[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"pulpitis\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:pulpitis":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,46,86,110,139,163,185,218,240,265,288,311,348],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100643451","buffered-versus-conventional-local-anesthesia-for-pain-and-anxiety-reduction-in-school-aged-children-with-pulpitis-100643451",false,"NCT07638254","Buffered Versus Conventional Local Anesthesia for Pain and Anxiety Reduction in School-Aged Children With Pulpitis","Efficacy of Buffered Versus Conventional Local Anesthesia for Reducing Pain and Anxiety During Dental Treatment in School-Aged Children Diagnosed With Pulpitis: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Children aged 6 to 12 years\n* Diagnosis of irreversible pulpitis due to dental caries in primary maxillary molars\n* American Society of Anesthesiologists (ASA) Physical Status Classification I\n* Cooperative or definitely cooperative behavior according to Frankl Behavioral Scale (Frankl III or IV)\n* Written informed consent provided by parent or legal guardian, and child assent when applicable\n* No use of analgesic or anti-inflammatory medication within 24 hours prior to the procedure\n\nExclusion Criteria:\n\n* Known allergy to any component of local anesthetic solution\n* History of negative or traumatic dental experiences within the previous 12 months that may interfere with behavioral assessment\n* Radiographic evidence of periapical pathology associated with the affected tooth\n* Presence of localized abscess or acute spreading infection at the injection site",true,"ALL","6 Years","12 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The objective of this clinical trial is to evaluate whether buffered local anesthesia is more effective than conventional local anesthesia in reducing pain responses in school-aged children requiring dental treatment for pulpitis. The study will also assess differences in physiological and self-reported indicators of pain and anxiety, as well as anesthetic onset and duration.\n\nThe main questions it aims to answer are:\n\nDoes buffered local anesthesia reduce behavioral pain scores measured by the FLACC scale compared to conventional local anesthesia? Does buffered local anesthesia improve physiological and psychometric indicators of pain and anxiety during dental procedures?\n\nMethodology: The researchers will compare buffered local anesthesia with conventional local anesthesia during routine dental treatment procedures such as pulpotomy or pulpectomy in primary molars.\n\nParticipants will:\n\nReceive either buffered or conventional local anesthesia during dental treatment Undergo pulpotomy or pulpectomy depending on clinical diagnosis Be monitored for pain and anxiety using FLACC scale, heart rate, skin conductance, and Wong-Baker Faces Pain Scale at different stages of treatment Have the onset and duration of anesthesia recorded during and after the procedure Be followed until recovery of soft tissue sensation after treatment",[28],"Pulpitis",[30,31,32],"Anesthesia, Dental","Anesthesia, Local","Buffers","RECRUITING","2026-06-04",{"date":36,"type":37},"2026-06-10","ACTUAL",{"date":39,"type":37},"2026-03-02",{"date":41,"type":22},"2026-10",{"name":43,"class":44},"Universidad Autonoma de San Luis Potosí","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":45},"100634983","metagenomic-analysis-and-postoperative-pain-in-infected-root-canals-using-different-irrigation-protocols-100634983","NCT07546773","Metagenomic Analysis and Postoperative Pain in Infected Root Canals Using Different Irrigation Protocols","Metagenomic Analysis and Post-operative Pain Assessment of Infected Root Canals Using Different Irrigation Protocols: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Adult patients aged 18-60 years\n* Requiring root canal treatment for teeth with necrotic pulp\n* Presence of periapical radiolucency confirmed radiographically\n* Good general health with no systemic diseases affecting healing outcomes\n* Willing to provide informed written consent\n* Available for follow-up appointments\n\nExclusion Criteria:\n\n* Patients with open apices\n* Severe periodontal disease\n* Currently taking antibiotics\n* Allergy to study materials (lidocaine, sodium hypochlorite, methylene blue, latex)\n* Pregnant or breastfeeding women\n* Compromised immunity or systemic conditions (e.g., uncontrolled diabetes, HIV, immunosuppressive therapy)\n* Previous root canal treatment on the study tooth\n* Tooth not restorable\n* Presence of vertical root fracture","18 Years","60 Years",{"count":56,"type":22},40,[25],"Achieving effective root canal disinfection while minimizing postoperative pain is a critical goal in endodontic therapy. Advanced irrigation protocols, such as ultrasonic activation, laser activation, negative pressure irrigation (PulpSucker device), and mechanical activation (Easy Clean device), have shown promise in enhancing bacterial reduction within the root canal system. However, their impact on postoperative pain has not been fully explored.