[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulpitis---irreversible\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulpitis---irreversible":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,47,83,112,135,155,187,214,239,269,296,321,343,364,382,408],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100643718","comparison-of-the-efficacy-of-inferior-alveolar-nerve-block-and-digital-anesthesia-in-pulpectomy-of-mandibular-permanent-molars-in-children-100643718",false,"NCT07634900","Comparison of the Efficacy of Inferior Alveolar Nerve Block and Digital Anesthesia in Pulpectomy of Mandibular Permanent Molars in Children","Inclusion Criteria:\n\n* Children aged 6-14 years\n* Patients presenting with acute dental pain\n* Patients requiring emergency endodontic treatment in mandibular permanent molars\n* Cooperative patients who allowed clinical procedures\n* Patients whose parents\u002Flegal guardians provided informed consent\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting pain perception\n* Patients with known allergy to local anesthetic agents\n* Patients who used analgesics within 12 hours before treatment\n* Patients with non-restorable teeth\n* Patients with a history of behavioral management problems preventing treatment","ALL","6 Years","14 Years",{"count":19,"type":20},128,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study aims to compare the effectiveness of inferior alveolar nerve block (IANB) and computer-controlled digital anesthesia in achieving adequate anesthesia in pediatric patients presenting with acute dental pain and requiring emergency endodontic treatment of mandibular permanent molars. Achieving profound anesthesia in such cases can be challenging due to acute inflammation.\n\nParticipants will be randomly assigned to receive either conventional IANB or digital anesthesia. Pain perception during the procedure will be assessed using validated pain scales. In addition, physiological parameters including heart rate and blood pressure will be recorded to evaluate the stress response associated with each anesthesia technique. Anesthesia success will be determined based on the absence of pain during treatment and the need for supplemental anesthesia.\n\nThe findings of this study are expected to provide evidence-based guidance for selecting the most effective and comfortable anesthesia technique in pediatric dental patients.",[26,27],"Pulpitis - Irreversible","Pulpitis - Reversible",[29,30,31,32,33],"Inferior alveolar nerve block","Digital anesthesia","Pediatric dentistry","Mandibular molar","Pain assessment","RECRUITING","2026-06-08",{"date":37,"type":38},"2026-06-09","ACTUAL",{"date":40,"type":38},"2026-04-01",{"date":42,"type":20},"2027-03-20",{"name":44,"class":45},"Inonu University","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":15,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":21,"phases":59,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":46},"100621819","outcomes-of-pulpotomy-and-root-canal-treatment-in-teeth-with-symptomatic-irreversible-pulpitis-100621819","NCT07375576","Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis","Evaluation of the Outcomes of Total Pulpotomy, Radicular Pulpotomy, and Root Canal Treatment in Teeth With Extremely Deep Caries and Symptomatic Irreversible Pulpitis","Inclusion Criteria:\n\n* Healthy patients of both sexes, aged between 15 and 45 years, with no systemic diseases, will be screened for inclusion in the study. Strict eligibility criteria will be applied.\n\nThe patients included in the study must have restorable, extremely deep carious lesions in the mandibular first and second molars, and first and second premolars; healthy periodontal status (periodontal pocket ≤ 3 mm); and a clinical diagnosis of symptomatic irreversible pulpitis (history of spontaneous pain, pain persisting after removal of the stimulus, exaggerated and prolonged response to cold testing, and a positive response to the electric pulp test).\n\nExclusion Criteria:\n\n* Teeth with cracks or cusp fractures, subgingival caries, or periapical radiolucency will not be included in the study.\n\nInformed consent will be obtained from all included patients.",true,"18 Years","45 Years",{"count":58,"type":20},99,[23],"The aim of this study is to evaluate the clinical effectiveness of total pulpotomy (TP), radicular pulpotomy (RP), and root canal treatment (RCT) in mandibular premolar and\u002For molar teeth diagnosed with symptomatic irreversible pulpitis, with respect to postoperative pain control and treatment success.Materials and Methods:A total of 99 mandibular premolar and molar teeth will be included in this study. The teeth will be randomly allocated into three groups (n = 33 per group): total pulpotomy, radicular pulpotomy, and root canal treatment.Root canal treatment will be performed using standardized endodontic protocols.Total pulpotomy will be carried out to the level of the canal orifices, followed by hemostasis achieved with 2.5% sodium hypochlorite (NaOCl). A 3-mm-thick layer of mineral trioxide aggregate (MTA) will be placed as the pulpotomy material.Radicular pulpotomy will be performed by removing the pulp tissue a few millimeters apical to the canal orifices. Hemostasis will be achieved using 2.5% NaOCl, and a 3-mm-thick layer of MTA will be placed as the pulpotomy agent.All treated teeth will be restored with glass ionomer cement, followed by a composite resin restoration.Postoperative pain intensity will be assessed using a visual analog scale (VAS) at the following time points: