[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulp-disease-dental\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulp-disease-dental":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,59,104,136,162,193,219,248,269,295,316,340,363,382,405,426],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100644947","oxymetazoline-versus-sodium-hypochlorite-as-hemostatic-agents-in-mta-pulpotomy-of-primary-molars-100644947",false,"NCT07675330","Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars","Comparative Evaluation of Clinical and Radiographic Success of Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars in a Group of Egyptian Children: A Randomized Controlled Trial","OXY - MTA","Inclusion Criteria:\n\n• Patients: Egyptian children with carious mandibular primary molars aged 4-8 years.\n\n• Teeth: Restorable mandibular primary molars with no clinical signs or symptoms of irreversible pulpitis.\n\n• Pre-operative Radiograph: No radiographic signs of internal or external root resorption and no furcation or periapical radiolucencies.\n\n\\-\n\nExclusion Criteria:\n\n* • Patients:\n\n  1. Uncooperative children.\n  2. Medically compromised children.\n  3. Patients whose parents refuse to participate or refuse to sign the informed consent.\n\n     * Teeth:\n\n  \u003C!-- -->\n\n  1. Previously accessed molars.\n  2. Mobile primary molars.\n  3. Presence of sinus tract or pain on percussion.","ALL","4 Years","8 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate clinical and radiographic success of oxymetazoline versus sodium hypochlorite as hemostatic agents in MTA pulpotomy of primary molars.",[28,29,30,31,32,33,34,35],"Pulp Disease, Dental","Pulp Therapy in Primary Molars","Pulpitis - Reversible","Pulp Inflammation","Vital Pulp Therapies","Carious Exposure of Pulp","Primary Molar Tooth","Primary Molar Pulpotomy",[37,38,39,40,41,42,43,44,45],"Pulp therapy in primary molars","pulpotomy","MTA pulpotomy for primary molars","Sodium hypochlorite","Oxymetazoline","Hemostatic agents","NaOCl","Oxy","Oxymetazoline nasal spray","NOT_YET_RECRUITING","2026-06-26",{"date":49,"type":50},"2026-06-30","ACTUAL",{"date":52,"type":22},"2026-08",{"date":54,"type":22},"2027-12",{"name":56,"class":57},"Cairo University","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":11,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":23,"phases":71,"briefSummary":73,"conditions":74,"keywords":83,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":4},"100634665","early-phase-1-chloramphenicol-tetracycline-zinc-oxide-and-eugenol-paste-ctz-paste-for-emergency-dental-treatment-in-public-health-settings-a-randomized-trial-100634665","NCT07542639","Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial","Clinical and Radiographic Efficacy of Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) in the Context of Emergency Dental Treatments in Brazilian Public Health: Randomized Clinical Trial","CTZ- emergency","Inclusion Criteria:\n\n* Pediatric patients presenting with:\n* Irreversible pulpitis in primary molars;\n* Pulp necrosis, with or without abscess, in primary molars.\n* Primary molars with sufficient remaining tooth structure to allow endodontic treatment.\n* Primary teeth in which the permanent successor tooth germ presents developmental stages compatible with Nolla stages 1 to 7, defined as:\n\nStage 1: Presence of bony crypt with no evidence of calcification; Stage 2: Initial calcification, with appearance of radiopaque points in the crown region; Stage 3: Approximately one-third of crown formation; Stage 4: Approximately two-thirds of crown formation; Stage 5: Crown almost complete, without full calcification; Stage 6: Crown completely formed, without initiation of root formation; Stage 7: Initial root formation.\n\n* Clinical and radiographic conditions indicating feasibility of tooth maintenance through endodontic treatment, including:\n* Permanent successor in developmental stages prior to Nolla Stage 8;\n* Preservation of the bony crypt.\n\nExclusion Criteria:\n\n* Pediatric patients presenting with:\n* Reversible pulpitis;\n* Indication for endodontic treatment in permanent teeth.\n* History of allergy or hypersensitivity to any components of the obturation materials (e.g., CTZ paste or zinc oxide-eugenol).\n* Clinical conditions that prevent adequate management in an outpatient setting.\n* Primary teeth in which the permanent successor:\n* Is in advanced developmental stages (Nolla Stage 8 or higher), and\u002For\n* Presents disruption of the bony crypt, contraindicating endodontic treatment.