[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulpitis---reversible\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulpitis---reversible":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,59,89,111,137,162],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":36,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100644947","oxymetazoline-versus-sodium-hypochlorite-as-hemostatic-agents-in-mta-pulpotomy-of-primary-molars-100644947",false,"NCT07675330","Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars","Comparative Evaluation of Clinical and Radiographic Success of Oxymetazoline Versus Sodium Hypochlorite as Hemostatic Agents in MTA Pulpotomy of Primary Molars in a Group of Egyptian Children: A Randomized Controlled Trial","OXY - MTA","Inclusion Criteria:\n\n• Patients: Egyptian children with carious mandibular primary molars aged 4-8 years.\n\n• Teeth: Restorable mandibular primary molars with no clinical signs or symptoms of irreversible pulpitis.\n\n• Pre-operative Radiograph: No radiographic signs of internal or external root resorption and no furcation or periapical radiolucencies.\n\n\\-\n\nExclusion Criteria:\n\n* • Patients:\n\n  1. Uncooperative children.\n  2. Medically compromised children.\n  3. Patients whose parents refuse to participate or refuse to sign the informed consent.\n\n     * Teeth:\n\n  \u003C!-- -->\n\n  1. Previously accessed molars.\n  2. Mobile primary molars.\n  3. Presence of sinus tract or pain on percussion.","ALL","4 Years","8 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to evaluate clinical and radiographic success of oxymetazoline versus sodium hypochlorite as hemostatic agents in MTA pulpotomy of primary molars.",[28,29,30,31,32,33,34,35],"Pulp Disease, Dental","Pulp Therapy in Primary Molars","Pulpitis - Reversible","Pulp Inflammation","Vital Pulp Therapies","Carious Exposure of Pulp","Primary Molar Tooth","Primary Molar Pulpotomy",[37,38,39,40,41,42,43,44,45],"Pulp therapy in primary molars","pulpotomy","MTA pulpotomy for primary molars","Sodium hypochlorite","Oxymetazoline","Hemostatic agents","NaOCl","Oxy","Oxymetazoline nasal spray","NOT_YET_RECRUITING","2026-06-26",{"date":49,"type":50},"2026-06-30","ACTUAL",{"date":52,"type":22},"2026-08",{"date":54,"type":22},"2027-12",{"name":56,"class":57},"Cairo University","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":4,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":17,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":4,"studyType":23,"phases":69,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":58},"100643718","comparison-of-the-efficacy-of-inferior-alveolar-nerve-block-and-digital-anesthesia-in-pulpectomy-of-mandibular-permanent-molars-in-children-100643718","NCT07634900","Comparison of the Efficacy of Inferior Alveolar Nerve Block and Digital Anesthesia in Pulpectomy of Mandibular Permanent Molars in Children","Inclusion Criteria:\n\n* Children aged 6-14 years\n* Patients presenting with acute dental pain\n* Patients requiring emergency endodontic treatment in mandibular permanent molars\n* Cooperative patients who allowed clinical procedures\n* Patients whose parents\u002Flegal guardians provided informed consent\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting pain perception\n* Patients with known allergy to local anesthetic agents\n* Patients who used analgesics within 12 hours before treatment\n* Patients with non-restorable teeth\n* Patients with a history of behavioral management problems preventing treatment","6 Years","14 Years",{"count":68,"type":22},128,[25],"This study aims to compare the effectiveness of inferior alveolar nerve block (IANB) and computer-controlled digital anesthesia in achieving adequate anesthesia in pediatric patients presenting with acute dental pain and requiring emergency endodontic treatment of mandibular permanent molars. Achieving profound anesthesia in such cases can be challenging due to acute inflammation.\n\nParticipants will be randomly assigned to receive either conventional IANB or digital anesthesia. Pain perception during the procedure will be assessed using validated pain scales. In addition, physiological parameters including heart rate and blood pressure will be recorded to evaluate the stress response associated with each anesthesia technique. Anesthesia success will be determined based on the absence of pain during treatment and the need for supplemental anesthesia.