[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulp-necrosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulp-necrosis":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,63,91,127,156,182,207,234,262],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":38,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":52,"lastUpdatePostDateStruct":53,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":4},"100634665","early-phase-1-chloramphenicol-tetracycline-zinc-oxide-and-eugenol-paste-ctz-paste-for-emergency-dental-treatment-in-public-health-settings-a-randomized-trial-100634665",false,"NCT07542639","Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) for Emergency Dental Treatment in Public Health Settings: A Randomized Trial","Clinical and Radiographic Efficacy of Chloramphenicol, Tetracycline, Zinc Oxide and Eugenol Paste (CTZ Paste) in the Context of Emergency Dental Treatments in Brazilian Public Health: Randomized Clinical Trial","CTZ- emergency","Inclusion Criteria:\n\n* Pediatric patients presenting with:\n* Irreversible pulpitis in primary molars;\n* Pulp necrosis, with or without abscess, in primary molars.\n* Primary molars with sufficient remaining tooth structure to allow endodontic treatment.\n* Primary teeth in which the permanent successor tooth germ presents developmental stages compatible with Nolla stages 1 to 7, defined as:\n\nStage 1: Presence of bony crypt with no evidence of calcification; Stage 2: Initial calcification, with appearance of radiopaque points in the crown region; Stage 3: Approximately one-third of crown formation; Stage 4: Approximately two-thirds of crown formation; Stage 5: Crown almost complete, without full calcification; Stage 6: Crown completely formed, without initiation of root formation; Stage 7: Initial root formation.\n\n* Clinical and radiographic conditions indicating feasibility of tooth maintenance through endodontic treatment, including:\n* Permanent successor in developmental stages prior to Nolla Stage 8;\n* Preservation of the bony crypt.\n\nExclusion Criteria:\n\n* Pediatric patients presenting with:\n* Reversible pulpitis;\n* Indication for endodontic treatment in permanent teeth.\n* History of allergy or hypersensitivity to any components of the obturation materials (e.g., CTZ paste or zinc oxide-eugenol).\n* Clinical conditions that prevent adequate management in an outpatient setting.\n* Primary teeth in which the permanent successor:\n* Is in advanced developmental stages (Nolla Stage 8 or higher), and\u002For\n* Presents disruption of the bony crypt, contraindicating endodontic treatment.\n* Teeth presenting internal root resorption that compromises the feasibility of endodontic treatment.","ALL","2 Years","11 Years",{"count":21,"type":22},110,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","The treatment of pulpal diseases in primary teeth represents a significant challenge in public health, particularly in emergency dental care settings, where factors such as limited clinical time, low child cooperation, and structural constraints directly impact treatment effectiveness. In these contexts, conventional pulpectomy using zinc oxide-eugenol (ZOE), although effective, may present operational limitations that restrict its large-scale applicability in public health systems.\n\nIn this scenario, non-instrumental endodontic treatment (NIET), based on the concept of Lesion Sterilization and Tissue Repair (LSTR), has emerged as a simplified alternative. Among the available options, CTZ paste shows potential for single-visit application, reducing clinical time and technical complexity.\n\nThis study aims to evaluate the clinical and radiographic non-inferiority of CTZ paste compared to conventional pulpectomy with ZOE in primary molars with pulp necrosis, with or without abscess or fistula, treated in emergency dental care settings.\n\nThis is a randomized, pragmatic, controlled, non-inferiority clinical trial conducted at a single center, with clinical and radiographic follow-up at 3, 6, and 12 months. Participants will be allocated into two groups: (1) NIET with CTZ paste and (2) conventional pulpectomy with ZOE.\n\nPrimary outcomes include pain resolution and absence of clinical signs of infection. Secondary outcomes include radiographic success, clinical time, child behavior (Frankl Scale), need for retreatment, and oral health-related quality of life.