preoperatively, and at 12 hours, 24 hours, 48 hours, and 7 days postoperatively. Clinical and radiographic evaluations will be performed at 3, 6, and 12 months to assess treatment success and periapical health.",[62,26,63],"Post-operative Pain","Success Rate",[65,66,67,68,69,70,71,72,73],"irreversibl pulpitis","total pulpotomy","radicular pulpotomy","vital pulp therapy (VPT)","root canal treatment (RCT)","pain assessment","vas scale","clinical follow - up","radiographic evaluation","2026-06-04",{"date":76,"type":38},"2026-06-05",{"date":78,"type":38},"2025-12-01",{"date":80,"type":20},"2027-08-01",{"name":82,"class":45},"Mustafa Kemal University",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":54,"sex":15,"minAge":55,"maxAge":91,"enrollmentInfo":92,"targetDuration":94,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":46},"100633862","scn9a-gene-expression-and-inflammatory-cytokines-100633862","NCT07532200","SCN9A Gene Expression and Inflammatory Cytokines","Association of SCN9A (Nav1.7) Gene Expression and Inflammatory Cytokines (IL-6, TNF-α, IL-1β) With the Success of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: A Prospective Case-Control Study","Gene Expressio","Inclusion Criteria:\n\n* Patients aged 18-60 years\n* Systemically healthy individuals (ASA I or II)\n* Presence of a mandibular first or second molar diagnosed with symptomatic irreversible pulpitis\n* Vital tooth confirmed by positive response to pulp sensibility tests (cold test\u002FEPT)\n* Moderate to severe preoperative pain (Heft-Parker VAS)\n* Patients requiring endodontic treatment under inferior alveolar nerve block\n* Ability and willingness to provide informed consent\n\nExclusion Criteria:\n\n* Patients who have taken analgesics, anti-inflammatory drugs, or antibiotics within the last 48 hours\n* Presence of systemic diseases affecting pain perception or inflammation (e.g., diabetes, neuropathic disorders)\n* Pregnant or lactating women\n* Teeth with periapical abscess, swelling, or sinus tract\n* Non-vital teeth or teeth with previous endodontic treatment\n* Patients with known allergy to local anesthetic agents\n* Patients with limited mouth opening or anatomical conditions affecting IANB administration\n* Inability to understand pain assessment scales or comply with study protocol","50 Years",{"count":93,"type":20},100,"1 Month","OBSERVATIONAL","Voltage-gated sodium channels, especially Nav1.7 encoded by the SCN9A gene, are key regulators of nociceptive transmission. Upregulation of SCN9A has been associated with increased neuronal excitability and heightened pain perception. In parallel, inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β) are known to sensitize peripheral nociceptors and reduce the efficacy of local anesthetics by modifying tissue environment and ion channel activity. However, the combined influence of SCN9A expression and inflammatory cytokines on anesthetic success in SIP has not been fully elucidated.\n\nThis prospective case-control study aims to evaluate the association between SCN9A gene expression and inflammatory cytokine levels with the clinical success of IANB in patients with SIP affecting mandibular molars. Approximately 90-100 patients will be recruited and categorized into two groups based on anesthetic outcome: successful anesthesia and failed anesthesia. All patients will receive a standardized IANB using 2% lidocaine with 1:100,000 epinephrine. Anesthetic success will be determined based on the absence of pain during access cavity preparation and instrumentation.\n\nFollowing access and pulp extirpation, pulpal tissue samples will be collected. SCN9A gene expression will be assessed using quantitative real-time polymerase chain reaction (RT-qPCR), with relative expression calculated using the 2\\^-ΔΔCt method. Inflammatory cytokine levels (IL-6, TNF-α, IL-1β) will be quantified using enzyme-linked immunosorbent assay (ELISA).\n\nThe primary outcome will be the difference in SCN9A expression between failed and successful anesthesia groups. Secondary outcomes will include comparison of cytokine levels and evaluation of correlations between SCN9A expression and inflammatory markers. Statistical analysis will include group comparisons, correlation analysis, logistic regression, and receiver operating characteristic (ROC) curve analysis to assess the predictive value of these biomarkers.",[26],[99,29,100,101,102],"Symptomatic irreversible pulpitis","Gene expression","RT-qPCR","Inflammatory cytokines","2026-05-27",{"date":105,"type":38},"2026-06-01",{"date":107,"type":38},"2026-04-10",{"date":109,"type":20},"2026-09-30",{"name":111,"class":45},"Jamia Millia Islamia",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":54,"sex":15,"minAge":16,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100633133","clinical-and-radiographic-assessment-of-bio-c-repair-biodentine-and-mineral-trioxide-aggregate-100633133","NCT07522723","Clinical and Radiographic Assessment of Bio C Repair, Biodentine and Mineral Trioxide Aggregate","Clinical and Radiographic Assessment of Bio C Repair, Biodentine and Mineral Trioxide Aggregate Used As Pulpotomy Agents In Vital Immature Permanent Molars With Irreversible Pulpits. A Randomized Control Trial","Inclusion Criteria:\n\n1. Children aged 6-10 years with asymptomatic\u002Fsymptomatic disease and having vital immature permanent posterior teeth with clinical exposure to dental caries of the pulp and bleeding.\n2. Posterior teeth had deep caries with pulp exposure.