[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulmonary-aspiration\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulmonary-aspiration":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,57,90,118,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100573804","preoperative-fasting-vs-not-fasting-in-critically-ill-patients-100573804",false,"NCT06751043","Preoperative Fasting vs. Not Fasting in Critically Ill Patients","FEEDS Trial - Fasting Preprocedurally in Enteral Nutrition: Evaluation of Divergent Approaches in Secure Airway","FEEDS","Inclusion Criteria:\n\n1. 1\\. Age ≥ 18\n2. Current admission to ICU\\*\n3. Secure airway\\*\\* with no plans for its removal prior to procedure\n4. Current non-trophic (\\> 10 mL\u002Fhr) tube (enteral) feeding\\*\\*\\* with no plans to discontinue prior to procedure for reasons other than preoperative fasting\n5. Planned eligible procedure (Examples are listed in Appendix C) with anesthesia care or nursing sedation. Eligible procedures are defined as non-emergent diagnostic or therapeutic interventions that:\n\n   * Do NOT have a well-established practice of preoperative fasting. (For example, bedside placement of a vascular catheter \\[arterial, central venous, peripheral venous\\] by the ICU team is NOT eligible for this trial since it has a widely established practice of no preoperative fasting and is not generally scheduled for a specific time.)\n   * Do NOT require fasting for preoperative gastrointestinal tract preparation\n   * Do NOT require removal\u002Freplacement of the endotracheal or tracheostomy tube\n   * Do NOT require prone or Trendelenburg (head-down) positioning.\n   * Typically require procedural sedation or anesthesia care.\n   * Generally, are scheduled for a specific time (although this time can change, or procedure may be cancelled).\n   * Are performed in the operating room, non-operating room procedural areas, or at the patient's bedside.\n\n     * All ICU types are eligible: surgical, medical, cardiac, neurological, trauma, mixed etc.\n\n       * Secure airway is defined as a cuffed endotracheal tube or a cuffed tracheostomy tube.\n\n         * Patients with all types of feeding tubes are eligible, regardless of tube insertion site (nasal, oral, surgically implanted) and tube tip location (pre- and post-pyloric) †As determined by the enrolling physician-investigator\n\nExclusion Criteria\n\n1. Inability to obtain informed consent\n2. Inability to enroll and randomize \\> 8 hours prior to planned procedure time\n3. Inability to deliver trial interventions\n4. Expected survival \\\u003C 48 hours as determined by the enrolling physician-investigator\n5. Critically ill burn patient\n6. Emergency procedure\n7. a. Gastrointestinal tract procedure that requires fasting based on surgical indications or b. airway\u002Flung procedure that requires removal of endotracheal or tracheostomy tube\n8. Plan for prone or Trendelenburg (head down) positioning during most of the procedure\n9. Major impairment of gastrointestinal motility or major structural disease of the gastrointestinal tract (e.g., severe gastroparesis, bowel obstruction, severe ileus, severely compromised lower esophageal sphincter, active gastrointestinal bleeding)\n10. Plan for postoperative extubation in the procedure area\n11. Prisoner\n12. Pregnant woman, woman of childbearing potential without a documented negative urine or serum pregnancy test during the current hospitalization, or woman who is breast feeding\n13. Refusal to enroll patient by treating physician\n14. Extracorporeal Membrane Oxygenation (ECMO) at the time of potential enrollment, except patients scheduled for ECMO decannulation as the study procedure and patients expected to be off of ECMO at the time of study procedure.\n15. Chronic mechanical ventilation at pre-admission level of care","ALL","18 Years",{"count":20,"type":21},1072,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if fasting or not fasting before a procedure has an effect on recovery in those who are critically ill. The main questions it aims to answer for patients on a breathing machine who are receiving tube feeding are:\n\n* Does the risk of lung complications and death differ between those who are not fasting, which may have a higher chance of allowing tube feeding to enter the lungs, and fasting, which temporarily stops nutrition before a procedure?\n* Is there a difference in recovery times, hospital stays, infection rates, need for organ support, safety, and nutrition for those who either fast or do not fast before a procedure?\n* What is the relationship between nutrition and clinical outcomes?\n\nResearchers will compare not fasting and fasting to see if it has an effect on recovery.\n\nParticipants will:\n\n* Be assigned by chance (like a coin toss) to one of two groups. One group (fasting group) will have their tube feeding stopped at least 8 hours before their procedure. The other group (not fasting group) will have their tube feeding stopped right before their procedure.