[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulmonary-edema\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulmonary-edema":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,46,71,88,115,150,179,202,222],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100053827","evaluating-the-use-of-prehospital-lung-ultrasound-in-ems-a-multicenter-pilot-study-100053827",false,"NCT07549334","Evaluating the Use of Prehospital Lung Ultrasound in EMS: A Multicenter Pilot Study","Inclusion Criteria:\n\n* Patient treated by Emergency Medical Services\n* Complaint of dyspnea\n\nAt least one of the following:\n\n* Oxygen saturation \\\u003C94% on room air\n* Abnormal lung sounds\n* Increased work of breathing\n* Pedal edema\n* Orthopnea\n\nExclusion Criteria:\n\n* Pediatric patients (\\\u003C18)\n* Traumatic etiology\n* Cardiac arrest at any point prehospitally\n* No ultrasound-trained paramedic involved in patient's care","ALL","18 Years",{"count":18,"type":19},1000,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this prospective nonrandomized study is to determine if prehospital lung ultrasound findings result in a change in patient management. This study will look at how lung ultrasound exam improves diagnosis of respiratory distress in patients being treated by Emergency Medical Services, such as patients with heart failure. Additional questions include:\n\n* How well can paramedics obtain and interpret ultrasound images?\n* How does ultrasound use change treatment received by patients?\n* How does ultrasound use impact patient outcomes? Participants will receive a lung ultrasound exam, but otherwise receive standard evaluation and care. Patients who receive ultrasound will be compared to those who did not receive ultrasound for logistical reasons and patients from before the use of ultrasound. Ultrasound will not be withheld from any patient for the purposes of the study.",[25,26],"Congestive Heart Failure(CHF)","Pulmonary Edema",[28,29,30,26,31,32],"Ultrasound","Emergency Medical Services","Pulmonary Ultrasound","Congestive Heart Failure","Paramedic","NOT_YET_RECRUITING","2026-07-09",{"date":36,"type":37},"2026-07-13","ACTUAL",{"date":39,"type":19},"2026-08",{"date":41,"type":19},"2028-12",{"name":43,"class":44},"Rutgers, The State University of New Jersey","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":70},"100456642","systolic-function-and-weaning-induced-pulmonary-edema-systowean-study-100456642","NCT05226247","Systolic Function and Weaning-induced Pulmonary Edema (SystoWean Study)","Evaluation of the Role of Systolic Dysfunction in Weaning Failure Related to Weaning-induced Pulmonary Edema: the SystoWean Study","SystoWean","Inclusion Criteria:\n\n1. Invasive mechanical ventilation for more than 48 hours\n2. Patients indicated, according to intensivists, for carrying out a spontaneous breathing trial weaning test, based on the presence of all of the following criteria:\n\n   1. SpO2\\> 90% with FiO2 ≤40% and PEEP ≤5 cmH2O\n   2. Cough effectiveness on tracheal aspirations\n   3. Lack of hemodynamic instability and of disorders of consciousness\n3. Patients at high risk of weaning-induced pulmonary edema (WIPO), defined by one or more of the following criteria:\n\n   1. Obesity, defined by a body mass index\\> 30 kg\u002Fm²\n   2. Chronic obstructive pulmonary disease\n   3. Chronic heart disease\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years and pregnant women\n2. Patients with a decision of not to resuscitate\n3. Poor echogenicity\n4. Severe mitral valve disease (leakage and\u002For stenosis, bioprosthesis)\n5. Patients with pacemaker\n6. Tracheostomy\n7. Chronic neuromuscular or neurodegenerative diseases",{"count":55,"type":19},250,[22],"The purpose of this study is to determine if the left and right ventricular systolic function is involved in the development of weaning failure related to weaning-induced pulmonary edema.",[59,26],"Mechanical Ventilation Complication","RECRUITING","2026-05-21",{"date":63,"type":37},"2026-05-22",{"date":65,"type":37},"2022-08-08",{"date":67,"type":19},"2026-09",{"name":69,"class":44},"Centre Hospitalier Universitaire de Nice",3,{"id":72,"slug":4,"hasResults":11,"nctId":12,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":20,"phases":76,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":45},"100635180","Evaluating the Feasibility of Prehospital Lung Ultrasound","Evaluating the Feasibility of Prehospital Lung Ultrasound: A Multicenter Pilot Study",{"count":18,"type":19},[22],"The goal of this prospective nonrandomized study is to determine if a lung ultrasound exam improves diagnosis of respiratory distress in patients being treated by Emergency Medical Services. The main question it aims to answer is whether ultrasound use increases likelihood of correctly diagnosing heart failure. Additional questions include:\n\n* How well can paramedics obtain and interpret ultrasound images?