\n\nThis randomized controlled clinical trial aims to compare bacterial reduction and postoperative pain levels in infected root canals using four different irrigation protocols. The study will use metagenomic analysis to evaluate changes in bacterial community composition and the Visual Analogue Scale (VAS) to assess patient-reported pain levels at multiple time points postoperatively.",[60,28],"Dental Pulp Necrosis",[62,63,64,65,66,67,68,69,70,71,72,73,74,75],"Root canal treatment","Irrigation protocol","Ultrasonic activation","Laser activation","Negative pressure irrigation","Mechanical activation","Metagenomic analysis","Postoperative pain","Visual analogue scale","Bacterial reduction","Endodontics","PulpSucker","Easy clean device","Next generation sequencing","NOT_YET_RECRUITING","2026-04-28",{"date":79,"type":37},"2026-05-04",{"date":81,"type":22},"2026-04-30",{"date":83,"type":22},"2028-01-15",{"name":85,"class":44},"Suez Canal University",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":4},"100622122","effects-of-topical-anesthesia-approaches-on-dental-pain-during-and-after-restorative-management-of-dental-caries-100622122","NCT07379515","Effects of Topical Anesthesia Approaches on Dental Pain During and After Restorative Management of Dental Caries","Effects of Topical Anesthesia Approaches on Dental Pain During and After Restorative Management of Dental Caries - Randomized Clinical Trial","Inclusion Criteria:\n\n* Healthy participants: American Society of Anesthesiology Class I or II\n* Adults aged 18-59 years\n* No history of allergy to local anesthesia or excipients included in the vial\n* Participant requiring caries management for a maxillary premolar tooth (ICDAS I-V), with reversible pulpitis.\n\nExclusion Criteria:\n\n* American Society of Anesthesiology Class III or higher\n* Participants with systemic conditions affecting pain perception\n* Participants on chronic pain medication\n* Pregnant or breastfeeding women\n* History of allergy to topical\u002Flocal anesthesia\n* Taking any analgesic 48 hours before testing, such as an NSAID, opioids, or\n* acetaminophen\n* Recent oral trauma\n* Deep carious lesion with irreversible pulpitis or pulpal necrosis","59 Years",{"count":95,"type":22},204,[25],"The purpose of the Research Study and Overview of Participation: This study will compare different approaches used to prevent pain when giving local anesthesia to numb the teeth while managing dental cavities and decay. Specifically, it seeks to determine which approach will reduce the pain and discomfort during or after the procedure. This will help dentists to choose the best approach to reduce patient's pain and discomfort and improve the overall experience of dental treatment.\n\nParticipants in the study would likely undergo the following:\n\n1. Screening and Consent: Participants would be assessed for eligibility (e.g., age, health status, and presence of dental caries requiring treatment) and would provide informed consent.\n2. Intervention: Participants would be randomly assigned to different groups based on the type or method of topical anesthesia being tested.\n3. Treatment Procedure: Dental caries management would be performed under local anesthesia, with the designated topical anesthetic applied beforehand.\n4. Pain Assessment: Participants would rate their pain levels during and after the procedure using validated pain measurement scales (e.g., visual analog scale).\n5. Follow-Up: Participants might be monitored for a short duration post-treatment to assess any residual pain or side effects.\n\nThis design ensures that the study collects reliable data on the effectiveness of the different topical anesthetic approaches while prioritizing patient safety and comfort.",[28,99],"Pain Management","2026-04-09",{"date":102,"type":37},"2026-04-13",{"date":104,"type":22},"2026-04-15",{"date":106,"type":22},"2027-03-31",{"name":108,"class":109},"Dubai Health","OTHER_GOV",{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":4,"eligibilityCriteria":116,"healthyVolunteers":16,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":23,"phases":120,"briefSummary":121,"conditions":122,"keywords":126,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":45},"100627744","predicting-vital-pulp-treatment-outcomes-in-symptomatic-pulpits-using-metabolic-biomarker-100627744","NCT07452614","Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker","Efficacy of Metabolic Biomarkers in Predicting Twelve-Month Outcomes of Vital Pulp Treatment in Symptomatic Teeth With Carious Pulp Exposure: A Controlled Clinical Trial","Inclusion Criteria:\n\n1. Age range of 16-50 years.