Following a Traumatic Birthing Experience","Inclusion Criteria:\n\n* Aged between 18-65 years.\n* Currently under the Black Country Perinatal Mental Health Service\n* Experiencing self-reported trauma symptoms related to a birthing experience within the last 18 months (this includes the birth itself, the postnatal hospital stay, and\u002For any neonatal admissions).\n* Access to technology (e.g., laptop, internet connection) to be able to access the online group.\n* Access to a confidential space within their home, and childcare for their baby\u002Fany other existing children.\n* Proficient levels of English Language to engage with the group.\n* Ability to engage in group therapy based on clinical presentation.\n* Capacity to consent to engage in the GTEP group and research study.\n\nExclusion Criteria:\n\n* Women\u002Fbirthing people whose baby is no longer under their care.\n* Severe and enduring mental health presentations (i.e., diagnosis of bipolar, psychosis and\u002For schizophrenia.\n* Significant sensory impairment (e.g., needing a British Sign Language interpreter).","65 Years",{"count":142,"type":21},10,[24],"This clinical study aims to evaluate the feasibility and initial efficacy of Group Traumatic Episode Protocol (GTEP) for reducing trauma symptoms (measured by the PCL-5 and City BiTS) for individuals following a traumatic birthing experience. A secondary aim is to evaluate the efficacy of GTEP in improving parental wellbeing (measured through the CORE-10) and parent-infant bonding (measured through the PBQ) following a traumatic birthing experience.\n\nParticipants (those who have experienced a traumatic birthing experience) will complete the GTEP intervention, delivered online. They will be asked to complete outcome measures and give feedback on their experience of the group.",[28,146,147],"Psychological Wellbeing","Bonding",[149,150,151,152,153,154],"GTEP","Group EMDR","Birth trauma","Psychological wellbeing","Perinatal","Parent infant bonding","2026-02-18",{"date":157,"type":39},"2026-02-19",{"date":159,"type":39},"2025-06-19",{"date":161,"type":21},"2026-06-30",{"name":163,"class":46},"University of Birmingham"]