\n\nThe findings are expected to provide robust evidence regarding the effectiveness of CTZ paste under real-world clinical conditions, contributing to the development of more accessible and effective protocols within public health systems, with the potential to expand access to conservative treatment and reduce early tooth extractions in pediatric dentistry.",[28,29,30,31,32,33,34,35,36,37],"Pulp Disease, Dental","Pulp Necrosis","Pulp Therapy in Primary Molars","Primary Teeth","Pulpectomy","Endodontics","Dental Care for Children","Treatment Outcome","Quality of Life","Health Services Accessibility",[39,40,41,42,43,44,45,46,47,48,49,50],"pulpectomy","pulpotomy","CTZ paste","NIET","Non-instrumental endodontic treatment","LSTR","Lesion sterilization and tissue repair","Endodontic infection","dental abscess","Fistula","Emergency dental treatment","Public health dentistry","NOT_YET_RECRUITING","2026-05-07",{"date":54,"type":55},"2026-05-12","ACTUAL",{"date":57,"type":22},"2026-06-08",{"date":59,"type":22},"2028-02-28",{"name":61,"class":62},"University of Sao Paulo","OTHER",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":44,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":23,"phases":73,"briefSummary":76,"conditions":77,"keywords":78,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":4},"100629491","phase-1-lesion-sterilization-and-tissue-repair-antibiotic-paste-versus-zinc-oxide-and-eugenol-pulpectomy-for-treatment-of-primary-molars-with-pulp-necrosis-100629491","NCT07475364","Lesion Sterilization and Tissue Repair Antibiotic Paste Versus Zinc Oxide and Eugenol Pulpectomy for Treatment of Primary Molars With Pulp Necrosis","Inclusion Criteria:\n\n* • Children of both genders\n\n  * 4 years and 10 years\n  * Pulp necrosis in mandibular primary molars with minimum of 2\u002F3 of the roots\n  * Consent from Parents\u002FGuardian of children.\n  * Sufficient crown structure for restoration\n\nExclusion Criteria:\n\n* • Children who have a physical or mental change.\n\n  * Involving systemic illnesses.\n  * History of allergy to drugs being utilized\n  * Antibiotics use within three months\n  * Teeth with aberrant root resorption or pulp canal obliteration on periapical radiography","4 Years","10 Years",{"count":72,"type":22},180,[74,75],"PHASE1","PHASE2","The goal of this clinical trial is to compare the efficacy of lesion sterilization and tissue repair (LSTR) antibiotic paste versus zinc oxide eugenol (ZOE) pulpectomy for the treatment of primary molars with pulp necrosis in pediatric patients.\n\nThe main questions it aims to answer are:\n\n* Is LSTR antibiotic paste (CTZ paste) effective in treating primary molars with pulp necrosis?\n* Is ZOE pulpectomy effective in treating primary molars with pulp necrosis, and how does its efficacy compare with LSTR therapy?\n\nResearchers will compare LSTR therapy (Group A) with ZOE pulpectomy (Group B) to determine which treatment provides better clinical and radiographic outcomes after six months.\n\nParticipants will:\n\n* Be randomly assigned to one of the two treatment groups after diagnosis of pulp necrosis in primary molars.\n* Receive treatment under standard behavior management techniques with local anesthesia following topical application of 2% lignocaine gel and rubber dam isolation.\n* Undergo either Lesion Sterilization and Tissue Repair (LSTR) therapy with CTZ paste or zinc oxide eugenol (ZOE) pulpectomy according to group allocation.\n* Return for a clinical and radiographic follow-up evaluation after six months to assess treatment outcomes.\n* Allow researchers to record their clinical findings and radiographic results to evaluate the efficacy of both treatment methods.",[29],[79,80,81],"LSTR therapy","primary molars","pulp therapy","2026-03-16",{"date":84,"type":55},"2026-03-19",{"date":86,"type":22},"2026-05-01",{"date":88,"type":22},"2027-05-01",{"name":90,"class":62},"University of Faisalabad",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":102,"phases":4,"briefSummary":103,"conditions":104,"keywords":107,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":126},"100615840","professional-practices-regarding-treatment-of-non-vital-primary-teeth-among-dental-surgeons-in-france-100615840","NCT07297836","Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France","Description of Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France","DTNV","Inclusion Criteria:\n\n* Being a dentist treating children\n\nExclusion Criteria:\n\n* Being a dentist treating children","18 Years",{"count":101,"type":22},100,"OBSERVATIONAL","When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates when performed correctly. Recommended by the American Academy of Pediatric Dentistry, this technique relies on rigorous disinfection and the use of materials adapted to natural exfoliation. Lesion sterilization tissue repair (LSTR), although more controversial due to the use of topical antibiotics, can also be considered in certain clinical situations. However, data on French practices in this area are very limited, hence the need to evaluate practitioners' treatment choices, their potential reservations, and the criteria guiding their decisions.",[105,29,106],"Pulpitis - Irreversible","Apical