\n2. Pulp exposure during treatment of deep caries.\n3. Absence of periodontitis or systemic disease.\n4. Only one or two proximal surfaces lost with remaining walls \\> 2 mm; and\n5. Good compliance and signed informed consent forms.\n\nExclusion Criteria:\n\n1. Patients who meet any of the following criteria will be excluded:\n2. Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;\n3. Teeth with a negative response to cold testing\n4. Current pregnancy or breastfeeding;\n5. Poor compliance or inability to complete the trial.\n6. The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study.\n7. Inadequate blood sample collection after pulpal exposure.","16 Years","50 Years",{"count":21,"type":22},[25],"This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.",[123,28,124,125],"Pulp Disease, Dental","Reversible Pulpitis","Irreversible Pulpitis (Toothache)",[127,128,28,129],"Vital pulp treatment","Metabolic biomarker","Carious pulp exposure","2026-03-26",{"date":132,"type":37},"2026-04-01",{"date":134,"type":37},"2026-02-20",{"date":136,"type":22},"2028-10",{"name":138,"class":44},"Abeer Ghalib Abdul-khaliq",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":147,"targetDuration":149,"studyType":150,"phases":4,"briefSummary":151,"conditions":152,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":45},"100627561","measurement-of-pro-resolving-inflammation-biomarkers-in-saliva-gingival-fluid-and-dental-pulp-in-patients-with-symptomatic-pulpitis-and-healthy-controls-100627561","NCT07450235","Measurement of Pro-resolving Inflammation Biomarkers in Saliva, Gingival Fluid, and Dental Pulp in Patients With Symptomatic Pulpitis and Healthy Controls","Strategic Inflammation Modulation and Advanced Regenerative Therapy of Dental PULP","SMART-PULP","Inclusion criteria\n\n* Age ≥ 18 years, male or female.\n* Patient consulting for symptomatic pulpitis (confirmed clinical and radiographic diagnosis) or for wisdom tooth extraction (healthy subject).\n* Patient able to understand the research and having signed a written consent form.\n* Permanent teeth only.\n\nExclusion criteria\n\n* Refusal to participate.\n* Pregnancy or breastfeeding.\n* Antibiotic or anti-inflammatory treatment in the week prior to sampling.\n* Clinically diagnosed inflammatory gingival or periodontal disease (gingivitis or periodontitis)\n* Chronic systemic inflammatory disease (e.g., uncontrolled diabetes, autoimmune diseases).\n* Patients under guardianship, conservatorship, or legal protection",{"count":148,"type":22},50,"3 Years","OBSERVATIONAL","This observational study aims to better understand inflammation inside the dental pulp (the inner tissue of the tooth) in patients with symptomatic pulpitis compared with healthy individuals.\n\nResearchers will measure inflammation-related biomarkers in saliva, gingival fluid, and dental pulp samples to determine whether these substances reflect the level of inflammation.\n\nThe study also evaluates whether saliva and oral fluids could be used as simple, non-invasive tools to detect and monitor pulp inflammation.\n\nWe hypothesize that patients with pulpitis will show different biomarker levels compared with healthy controls.",[28,153],"Healthy","2026-02-26",{"date":156,"type":37},"2026-03-04",{"date":158,"type":22},"2026-03-01",{"date":160,"type":22},"2028-12",{"name":162,"class":44},"Université de Nantes",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":150,"phases":4,"briefSummary":173,"conditions":174,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":4},"100625146","clinical-and-radiographic-evaluation-of-primary-endodontic-treatment-and-non-surgical-endodontic-retreatments-100625146","NCT07418840","Clinical and Radiographic Evaluation of Primary Endodontic Treatment and Non-surgical Endodontic Retreatments","Clinical and Radiographic Evaluation of Primary Endodontic Treatments and Non-Surgical Endodontic Retreatments Performed in a Hospital Setting, a Prospective Study","CR-ET","Inclusion Criteria:\n\n* Patients requiring primary endodontic treatment or non-surgical endodontic retreatment due to symptomatic or asymptomatic irreversible pulpitis, symptomatic or asymptomatic apical periodontitis, or an acute or chronic abscess.\n* Patients aged over 18 years.