\n* Teeth presenting internal root resorption that compromises the feasibility of endodontic treatment.","2 Years","11 Years",{"count":70,"type":22},110,[72],"EARLY_PHASE1","The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and structural constraints directly impact treatment effectiveness. In these contexts, conventional pulpectomy using zinc oxide-eugenol (ZOE), although effective, may present operational limitations that restrict its large-scale applicability in public health systems.\n\nIn this scenario, non-instrumental endodontic treatment (NIET), based on the concept of Lesion Sterilization and Tissue Repair (LSTR), has emerged as a simplified alternative. Among the available options, CTZ paste shows potential for single-visit application, reducing clinical time and technical complexity.\n\nThis study aims to evaluate the clinical and radiographic non-inferiority of CTZ paste compared to conventional pulpectomy with ZOE in primary molars with pulp necrosis, with or without abscess or fistula, treated in emergency dental care settings.\n\nThis is a randomized, pragmatic, controlled, non-inferiority clinical trial conducted at a single center, with clinical and radiographic follow-up at 3, 6, and 12 months. Participants will be allocated into two groups: (1) NIET with CTZ paste and (2) conventional pulpectomy with ZOE.\n\nPrimary outcomes include pain resolution and absence of clinical signs of infection. Secondary outcomes include radiographic success, clinical time, child behavior (Frankl Scale), need for retreatment, and oral health-related quality of life.\n\nThe findings are expected to provide robust evidence regarding the effectiveness of CTZ paste under real-world clinical conditions, contributing to the development of more accessible and effective protocols within public health systems, with the potential to expand access to conservative treatment and reduce early tooth extractions in pediatric dentistry.",[28,75,29,76,77,78,79,80,81,82],"Pulp Necrosis","Primary Teeth","Pulpectomy","Endodontics","Dental Care for Children","Treatment Outcome","Quality of Life","Health Services Accessibility",[84,38,85,86,87,88,89,90,91,92,93,94],"pulpectomy","CTZ paste","NIET","Non-instrumental endodontic treatment","LSTR","Lesion sterilization and tissue repair","Endodontic infection","dental abscess","Fistula","Emergency dental treatment","Public health dentistry","2026-05-07",{"date":97,"type":50},"2026-05-12",{"date":99,"type":22},"2026-06-08",{"date":101,"type":22},"2028-02-28",{"name":103,"class":57},"University of Sao Paulo",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":111,"sex":17,"minAge":112,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":58},"100627744","predicting-vital-pulp-treatment-outcomes-in-symptomatic-pulpits-using-metabolic-biomarker-100627744","NCT07452614","Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker","Efficacy of Metabolic Biomarkers in Predicting Twelve-Month Outcomes of Vital Pulp Treatment in Symptomatic Teeth With Carious Pulp Exposure: A Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age range of 16-50 years.\n2. Pulp exposure during treatment of deep caries.\n3. Absence of periodontitis or systemic disease.\n4. Only one or two proximal surfaces lost with remaining walls \\> 2 mm; and\n5. Good compliance and signed informed consent forms.\n\nExclusion Criteria:\n\n1. Patients who meet any of the following criteria will be excluded:\n2. Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;\n3. Teeth with a negative response to cold testing\n4. Current pregnancy or breastfeeding;\n5. Poor compliance or inability to complete the trial.\n6. The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study.\n7. Inadequate blood sample collection after pulpal exposure.",true,"16 Years","50 Years",{"count":115,"type":22},60,[25],"This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.",[28,119,120,121],"Pulpitis","Reversible Pulpitis","Irreversible Pulpitis (Toothache)",[123,124,119,125],"Vital pulp treatment","Metabolic biomarker","Carious pulp exposure","RECRUITING","2026-03-26",{"date":129,"type":50},"2026-04-01",{"date":131,"type":50},"2026-02-20",{"date":133,"type":22},"2028-10",{"name":135,"class":57},"Abeer Ghalib Abdul-khaliq",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":149,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":58},"100605921","comparison-of-hyaluronic-acid-theracal-and-mineral-trioxide-aggregate-as-pulpotomy-agents-in-primary-molars-100605921","NCT07168811","Comparison of Hyaluronic Acid, TheraCal, and Mineral Trioxide Aggregate as Pulpotomy Agents in Primary Molars","Comparative Clinical and Radiographic Evaluation of Hyaluronic Acid, TheraCal, and Mineral Trioxide Aggregate as Pulpotomy Agents in Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age 4-8 years,\n* Co-operative patient\n* At least one restorable mandibular second primary molars with deep carious lesions requiring pulpotomy.