Periodontitis",[32,108,109,110,111,112,113,114,115,105,106],"Pulp necrosis","Primary teeth","Non-vital primary teeth","Irreversible pulpitis","Natural exfoliation","Lesion Sterilization","Tissue Repair","Topical antibiotics","RECRUITING","2026-02-27",{"date":119,"type":55},"2026-03-03",{"date":121,"type":55},"2025-11-07",{"date":123,"type":22},"2026-11-07",{"name":125,"class":62},"University Hospital, Strasbourg, France",1,{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":23,"phases":137,"briefSummary":139,"conditions":140,"keywords":141,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":126},"100626457","antibacterial-effect-and-postoperative-pain-after-triton-irrigation-protocol-in-necrotic-mandibular-molar-100626457","NCT07435883","Antibacterial Effect and Postoperative Pain After Triton Irrigation Protocol in Necrotic Mandibular Molar","Evaluation of Antibacterial Effect and Postoperative Pain Following Irrigation Protocol Using Triton in Necrotic Mandibular Molars. A Randomized Clinical Control Trial","Inclusion Criteria:\n\n* Patients aged 18-45 years with no sex predilection\n* Medically free Patients with no systemic conditions that can affect post operative pain response.\n* Patients should not be taking any pain medications 24 hours before intervention\n* Positive patients' acceptance for participating in the study\n* Patient able to sign informed consent\n* Permanent mandibular molars diagnosis with pulpal necrosis with asymptomatic apical periodontitis.\n* Mandibular molars without any anatomical variations or severe curvatures with mesial roots configuration weine class 3 and a distal root with 2 distal canals\n\nExclusion Criteria:\n\n* Medically compromised patients\n\n  * Patients who have received antibiotic therapy within the last 2 weeks.\n  * Pregnant or lactating women.\n  * Patients with known allergy to any of the irrigants used.\n  * Patients with swelling or acute peri-apical abscess or fistulous tract.\n  * Teeth that have:\n  * Wide or open apex .\n  * Vital pulp tissue .","45 Years",{"count":136,"type":22},36,[138],"NA","This randomized clinical study evaluates the antibacterial effectiveness and postoperative pain following root canal irrigation using the Triton irrigation protocol in necrotic mandibular molars. Thirty-six patients requiring root canal treatment will be included. The study aims to compare bacterial reduction and postoperative pain outcomes after treatment. Results may help improve irrigation protocols and patient comfort during endodontic therapy.",[29],[142,143,144,145,146,147],"root canal treatment","endodontics","irrigation protocol","triton irrigation","postoperative pain","antibacterial effect","2026-02-21",{"date":117,"type":55},{"date":151,"type":22},"2026-03",{"date":153,"type":22},"2026-10",{"name":155,"class":62},"sara hosny mostafa",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":169,"conditions":170,"keywords":171,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":126},"100622843","phase-4-antibacterial-effect-of-two-different-intracanal-medicaments-and-their-effect-on-post-operative-pain-100622843","NCT07388888","Antibacterial Effect of Two Different Intracanal Medicaments and Their Effect on Post-operative Pain","Comparative Evaluation of Anti-Bacterial Efficacy Of Two Different Intracanal-Medicaments and Their Effect On Post-Operative Pain Level (A Randomized Clinical Trial)","Ca(OH)2 - CNPs","Inclusion Criteria:\n\n* free medical history,\n* mature infected permanent single rooted teeth diagnosed clinically and radiographically with adequate coronal structure for proper isolation, temporization and restoration.\n\nExclusion Criteria:\n\n* Patients who are not included in the age range of the study or having a systemic condition.\n* Teeth with severe fractures or resorption or periodontally compromised.","50 Years",{"count":166,"type":22},52,[168],"PHASE4","Evaluation of antibacterial effect of two different intracanal medicaments on bacterial load in infected mature permanent teeth and their effect on post-operative pain level.",[29],[172],"effect of two intracanal medicaments on bacterial load and post operative pain level in mature teeth with necrotic pulp","2026-01-28",{"date":175,"type":55},"2026-02-05",{"date":177,"type":22},"2026-02",{"date":179,"type":22},"2027-04",{"name":181,"class":62},"Ain Shams University",{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":189,"enrollmentInfo":190,"targetDuration":4,"studyType":23,"phases":191,"briefSummary":192,"conditions":193,"keywords":194,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":126},"100615252","this-study-compares-two-different-ways-of-cleaning-and-shaping-root-canals-during-root-canal-treatment-the-step-down-technique-and-the-step-back-technique-iu-want-to-find-out-which-method-causes-less-pain-after-the-procedure-patients-will-be-randomly-placed-into-one-of-the-two-groups-treated-wit-100615252","NCT07290192","This