\n* How does ultrasound use change treatment received by patients?\n* How does ultrasound use impact patient outcomes? Participants will receive a lung ultrasound exam, but otherwise receive standard evaluation and care. Patients who receive ultrasound will be compared to those who did not receive ultrasound for logistical reasons and patients from before the use of ultrasound. Ultrasound will not be withheld from any patient for the purposes of the study.",[25,26],[28,29,30,26,31,32],"2026-04-17",{"date":82,"type":37},"2026-04-24",{"date":84,"type":19},"2026-04",{"date":86,"type":19},"2028-04",{"name":43,"class":44},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":20,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":114},"100460483","phase-4-optimized-treatment-of-pulmonary-edema-or-congestion-100460483","NCT05276219","Optimized Treatment of Pulmonary Edema or Congestion","Vasodilation or Loop-diuretics for Initial Treatment of Pulmonary Edema or Congestion Due to Acute Heart Failure - a Randomized Placebo-controlled Trial","Decongest","Inclusion criteria\n\n1. Age ≥ 18 years\n2. Acute (within minutes to days) onset or worsening of subjective dyspnea\\*\n3. Systolic blood pressure ≥100 mmHg\n4. Oxygen saturation \\\u003C94% or need of oxygen\n5. Signs or suspicion of congestion (peripheral edema, rales, and\u002For clinical suspicion of congestion) \\*\n\n   * by the best assessment from a medical doctor. Inclusion must not wait on x-ray or other measures: patients suspected of pulmonary congestion should be included immediately.\n\nExclusion criteria\n\n1. More than 40 mg IV furosemide within the last three hours before randomization including prehospital treatment.\n2. More than 3 hours from hospital-admission to randomization\n3. Ongoing ventricular taky- or brady-arrythmias or supraventricular arrhythmias with HR \\> 180 or \\\u003C 40 bpm.\n4. Suspected severe infection or sepsis.\n\nExclusion criteria are purposely liberal, so patients can be included in accordance with everyday clinical practice. However, a safety criterion will be implemented:\n\nIf blood pressure drops below 90 mmHg in 2 measurements with 5 minutes apart and\u002For if urine production is below 50 ml after 1 hour, the intervention will be stopped, and patients can receive furosemide and nitrates freely.\n\nWe purposely chose not to exclude patients with aortic stenosis, since observational studies did not find excess risk of given nitrates to patients with pulmonary edema and aortic stenosis",{"count":97,"type":19},1104,[99],"PHASE4","Background:\n\nIntravenous (IV) loop-diuretics have been a key component in treating pulmonary edema since the nineteen sixties and has a Class 1 recommendation in the 2021 European Society of Cardiology guidelines for heart failure. Conversely, vasodilation was downgraded in the treatment of acute heart failure due to a lack of trials that compare vasodilation with loop-diuretics in a hyperacute clinical setting. This clinical equipoise will be tested in a trial including patients with pulmonary congestion immediately at hospital admission.\n\nPrimary objective:\n\nTo determine the superior strategy of loop-diuretics (furosemide), vasodilation (nitrates) or the combination during emergency treatment.\n\nDesign: Investigator-initiated, randomized, double-blinded, placebo-controlled trial with 1:1:1 allocation.\n\nIntervention:\n\nIntervention-phase will last 6 hours from study-inclusion, and patients will be allocated to one of three groups:\n\n* Boluses of 40 mg IV furosemide + nitrate-placebo as soon as possible and repeated up to 10 times.\n* Boluses of 3 mg IV isosorbide dinitrate + furosemide-placebo as soon as possible.\n* Boluses of both 3 mg IV isosorbide dinitrate + of 40 mg as soon as possible.",[26,31,102],"Acute Heart Failure",[104,105],"acute heart failure","Pulmonary edema",{"date":107,"type":37},"2026-04-22",{"date":109,"type":37},"2023-09-14",{"date":111,"type":19},"2027-05-31",{"name":113,"class":44},"Rigshospitalet, Denmark",4,{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":20,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100557458","clinical-utility-of-portable-dynamic-chest-x-ray-ddr-in-the-icu-100557458","NCT06538376","Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU","Clinical Utility of Portable Dynamic Chest X-Ray (DDR) in the ICU: Clinical Trial to Demonstrate the Feasibility of Deploying DDR Technology in the ICU - A Study to Prove Its Increased Diagnostic Value","Inclusion Criteria: Participants must meet all the following inclusion criteria to participate in this study:\n\n* Adults (at least 18 years of age) including both intubated\u002Fventilated and non-intubated patients\n* Likely to have pathology related to either, abnormal diaphragmatic excursion and lung aeration, pulmonary perfusion, increased lung water content or all the above, as well as for cricopharyngeal dysfunction\u002Fswallowing difficulties at risk for aspiration.