\n3. Posterior teeth that exhibited preoperative symptoms, such as referred pain, spontaneous pain or pain induced during thermal and cold sensitivity tests, with a range of symptoms that can last from seconds to hours compared to the control teeth.\n4. Posterior teeth without prominent radiolucency in the furcation or periapical regions.\n5. The posterior teeth could be restored.\n6. Children with prior parental consent.\n\nExclusion Criteria:\n\n* • (1) Patients with contraindications of the to-be-performed dental treatment.\n\n  * (2) Teeth with completed VPT or RCT.\n  * (3) Teeth with furcation, prominent radiolucency in the periapical regions, or external or internal resorption.\n  * (4) Teeth with pulpitis attributed to tooth fracture, cracking, periodontitis or wedge-shaped defects.\n  * (5) Teeth without any response to experiments of vitality. (\n  * 6\\) Teeth with formed root\u002Fclosed apex.\n  * (7) Teeth with edema, fistula and excessive mobility not associated with periodontal disease.","10 Years",{"count":121,"type":20},60,[23],"The aim of this study is to assess Clinical and Radiographical effect of Bio C repair, Biodentine and Mineral Trioxide Aggregate when used as pulpotomy Agents in Immature Permanent Molars with Pulpits.",[26],"NOT_YET_RECRUITING","2026-04-04",{"date":128,"type":38},"2026-04-13",{"date":130,"type":20},"2026-04-20",{"date":132,"type":20},"2027-05",{"name":134,"class":45},"Cairo University",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":54,"sex":15,"minAge":17,"maxAge":91,"enrollmentInfo":143,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":4},"100628780","observational-cross-sectional-study-aiming-to-determine-the-correlation-between-pulpal-status-and-il-8-and-presepsin-levels-in-the-pulpal-blood-100628780","NCT07466095","Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood.","Assessing the Differential Performance of the Inflammatory Biomarkers Interleukin-8 and Presepsin in Patients Exhibiting Clinical Symptoms Suggestive of Reversible and Irreversible Pulpitis: A Preliminary Cross -Sectional Study","Cross-section","Inclusion Criteria:\n\n* Male and female patients. Age between 14 years and 50 years . Diagnosis established in accordance with the American Association of Endodontists (AAE) (2013) for normal pulp, reversible pulpitis, or symptomatic irreversible pulpitis. Participants will be asked if they wish to be included in the study (implying informed consent).\n\nNormal pulp Sound, unrestored non-carious vital teeth will be included. The teeth with healthy pulp. The teeth indicated for orthodontic extraction or elective root canal treatment before prosthodontic intervention.\n\nThere with no clinical signs or symptoms of pulpitis. There with no history of pain. The response to the cold test within normal limits. No sensitivity to percussion. No periodontal ligament space widening (Periapical Index (PAI) = 1). Teeth with Reversible Pulpitis \\[RP\\] Medically healthy patients will be included.\n\nPatients with extremely deep carious lesion (according to Bjørndal, 2017) One or more of the following signs and symptoms present:\n\nClinical symptoms of minor intensity. Slightly exaggerated reaction to cold or sweet stimuli. No history of spontaneous pain. Response to the cold test within normal limits. No sensitivity to chewing. No sensitivity to percussion. No widening of the periodontal ligament space (Periapical Index (PAI) = 1). Teeth with Irreversible Pulpitis \\[IRP\\] Medically healthy patients will be included. Patients with extremely deep carious lesion\n\nOne or more of the following signs and symptoms were present:\n\nHistory of continuous moderate or severe pain. Either provoked or spontaneous lingering pain initiated by provocation (cold test).\n\nTenderness to chewing or percussion. No widening of the periodontal ligament space (Periapical Index (PAI) = 1) (Orstavik,1988)\n\nExclusion Criteria:\n\n* Absence of a response to pulp sensibility tests. Non-restorable teeth. Periodontal involvement. Presence of a sinus tract. Presence of periapical pathology on radiograph. Presence of resorption (external or internal). Cracked teeth. Immature teeth with an open apex. Presence of any systemic disease. Pregnant females. History of intake of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) or antibiotics within the last 1 week.\n\nPatients who needed prophylactic antibiotics. No pulp exposure after complete caries removal. Inadequate blood volume collection after pulpal exposure.",{"count":144,"type":20},50,"Observational cross-sectional study aims to determine the correlation between pulpal status and IL-8 and Presepsin levels in the pulpal blood.",[26,27],"2026-03-08",{"date":149,"type":38},"2026-03-12",{"date":151,"type":20},"2026-11-01",{"date":153,"type":20},"2027-12-01",{"name":134,"class":45},{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":161,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":164,"conditions":165,"keywords":168,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":46},"100615840","professional-practices-regarding-treatment-of-non-vital-primary-teeth-among-dental-surgeons-in-france-100615840","NCT07297836","Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France","Description of Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France","DTNV","Inclusion Criteria:\n\n* Being a dentist treating children\n\nExclusion Criteria:\n\n* Being a dentist treating children",{"count":93,"type":20},"When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates when performed correctly. Recommended by the American Academy of Pediatric Dentistry, this