Study Compares Two Different Ways of Cleaning and Shaping Root Canals During Root-canal Treatment: the Step-down Technique and the Step-back Technique. Iu Want to Find Out Which Method Causes Less Pain After the Procedure. Patients Will be Randomly Placed Into One of the Two Groups, Treated Wit","Comparison of Impact of Step Down Verses Step Back Preparation Technique of Root Canals on Post Operative Pain in Patients Having Pulp Necrosis","Inclusion Criteria:\n\n* patients age between 18 to 65 years Healthy patients with ASA classification 1 and 2 Patients of both genders Patients who agreed to attend recall appointments Patients having single rooted tooth with pulp necrosis without pre-existing periapical pathosis and apical periodontitis\n\nExclusion Criteria:\n\n* Patients with history of chronic pain Previously RCT treated tooth Teeth with apical pathosis ,with irreversible pulpitis Patients having systemic illness Multirooted teeth Patients consumed analgesics between appointments Teeth with calcified canals Cases of root fracture Children Pregnant and lactating mothers Smokers","65 Years",{"count":21,"type":22},[138],"This randomized clinical trial aims to compare the step-back and step-down root canal preparation techniques in patients with pulp necrosis. The study will evaluate which technique results in less postoperative pain. Participants will be randomly assigned to one of the two groups. Pain intensity will be recorded at specific time points after the procedure using a standardized pain scale. The goal is to identify the technique that provides better patient comfort after root canal treatment.This study is a randomized clinical trial designed to compare the effects of two root canal preparation techniques-step-back and step-down-on postoperative pain in patients diagnosed with pulp necrosis. Participants will be randomly assigned to one of the two groups.",[29],[195,108,196,197],"Post operative pain","Step back technique","Step down technique","2025-12-06",{"date":200,"type":55},"2025-12-18",{"date":202,"type":22},"2026-02-01",{"date":204,"type":22},"2027-02-01",{"name":206,"class":62},"Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi",{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":214,"sex":17,"minAge":69,"maxAge":215,"enrollmentInfo":216,"targetDuration":4,"studyType":23,"phases":218,"briefSummary":219,"conditions":220,"keywords":222,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":232,"locationsCount":4},"100610679","evaluation-of-pulpotomy-versus-pulpectomy-in-primary-molars-with-irreversible-pulpitis-or-necrotic-pulp-100610679","NCT07230717","Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp","Clinical and Radiographic Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria\n\n* Patients in healthy medical conditions\n* Bilateral\u002Fcontralateral primary molars diagnosed with irreversible pulpitis or necrotic pulp\n* Periapical or bifurcation radiolucency\n* Chronic apical intraoral abscess\n* Sinus tract or fistula formation\n* No tooth mobility or grade I mobility\n* External root resorption less than or equal to 1\u002F3rd of the roots\n* Tooth should be restorable\n\nExclusion Criteria\n\n* Patients who are medically compromised (with systemic conditions)\n* Acute extraoral abscess\n* Grade II or III tooth mobility\n* External root resorption in more than 1\u002F3 of roots\n* Physiological root resorption of more than 1\u002F3 of the roots or near exfoliation\n* Non-restorable teeth",true,"8 Years",{"count":217,"type":22},30,[138],"Preserving primary teeth until their normal exfoliation time is crucial for maintaining the child's normal function, esthetics, arch integrity, and correct eruption of permanent successors. Given the growing interest in conservative procedures and the clinical need for simpler, more predictable pulp therapy outcomes in children, evaluating pulpotomy with Pulpotec as a potential alternative to pulpectomy is essential.\n\nThe aim of this study is to evaluate the clinical and radiographic success of pulpotomy using Pulpotec versus pulpectomy using Metapex, a calcium hydroxide with iodoform paste, to treat primary molars in children diagnosed with irreversible pulpitis or necrotic pulp in the Postgraduate Pediatric Dental Clinic at Ajman University, UAE. A total of 25 contralateral paired molar samples from children aged 4 to 8 will be included in this split-mouth randomized controlled study. Each child will serve as their own control, with one tooth randomized to the intervention group (Pulpotomy using Pulpotec) and the other to the control group (Pulpectomy using Metapex) to assess patients' clinical and radiographic outcomes over a 12-month