\n* Signed written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Inability to undergo consistent and continuous follow-up.\n* Patients with teeth affected by vertical root fractures.\n* Patients with teeth presenting periodontal compromise requiring extraction.\n* Pregnant or breastfeeding patients.\n* Inability to provide written informed consent.",{"count":172,"type":22},75,"Background:\n\nPulpitis and apical periodontitis are inflammatory conditions of the dental pulp and periapical tissues, primarily caused by microbial invasion. The global prevalence of pulpitis is considered high but underestimated, as up to 40% of cases are asymptomatic. Similarly, the prevalence of apical periodontitis varies widely (16-86%) depending on population characteristics, systemic conditions, and socioeconomic status, and it is reported to be higher in hospital settings. Endodontic therapy aims to disinfect and seal the root canal system, promoting healing of apical periodontitis or maintaining periapical health. Reported success rates for primary and non-surgical retreatment procedures are comparable (75% and 77%, respectively), though outcomes tend to be more favorable in vital teeth compared to those with apical periodontitis (84% vs. 75%). Despite the widespread use of endodontic therapy, few studies have assessed treatment outcomes in a hospital setting.\n\nObjectives:\n\nThe primary aim of this prospective study is to evaluate the success of primary and non-surgical endodontic retreatments performed in a hospital environment.\n\nSecondary objectives include assessing (1) the survival of treated teeth, (2) patient-related outcomes (PROs), and (3) the influence of systemic diseases or ongoing therapies on treatment outcomes.\n\nMethods:\n\nThis is a monocentric, prospective, observational, study to be conducted at the Dental Clinic of the A. Gemelli University Hospital, Rome. Adult patients (\\>18 years) requiring primary or non-surgical endodontic retreatment due to symptomatic or asymptomatic irreversible pulpitis, apical periodontitis, or acute\u002Fchronic abscesses will be enrolled after providing written informed consent in accordance with the Declaration of Helsinki.\n\nExclusion criteria include inability to complete follow-up, vertical root fractures, advanced periodontal disease requiring extraction, pregnancy or breastfeeding, and inability to provide informed consent.\n\nPatients will undergo standard endodontic therapy according to the European Society of Endodontology (ESE) guidelines. Clinical and radiographic evaluations will be performed preoperatively, intraoperatively, and postoperatively. Radiographic assessments will be based on the Periapical Index (PAI), and follow-ups will occur at 6 months, 1 year, and annually for up to 4 years, with a final clinical follow-up at 5 years.\n\nPatient-related outcomes will be evaluated using the Numerical Rating Scale (NRS-12) for pain and the Oral Health Impact Profile (OHIP-14) questionnaire before treatment and at 1, 3, and 7 days post-treatment.\n\nOutcome Measures:\n\nThe primary endpoint is the rate of endodontic success, defined by the absence of clinical symptoms (pain, swelling, sinus tract, tenderness) and radiographic healing or maintenance of periapical health (Periapical Apex Index, PAI).\n\nSecondary endpoints include the incidence of postoperative complications, survival rate of treated teeth, associations between systemic conditions and endodontic outcomes, and patient-reported outcome measures.\n\nStatistical Analysis:\n\nThe sample size was calculated according to Lachin et al., assuming an expected success rate of 85%, a 5% margin of error, and 90% power, resulting in a minimum of 74 patients.\n\nQualitative variables will be expressed as frequencies and percentages, while quantitative variables will be summarized as mean ± SD or median, depending on distribution. Normality will be tested with the Kolmogorov-Smirnov test.\n\nAssociations between categorical variables will be evaluated using Pearson's χ² or Fisher's exact test, and continuous variables with Student's t-test, Mann-Whitney U, ANOVA, or Kruskal-Wallis tests as appropriate. Repeated measures ANOVA or Friedman tests will be applied to detect longitudinal changes.\n\nMixed-effects models ((G)LMM) will be used to analyze changes in PAI, NRS-12, and OHIP-14 over time while adjusting for confounders. Logistic regression will identify independent predictors of success, and Kaplan-Meier survival curves (log-rank test) will estimate tooth survival over follow-up. Significance will be set at p \\\u003C 0.05. Statistical analyses will be performed using IBM SPSS Statistics v25.0 (IBM Corp., Armonk, NY, USA).