\n* Absence of gingival swelling or sinus tract.\n* Absence of spontaneous pain.\n* Absence of pain on percussion.\n* Controlled bleeding.\n* First treatment the tooth.\n* Possibility of restoring the tooth with a stainless steel crown.\n* No Radiographic evidence of changes associated with pulp degeneration, such as widening of PDL space, internal root resorption, external root resorption, inter-radicular or periapical bone destruction (radiolucency).\n\nExclusion Criteria:\n\n* Swelling, sinus tract, or fistula.\n* Spontaneous pain.\n* Necrotic pulp, pathological mobility.\n* Cases require for general anesthesia.\n* A history of repeated need for analgesics.\n* Patients with any systemic diseases.\n* Uncontrolled bleeding.\n* Selected deciduous teeth without a permanent successor",{"count":144,"type":22},66,[25],"This randomized clinical trial aims to evaluation the clinical and radiographic outcomes of hyaluronic acid, TheraCal, and Mineral Trioxide Aggregate (MTA) when used as pulpotomy agents in primary molars.\n\nThe main question it aims to answer is:\n\nIn children with restorable mandibular second primary molars requiring pulpotomy, does the use of hyaluronic acid or TheraCal LC, compared to MTA, result in improved clinical and radiographic success rates over a 12-month follow-up period?",[148,28],"Pulpotomies Primary Teeth",[150,151,152],"Hyaluronic Acid","TheraCal","MTA","2025-09-04",{"date":155,"type":50},"2025-09-11",{"date":157,"type":22},"2025-10-01",{"date":159,"type":22},"2026-11-01",{"name":161,"class":57},"Al-Azhar University",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":111,"sex":17,"minAge":169,"maxAge":113,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":175,"conditions":176,"keywords":179,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":58},"100532011","phase-2-the-antimicrobial-potential-of-diclofenac-sodium-as-an-intracanal-medicament-100532011","NCT06207253","The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament","The Antimicrobial Potential of Diclofenac Sodium as an Intracanal Medicament During Root Canal Treatment: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients with teeth diagnosed with apical periodontitis\n* Periapical Index (PAI) ≥ 2\n* The teeth are restorable\n\nExclusion Criteria:\n\n* Teeth with immature roots\n* Non restorable teeth\n* Medically compromised patients with systemic complication that would alter the treatment.\n* Teeth with internal\u002Fexternal root resorption\n* Patient with an allergy to diclofenac sodium","18 Years",{"count":171,"type":22},48,[173,174],"PHASE2","PHASE3","The goal of this randomized clinical trial is to evaluate the capability of the material to exert bacterial reduction of diclofenac sodium versus of that calcium hydroxide paste when these materials are used as intracanal medications in permanent molar teeth with chronic apical periodontitis.\n\nThe main question\\[s\\] it aims to answer are:\n\n• Will the diclofenac sodium (NSAIDs) possess antimicrobial efficacy to be used effectively as an intracanal medicament similar to that of calcium hydroxide in primary endodontic treatment? Participants will be allocated randomly into three equal groups by using computer generated randomization, according to the type of intracanal medication.",[177,28,178],"Endodontic Disease","Intracanal Medication",[180,181,182,183],"Sodium diclofenac","Intracanal medication","Calcium hydroxide","Apical periodontitis","2025-05-26",{"date":186,"type":50},"2025-05-30",{"date":188,"type":22},"2025-11",{"date":190,"type":22},"2025-12",{"name":192,"class":57},"British University In Egypt",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":111,"sex":17,"minAge":18,"maxAge":200,"enrollmentInfo":201,"targetDuration":4,"studyType":23,"phases":202,"briefSummary":204,"conditions":205,"keywords":207,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":4},"100587215","phase-1-comparison-of-3mixtatin-pulpotomy-and-metapex-pulpectomy-in-primary-molars-with-irreversible-pulpitis-100587215","NCT06925490","Comparison of 3Mixtatin Pulpotomy and Metapex Pulpectomy in Primary Molars With Irreversible Pulpitis","Clinical and Radiographic Evaluation of Pulpotomy Using 3Mixtatin Versus Pulpectomy Using Metapex in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis in Children Aged 4 to 9 Years: A Randomized Clinical Trial.","Inclusion Criteria:\n\n* Children aged from 4 to 9 years with vital primary molars showing signs of irreversible pulpitis.