follow-up period. Patients will have their dental anxiety psychometrically assessed using the RMS pictorial scale. In addition, a pulse oximeter will be used as a biological marker in the study to measure oxygen saturation and pulse rate.",[221,105,29],"Pulp Therapy",[223,32,80,224,225],"Pulpotomy","irreversible pulpitis","necrotic pulp","2025-11-13",{"date":228,"type":55},"2025-11-17",{"date":230,"type":22},"2025-12-01",{"date":88,"type":22},{"name":233,"class":62},"Ajman University",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":11,"sex":17,"minAge":242,"maxAge":189,"enrollmentInfo":243,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":249,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":126},"100600014","effect-of-rotary-file-number-on-mb2-canal-negotiation-and-postoperative-pain-100600014","NCT07091981","Effect of Rotary File Number on MB2 Canal Negotiation and Postoperative Pain","Effect of Number of Rotary Instruments on Negotiating Second Mesiobuccal Canals to Working Length and on Postoperative Pain: A Randomized Clinical Trial","MB2-PAIN","Inclusion Criteria:\n\n* Systemically healthy individuals aged between 20 and 65 years\n* Requiring primary endodontic treatment of maxillary first molars\n* Diagnosis of asymptomatic apical periodontitis and pulp necrosis based on clinical and radiographic findings\n* Presence of a second mesiobuccal (MB2) canal in the maxillary first molar\n* Absence of or only minimal preoperative pain or symptoms\n* Periapical lesions smaller than 5 mm in diameter\n* Ability to comply with follow-up visits and effectively communicate during the treatment process\n\nExclusion Criteria:\n\n* Presence of symptomatic apical periodontitis or acute apical abscess\n* Retreatment cases (teeth previously treated endodontically)\n* Use of medications such as narcotics, antibiotics, sedatives, or antidepressants within one week prior to treatment\n* Presence of a sinus tract, periapical abscess, or facial cellulitis\n* Pregnancy or breastfeeding\n* Inability to understand or follow the study instructions","20 Years",{"count":244,"type":22},152,[138],"This randomized controlled clinical trial aims to evaluate the effect of the number of rotary files on working length negotiation and postoperative pain in the second mesiobuccal (MB2) canals of maxillary first molars. Patients are assigned to one of four groups according to the number of rotary files used: single-, two-, three-, or four-file systems. Postoperative pain is assessed on each of the seven consecutive postoperative days (Days 1-7) using a visual analog scale (VAS), and working length negotiation success is recorded during canal instrumentation.",[248,29],"Postoperative Pain",[250,251,252],"VAS Pain Scale","Endodontic Treatment","Rotary Files","2025-07-29",{"date":255,"type":55},"2025-08-01",{"date":257,"type":55},"2025-06-18",{"date":259,"type":22},"2025-09-05",{"name":261,"class":62},"Mehmet Adıgüzel",{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":214,"sex":17,"minAge":69,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":280,"overallStatus":51,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":126},"100590717","moringa-oleifera-vs-sodium-hypochlorite-for-root-canal-irrigation-in-nonvital-primary-molars-100590717","NCT06971055","Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars","Evaluation of Antimicrobial Efficacy of Moringa Oleifera Leaf Extract Versus Sodium Hypochlorite as Root Canal Irrigants in Pulpectomy of Nonvital Primary Molars: A Randomized Clinical Trial","MORvNAOCL","Inclusion Criteria:\n\n* Children aged 4 to 7 years\n* Clinically and radiographically diagnosed with nonvital primary molars requiring pulpectomy\n* Cooperative children who can undergo dental treatment\n* Healthy-appearing children with no systemic, physical, or mental disorders\n\nExclusion Criteria:\n\n* Medically compromised or uncooperative children\n* Primary molars indicated for extraction due to:\n* Advanced root resorption (more than two-thirds)\n* Teeth near exfoliation\n* Deep subgingival caries preventing proper restoration\n* Excessive mobility (Miller's Grade 2 or higher)","7 Years",{"count":272,"type":22},38,[138],"This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric patients. The study will assess bacterial reduction using blood agar",[276,29,277,278,279],"Dental Caries","Primary Tooth Pulpectomy","Pediatric Dentistry","Endodontic Infection",[281,282,283,32,284,285,286,287,288],"Moringa oleifera","Sodium hypochlorite","Root canal irrigants","Primary molars","Enterococcus faecalis","Antimicrobial efficacy","Pediatric endodontics","Coagulase-Negative Staphylococci","2025-05-29",{"date":291,"type":55},"2025-06-03",{"date":293,"type":22},"2025-07-20",{"date":295,"type":22},"2026-01-01",{"name":297,"class":62},"Cairo University"]