\n* The subject or a legally authorized representative has provided written informed consent.\n\nExclusion Criteria: Candidates meeting any of the exclusion criteria at baseline will be excluded from study participation. These criteria are:\n\n* Special populations, including women with known pregnancy, prisoners, or institutionalized individuals\n* Patients where additional radiation is clinically contraindicated\n* Care team does not provide assent for approaching patient\u002Fsurrogate\n* For women of child-bearing potential, defined as premenopausal women, a pregnancy test will be administered to determine pregnancy status and confirm eligibility for the study. A pregnancy test will NOT be administered to women who are post-menopausal or have documentation of surgical sterilization.",{"count":123,"type":19},230,[22],"Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second. It is coupled with an analytical software that allows it to provide more advanced measures of lung motion, ventilation, and perfusion compared to traditional chest radiography. While implementation of DDR fixed machines are beginning elsewhere in the US, this trial involves the first applications of an FDA-approved portable DDR machine, for use at the bedside in the ICU.\n\nThe goal of this clinical trial is to determine the feasibility and safety of portable DDR technology in the ICU, as well as to evaluate the improved clinical diagnostic value of the portable DDR system over current standards of care.\n\nParticipants will receive one to three sets of DDR images, which will then be compared to their clinical gold standard exams (such as chest x-rays, CTs, or VQ scans) to assess and improve the precision and accuracy of measurements such as diaphragmatic motion, lung movement, and perfusion.",[26,127,128,129,130,131,132,133,134,135,136,137,138,139],"Pneumonia","Atelectasis","Pleural Effusion","Acute Rejection of Lung Transplant (Disorder)","Airway Obstruction","Rib Fractures","Acute Copd Exacerbation","Asthma COPD","Pulmonary Embolism","Hemothorax","Pneumothorax","Mesothelioma","Diaphragmatic Paralysis","2025-10-28",{"date":142,"type":37},"2025-10-29",{"date":144,"type":37},"2023-12-12",{"date":146,"type":19},"2027-11",{"name":148,"class":44},"Brigham and Women's Hospital",1,{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":157,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":158,"targetDuration":4,"studyType":160,"phases":4,"briefSummary":161,"conditions":162,"keywords":166,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":149},"100469356","cardiac-function-in-swimming-induced-pulmonary-edema-sipe-100469356","NCT05391737","Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE)","Cardiac Function in Swimming-Induced Pulmonary Edema (SIPE) - a Case Control Study","Inclusion Criteria:\n\nfor patients:\n\n* respiratory symptoms during or after swimming at the Vansbrosimningen open water swimming event\n* diagnosis SIPE by signs of pulmonary edema on lung ultrasound\n* peripheral oxygen saturation ≤95%\n\nfor controls:\n\n* completion of a swimming race of the Vansbrosimningen open water swimming event.\n* no respiratory symptoms during or after swimming\n* no signs of pulmonary edema on lung ultrasound\n* matched to patients with SIPE regarding sex and age\n\nExclusion criteria:\n\n* declined consent\n* hemodynamic instability or decreased consciousness",true,{"count":159,"type":19},120,"OBSERVATIONAL","Acute or chronic cardiac dysfunction could be a contributing factor to swimming-induced pulmonary edema (SIPE). Knowledge on cardiac function in SIPE is limited and recommendations for cardiac evaluation of patients with SIPE are lacking. The present study was designed to assess cardiac function in patients with SIPE and in asymptomatic swimmers.",[163,26,164,165],"Swimming Induced Pulmonary Edema (SIPE)","Lung Diseases","Heart Function Tests",[167,168,169],"Echocardiography","Electrocardiography","Troponin","2025-02-25",{"date":172,"type":37},"2025-02-27",{"date":174,"type":37},"2022-07-06",{"date":176,"type":19},"2026-12",{"name":178,"class":44},"Dalarna County Council, Sweden",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":20,"phases":188,"briefSummary":189,"conditions":190,"keywords":191,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":196,"startDateStruct":197,"completionDateStruct":199,"leadSponsor":201,"locationsCount":149},"100456717","pep-device-for-treatment-of-swimming-induced-pulmonary-edema-sipe-100456717","NCT05227222","PEP-device for Treatment of Swimming-induced Pulmonary Edema (SIPE)","Evaluation of Positive Expiratory Pressure Device (PEP-device) for Treatment of Swimming Induced Pulmonary Edema (SIPE) - a Randomized Single-blinded Controlled Study","Inclusion Criteria:\n\n* clinical