\n\nThe findings of this study are expected to provide evidence-based guidance for selecting the most effective and comfortable anesthesia technique in pediatric dental patients.",[72,30],"Pulpitis - Irreversible",[74,75,76,77,78],"Inferior alveolar nerve block","Digital anesthesia","Pediatric dentistry","Mandibular molar","Pain assessment","RECRUITING","2026-06-08",{"date":82,"type":50},"2026-06-09",{"date":84,"type":50},"2026-04-01",{"date":86,"type":22},"2027-03-20",{"name":88,"class":57},"Inonu University",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":17,"minAge":66,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":100,"phases":4,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100628780","observational-cross-sectional-study-aiming-to-determine-the-correlation-between-pulpal-status-and-il-8-and-presepsin-levels-in-the-pulpal-blood-100628780","NCT07466095","Observational Cross-sectional Study Aiming to Determine the Correlation Between Pulpal Status and IL-8 and Presepsin Levels in the Pulpal Blood.","Assessing the Differential Performance of the Inflammatory Biomarkers Interleukin-8 and Presepsin in Patients Exhibiting Clinical Symptoms Suggestive of Reversible and Irreversible Pulpitis: A Preliminary Cross -Sectional Study","Cross-section","Inclusion Criteria:\n\n* Male and female patients. Age between 14 years and 50 years . Diagnosis established in accordance with the American Association of Endodontists (AAE) (2013) for normal pulp, reversible pulpitis, or symptomatic irreversible pulpitis. Participants will be asked if they wish to be included in the study (implying informed consent).\n\nNormal pulp Sound, unrestored non-carious vital teeth will be included. The teeth with healthy pulp. The teeth indicated for orthodontic extraction or elective root canal treatment before prosthodontic intervention.\n\nThere with no clinical signs or symptoms of pulpitis. There with no history of pain. The response to the cold test within normal limits. No sensitivity to percussion. No periodontal ligament space widening (Periapical Index (PAI) = 1). Teeth with Reversible Pulpitis \\[RP\\] Medically healthy patients will be included.\n\nPatients with extremely deep carious lesion (according to Bjørndal, 2017) One or more of the following signs and symptoms present:\n\nClinical symptoms of minor intensity. Slightly exaggerated reaction to cold or sweet stimuli. No history of spontaneous pain. Response to the cold test within normal limits. No sensitivity to chewing. No sensitivity to percussion. No widening of the periodontal ligament space (Periapical Index (PAI) = 1). Teeth with Irreversible Pulpitis \\[IRP\\] Medically healthy patients will be included. Patients with extremely deep carious lesion\n\nOne or more of the following signs and symptoms were present:\n\nHistory of continuous moderate or severe pain. Either provoked or spontaneous lingering pain initiated by provocation (cold test).\n\nTenderness to chewing or percussion. No widening of the periodontal ligament space (Periapical Index (PAI) = 1) (Orstavik,1988)\n\nExclusion Criteria:\n\n* Absence of a response to pulp sensibility tests. Non-restorable teeth. Periodontal involvement. Presence of a sinus tract. Presence of periapical pathology on radiograph. Presence of resorption (external or internal). Cracked teeth. Immature teeth with an open apex. Presence of any systemic disease. Pregnant females. History of intake of Non-Steroidal Anti-inflammatory Drugs (NSAIDs) or antibiotics within the last 1 week.\n\nPatients who needed prophylactic antibiotics. No pulp exposure after complete caries removal. Inadequate blood volume collection after pulpal exposure.",true,"50 Years",{"count":21,"type":22},"OBSERVATIONAL","Observational cross-sectional study aims to determine the correlation between pulpal status and IL-8 and Presepsin levels in the pulpal blood.",[72,30],"2026-03-08",{"date":105,"type":50},"2026-03-12",{"date":107,"type":22},"2026-11-01",{"date":109,"type":22},"2027-12-01",{"name":56,"class":57},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":58},"100622692","pelargonium-graveolens-essential-oil-as-a-pulpotomy-agent-in-primary-teeth-100622692","NCT07386925","Pelargonium Graveolens Essential Oil as a Pulpotomy Agent in Primary Teeth","Clinical and Radiographic Evaluation of Pelargonium Graveolens Essential Oil as a Pulpotomy Agent in Primary Teeth","Inclusion Criteria:\n\n* Restorable primary molars with deep carious lesions.\n* Absence of gingival swelling or sinus tract.\n* Absence of spontaneous pain\n* Absence of pain on percussion.\n* Absence of discontinuity of lamina dura\n* Absence of internal root resorption.\n* Absence of external root resorption.\n* Absence of inter-radicular or periapical bone destruction (radiolucency).