technique relies on rigorous disinfection and the use of materials adapted to natural exfoliation. Lesion sterilization tissue repair (LSTR), although more controversial due to the use of topical antibiotics, can also be considered in certain clinical situations. However, data on French practices in this area are very limited, hence the need to evaluate practitioners' treatment choices, their potential reservations, and the criteria guiding their decisions.",[26,166,167],"Pulp Necrosis","Apical Periodontitis",[169,170,171,172,173,174,175,176,177,26,167],"Pulpectomy","Pulp necrosis","Primary teeth","Non-vital primary teeth","Irreversible pulpitis","Natural exfoliation","Lesion Sterilization","Tissue Repair","Topical antibiotics","2026-02-27",{"date":180,"type":38},"2026-03-03",{"date":182,"type":38},"2025-11-07",{"date":184,"type":20},"2026-11-07",{"name":186,"class":45},"University Hospital, Strasbourg, France",{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":54,"sex":15,"minAge":194,"maxAge":56,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":197,"briefSummary":198,"conditions":199,"keywords":200,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":209,"leadSponsor":211,"locationsCount":213},"100619129","the-role-of-the-pre-operative-condition-and-artificial-intelligence-assisted-diagnosis-in-predicting-the-success-of-full-pulpotomy-in-symptomatic-permanent-mature-molars-100619129","NCT07340606","The Role of the Pre-operative Condition and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature Molars","The Role of Wolters Pulpitis Classification, Apical Periodontitis, and Artificial Intelligence-Assisted Diagnosis in Predicting the Success of Full Pulpotomy in Symptomatic Permanent Mature Molars: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Mature permanent molars with irreversible pulpitis.\n* Presence of bleeding from all canals.\n* The tooth is not periodontally compromised.\n\nExclusion Criteria:\n\n* Non-vital teeth.\n* Uncontrolled bleeding from any of the canals after ten minutes of application of hemostatic agent.\n* Molars with immature roots.","20 Years",{"count":196,"type":20},58,[23],"This study aims to evaluate the effect of prognostic factors, such as the severity of pulpal inflammation, carious pulp exposure, and the presence of apical periodontitis, on the success of full pulpotomy in mature permanent molars with irreversible pulpitis. It also aims to investigate the role of artificial intelligence-assisted diagnosis in predicting the prognosis of full pulpotomy.",[26],[201,202,203,204],"irreversible pulpitis","full pulpotomy","artificial intelligence","apical periodontitis","2026-01-17",{"date":207,"type":38},"2026-01-21",{"date":205,"type":38},{"date":210,"type":20},"2026-09-01",{"name":212,"class":45},"Misr International University",2,{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":221,"minAge":55,"maxAge":56,"enrollmentInfo":222,"targetDuration":4,"studyType":21,"phases":224,"briefSummary":225,"conditions":226,"keywords":227,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":46},"100616509","effect-of-menstrual-phase-on-the-anesthetic-efficacy-100616509","NCT07306533","Effect of Menstrual Phase on the Anesthetic Efficacy","Effect of Menstrual Phase on the Anesthetic Efficacy of Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis in Mandibular Molars","Inclusion Criteria\n\n* Female patients aged 20-40 years.\n* Regular menstrual cycles (28 ± 3 days).\n* Diagnosed with symptomatic irreversible pulpitis in mandibular molars.\n* Indicated for root canal therapy.\n* Willing to provide informed consent. Exclusion Criteria\n* Use of oral contraceptives or hormonal therapy.\n* Irregular menstrual cycles.\n* Pregnancy or lactation.\n* Systemic disease affecting pain perception (e.g., diabetes, neuropathies).\n* Recent use of analgesics or sedatives (within 24 hours).\n* Allergy to local anesthetics.","FEMALE",{"count":223,"type":20},150,[23],"The goal of this observational prospective clinical study is to learn whether the menstrual phase influences the anesthetic efficacy of inferior alveolar nerve block (IANB) in female patients aged 20-40 years with symptomatic irreversible pulpitis in mandibular molars. The main questions it aims to answer are:\n\nDoes the success rate of IANB vary across different phases of the menstrual cycle?\n\nAre certain menstrual phases associated with a higher likelihood of anesthetic failure during endodontic access preparation?\n\nResearchers will compare five menstrual phase groups (menstrual, follicular, ovulatory, luteal, and premenstrual) to see if hormonal fluctuations affect anesthetic success.\n\nParticipants will:\n\nReceive a standardized inferior alveolar nerve block using 2% lidocaine with 1:80,000 epinephrine\n\nUndergo cold testing and access cavity preparation to assess anesthetic success\n\nHave intraoperative pain recorded using the Heft-Parker Visual Analog Scale (HPVAS), with menstrual phase information recorded confidentially and blinded to the treating clinician",[26],[228,229,230],"IANB","pulpitis","anesthesia","2025-12-25",{"date":233,"type":38},"2025-12-29",{"date":235,"type":38},"2025-09-11",{"date":237,"type":20},"2026-03-10",{"name":111,"class":45},{"id":240,"slug":241,"hasResults":11,"nctId":242,"briefTitle":243,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":54,"sex":15,"minAge":55,"maxAge":246,"enrollmentInfo":247,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":249,"conditions":250,"keywords":255,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":261,"lastUpdatePostDateStruct":262,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":4},"100588191","comparison-of-aquaporin--4--5--9-and-il-8-levels-in-gcf-dentin-fluid-and-pulp-samples-100588191","NCT06938191","Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples","Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in Gingival Crevicular Fluid, Dentin Fluid and Pulp Samples of Healthy and Acute Irreversible Pulpitis Teeth","Inclusion Criteria:\n\n* Patients aged 18 to 64 years.