\n\nExpected Results and Conclusions:\n\nThis study is expected to provide data on the clinical and radiographic success rates of primary and non-surgical endodontic treatments performed in a hospital setting. It will also clarify the impact of systemic diseases and patient-related factors on treatment outcomes. The findings may help optimize clinical protocols and patient management strategies in hospital-based endodontic care, contributing to evidence-based improvement of dental services and patient quality of life.",[175,28],"Periapical Periodontitis","2026-02-11",{"date":178,"type":37},"2026-02-18",{"date":180,"type":22},"2026-03-15",{"date":182,"type":22},"2032-10-15",{"name":184,"class":44},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":150,"phases":4,"briefSummary":195,"conditions":196,"keywords":201,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":4},"100588191","comparison-of-aquaporin--4--5--9-and-il-8-levels-in-gcf-dentin-fluid-and-pulp-samples-100588191","NCT06938191","Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples","Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in Gingival Crevicular Fluid, Dentin Fluid and Pulp Samples of Healthy and Acute Irreversible Pulpitis Teeth","Inclusion Criteria:\n\n* Patients aged 18 to 64 years.\n* Patients without any known systemic disease.\n* Patients requiring root canal treatment for prosthetic purposes (Healthy pulp group).\n* Patients with third molars (wisdom teeth) indicated for extraction due to orthodontic or other clinical reasons (Healthy pulp group).\n* Patients diagnosed with symptomatic irreversible pulpitis based on the criteria established by the American Association of Endodontists (AAE) (Symptomatic irreversible pulpitis group).\n* Patients scheduled for routine root canal treatment at the Department of Endodontics, Faculty of Dentistry, Kırıkkale University.\n* Patients who have provided written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with any known systemic disease.\n* Pregnant women or those suspected of being pregnant.\n* Patients who have used antibiotics, anti-inflammatory drugs, or antidepressants within the past 4 weeks.\n* Patients with significant dental plaque or calculus, gingival redness or bleeding, severe gingivitis, generalized periodontitis, or periodontal pockets deeper than 4 mm.\n* Patients with teeth showing internal or external root resorption.\n* Patients for whom complete rubber dam isolation cannot be achieved.\n* Patients with teeth exhibiting signs of necrosis, apical lesions, swelling, or presence of a sinus tract.\n* Patients with immature teeth presenting open apices.\n* Patients with third molars (wisdom teeth) that are not fully erupted or have been previously diagnosed with pericoronitis.","64 Years",{"count":194,"type":22},70,"This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible pulpitis and investigate whether there is a correlation between them.\n\nA total of 70 patients aged 18-64 years with healthy (Group 1) and symptomatic irreversible pulpitis (Group 2) diagnosed at Kırıkkale University, Faculty of Dentistry, Department of Endodontics who will undergo routine root canal treatment will be included in the study, with a minimum of 35 participants for each group. Before starting treatment, DOS samples will be taken from healthy, symptomatic, irreversible pulpitis-diagnosed teeth and teeth contralateral to these teeth. A dentin fluid sample will be taken by holding the membrane on the dentin surface, and the pulp tissue will be removed and transferred to Eppendorf tubes. The treatment process will be completed by applying routine root canal procedures to the teeth. The samples' Aquaporin -4, -5, -9, and IL-8 levels will be analyzed by specific enzyme-linked immunosorbent assay (ELISA).",[28,197,198,199,200],"Pulpitis - Irreversible","Pulp Inflammation","Healthy Pulp","Biomarkers",[202,203,204,205,206,207,208],"healthy pulp","pulpitis","irreversible pulpitis","aquaporin-4","IL-8","aquaporin-5","aquaporin-9","2025-11-27",{"date":211,"type":37},"2025-12-01",{"date":213,"type":22},"2025-12",{"date":215,"type":22},"2026-09-12",{"name":217,"class":44},"Kırıkkale University",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":4,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":236,"leadSponsor":238,"locationsCount":45},"100611604","effectiveness-of-pulpotomy-vs-root-canal-treatment-in-extremely-deep-caries-100611604","NCT07242742","Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries","Effectiveness of Pulpotomy vs. Root Canal Treatment in Extremely Deep Caries: A Randomized Controlled Trial Conducted in Supervised Undergraduate Clinics","Inclusion Criteria:\n\n* Aged 