\n\nExclusion Criteria:\n\n* presence of spontaneous pain\n* presence of gingival swelling or sinus tract\n* presence of internal or external root resorption\n* pain on percussion.","7 Years",{"count":120,"type":22},30,[25],"The success of pulpotomy in primary teeth is critical for preserving function and arch integrity in children and depends largely on the biological properties of the medicament used. Given the limitations of mineral trioxide aggregate, Pelargonium graveolens essential oil has emerged as a potential alternative; however, its clinical performance as a pulpotomy agent remains insufficiently investigated.",[30,124],"Pulpotomies on Primary Molars",[126,38,127],"Pelargonium graveolens","MTA","2026-01-28",{"date":130,"type":50},"2026-02-04",{"date":132,"type":22},"2026-02",{"date":134,"type":22},"2026-11",{"name":136,"class":57},"Tanta University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":152,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":58},"100606106","evaluation-of-cytokines-level-as-an-indicator-of-pulp-inflammation-and-its-relation-to-the-success-rates-of-pulpotomy-in-primary-molars-affected-with-proximal-versus-occlusal-decay-100606106","NCT07171229","Evaluation of Cytokines Level as an Indicator of Pulp Inflammation and Its Relation to the Success Rates of Pulpotomy in Primary Molars Affected With Proximal Versus Occlusal Decay","Evaluation of Cytokines Level as an Indicator of Pulp Inflammation and Its Relation to the Success Rates of Pulpotomy in Primary Molars Affected With Proximal Versus Occlusal Decay: Non-Randomized Clinical Trial","Inclusion Criteria:\n\n* Children with provoked pain.\n* Caries in proximal surface to the dentine full thickness.\n* Caries in occlusal surface to the dentine full thickness.\n* Radicular pulp health is verified by achieving hemostasis within eight minutes of compression using a cotton pellet with 5% sodium hypochlorite.\n\nExclusion Criteria:\n\n* Unrestorable primary molars.\n* Primary molars with spontaneous pain.\n* Medically compromised patients who have systemic disease.\n* Uncooperative children who refuse treatment.\n* Children whose parents are unwilling to place stainless steel crowns.\n* Children whose parents or caregivers refuse to participate in the study or are unable to attend follow-up visits.","9 Years",{"count":146,"type":22},58,[25],"pulpotomy will be done I primary molars with occlusal or proximal decay and level of cytokines will be measured as an indicator for pulp inflammation levels",[30,150,151],"Occlusal Caries","Proximal Caries",[38,153],"cytokines","2025-09-10",{"date":156,"type":50},"2025-09-12",{"date":158,"type":22},"2025-09-01",{"date":160,"type":22},"2026-10-01",{"name":56,"class":57},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":97,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":169,"targetDuration":4,"studyType":23,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":58},"100578298","clinical-and-radiographic-evaluation-of-chitosan-versus-formocresol-after-vital-pulpotomy-of-primary-molars-100578298","NCT06809478","Clinical and Radiographic Evaluation of Chitosan Versus Formocresol After Vital Pulpotomy of Primary Molars","Clinical and Radiographic Evaluation of Chitosan Versus Formocresol After Vital Pulpotomy of Primary Molars: a Randomized Clinical Study","Inclusion Criteria:\n\n* Healthy cooperative children with at least one deep carious mandibular primary molar indicated for vital pulpotomy.\n* In age range from 4 to 8 years old.\n* Both sexes will be included.\n* Patients with provoked pain.\n* Restorable teeth.\n\nExclusion Criteria:\n\n* Excessive haemorrhage that cannot be stopped by a damp cotton pellet after several minutes.\n* With congenital anomalies in teeth e.g., taurodontism, concrescence or fusion.\n* Patients who show allergic reaction to any material will be used in this trial.\n* Will not be able to stick to follow up protocol in the trial and refuse to give communication data.\n* Patient's guardians refuse to sign up an informed consent before participating in this trial.",{"count":21,"type":22},[25],"The goal of this clinical trial is to evaluate whether Chitosan liquid will show similar clinical and radiographical success rate compared to Formocresol when used in vital pulp therapy in primary molars.\n\nThe main question it aims to answer is:\n\n* Will Chitosan liquid, in comparison to Formocresol, show similar clinical outcomes in relation to presence\u002Fabsence of post-operative pain, swelling, sinus and\u002For fistula formation when used in vital pulpotomy in primary molars?\n* Will Chitosan liquid, in comparison to Formocresol, show similar radiographical outcomes in relation to presence\u002Fabsence of furcal involvement, periapical lesion, pathological root resorption and\u002For widening of periodontal membrane space when used in vital pulpotomy in primary molars?\n\nFollowing conventional pulpotomy procedure, the primary investigator will evaluate the effect of placing a cotton pellet damp with Chitosan liquid directly on radicular vital pulp compared to that of placing a cotton pellet damp with Formocresol on radicular vital pulp.\n\nPrimary teeth included in both arms of the study will be restored by zinc oxide and eugenol and covered by a stainless steel crown as final restoration.\n\nThe clinical trail will be followed up for 1 year. Clinical outcomes will be evaluated every 3 months. Radiographic outcomes will be evaluated every 6 months.",[30,173],"Pulpotomy",[38,175,176,177],"formocresol","chitosan","primary molars","2025-02-01",{"date":180,"type":50},"2025-02-05",{"date":182,"type":22},"2025-04",{"date":184,"type":22},"2026-07",{"name":56,"class":57}]