\n* Patients without any known systemic disease.\n* Patients requiring root canal treatment for prosthetic purposes (Healthy pulp group).\n* Patients with third molars (wisdom teeth) indicated for extraction due to orthodontic or other clinical reasons (Healthy pulp group).\n* Patients diagnosed with symptomatic irreversible pulpitis based on the criteria established by the American Association of Endodontists (AAE) (Symptomatic irreversible pulpitis group).\n* Patients scheduled for routine root canal treatment at the Department of Endodontics, Faculty of Dentistry, Kırıkkale University.\n* Patients who have provided written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with any known systemic disease.\n* Pregnant women or those suspected of being pregnant.\n* Patients who have used antibiotics, anti-inflammatory drugs, or antidepressants within the past 4 weeks.\n* Patients with significant dental plaque or calculus, gingival redness or bleeding, severe gingivitis, generalized periodontitis, or periodontal pockets deeper than 4 mm.\n* Patients with teeth showing internal or external root resorption.\n* Patients for whom complete rubber dam isolation cannot be achieved.\n* Patients with teeth exhibiting signs of necrosis, apical lesions, swelling, or presence of a sinus tract.\n* Patients with immature teeth presenting open apices.\n* Patients with third molars (wisdom teeth) that are not fully erupted or have been previously diagnosed with pericoronitis.","64 Years",{"count":248,"type":20},70,"This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible pulpitis and investigate whether there is a correlation between them.\n\nA total of 70 patients aged 18-64 years with healthy (Group 1) and symptomatic irreversible pulpitis (Group 2) diagnosed at Kırıkkale University, Faculty of Dentistry, Department of Endodontics who will undergo routine root canal treatment will be included in the study, with a minimum of 35 participants for each group. Before starting treatment, DOS samples will be taken from healthy, symptomatic, irreversible pulpitis-diagnosed teeth and teeth contralateral to these teeth. A dentin fluid sample will be taken by holding the membrane on the dentin surface, and the pulp tissue will be removed and transferred to Eppendorf tubes. The treatment process will be completed by applying routine root canal procedures to the teeth. The samples' Aquaporin -4, -5, -9, and IL-8 levels will be analyzed by specific enzyme-linked immunosorbent assay (ELISA).",[251,26,252,253,254],"Pulpitis","Pulp Inflammation","Healthy Pulp","Biomarkers",[256,229,201,257,258,259,260],"healthy pulp","aquaporin-4","IL-8","aquaporin-5","aquaporin-9","2025-11-27",{"date":78,"type":38},{"date":264,"type":20},"2025-12",{"date":266,"type":20},"2026-09-12",{"name":268,"class":45},"Kırıkkale University",{"id":270,"slug":271,"hasResults":11,"nctId":272,"briefTitle":273,"officialTitle":274,"acronym":4,"eligibilityCriteria":275,"healthyVolunteers":54,"sex":15,"minAge":276,"maxAge":277,"enrollmentInfo":278,"targetDuration":4,"studyType":21,"phases":280,"briefSummary":281,"conditions":282,"keywords":284,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":292,"leadSponsor":294,"locationsCount":4},"100610679","evaluation-of-pulpotomy-versus-pulpectomy-in-primary-molars-with-irreversible-pulpitis-or-necrotic-pulp-100610679","NCT07230717","Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp","Clinical and Radiographic Evaluation of Pulpotomy Versus Pulpectomy in Primary Molars With Irreversible Pulpitis or Necrotic Pulp: A Split-Mouth Randomized Clinical Trial","Inclusion Criteria\n\n* Patients in healthy medical conditions\n* Bilateral\u002Fcontralateral primary molars diagnosed with irreversible pulpitis or necrotic pulp\n* Periapical or bifurcation radiolucency\n* Chronic apical intraoral abscess\n* Sinus tract or fistula formation\n* No tooth mobility or grade I mobility\n* External root resorption less than or equal to 1\u002F3rd of the roots\n* Tooth should be restorable\n\nExclusion Criteria\n\n* Patients who are medically compromised (with systemic conditions)\n* Acute extraoral abscess\n* Grade II or III tooth mobility\n* External root resorption in more than 1\u002F3 of roots\n* Physiological root resorption of more than 1\u002F3 of the roots or near exfoliation\n* Non-restorable teeth","4 Years","8 Years",{"count":279,"type":20},30,[23],"Preserving primary teeth until their normal exfoliation time is crucial for maintaining the child's normal function, esthetics, arch integrity, and correct eruption of permanent successors. Given the growing interest in conservative procedures and the clinical need for simpler, more predictable pulp therapy outcomes in children, evaluating pulpotomy with Pulpotec as a potential alternative to pulpectomy is essential.