\n* Be monitored via medical record for amount of protein and calories received, and any complications related to fasting\u002Fnot fasting.\n\n  * Data from routine electronic medical records will be reviewed to determine how participants are doing 3 months after their procedure.\n\n'",[27,28,29,30],"Critical Illness","Surgical Procedure, Unspecified","Pulmonary Aspiration","Fasting",[32,33,34,35,36,37,38,39,40,41,42,43],"pulmonary aspiration","enteral nutrition","tube feeding","preoperative fasting","perioperative medicine","surgery in critically ill","procedures in critically ill","nutrition in critical illness","perioperative safety","preoperative management","preoperative fasting in secure airway","anesthesia in critically ill","RECRUITING","2026-06-10",{"date":47,"type":48},"2026-06-12","ACTUAL",{"date":50,"type":48},"2025-04-28",{"date":52,"type":21},"2028-05",{"name":54,"class":55},"Massachusetts General Hospital","OTHER",19,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":11,"sex":64,"minAge":18,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":89},"100630009","gastric-ultrasound-after-clear-fluid-intake-in-diabetic-and-non-diabetic-pregnant-women-100630009","NCT07482098","Gastric Ultrasound After Clear Fluid Intake in Diabetic and Non-Diabetic Pregnant Women","Effect of Preoperative Clear Fluid Intake on Gastric Volume in Diabetic and Non-Diabetic Pregnant Women Assessed by Gastric Ultrasonography","Inclusion Criteria:\n\n* Pregnant women aged 18-40 years\n* Scheduled for elective cesarean section under spinal anesthesia\n* Singleton pregnancy\n* ASA physical status II\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Contraindication to spinal anesthesia\n* Known allergy to study medications\n* Multiple pregnancy\n* Severe systemic disease (ASA III or higher)\n* Pre-existing neurological disease\n* Infection at the spinal puncture site","FEMALE","40 Years",{"count":67,"type":21},80,"OBSERVATIONAL","Pulmonary aspiration of gastric contents during anesthesia is a serious perioperative complication associated with significant morbidity and mortality. Pregnant patients are at increased risk of aspiration due to physiological changes such as delayed gastric emptying and increased intra-abdominal pressure. In addition, diabetes may impair gastric motility because of autonomic neuropathy, potentially leading to gastroparesis and increased gastric residual volume.\n\nCurrent fasting guidelines allow the intake of clear fluids up to two hours before anesthesia. However, the effect of preoperative oral clear fluid intake on gastric volume in diabetic pregnant patients remains unclear.\n\nThis prospective observational study aims to compare gastric volume measured by gastric ultrasonography in diabetic and non-diabetic pregnant women undergoing elective cesarean delivery. All participants will receive 200 ml of water two hours before surgery. Gastric ultrasonography will be performed before fluid intake and two hours after intake to evaluate gastric volume and gastric content.\n\nThe results of this study may help improve the assessment of aspiration risk and guide perioperative fasting recommendations in pregnant patients, particularly those with diabetes.",[71,72,29],"Pregnancy","Diabetes in Pregnancy",[74,75,76,77,78,79],"Gastric Ultrasound","Cesarean Delivery","Preoperative Fasting","Gastric Volume","Aspiration Risk","Pregnant Women","2026-06-02",{"date":82,"type":48},"2026-06-04",{"date":84,"type":48},"2025-12-01",{"date":86,"type":21},"2026-07",{"name":88,"class":55},"Ankara City Hospital Bilkent",1,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":100,"conditions":101,"keywords":104,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":89},"100621827","hba1c-levels-and-gastric-emptying-assessed-by-gastric-ultrasound-100621827","NCT07375680","HbA1c Levels and Gastric Emptying Assessed by Gastric Ultrasound","Evaluation of the Effect of Hemoglobin A1c Levels on Gastric Emptying Assessed by Gastric Ultrasound","Inclusion Criteria:\n\nAdults aged 18 to 70 years. ASA physical status I-III. Scheduled for elective surgery under general anesthesia. Ability to provide written informed consent.\n\nExclusion Criteria:\n\nScheduled for emergency surgery. Refusal or inability to provide informed consent. Pregnancy. Age \\\u003C18 years or \\>70 years. History of gastric surgery. Neuromuscular disease. Current use of opioid or anticholinergic medications.","70 Years",{"count":99,"type":21},134,"Delayed gastric emptying increases the risk of pulmonary aspiration during general anesthesia. Diabetes mellitus and poor long-term glycemic control have been associated with impaired gastric motility. Hemoglobin A1c (HbA1c) is a marker of long-term glycemic control; however, its relationship with gastric emptying in surgical patients is not fully understood.