\n* Children with spontaneous pain lasting a few seconds to several hours.\n* Pain is intensified by thermal stimulus and persists after its removal.\n* Pulp hemorrhage after performing access cavity and deroofing of pulp chamber showing reddish pink healthy pulp tissue.\n* Radicular pulp health is verified by achieving hemostasis within eight minutes of compression using a cotton pellet with 5% sodium hypochlorite.\n* Absence of peri-apical or inter-radicular radiolucency, widening of periodontal ligament space, internal or external root resorption.\n\nExclusion Criteria:\n\n* Unrestorable primary molars.\n* Primary molars with uncontrolled pulp hemorrhage or pulp necrosis.\n* Medically compromised patients who have systemic disease.\n* Uncooperative children who refuse treatment.\n* Children whose parents are unwilling to place stainless steel crowns.\n* Children whose parents or caregivers refuse to participate in the study or are unable to attend follow-up visits.","9 Years",{"count":21,"type":22},[203],"PHASE1","The present study aims to evaluate the clinical and radiographic success of pulpotomy using 3Mixtatin versus pulpectomy using Metapex in primary molars with irreversible pulpitis in children aged 4 to 9 years.",[206,76,28],"Irreversible Pulpitis",[208,209,210,84,38],"3Mixtatin","irreversible pulpitis","metapex","2025-04-25",{"date":213,"type":50},"2025-04-27",{"date":215,"type":22},"2025-06",{"date":217,"type":22},"2026-10",{"name":56,"class":57},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":111,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":227,"targetDuration":4,"studyType":23,"phases":228,"briefSummary":229,"conditions":230,"keywords":233,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":245,"leadSponsor":247,"locationsCount":58},"100583083","clinical-and-radiographic-evaluation-of-potassium-nitrate-in-polycarboxylate-versus-mineral-trioxide-aggregate-in-vital-pulpotomy-in-primary-molars-100583083","NCT06871709","Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars","Clinical and Radiographic Evaluation of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate in Vital Pulpotomy in Primary Molars: a Randomized Clinical Trial","❖ Inclusion Criteria:\n\n1. Children aged 4 to 7 years, in good general health.\n2. Children with vital, deeply carious primary molars.\n3. No history of spontaneous pain, pathological mobility, draining sinus tract, redness or swelling of the vestibule.\n4. Normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test.\n5. No sign of radiolucency in periapical or furcation area.\n6. No widening of PDL space or loss of lamina dura continuity.\n7. No evidence of internal\u002Fexternal pathological root resorption.\n\nExclusion Criteria:\n\n1. Children with a physical disability or medical disability.\n2. Unrestorable molars.\n3. Uncooperative patient.\n4. Parent unable to attend Follow- up visits.\n5. Parents refuse to give written informed consent.\n6. If the access was opened and irreversible pulpitis was evident.","7 Years",{"count":21,"type":22},[25],"The purpose of this RCT is to compare the clinical\u002Fradiographic outcomes of Potassium nitrate in polycarboxylate cement and MTA as pulpotomy biomaterials used for asymptomatic vital primary lower second molar and this will help to clinically evaluate the use of alternative material in vital pulpotomy in primary molars with deep carious cavities.\n\nEmphasis is set on avoiding total pupectomy and maintaining radicular pulp vitality therefore maintain the tooth in a viable condition till it's shedding and eruption of the permanent successor.",[32,231,28,148,232],"Pulpotomy","Pulp Therapy",[234,235,152,231,236,237,238,239,240],"Mineral Trioxide Aggregate","Potassium Nitrate","Vital Pulpotomy","Vital Pulp therapy","Primary Molars","pulp therapy","Pulp disease","2025-03-06",{"date":243,"type":50},"2025-03-12",{"date":186,"type":22},{"date":246,"type":22},"2026-12-30",{"name":56,"class":57},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":11,"sex":17,"minAge":169,"maxAge":4,"enrollmentInfo":255,"targetDuration":18,"studyType":257,"phases":4,"briefSummary":258,"conditions":259,"keywords":4,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":58},"100580987","the-effect-of-different-risk-factors-on-the-success-rate-of-vpt-100580987","NCT06844448","The Effect of Different Risk Factors on the Success Rate of VPT","The Effect of Different Risk Factors on the