\n\nThe aim of this study is to evaluate the clinical and radiographic success of pulpotomy using Pulpotec versus pulpectomy using Metapex, a calcium hydroxide with iodoform paste, to treat primary molars in children diagnosed with irreversible pulpitis or necrotic pulp in the Postgraduate Pediatric Dental Clinic at Ajman University, UAE. A total of 25 contralateral paired molar samples from children aged 4 to 8 will be included in this split-mouth randomized controlled study. Each child will serve as their own control, with one tooth randomized to the intervention group (Pulpotomy using Pulpotec) and the other to the control group (Pulpectomy using Metapex) to assess patients' clinical and radiographic outcomes over a 12-month follow-up period. Patients will have their dental anxiety psychometrically assessed using the RMS pictorial scale. In addition, a pulse oximeter will be used as a biological marker in the study to measure oxygen saturation and pulse rate.",[283,26,166],"Pulp Therapy",[285,169,286,201,287],"Pulpotomy","primary molars","necrotic pulp","2025-11-13",{"date":290,"type":38},"2025-11-17",{"date":78,"type":20},{"date":293,"type":20},"2027-05-01",{"name":295,"class":45},"Ajman University",{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":11,"sex":15,"minAge":119,"maxAge":302,"enrollmentInfo":303,"targetDuration":4,"studyType":21,"phases":305,"briefSummary":306,"conditions":307,"keywords":310,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":4},"100590823","comparison-of-endodontic-flare-up-in-single-visit-root-canal-treatment-versus-multiple-visit-root-canal-treatment-in-patients-visiting-scd-swat-100590823","NCT06972433","Comparison of Endodontic Flare up in Single Visit Root Canal Treatment Versus Multiple Visit Root Canal Treatment in Patients Visiting Scd, Swat.","Inclusion Criteria:\n\n* Children in the age group \\>10 years with deep caries approximating pulp on radiograph and indicated for a root canal treatment.\n* Proper bone support.\n* No evidence of severe mobility\u002Fdischarge of frank pus\n* Radiographically tooth indicated for root canal treatment.\n* Permanent first molars with periapical radiolucency not exceeding 3 mm × 3 mm in size.\n* Complete root formation.\n* Teeth in which the initial master file (K-File)binds at the apex were of ISO size 45 or less.\n\nExclusion Criteria:\n\n* Tooth\u002Fteeth with extensive periodontal pathology\u002F periapical radiolucency.\n* Teeth with evidence of internal or external root resorption involving more than one third of the root length.\n* Children with facial cellulitis or significant extraoral swelling.\n* Patients with any systemic diseases.\n* Patients who had been taking Antibiotics ,nonsteroidal anti-inflammatory drugs, corticosteroids at time of treatment.\n* Pregnant patients","60 Years",{"count":304,"type":20},344,[23],"This randomized controlled trial aims to compare the incidence of endodontic flare-ups in patients undergoing single-visit versus multiple-visit root canal treatment (RCT) at Saidu College of Dentistry, Swat. The study will recruit 344 patients aged above 10 and below 60 years, with permanent first molars indicated for RCT and meeting specific clinical and radiographic criteria. Participants will be randomly allocated into two groups: one receiving single-visit RCT and the other receiving multiple-visit RCT. Pain and flare-up incidence will be evaluated using the Visual Analog Scale (VAS) and swelling grading criteria at 6, 24, and 48 hours post-treatment. The primary outcome is the frequency of endodontic flare-ups requiring additional intervention. The study also examines the role of occlusal reduction in managing postoperative discomfort. Data will be analyzed using SPSS v23 with chi-square and Fisher's exact tests to compare outcomes. The findings aim to inform evidence-based protocols for endodontic treatment in the local population.",[308,309,26],"Postoperative Complication","Root Canal Therapy",[311],"enddoontic flare-ups, root canal therapy, single visit root canal treatment, multiple visit root canal treatment","2025-05-13",{"date":314,"type":38},"2025-05-15",{"date":316,"type":20},"2026-01-01",{"date":318,"type":20},"2026-06-30",{"name":320,"class":45},"College of Physicians and Surgeons Pakistan",{"id":322,"slug":323,"hasResults":11,"nctId":324,"briefTitle":325,"officialTitle":326,"acronym":4,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":15,"minAge":55,"maxAge":328,"enrollmentInfo":329,"targetDuration":4,"studyType":21,"phases":331,"briefSummary":332,"conditions":333,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":46},"100586277","outcome-of-pulpotomy-with-mta-and-biodentin-in-permanent-teeth-with-caries-exposure-100586277","NCT06913283","Outcome of Pulpotomy With MTA and Biodentin in Permanent Teeth With Caries Exposure","Outcome of Pulpotomy Using Mineral Trioxide Aggregate and Biodentin in the Mature Permanent Teeth With Carious Exposure","Inclusion Criteria:\n\n* mature permanent teeth\n\nExclusion Criteria:\n\n* Teeth with restorations","40 Years",{"count":330,"type":20},136,[23],"The success of pulpotomy treatment is affected by the type of biologically active material used.The effects of MTA and biodentine are compared in mature permanent teeth with caries exposure.It is expected that pulpotomy using biodentine will have a high success rate in caries exposed mature teeth compared to mineral trioxide aggregate.",[26],"2025-04-20",{"date":336,"type":38},"2025-04-24",{"date":338,"type":20},"2025-05-02",{"date":340,"type":20},"2025-07",{"name":342,"class":45},"Altamash Institute of Dental