12 years or older\n* Mature maxillary or mandibular permanent tooth with extremely deep restorations\u002Fcaries penetrating the entire thickness of dentine on the radiograph without a radiopaque zone separating the lesion from the pulp (Bjorndal et al., 2019)\n* Tooth may or may not be symptomatic at the time of recruitment but must be responsive to cold and EPT sensibility testing\n* Tooth is restorable and can be adequately isolated during treatment\n* One tooth per patient\n\nExclusion Criteria:\n\n* Teeth with difficult access and unpredictable isolation using a rubber dam\n* Teeth aberrant root canal morphology, extreme root curvatures (\\>30 degrees), calcified canals\u002Fsclerosed pulp\n* Teeth indicated for elective root canal treatment for restorative purposes\n* Teeth with apical periodontitis\n* Presence of apical radiolucency\n* Any evidence of purulence or excessive bleeding that cannot be controlled with a cotton pellet with 1.25% hypochlorite for 10 minutes\n* History of trauma to the tooth\n* Teeth with active periodontal disease (pocket depth \\>5mm)\n* Patients with complex medical histories that may affect their caries experience and healing ability (immunocompromised, radiotherapy etc.)\n* Patients who are pregnant or breast-feeding\n* Patients who are unable to consent",{"count":226,"type":22},93,[25],"Recent clinical trials comparing pulpotomy versus root canal treatment (RCT) have shown promising outcomes; however, the current evidence lacks generalisability to general practitioners. It remains to be elucidated whether these favourable results can be replicated in a primary care setting. This study aims to address that gap by involving senior dental students undergoing supervised university education and training, with the potential to inform future best practice guidelines and promote the adoption of vital pulp therapy (VPT) as a predictable treatment alternative in the general dental population.\n\nThe clinical procedure involves complete caries-free excavation carried out under rubber dam isolation. After confirming vital pulp status-demonstrated by bleeding upon entry, participants will be randomised to receive one of two treatments: RCT or full pulpotomy.\n\nOutcomes will include clinical and radiographic success or failure of the intervention at 12 months. Additionally, patient-reported outcomes will be collected, specifically pain experienced and the use of analgesia during the immediate post-operative period (days 3 and 7).",[230,28],"Extremely Deep Caries","2025-11-17",{"date":233,"type":37},"2025-11-21",{"date":235,"type":37},"2025-07-16",{"date":237,"type":22},"2027-07",{"name":239,"class":44},"National University Hospital, Singapore",{"id":241,"slug":242,"hasResults":11,"nctId":243,"briefTitle":244,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":247,"targetDuration":4,"studyType":23,"phases":249,"briefSummary":250,"conditions":251,"keywords":253,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":45},"100594349","postoperative-pain-evaluation-after-obturation-with-different-sealers-100594349","NCT07018284","Postoperative Pain Evaluation After Obturation With Different Sealers","Assessment of Postoperative Pain Incidence in Teeth Affected by Pulpitis, Necrosis, or Previously Treated, Following Obturation With Bioceramic or Resin-based Sealers","Inclusion Criteria:\n\nPatients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.\n\nExclusion Criteria:\n\n* Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).\n* Asymptomatic presentation\n* Teeth with root fractures, resorption, or open apices.\n* Incomplete clinical or radiographic records.\n* Cases with poor-quality radiographs or lack of standardization for evaluation",{"count":248,"type":22},270,[25],"This study aims to evaluate the incidence and intensity of postoperative pain in patients undergoing root canal treatment on teeth diagnosed with pulpitis, pulp necrosis, or with previous endodontic treatment. Teeth will be obturated using either bioceramic or resin-based sealers. The primary objective is to determine whether the type of sealer significantly influences the level of postoperative pain as reported by patients. Pain intensity will be assessed using the Visual Analogue Scale (VAS) at three time points: immediately after treatment, 24 hours, and 72 hours postoperatively. The findings are expected to provide clinical insight into which obturation material may be more effective in minimizing postoperative discomfort.",[175,28,252],"Necorsis",[254,255,72],"Bioceramic sealers","Resin-based sealers","2025-06-04",{"date":258,"type":37},"2025-06-12",{"date":260,"type":37},"2025-06-01",{"date":262,"type":22},"2026-01-30",{"name":264,"class":44},"University