[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulpal-necrosis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulpal-necrosis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100613304","phase-2-triple-antibiotic-paste-vs-simvastatin-for-lesion-sterilization-and-tissue-repair-in-primary-molars-100613304",false,"NCT07264842","Triple Antibiotic Paste vs Simvastatin for Lesion Sterilization and Tissue Repair in Primary Molars.","Triple Antibiotic Paste Versus Simvastatin for LSTR Treatment of Primary Molars With Pulp Necrosis: A Randomized Controlled Trial","LSTR","Inclusion Criteria:\n\n* Young, healthy patient, ranging in age from 5-8 years.\n* Has parents\u002F guardians who give consent to allow their minor to participate in the study and willing to monitor their progress.\n* Having maxillary and mandibular primary molars with:\n\n  * Spontaneous pain or tenderness to percussion.\n  * Deep cavity extending to the pulp chamber.\n  * Chronic Abscess or draining sinus.\n  * Restorable.\n  * To be kept for less than a year.\n  * Irregular mobility that is not related to exfoliation.\n\nExclusion Criteria:\n\n* Uncooperative patients.\n* Children with a history of allergic reaction with antibiotics.\n* Teeth with physiological root resorption but root length is more than two thirds, root canal obliteration, severe internal resorption, internal calcifications, or piercing into the bifurcation.","ALL","5 Years","8 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","This randomized, double-blinded, parallel-controlled clinical trial aims to compare the effectiveness of Triple Antibiotic Paste (TAP) and Simvastatin in Lesion Sterilization and Tissue Repair (LSTR) of primary molars with pulp necrosis.\n\nA total of 60 children (aged 5-8 years) with non-vital primary molars will be recruited from the Department of Operative Dentistry and Endodontics, Dow International Dental College, Karachi. Participants will be randomly assigned to one of two groups:\n\nGroup 1 (Control): LSTR using Triple Antibiotic Paste (Ciprofloxacin + Metronidazole + Cefixime).\n\nGroup 2 (Intervention): LSTR using Simvastatin paste.\n\nBoth materials will be placed after non-instrumentation cleaning and sealed with glass ionomer cement, followed by stainless steel crown placement. Patients will be evaluated clinically and radiographically at 1, 2, and 3 months post-treatment.\n\nPrimary outcomes include clinical success (absence of pain, swelling, or sinus tract) and radiographic success (reduction or absence of periapical radiolucency). Data will be analyzed using SPSS v26, with chi-square and t-tests applied as appropriate; p \\\u003C 0.05 will be considered significant.\n\nThis study seeks to determine whether Simvastatin, owing to its antibacterial, anti-inflammatory, and regenerative properties, can serve as a viable alternative to antibiotic-based LSTR in managing necrotic primary teeth.",[28],"Pulpal Necrosis",[30],"Lesion Sterilization and Tissue Repair","RECRUITING","2026-03-08",{"date":34,"type":35},"2026-03-10","ACTUAL",{"date":37,"type":35},"2024-06-26",{"date":39,"type":22},"2026-07-31",{"name":41,"class":42},"Dow University of Health Sciences","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100609115","evaluation-of-regenerative-endodontic-treatment-for-immature-teeth-100609115","NCT07210359","Evaluation of Regenerative Endodontic Treatment for Immature Teeth","Evaluation of Regenerative Endodontic Treatment for Immature Teeth Using Two Different Forms of Demineralized Dentin Matrix and RetroMTA: Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Systemically healthy patients (i.e., free of any systemic diseases).\n* Patients presenting with immature permanent single-rooted teeth.\n* Age: 9 -15 years.\n* Teeth diagnosed as either vital (asymptomatic irreversible pulpitis or symptomatic irreversible pulpitis and the bleeding didn't stop after 5 minutes application of hemostatic agent) or non-vital pulp.\n\nExclusion Criteria:\n\n* Patients who are allergic to any drugs used in this study or with systemic illness\n* Teeth that are grossly decayed or fractured and require post and core as final restorations\n* Presence of periodontal pockets greater than 4 mm.\n* Radiographical evidence of apical foramen less than 1 mm.\n* Presence of periapical radiolucency exceeding 10 mm.\n* Presence of external or internal root resorption.