Success Rate of VPT: an Observational Prospective Cohort Study","Inclusion Criteria:\n\n* Patients over 18 years of age who have at least one tooth with a pulp chamber that has been opened during a dental procedure or is likely to be opened during restoration of the tooth\n* The tooth is responsive to a sensitivity test with cold spray\n* The coronal part must be restorable\n* The periodontal depth around the tooth should be 0 according to the Dental Practicality Index Periodontal Treatment Need, i.e. the probing depth around the tooth should not be greater than 3.5 mm\n\nExclusion Criteria:\n\n* Internal\u002Fexternal resorption in the tooth\n* If the root development of the tooth is not yet complete or if it is a deciduous tooth\n* Absolute isolation cannot be performed during the procedure\n* If pulp exposure does not occur even after complete removal of caries\n* The crown of the tooth cannot be restored\n* Periodontium surrounding tooth affected by moderate\u002Fsevere marginal periodontitis (probing depth deeper than 3.5 mm)\n* Pulp exposure due to traumatic injury\n* Baseline radiograph shows signs of severe pulp palcification\n* Periapical lesion is around the root (Periapical index of the tooth \\>2)",{"count":256,"type":22},400,"OBSERVATIONAL","This study aims to evaluate the effectiveness of various vital pulp therapy (VPT) methods, such as direct pulp capping, partial pulpotomy, and total pulpotomy, in maintaining pulp vitality following pulp exposure. It explores the success rates of these treatments compared and investigates co-factors influencing these rates, including age. This prospective cohort study involves patients over 18 with restorable teeth and exposed pulp chambers. Success is measured through clinical and radiological criteria over a follow-up period of up to four years. The study also aims to identify if there's an age threshold affecting the preference for VPT over root canal therapy.",[260,28,206,120,119],"Dental Caries Extending to Pulp","2025-03-03",{"date":241,"type":50},{"date":264,"type":50},"2024-06-01",{"date":266,"type":22},"2030-06-01",{"name":268,"class":57},"Semmelweis University",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":275,"eligibilityCriteria":276,"healthyVolunteers":111,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":277,"targetDuration":4,"studyType":23,"phases":279,"briefSummary":280,"conditions":281,"keywords":284,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":294},"100581779","zinc-oxide-ozonated-olive-oil-in-lstr-100581779","NCT06854744","Zinc Oxide Ozonated Olive Oil in LSTR","Zinc Oxide Ozonated Oil Versus Modified Triple Antibiotic Paste as a Lesion Sterilization and Tissue Repair Technique in Primary Molars","Zn-OO\u002FMTAP","Inclusion Criteria: 1- Cooperative patients in the age group of (4-7) years with no associated systemic illness.\n\n2- Bilateral mandibular primary molars showing signs and symptoms of pulp necrosis or chronic pulp infection with\u002Fwithout hemorrhage, suppuration, or purulence.\n\n3- Spontaneous pain or tenderness to percussion. 4- Presence of chronic apical abscess, sinus tract, or grade I mobility. 5-The tooth should be restorable. 6- Radiographic characteristics are:\n\n1. Widening of Periodontal ligament space.\n2. Radicular involvement.\n3. Furcation involvement less than or equal to half of the shortest root in the vertical dimension\n\n   \\-\n\n   Exclusion Criteria: Exclusion criteria :\n   1. Physiologic root resorption is more than one-third of its length.\n   2. Excessive internal resorption.\n   3. Non-restorable teeth exhibiting greater than grade I mobility.\n   4. Perforation into the bifurcation.\n   5. Any underlying pathological lesion.\n   6. Any previous history of allergy to the antibiotics used in the study. -",{"count":278,"type":22},30,[25],"This study will be carried out to evaluate and compare the clinical and radiographic effect of zinc oxide-ozonated olive oil (ZnO-OO) versus Modified Triple Antibiotic Paste (MTAP) as a Lesion Sterilization and Tissue Repair Technique in Primary Molars",[282,283,28,76],"Pulpitis - Irreversible","Ozone",[285],"ZnOO \u002FMTAP","2025-02-25",{"date":261,"type":50},{"date":289,"type":50},"2024-01-15",{"date":291,"type":22},"2025-04",{"name":293,"class":57},"Tanta University",2,{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":111,"sex":17,"minAge":169,"maxAge":4,"enrollmentInfo":302,"targetDuration":4,"studyType":23,"phases":304,"briefSummary":305,"conditions":306,"keywords":4,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":58},"100580406","effect-of-cavity-disinfectants-on-post-operative-pain--success-of-partial-caries-removal-100580406","NCT06836882","Effect of Cavity Disinfectants on Post Operative Pain & Success of Partial Caries Removal","The Effect of Sodium Hypochlorite and Chlorhexidine as Cavity Disinfectants on the Post Operative Pain and Success of Partial Caries Removal in Deep Carious Lesion With Moderate Pulpitis in Permanent Teeth: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. The patient should be ≥18 years of age.