Medicine",{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":4,"eligibilityCriteria":349,"healthyVolunteers":11,"sex":15,"minAge":276,"maxAge":350,"enrollmentInfo":351,"targetDuration":4,"studyType":21,"phases":352,"briefSummary":353,"conditions":354,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":4},"100587504","clinical-and-radiographic-evaluation-of-pulpotomy-using-neoputty-mta-versus-pulpectomy-using-metapex-in-vital-primary-molars-diagnosed-with-symptomatic-irreversible-pulpitis-in-children-aged-4-to-9-years-100587504","NCT06929247","Clinical and Radiographic Evaluation of Pulpotomy Using Neoputty MTA Versus Pulpectomy Using Metapex in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis in Children Aged 4 to 9 Years.","Clinical and Radiographic Evaluation of Pulpotomy Using Neoputty MTA Versus Pulpectomy Using Metapex in Vital Primary Molars Diagnosed With Symptomatic Irreversible Pulpitis in Children Aged 4 to 9 Years: A Randomized Controlled Trial","Inclusion Criteria:\n\n* 1\\. Symptoms typical of irreversible pulpitis, such as spontaneous, unprovoked pain lasting from a few seconds to several hours prior to the dental visit, or pain exacerbated by hot and\u002For cold stimuli that lingers even after the stimuli are removed.\n\n  2\\. Confirmation of tooth vitality post-deroofing the pulp chamber, indicated by the presence of uniformly reddish-pink vascular tissue (healthy pulp) upon visual inspection of pulpal hemorrhage.\n\n  3\\. Confirmation of radicular pulp health post-coronal pulp amputation, demonstrated by achieving radicular pulp hemostasis within 8 minutes using a 5% sodium hypochlorite (NaOCl)-dampened cotton pellet.\n\n  4\\. The primary molar must be restorable with a stainless-steel crown. 5. Any physiological root resorption present must be less than one-third of the normal root length.\n\nExclusion Criteria:\n\n* 1\\. Clinical signs of pulpal infection, such as pathologic tooth mobility, parulis\u002Ffistula, or soft tissue swelling.\n\n  2\\. Pre-operative periapical radiographs indicating furcal radiolucency extending more than half the distance from the furcation to the periapical area.\n\n  3\\. Pre-operative periapical radiographs showing periapical radiolucency. 4. Pre-operative periapical radiographs indicating pathological root resorption.\n\n  5\\. Signs of necrosis in pulp tissue post-deroofing, such as avascular or minimally bleeding pulp, or yellowish necrotic areas\u002Fpurulent exudate.\n\n  6\\. Evidence of extensive radicular pulp inflammation post-coronal pulp amputation, indicated by bleeding that continues after 8 minutes of compression with a NaOCl-soaked cotton pellet.\n\n  7\\. Parents unwilling to place full coverage crowns post-treatment. 8. If both primary molars in the quadrant are painful and the clinical diagnosis of irreversible pulpitis between the teeth is not sharply defined.","9 Years",{"count":248,"type":20},[23],"itle: Evaluation of Pulpotomy using Neoputty MTA vs. Pulpectomy using Metapex in Children (4-9 years).\n\nObjective: Compare clinical and radiographic success of pulpotomy vs. pulpectomy for vital primary molars with irreversible pulpitis.\n\nDesign: Randomized controlled trial with 2-arm parallel groups.\n\nParticipants: Healthy children aged 4-9 with specific inclusion\u002Fexclusion criteria.\n\nOutcomes: Primary (pain relief, absence of complications) and secondary (radiographic success).",[26],"2025-04-14",{"date":357,"type":38},"2025-04-16",{"date":359,"type":20},"2025-04",{"date":361,"type":20},"2026-04",{"name":363,"class":45},"Mohamed Nashaat Mohamed",{"id":365,"slug":366,"hasResults":11,"nctId":367,"briefTitle":368,"officialTitle":368,"acronym":4,"eligibilityCriteria":369,"healthyVolunteers":54,"sex":15,"minAge":276,"maxAge":350,"enrollmentInfo":370,"targetDuration":4,"studyType":21,"phases":372,"briefSummary":373,"conditions":374,"keywords":4,"overallStatus":125,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":381,"locationsCount":4},"100586991","clinical-and-radiographic-success-of-pulpotomy-using-neoputty-mineral-trioxide-aggregate-versus-pulpectomy-using-endoflas-in-primary-molars-with-irreversible-pulpitis-a-randomized-controlled-trial-100586991","NCT06922578","Clinical and Radiographic Success of Pulpotomy Using Neoputty Mineral Trioxide Aggregate Versus Pulpectomy Using Endoflas In Primary Molars With Irreversible Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children with spontaneous pain lasting a few seconds to several hours.\n* Pain is intensified by thermal stimulus and persists after its removal.\n* Pulp hemorrhage after performing access cavity and deroofing of pulp chamber showing reddish pink healthy pulp tissue.\n* Radicular pulp health is verified by achieving hemostasis within six minutes of compression using a cotton pellet with 2% sodium hypochlorite.\n* Absence of peri-apical or inter-radicular radiolucency, widening of periodontal ligament space, internal or external root resorption.\n\nExclusion Criteria:\n\n* Unrestorable primary molars.\n* Primary molars with uncontrolled pulp hemorrhage or pulp necrosis.\n* Medically compromised patients who have systemic disease.\n* Uncooperative children who refuse treatment.",{"count":371,"type":20},66,[23],"The goal of this randomized clinical trial is to evaluate the clinical and radiographic success of pulpotomy using Neoputty MTA vital primary molars diagnosed with symptomatic irreversible pulpitis.