[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulmonary-arterial-hypertension-associated-with-connective-tissue-disease-disorder\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulmonary-arterial-hypertension-associated-with-connective-tissue-disease-disorder":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100524093","phase-2-129-xenon-mri-as-a-biomarker-for-diagnosis-and-response-to-therapy-in-pulmonary-arterial-hypertension-pah-100524093",false,"NCT06104228","129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)","Xenon PAH Bio","Inclusion Criteria:\n\nArm 1 -IPAH\n\n* Age: 18-75 years\n* WHO functional class 2 or 3\n* Mean pulmonary artery pressures \\> 20 mmHg\n* Pulmonary capillary wedge pressure ≤15 mmHg\n* Pulmonary vascular resistance \\> 2 Wood Units (WU)\n* No other cause identified for PAH\n\nArm 2 -PAH-CTD\n\n* Age: 18-75 years\n* WHO functional class (FC) 2 or 3\n* Mean pulmonary artery pressures \\> 20 mmHg\n* Pulmonary capillary wedge pressure ≤15 mmHg\n* Pulmonary vascular resistance \\> 2 WU\n* Diagnosis of connective tissue disease\n\nExclusion Criteria:\n\n* PH other than Idiopathic PAH or PAH associated with CTD; any conditions that prevent the performance of 129Xe MRI scans will be excluded from the study.","ALL","18 Years","75 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The overall study objectives outlined in this study are to derive 129Xe MRI pulmonary vascular biomarker signatures that differentiate common subtypes of PAH and to determine the ability of 129Xe MRI to longitudinally monitor disease progression and response to therapy in PAH, with the aid of additional assessments, such as labs, echocardiography, and six-minute walk distance (6MWD).",[27,28,29,30],"Pulmonary Arterial Hypertension","Idiopathic Pulmonary Arterial Hypertension","Pulmonary Arterial Hypertension Associated With Connective Tissue Disease (Disorder)","Connective Tissue Diseases","RECRUITING","2026-02-23",{"date":34,"type":35},"2026-02-24","ACTUAL",{"date":37,"type":35},"2024-08-12",{"date":39,"type":21},"2027-03-31",{"name":41,"class":42},"Bastiaan Driehuys","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100609664","rutgers-university-study-of-the-genetics-of-pulmonary-hypertension-100609664","NCT07217522","Rutgers University Study of the Genetics of Pulmonary Hypertension","RUGCC-PH","Inclusion Criteria:\n\n* age 18 years or older\n* currently living in the United States\n* able to understand and follow written instructions in English\n* have access to the internet and a computer, laptop, tablet or smart phone\n* willing to provide written informed consent for participation\n* willing to provide DNA via a saliva sample using a collection kit mailed to the study participant's home\n* willing to complete a survey with questions about health related to the study of pulmonary hypertension.\n\nExclusion Criteria:\n\n* Age 17 or below\n* Not currently living in the United States\n* Not able to participate in an online research study in English",true,{"count":53,"type":21},10000,"OBSERVATIONAL","The goal of this observational study is to learn more about how genes impact the risk of pulmonary hypertension. Anyone 18 or older living in the US is eligible, and a diagnosis of PH is NOT required. Study participation is online, and it takes about 20 minutes to complete health surveys and request a saliva collection kit sent through US mail. In return, study participants may opt to receive information about their genetic ancestry at no cost.",[57,27,58,59,29,60,61,62],"Pulmonary Hypertension","Pulmonary Arterial Hypertension (PAH) (WHO Group 1 PH)","Pulmonary Arterial Hypertension Associated With Connective Tissue Disease","Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)","Pulmonary Arterial Hypertension of Congenital Heart Disease","Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension","2025-10-30",{"date":65,"type":35},"2025-11-03",{"date":67,"type":35},"2025-08-23",{"date":69,"type":21},"2027-12-31",{"name":71,"class":42},"Rutgers, The State University of New Jersey"]