\n2. Restorable mature permanent 1st and 2nd Mandibular molars with extremely deep caries (≥2\u002F3 dentine involvement)\n3. Tooth should give positive response to pulp sensibility testing.\n4. Clinical diagnosis of moderate pulpitis.\n5. Radiographic finding of periapical index (PAI) score ≤2.\n6. Healthy periodontium (probing pocket depth ≤3 mm and mobility within normal limit)\n\nExclusion Criteria:\n\nPresence of vertical root fracture Presence of root perforations ASA-3 or ASA-4 according to the classification of the American Society of Anesthesiologists) Presence of root resorption Combined endodontic-periodontic lesions. Pregnancy",{"count":303,"type":22},159,[25],"To investigate The Effect of Sodium hypochlorite and Chlorhexidine as cavity Disinfectants on the post operative pain and Success of Partial Caries Removal in deep carious lesion with moderate pulpitis in permanent teeth",[28],"2025-02-15",{"date":309,"type":50},"2025-02-20",{"date":311,"type":50},"2024-05-23",{"date":313,"type":22},"2025-12-23",{"name":315,"class":57},"Postgraduate Institute of Dental Sciences Rohtak",{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":324,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":329,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":58},"100563089","phase-1-clinical-and-radiographic-evaluation-of-hyaluronic-acid-gengigel-teething-versus-mineral-trioxide-aggregate-angelus-as-pulpotomy-agent-in-vital-primary-molars-100563089","NCT06611631","Clinical and Radiographic Evaluation of Hyaluronic Acid (Gengigel Teething) Versus Mineral Trioxide Aggregate( Angelus) as Pulpotomy Agent in Vital Primary Molars","Clinical and Radiographic Evaluation of Hyaluronic Acid (Gengigel Teething) Versus Mineral Trioxide Aggregate( Angelus) as Pulpotomy Agent in Vital Primary Molars: A Randomized Clinical Trial","HA - MTA","Inclusion Criteria:\n\n* Patients:\n\nAged 4-8 years, in good general health and medically within normal.\n\nTeeth:\n\n* Restorable mandibular primary molars.\n* History of reversible pulpitis.\n\nPre-operative Radiographic criteria:\n\n* Absence of periapical or inter-radicular radiolucencies.\n* Absence of widening of periodontal ligaments (PDL) space.\n* Absence of internal or external root resorption.\n\nExclusion Criteria:\n\nPatients:\n\n* With systemic disorders.\n* Physical or mental disabilities.\n* Unable to attend follow- up visits.\n* Refusal of Participation.\n* Refusal to sign the informed consent.\n\nTeeth:\n\n* Previously accessed teeth.\n* Mobile mandibular primary molars.\n* Swelling in the vestibule or on palpation.\n* Pain on percussion",{"count":325,"type":22},34,[203],"The goal of this clinical trial is to Clinical and Radiographic Evaluation of Hyaluronic Acid (Gengigel Teething) Versus Mineral Trioxide Aggregate( Angelus) as Pulpotomy Agent in Vital Primary Molars.\n\nThe main question it aims to answer is:\n\nIs there a difference in the clinical or radiographic success when using Hyaluronic acid (Gengigel Teething, Ricerfarma , Italy) versus mineral trioxide aggregate (Angelus, Londrina ,Brazil) in pulpotomy of carious primary molars in children?",[148,28],[330,331,152,234],"hyaluronic acid","HA","2024-11-01",{"date":334,"type":50},"2024-11-04",{"date":336,"type":22},"2025-03",{"date":338,"type":22},"2026-04",{"name":56,"class":57},{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":111,"sex":17,"minAge":347,"maxAge":348,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":351,"briefSummary":352,"conditions":353,"keywords":354,"overallStatus":126,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":362,"locationsCount":58},"100531186","phase-2-anti-bacterial-potential-of-nano-calcium-hydroxide-as-an-intracanal-medication-100531186","NCT06196515","Anti-bacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication","Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial","Inclusion Criteria:\n\n* healthy males and females.\n* age range between 21-49.\n* patients with no physical disability or psychological problems.\n* patients presenting with single permanent molar with signs and\u002For symptoms of apical periodontitis, and having Periapican index ≥ 2.