diagnosis of swimming induced pulmonary edema (SIPE) with need of acute treatment\n* peripheral oxygen saturation ≥92%\n* 18 years or older\n* informed consent\n\nExclusion Criteria:\n\n* declined consent\n* suspected acute coronary syndrome\n* severe asthma diagnosed together with pulmonary edema with requirement of beta-agonist-inhalation prior to treatment of pulmonary edema\n* hemodynamic instability or decreased consciousness",{"count":187,"type":19},40,[22],"In swimming induced pulmonary edema (SIPE), there is a lack of knowledge regarding optimal treatment. The present study was designed to assess the benefit of treatment with positive expiratory pressure device (PEP-device) compared to spontaneous recovery in patients with SIPE without hypoxia in the out-of-hospital environment.",[163,26,164],[192,193,194,195],"positive expiratory pressure","therapeutics","ultrasonography","oximetry",{"date":172,"type":37},{"date":198,"type":37},"2022-07-02",{"date":200,"type":19},"2027-07-15",{"name":178,"class":44},{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":208,"eligibilityCriteria":209,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":210,"targetDuration":4,"studyType":20,"phases":212,"briefSummary":213,"conditions":214,"keywords":215,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":218,"startDateStruct":219,"completionDateStruct":220,"leadSponsor":221,"locationsCount":149},"100386122","o2-versus-cpap-treatment-of-patients-undergoing-sipe-therapy-octopus-100386122","NCT04307615","O2 Versus CPAP Treatment of Patients Undergoing SIPE Therapy (OCTOPUS)","Evaluation of Continous Positive Airway Pressure (CPAP) in Swimming Induced Pulmonary Edema (SIPE) -a Randomized Single-blinded Controlled Study","OCTOPUS","Inclusion Criteria:\n\n* clinical diagnosis of swimming induced pulmonary edema (SIPE) with need of acute treatment (oxygen saturation ≤91%)\n* 18 years and older\n* informed consent\n\nExclusion Criteria:\n\n* declined consent\n* suspected acute coronary syndrome\n* severe asthma diagnosed together with pulmonary edema where beta-agonist-inhalation is needed prior to treatment of pulmonary edema\n* hemodynamic instability or decreased consciousness",{"count":211,"type":19},90,[22],"In swimming induced pulmonary edema (SIPE), there is a lack of knowledge regarding optimal treatment. The present study was designed to assess the benefit of continuous positive airway pressure (CPAP) compared to oxygen as a first line treatment of SIPE in the out-of-hospital environment.",[163,26,164],[216,217,193,194,195],"continuous positive airway pressure (CPAP)","oxygen",{"date":172,"type":37},{"date":198,"type":37},{"date":200,"type":19},{"name":178,"class":44},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":157,"sex":15,"minAge":16,"maxAge":229,"enrollmentInfo":230,"targetDuration":4,"studyType":20,"phases":232,"briefSummary":233,"conditions":234,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":235,"lastUpdatePostDateStruct":236,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":241,"locationsCount":45},"100443092","screening-for-individual-susceptibility-factors-to-immersion-pulmonary-edema-100443092","NCT05049889","Screening for Individual Susceptibility Factors to Immersion Pulmonary Edema","RFSI-OPI","Inclusion Criteria:\n\n* Military or civilian diver with at least 100 dives\n* Between the ages of 18 and 60\n* Good physical condition (able to run\u002Fswim for 30 minutes at a constant pace).\n\nExclusion Criteria:\n\n* Divers with a current temporary medical incapacity to dive\n* Persons with contraindications to physical exercise and\u002For scuba diving\n* Pregnant or breastfeeding women","60 Years",{"count":231,"type":19},63,[22],"Immersion Pulmonary Edema (IPE) is a relatively new form of hemodynamic pulmonary edema. The number of cases has been increasing over the last ten years and it has become the second most common cause of hospitalization for military divers, after decompression sickness. The pathophysiological mechanisms of IPE are not completely known. Its occurrence is linked to a combination of factors related to the environmental constraints of diving, as well as to the diver's equipment. The main external factors are increased hydrostatic pressure, cold, intense effort and emotional stress. The impact of internal factors is not known. At this time, no severe forms of IPE have been identified in the military. However, it is important to identify this pathology at an early stage, even if the signs appear minor, because the continuation of underwater activity can significantly worsen the clinical picture. The risk of recurrence (greater than 15%) could result in a severe or even lethal accident.",[26],"2022-09-13",{"date":237,"type":37},"2022-09-14",{"date":239,"type":37},"2022-08-17",{"date":39,"type":19},{"name":242,"class":44},"Direction Centrale du Service de Santé des Armées"]