of Siena",{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":278,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":285,"leadSponsor":287,"locationsCount":45},"100594427","success-of-endodontic-treatment-with-different-obturation-techniques-and-sealer-cements-100594427","NCT07019298","Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements","Evaluation of the Success Rate of Endodontic Treatment Using Different Obturation Techniques and Root Canal Sealer Cements: A Randomized Controlled Trial","Inclusion Criteria:\n\nPatients aged 18 years and older. Teeth with a diagnosis of pulpal necrosis or irreversible pulpitis. Informed consent provided for data usage.\n\nExclusion Criteria:\n\n* Patients with systemic conditions that may impair healing (e.g., uncontrolled diabetes, immunosuppression).\n* Teeth with root fractures, resorption, or open apices.\n* Incomplete clinical or radiographic records.\n* Cases with poor-quality radiographs or lack of standardization for evaluation",{"count":248,"type":22},[25],"The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida, USA), as well as between two obturation techniques: continuous wave and single cone. The study includes 270 patients, with a minimum follow-up period of 6 months. Clinical and radiographic variables will be assessed, including quality of obturation, lesion healing, and restoration. The study seeks to determine if the use of bioceramic sealer is effective regardless of the obturation technique used, highlighting the importance of clinical follow-up to evaluate endodontic treatment success.",[28,276,175,277],"Periapical Lesions","Periapical Pathology",[72,279,280,281],"Endodontic Sealer","Calcium Silicate-Based Sealer","Ah Plus",{"date":283,"type":37},"2025-06-13",{"date":260,"type":37},{"date":286,"type":22},"2029-06-01",{"name":264,"class":44},{"id":289,"slug":290,"hasResults":11,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":295,"targetDuration":297,"studyType":150,"phases":4,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":45},"100580987","the-effect-of-different-risk-factors-on-the-success-rate-of-vpt-100580987","NCT06844448","The Effect of Different Risk Factors on the Success Rate of VPT","The Effect of Different Risk Factors on the Success Rate of VPT: an Observational Prospective Cohort Study","Inclusion Criteria:\n\n* Patients over 18 years of age who have at least one tooth with a pulp chamber that has been opened during a dental procedure or is likely to be opened during restoration of the tooth\n* The tooth is responsive to a sensitivity test with cold spray\n* The coronal part must be restorable\n* The periodontal depth around the tooth should be 0 according to the Dental Practicality Index Periodontal Treatment Need, i.e. the probing depth around the tooth should not be greater than 3.5 mm\n\nExclusion Criteria:\n\n* Internal\u002Fexternal resorption in the tooth\n* If the root development of the tooth is not yet complete or if it is a deciduous tooth\n* Absolute isolation cannot be performed during the procedure\n* If pulp exposure does not occur even after complete removal of caries\n* The crown of the tooth cannot be restored\n* Periodontium surrounding tooth affected by moderate\u002Fsevere marginal periodontitis (probing depth deeper than 3.5 mm)\n* Pulp exposure due to traumatic injury\n* Baseline radiograph shows signs of severe pulp palcification\n* Periapical lesion is around the root (Periapical index of the tooth \\>2)",{"count":296,"type":22},400,"4 Years","This study aims to evaluate the effectiveness of various vital pulp therapy (VPT) methods, such as direct pulp capping, partial pulpotomy, and total pulpotomy, in maintaining pulp vitality following pulp exposure. It explores the success rates of these treatments compared and investigates co-factors influencing these rates, including age. This prospective cohort study involves patients over 18 with restorable teeth and exposed pulp chambers. Success is measured through clinical and radiological criteria over a follow-up period of up to four years. The study also aims to identify if there's an age threshold affecting the preference for VPT over root canal therapy.",[300,123,301,124,28],"Dental Caries Extending to Pulp","Irreversible Pulpitis","2025-03-03",{"date":304,"type":37},"2025-03-06",{"date":306,"type":37},"2024-06-01",{"date":308,"type":22},"2030-06-01",{"name":310,"class":44},"Semmelweis University",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":17,"minAge":149,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":23,"phases":320,"briefSummary":321,"conditions":322,"keywords":328,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":4},"100567965","caries-location-and-its-effect-on-the-success-rate-of-indirect-pulp-treatment-in-primary-molars-100567965","NCT06675058","Caries Location and Its Effect on the Success Rate of Indirect Pulp Treatment in Primary Molars","Caries Location and Its Effect on the Success Rate of Indirect Pulp Treatment in Primary Molars: A Comparative Clinical Study","Inclusion Criteria:\n\n* Participant criteria:\n\n  1. Children aged between 3-7 years\n  2. Children in complete physical and mental health.