\n\nExclusion Criteria:\n\n* pregnant women.\n* patients with immune-compromised disease.\n* patients with complicated systemic diseases.\n* patients who took antibiotics within a period of 1 month.\n* patients with known sensitivity to the medicaments or pharmaceuticals used in this study.\n* Non-restorable teeth including root fractures, and\u002For advanced periodontal involvement.","21 Years","49 Years",{"count":350,"type":22},54,[173,174],"The aim of the study is to evaluate the anti-bacterial potential of Nano Calcium Hydroxide as an intracanal medication in primary endodontic treatment of permanent molars.",[177,28],[355],"intracanal medication","2024-08-16",{"date":358,"type":50},"2024-08-19",{"date":360,"type":22},"2024-08",{"date":190,"type":22},{"name":192,"class":57},{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":226,"enrollmentInfo":370,"targetDuration":4,"studyType":23,"phases":371,"briefSummary":372,"conditions":373,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":374,"lastUpdatePostDateStruct":375,"startDateStruct":377,"completionDateStruct":379,"leadSponsor":381,"locationsCount":4},"100556359","evaluation-of-success-rate-of-partial-pulpotomy-versus-complete-pulpotomy-in-primary-molars-using-neoputty-mta-100556359","NCT06524076","Evaluation of Success Rate of Partial Pulpotomy Versus Complete Pulpotomy in Primary Molars Using NeoPUTTY MTA","Clinical and Radiographic Evaluation of Partial Pulpotomy Versus Complete Pulpotomy in Vital Pulp Therapy in Primary Molars Using NeoPUTTY™ (MTA): Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients:\n\n  * Aged 4-7 years, in good general health and medically within normal.\n\nTeeth:\n\n* Restorable mandibular second primary molars.\n* History of reversible pulpitis.\n\nPreoperative radiograph:\n\n* Absence of periapical or inter-radicular radiolucency.\n* Absence of widening of periodontal ligaments (PDL) space.\n* Absence of internal or external root resorption.\n\nExclusion Criteria:\n\n* Patients:\n\n  * With systemic disorders.\n  * Physical or mental disabilities.\n  * Unable to attend follow-up visits.\n  * Refusal of Participation.\n  * Refusal to sign the informed consent.\n\nTeeth:\n\n* Previously accessed teeth.\n* Mobile mandibular second primary molar.\n* Swelling in the vestibule or on palpation.\n* Pain on percussion.",{"count":115,"type":22},[25],"Evaluating the clinical and radiographic success of partial pulpotomy compared to complete pulpotomy in vital primary second molars with reversible pulpitis using NeoPUTTY™ (MTA).",[28],"2024-08-13",{"date":376,"type":50},"2024-08-14",{"date":378,"type":22},"2024-09-22",{"date":380,"type":22},"2025-12-22",{"name":56,"class":57},{"id":383,"slug":384,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":111,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":389,"targetDuration":4,"studyType":23,"phases":390,"briefSummary":391,"conditions":392,"keywords":394,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":4},"100552888","phase-1-3mixtatin-and-mta-vital-pulpotomy-in-primary-molars-100552888","NCT06478940","3Mixtatin and MTA Vital Pulpotomy in Primary Molars","Clinical and Radiographic Evaluation of 3Mixtatin Versus MTA Used as Pulpotomy Agents in Vital Primary Molars: A Randomized Clinical Trial","Inclusion Criteria:\n\n* • Children 4-8 years old\n\n  * Vital deeply carious primary molars.\n  * No history of spontaneous pain, pathologic mobility, draining sinus tract, redness or swelling of the vestibule.\n  * Normal gingival and periodontal condition, with no sensitivity to vestibular palpation, and no pain on percussion test.\n  * Patient and parent showing cooperation and compliance.\n\nExclusion Criteria:\n\n* • Uncooperative children to avoid time waste and attrition bias.\n\n  * Unrestorable molars\n  * Sign of radiolucency in periapical or furcation area\n  * Widening of PDL space or loss of lamina dura continuity\n  * Evidence of internal\u002Fexternal pathologic root resorption\n  * During operative procedure, when hemorrhage control is not achievable after pulpotomy.\n  * Children with systemic disease as some systemic diseases may have effect on the outcome.\n  * Unable to attend follow-up visits to avoid attrition bias by decreasing number of drop off cases.