\n\nThis prospective observational study aims to evaluate the association between HbA1c levels and gastric emptying using preoperative bedside gastric ultrasonography. Adult patients scheduled for elective surgery under general anesthesia will undergo gastric ultrasound examination after standard fasting. Gastric antral cross-sectional area and estimated gastric volume will be assessed and compared according to HbA1c levels.\n\nThe findings of this study may help improve preoperative risk stratification for aspiration and support individualized anesthetic management in patients with impaired glycemic control.",[102,103,29],"Delayed Gastric Emptying","Diabetes Mellitus",[105,106,107,108],"Hemoglobin A1c","Gastric Ultrasonography","General Anesthesia","Preoperative Assessment","2026-04-06",{"date":111,"type":48},"2026-04-08",{"date":113,"type":48},"2026-02-15",{"date":115,"type":21},"2026-09",{"name":117,"class":55},"Kutahya Health Sciences University",{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":133,"lastUpdatePostDateStruct":134,"startDateStruct":136,"completionDateStruct":137,"leadSponsor":139,"locationsCount":89},"100566364","protective-benefits-of-a-clear-liquid-diet-on-residual-gastric-content-in-patients-taking-glucagon-like-peptide-1-receptor-glp-1-ra-agonist-prior-to-anesthesia-100566364","NCT06654219","Protective Benefits of a Clear Liquid Diet on Residual Gastric Content in Patients Taking Glucagon Like Peptide-1 Receptor (GLP-1 RA) Agonist Prior to Anesthesia","Protective Benefits of a Clear Liquid Diet on Residual Gastric Content in Patients Taking Glucagon Like Peptide-1 Receptor Agonist Prior to Anesthesia","Inclusion Criteria:\n\n* Patients taking Glucagon Like Peptide-1 Receptor (GLP-1 RA) agonists\n* Undergoing upper endoscopy only - no colonoscopy due to prep\n\nExclusion Criteria:\n\n* Previous gastric resection or bypass\n* Gastric band in situ\n* Previous fundoplication\n* Large hiatal hernia\n* Pregnant patients\n* Recent trauma\n* Inability to turn to the right lateral decubitus position.\n* Patients on erythromycin, metoclopramide, domperidone, opioids.\n* Gastroparesis previous",{"count":126,"type":21},136,[24],"The purpose of this study is to determine if prolonged fasting from solids and transitioning to a CLD for 24 hours is protective to decrease RGC in patients on GLP-1 RAs presenting for upper endoscopy, to determine if prolonged fasting is associated with increased thirst, hunger and anxiety, To determine if signs and symptoms of nausea, vomiting, retching, abdominal bloating, and abdominal pain are present on the day of surgery, to see if there is any variability between preoperative gastric ultrasound assessment and volume of gastric contents visualized on upper endoscopy, to determine time of gastric emptying by serial Gastric ultrasonography (GUS) scans every 2 hours in subjects who presented with an initial at-risk scan, to determine the choice of anesthesia used based on preoperative GUS results, to determine if there were any adverse events recorded in this study group, to determine if duration of GLP-1 RA therapy has an association with residual gastric content (RGC). and to determine if dosing of GLP-1 RA has an association with RGC.",[29],[131,132],"Glucagon Like Peptide-1 Receptor (GLP-1 RA)","full stomach","2025-10-30",{"date":135,"type":48},"2025-11-03",{"date":133,"type":48},{"date":138,"type":21},"2026-05-01",{"name":140,"class":55},"The University of Texas Health Science Center, Houston",{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":64,"minAge":18,"maxAge":65,"enrollmentInfo":148,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":89},"100563864","ultrasound-assessment-of-gastric-volume-in-diabetic-versus-non-diabetic-term-pregnant-women-undergoing-cesarean-section-100563864","NCT06621706","Ultrasound Assessment of Gastric Volume in Diabetic Versus Non-Diabetic Term Pregnant Women Undergoing Cesarean Section","Ultrasound Assessment of Gastric Volume in Diabetic Versus Non-Diabetic Term Pregnant Women Undergoing Elective Cesarean Section: A Prospective Randomized Clinical Trial","Inclusion Criteria:\n\n* pregnant women undergoing elective caesarean section\n* aged between 18-40 years\n* belonging to ASA II-III\n* gestational age greater than 37 weeks\n* BMI\\\u003C 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* patients who refuse to give consent\n* patients taken to surgery on an emergency basis, -pregnant patients with upper gastrointestinal (GI) diseases and pathologies\n* patients with a history of using medications that affect gastrointestinal motility (e.g., opioids), severe organ dysfunction\n* pre-existing neurological deficits, intellectual disabilities and anatomical deformities.",{"count":149,"type":21},140,"The aim of the work to compare estimated gastric volumes through ultrasound in fasting diabetic and non-diabetic pregnant women scheduled for caesarean section.",[29,152],"Gastric Content Aspiration",[154,155,156],"Diabetic","Gastric ultrasonography","Pregnant","2024-09-29",{"date":159,"type":48},"2024-10-01",{"date":161,"type":48},"2024-09-25",{"date":163,"type":21},"2025-09-25",{"name":165,"class":55},"Beni-Suef University"]