\n* Patients with a history of major surgeries like cardiac, kidney transplantation, haemodialysis.",true,"9 Years","15 Years",{"count":55,"type":22},36,[57],"NA","The goal of this clinical trial is to evaluate if regenerative endodontic treatment using two different forms of demineralized dentin matrix (DDM) can effectively treat immature permanent single-rooted teeth compared to treatment using RetroMTA in patients aged 9 to 15 years. The main questions it aims to answer are:\n\nDoes the use of DDM improve clinical and radiographic outcomes such as root length, dentinal wall thickness, and apex closure?\n\nIs DDM a viable bioactive alternative to RetroMTA as a coronal sealing material in regenerative endodontic procedures?\n\nResearchers will compare three groups: one using RetroMTA, one using a DDM-TheraCal LC mixture, and one using TDM-Hydrogel, to see if these materials differ in their effects on regenerative outcomes.\n\nParticipants will:\n\nUndergo two treatment visits including canal disinfection, induction of bleeding to form a blood clot scaffold,\n\nReceive placement of one of the study materials over the blood clot as a coronal barrier,\n\nHave clinical examinations and CBCT imaging at baseline and multiple follow-ups up to 12 months to assess treatment success through signs, symptoms, and radiographic changes.",[28],"2025-09-29",{"date":62,"type":35},"2025-10-07",{"date":64,"type":35},"2025-09-15",{"date":66,"type":22},"2026-12",{"name":68,"class":42},"Kafrelsheikh University",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":80,"phases":4,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":43},"100580916","bite-force-measurements-100580916","NCT06843525","Bite Force Measurements","Exploring a Neuropathic Basis for Acute Pulpal Pain- a Clinical Pilot","Inclusion Criteria:\n\n* Individuals who present for\n* a lower 1st or 2nd molar filling in an otherwise healthy tooth, i.e., does not have large decay that has already infected the nerve of the tooth, or there is increased mobility due to gum disease or a root canal treatment on a lower molar tooth and there is no history of injury to the tooth, or\n* a lower molar root canal treatment, and\n* are 18 years or older\n* capable of providing informed consent, are eligible to participate in the study, as long as they satisfy the criteria below.\n* The opposing tooth is present, symptom-free and has adequate tooth structure that allows it to make contact with the tooth it bites against, and\n* are English-speaking\n\nExclusion Criteria:\n\n* Any patient, even if satisfying the criteria above, may not take part if any of the below is true:\n* Compromised ability to guard their self-interest, for e.g., prisoners, children, pregnant women, patients with intellectual\u002Fcognitive disability are not enrolled in the study.\n* Take prescription pain medications for long-standing health conditions\n* Addiction\u002F substance dependence\n* Swelling that extends beyond the tooth in question\n* Are already taking an antibiotic to treat an infection\u002Fswelling\n* Missing complementary molar on the same or opposite side of the mouth\n* Missing more than 2 teeth in a quadrant (other than 3rd molars)\n* Any other molar in the pair either on the side of the tooth of interest or the molar pair on the other side is painful to biting pressure or upon 'tapping' the tooth with the handle of the mouth mirror\n* The patient has taken a pain medication within the last 6 hours","18 Years","89 Years",{"count":79,"type":22},112,"OBSERVATIONAL","ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids. Addressing the need for non-opioid pain alternatives is crucial. Emerging evidence suggests that dental pain from pulpal and periodontal conditions (affecting the tooth's nerve and surrounding tissues) involves neuropathic mechanisms, such as mechanical allodynia (MA) and central sensitization (CS). These mechanisms can amplify pain perception, causing typically non-painful actions, like chewing, to become painful and resulting in hypersensitivity extending beyond the affected tooth. Reliably identifying these mechanisms with quantitative measures can support improved pain assessment and targeted non-opioid treatment. This minimally invasive prospective cohort study will use the FDA-approved Innobyte® device, a precise bite-force measurement tool, to evaluate periodontal health and to quantify mechanical pain thresholds in patients requiring endodontic treatment (root canal therapy).",[83,84,28],"Irreversible Pulpitis","Apical Periodontitis","2025-07-22",{"date":87,"type":35},"2025-07-24",{"date":89,"type":35},"2025-05-16",{"date":91,"type":22},"2026-11-01",{"name":93,"class":42},"Rutgers, The State University of New Jersey"]