\n  3. Children with free medical history.\n  4. Patient with favorable attitudes, which will be assessed by using Frankl behavior rating.\n\nTeeth criteria:\n\n1. Primary molars with active occlusal or proximal deep caries.\n2. Teeth with reversible pulpitis\n3. Asymptomatic teeth or teeth with provoked pain of short duration\n4. Teeth should be restorable.\n\nExclusion Criteria:\n\n* Clinical signs or symptoms suggesting evidence of pulp degeneration or a non -vital tooth such as:\n\n  * Clinical symptoms or history indicating irreversible pulpitis as (spontaneous pain, throbbing pain).\n  * Tenderness to percussion.\n  * Soft tissue swelling, abscess, draining fistula or sinus tracts.\n  * Pathological Tooth mobility.\n\nPresence of the following Radiographic criteria:\n\n* Periapical or inter-radicular radiolucency.\n* Internal or external pathological root resorption.\n* Furcation involvement\n* Widening of periodontal space.","7 Years",{"count":148,"type":22},[25],"The following study will be created to evaluate how the location of caries affects the effectiveness of indirect pulp treatment in primary molars. aiding in the development of evidence-based recommendations for pediatric dentists.",[323,324,325,326,124,28,327],"Deep Caries Lesion of Primary Teeth","Dental Pulp Diseases","Deep Proximal Caries","Deep Occlusal Caries","Decayed Teeth",[329,330,331,332,333,334,335,336,124,28,337,338],"Indirect Pulp Treatment","IPT","Caries location","Caries Site","Proximal and occlusal Caries","Proximal Caries","Occlusal Caries","Pulp Therapy","deciduous teeth","Caries in milk teeth","2024-11-04",{"date":341,"type":37},"2024-11-05",{"date":343,"type":22},"2024-12-01",{"date":345,"type":22},"2026-08-18",{"name":347,"class":44},"Cairo University",{"id":349,"slug":350,"hasResults":11,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":4,"eligibilityCriteria":354,"healthyVolunteers":16,"sex":17,"minAge":355,"maxAge":356,"enrollmentInfo":357,"targetDuration":4,"studyType":23,"phases":359,"briefSummary":360,"conditions":361,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":4},"100552053","evaluation-of-pulpotomy-using-two-different-agents-in-mature-anterior-teeth-with-pulpitis-100552053","NCT06468085","Evaluation of Pulpotomy Using Two Different Agents in Mature Anterior Teeth With Pulpitis","Clinical and Radiographic Evaluation of Premixed Bioceramic Putty and Biodentine™ Pulpotomy in Mature Permanent Anterior Teeth With Signs of Pulpitis: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Children and adolescents of both sexes aged between 9 and 14 years old.\n* Vital mature permanent anterior teeth with deep caries lesions that approach the pulp with signs of pulpitis and respond positive to cold pulp testing.\n* Vital mature permanent anterior teeth with pulpal exposure that occurred during caries excavation.\n* Patients presented immediately after suffering recent trauma (at the same day) to mature anterior teeth that had resulted in a crown fracture with pulp exposure.\n\nExclusion Criteria:\n\n* Teeth with signs of infection such as swelling, sinus tract or pathological mobility or excessive mobility.\n* Teeth with excessive bleeding from amputated radicular stumps\n* Teeth showing radiographic evidence of pathologic root resorption, periapical pathology and calcifications in the canals.\n* Lack of patient\u002Fparent compliance and cooperation.\n* Children who are physically or mentally disabled or having any medical condition that will complicate the treatment.\n* Patients allergic to any medicaments used.","9 Years","14 Years",{"count":358,"type":22},48,[25],"the study will evaluate the clinical and radiological success of mature permanent anterior teeth pulpotomy in children and adolescents with signs of pulpitis using two different Biomimetic materials (NeoPutty® and Biodentine™) as a pulp dressing material in comparison to root canal treatment at 3, 6, 9 and 12 months follow up.",[28],"2024-06-20",{"date":364,"type":37},"2024-06-21",{"date":366,"type":22},"2024-07-01",{"date":368,"type":22},"2026-07-01",{"name":370,"class":44},"Ain Shams University"]