\n\nThe main question it aims to answer is:\n\nWill Neoputty MTA pulpotomy have higher clinical and radiographic success in comparison to Endoflas pulpectomy in primary molars with irreversible pulpitis?",[26],"2025-04-03",{"date":377,"type":38},"2025-04-10",{"date":379,"type":20},"2025-05-01",{"date":105,"type":20},{"name":134,"class":45},{"id":383,"slug":384,"hasResults":11,"nctId":385,"briefTitle":386,"officialTitle":387,"acronym":388,"eligibilityCriteria":389,"healthyVolunteers":54,"sex":15,"minAge":276,"maxAge":390,"enrollmentInfo":391,"targetDuration":4,"studyType":21,"phases":392,"briefSummary":393,"conditions":394,"keywords":398,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":400,"lastUpdatePostDateStruct":401,"startDateStruct":403,"completionDateStruct":405,"leadSponsor":406,"locationsCount":213},"100581779","zinc-oxide-ozonated-olive-oil-in-lstr-100581779","NCT06854744","Zinc Oxide Ozonated Olive Oil in LSTR","Zinc Oxide Ozonated Oil Versus Modified Triple Antibiotic Paste as a Lesion Sterilization and Tissue Repair Technique in Primary Molars","Zn-OO\u002FMTAP","Inclusion Criteria: 1- Cooperative patients in the age group of (4-7) years with no associated systemic illness.\n\n2- Bilateral mandibular primary molars showing signs and symptoms of pulp necrosis or chronic pulp infection with\u002Fwithout hemorrhage, suppuration, or purulence.\n\n3- Spontaneous pain or tenderness to percussion. 4- Presence of chronic apical abscess, sinus tract, or grade I mobility. 5-The tooth should be restorable. 6- Radiographic characteristics are:\n\n1. Widening of Periodontal ligament space.\n2. Radicular involvement.\n3. Furcation involvement less than or equal to half of the shortest root in the vertical dimension\n\n   \\-\n\n   Exclusion Criteria: Exclusion criteria :\n   1. Physiologic root resorption is more than one-third of its length.\n   2. Excessive internal resorption.\n   3. Non-restorable teeth exhibiting greater than grade I mobility.\n   4. Perforation into the bifurcation.\n   5. Any underlying pathological lesion.\n   6. Any previous history of allergy to the antibiotics used in the study. -","7 Years",{"count":279,"type":20},[23],"This study will be carried out to evaluate and compare the clinical and radiographic effect of zinc oxide-ozonated olive oil (ZnO-OO) versus Modified Triple Antibiotic Paste (MTAP) as a Lesion Sterilization and Tissue Repair Technique in Primary Molars",[26,395,396,397],"Ozone","Pulp Disease, Dental","Primary Teeth",[399],"ZnOO \u002FMTAP","2025-02-25",{"date":402,"type":38},"2025-03-03",{"date":404,"type":38},"2024-01-15",{"date":359,"type":20},{"name":407,"class":45},"Tanta University",{"id":409,"slug":410,"hasResults":11,"nctId":411,"briefTitle":412,"officialTitle":413,"acronym":4,"eligibilityCriteria":414,"healthyVolunteers":54,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":415,"targetDuration":4,"studyType":21,"phases":417,"briefSummary":418,"conditions":419,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":425,"leadSponsor":427,"locationsCount":46},"100555589","prognostic-biomarkers-for-pulpotomy-outcome-100555589","NCT06514053","Prognostic Biomarkers for Pulpotomy Outcome","Discovering Prognostic Biomarkers for Pulpotomy Outcome in Permanent Mature Teeth With Irreversible Pulpitis","Inclusion Criteria:\n\n* Permanent molars showing clinical and radiographic evidence of a deep carious lesion (extend to the three-quarters thickness of dentine radiographically) extending close to the pulp chamber\n* Clinical diagnosis of irreversible pulpitis, including spontaneous pain, lingering pain with cold stimulation, no or mild tenderness to percussion, normal apical tissue or widening of the periodontal ligament space but with no signs of periapical periodontitis (i.e., PAI score 1 or 2)\n* Positive response to cold and electric pulp test.\n\nExclusion Criteria:\n\n* Tooth with no response to the cold and electric tests, presence of apical radiolucency (greater than periodontal widening), signs of canal calcification and resorption, history of trauma, unrestorable or nonfunctional teeth, and evidence of perio-endo lesion\n* Intraoperative bleeding time is more than 10 minutes or less than 10 μL pulpal blood can be obtained\n* Patients with a compromised immune status (such as HIV or organ transplant) or with any history of taking analgesics\u002Fantibiotics in the past one week.",{"count":416,"type":20},192,[23],"This study will recruit 180 molars diagnosed with irreversible pulpitis. Full pulpotomy will be performed on 120 teeth, while RCT (root canal treatment) will be conducted on another cohort of 60 teeth as the control for assessing long-term outcomes. Additionally, 12 blood samples and pulp tissues from healthy teeth receiving elective RCT will be collected as the controls. The first pulpal blood sample will be collected after caries removal and pulp exposure. Subsequently, the entire coronal pulp tissue will be removed and collected for histological examination, image-based spatial and scRNA-seq analyses. A second pulpal blood sample will be collected from the radicular pulp tissue. Both blood samples will be used to profile the inflammation-related biomarkers through multiplex immunoassays. The remaining pulp tissue will be covered by Biodentine and restored with resin-based composite. Pulpotomy treatment outcomes will be evaluated clinically and radiographically at 6 and 12 months. The biomarkers identified in the pulpal blood and histology and the single-cell transcriptomes of the coronal pulp will be compared with the treatment \"success\" and \"failure\" groups upon one year. The outcome of RCT will be compared with that of full pulpotomy at 24 months.",[26],"2024-07-20",{"date":422,"type":38},"2024-07-23",{"date":424,"type":38},"2024-01-01",{"date":426,"type":20},"2026-12",{"name":428,"class":45},"The University of Hong Kong"]