\n  * Refusal of participation as the parent of child has the authority of participation.",{"count":21,"type":22},[203],"The aim of the study is to evaluate clinical and radiographic success of using 3Mixtain versus mineral trioxide aggregate in pulpotomy of deeply carious Primary molars.",[28,393],"Deciduous Teeth",[395,396],"pulpotomy - vital pulp therapy","primary molars- baby teeth","2024-06-23",{"date":399,"type":50},"2024-06-27",{"date":401,"type":22},"2024-08-01",{"date":403,"type":22},"2025-09-01",{"name":56,"class":57},{"id":406,"slug":407,"hasResults":11,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":111,"sex":17,"minAge":412,"maxAge":413,"enrollmentInfo":414,"targetDuration":4,"studyType":257,"phases":4,"briefSummary":416,"conditions":417,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":419,"lastUpdatePostDateStruct":420,"startDateStruct":422,"completionDateStruct":424,"leadSponsor":425,"locationsCount":4},"100552038","knowledge-of-vital-pulp-therapy-in-permanent-teeth-after-educational-programme-a-before-and-after-study-100552038","NCT06467890","Knowledge of Vital Pulp Therapy in Permanent Teeth After Educational Programme: A Before and After Study","Knowledge of Vital Pulp Therapy in Permanent Teeth Among a Group of Dental Interns After Educational Programme: A Before and After Study","Inclusion Criteria:\n\n* Dental interns enrolled in the Pediatric Dentistry Department, Cairo University .\n* Candidates who are willing to participate\n\nExclusion Criteria:\n\n* Responses with incomplete information","20 Years","30 Years",{"count":415,"type":22},550,"evaluating the extent of knowledge of vital pulp therapy in permanent dentition among a group of dental interns in Egypt after educational programme.",[28,418],"Knowledge","2024-06-18",{"date":421,"type":50},"2024-06-21",{"date":423,"type":22},"2024-09-01",{"date":186,"type":22},{"name":56,"class":57},{"id":427,"slug":428,"hasResults":11,"nctId":429,"briefTitle":430,"officialTitle":431,"acronym":4,"eligibilityCriteria":432,"healthyVolunteers":111,"sex":17,"minAge":433,"maxAge":434,"enrollmentInfo":435,"targetDuration":4,"studyType":23,"phases":436,"briefSummary":437,"conditions":438,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":439,"lastUpdatePostDateStruct":440,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":4},"100545314","outcomes-of-neomta-and-neoputty-pulpotomies-in-primary-molars-100545314","NCT06380296","Outcomes of NeoMTA and NeoPUTTY Pulpotomies in Primary Molars","Clinical and Radiographic Outcomes of NeoMTA and NeoPUTTY Pulpotomies in Primary Molars: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Healthy children aged between 3 and 10 years\n* Primary molars with no history of spontaneous or persistent pain\n* Restorable primary molars with deep carious lesions approximating or reaching the pulp\n* Primary molars with at least 2\u002F3rd of the root length present\n* Radiographically, the inclusion criteria were as follows: deep dentin caries approximating or reaching the pulp; no more than one-third of physiologic root resorption; no widening of the periodontal ligament (PDL) space; no pathologic internal or external root resorption; and no apical or furcal radiolucency.\n* Children who can understand and speak French or English.\n\nExclusion Criteria:\n\n* Primary molars with pathological mobility, tenderness to percussion, swelling, or sinus tract\n* Primary molars without hemostasis after coronal pulp amputation within five minutes.\n* Primary molars with widening of the periodontal ligament (PDL) space; pathologic internal or external root resorption; and apical or furcal radiolucency","3 Years","10 Years",{"count":21,"type":22},[25],"The goal of this clinical trial is to evaluate the outcomes of different medications used for pulpotomies (baby root canal) in children. The main question it aims to answer is: • what are the long-term clinical and radiographic success of pulpotomies in baby teeth using two different medications (NeoMTA and NeoPUTTY) over a 24-month follow-up period? Healthy children aged between 3 and 10 years undergoing dental treatment under general anesthesia who have deep caries lesions approximating or reaching the nerve will be invited to participate in this study. Pulpotomies (baby root canal) will be performed by trained dentists following a protocol. Children will receive pulpotomies either with NeoMTA or NeoPUTTY, two medications indicated for the procedure. Participants will be asked to come for an appointment at 1, 6, 12 and 24 months after the procedure. Researcher will compare the clinical and radiographic performance of pulpotomies (baby root canal) done with both medications.",[28],"2024-04-18",{"date":441,"type":50},"2024-04-23",{"date":443,"type":22},"2024-04",{"date":445,"type":22},"2027-03",{"name":447,"class":57},"McGill University Health Centre\u002FResearch Institute of the McGill University Health Centre"]